The Effects of Bilateral Subthalamic Nucleus Stimulation on Cognitive and Neuropsychiatric Functions in Parkinson’s Disease: A Case-Control Study #
Identifieur interne : 000099 ( Main/Exploration ); précédent : 000098; suivant : 000100The Effects of Bilateral Subthalamic Nucleus Stimulation on Cognitive and Neuropsychiatric Functions in Parkinson’s Disease: A Case-Control Study #
Auteurs : Reza Mahdavi [Iran] ; Seyed Malakouti [Iran] ; Gholam Shahidi [Iran] ; Mansour Parvaresh [Iran]Source :
- Basic and Clinical Neuroscience [ 2008-126X ] ; 2013.
Abstract
Parkinson's disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (STN), much progress has been made in the treatment of drug resistant patient. This new method of neurosurgery may have some neuropsychological side effects on the patients. The main aim of this study is to evaluate the effects of this kind of treatment on the different neuropsychological aspect of patients.
The case-control study designed for comparing two groups of patients with Parkinson's disease. Thirty patients, who underwent electrode implantation and Deep Brain Stimulation (DBS), compare with 60 patients treated with antiparkinson's drugs. These two groups matched in age, sex, Parkinson's disease duration and Parkinson's severity scores. Measurements: the UPDR scale was used to assess the severity of the Parkinson's severity. Beck Depression Inventory questionnaire (BDI) and Hamilton Anxiety Rating Scale questionnaire (HARS) were used to evaluate the depression and anxiety consequences of DBS.
Mini Mental Status Examination (MMSE) and Clock Drawing Test (CDT) were used to evaluate the cognitive and executive function of the study subjects.
Patients with STN stimulation showed lower level of anxiety and depression, however, the cognitive status were more deteriorated in study subjects than control group.
Patient with DBS surgery have to be followed up for neuropsychiatric symptoms particularly for the cognitive deterioration in long term period.
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PubMed: 25337350
PubMed Central: 4202573
Affiliations:
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Institute- Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran Psychiatric Institute- Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Shahidi, Gholam Ali" sort="Shahidi, Gholam Ali" uniqKey="Shahidi G" first="Gholam" last="Shahidi">Gholam Shahidi</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Department of Neurology, Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurology, Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Parvaresh Rizi, Mansour" sort="Parvaresh Rizi, Mansour" uniqKey="Parvaresh Rizi M" first="Mansour" last="Parvaresh">Mansour Parvaresh</name><affiliation wicri:level="1"><nlm:aff id="AF0004">Department of neurosurgery, Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of neurosurgery, Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25337350</idno><idno type="pmc">4202573</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202573</idno><idno type="RBID">PMC:4202573</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000261</idno><idno type="wicri:Area/Pmc/Curation">000261</idno><idno type="wicri:Area/Pmc/Checkpoint">000059</idno><idno type="wicri:Area/Ncbi/Merge">000473</idno><idno type="wicri:Area/Ncbi/Curation">000473</idno><idno type="wicri:Area/Ncbi/Checkpoint">000473</idno><idno type="wicri:doubleKey">2008-126X:2013:Mahdavi R:the:effects:of</idno><idno type="wicri:Area/Main/Merge">000099</idno><idno 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first="Seyed" last="Malakouti">Seyed Malakouti</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Tehran Psychiatric Institute- Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran Psychiatric Institute- Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Shahidi, Gholam Ali" sort="Shahidi, Gholam Ali" uniqKey="Shahidi G" first="Gholam" last="Shahidi">Gholam Shahidi</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Department of Neurology, Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurology, Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Parvaresh Rizi, Mansour" sort="Parvaresh Rizi, Mansour" uniqKey="Parvaresh Rizi M" first="Mansour" last="Parvaresh">Mansour Parvaresh</name><affiliation wicri:level="1"><nlm:aff id="AF0004">Department of neurosurgery, Tehran University of Medical Science, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of neurosurgery, Tehran University of Medical Science, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Basic and Clinical Neuroscience</title><idno type="ISSN">2008-126X</idno><idno type="e-ISSN">2228-7442</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title><p>Parkinson's disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (STN), much progress has been made in the treatment of drug resistant patient. This new method of neurosurgery may have some neuropsychological side effects on the patients. The main aim of this study is to evaluate the effects of this kind of treatment on the different neuropsychological aspect of patients.</p></sec><sec id="st2"><title>Methods</title><p>The case-control study designed for comparing two groups of patients with Parkinson's disease. Thirty patients, who underwent electrode implantation and Deep Brain Stimulation (DBS), compare with 60 patients treated with antiparkinson's drugs. These two groups matched in age, sex, Parkinson's disease duration and Parkinson's severity scores. Measurements: the UPDR scale was used to assess the severity of the Parkinson's severity. Beck Depression Inventory questionnaire (BDI) and Hamilton Anxiety Rating Scale questionnaire (HARS) were used to evaluate the depression and anxiety consequences of DBS.</p><p>Mini Mental Status Examination (MMSE) and Clock Drawing Test (CDT) were used to evaluate the cognitive and executive function of the study subjects.</p></sec><sec id="st3"><title>Results</title><p>Patients with STN stimulation showed lower level of anxiety and depression, however, the cognitive status were more deteriorated in study subjects than control group.</p></sec><sec id="st4"><title>Discussion</title><p>Patient with DBS surgery have to be followed up for neuropsychiatric symptoms particularly for the cognitive deterioration in long term period.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mahdavi, Reza" sort="Mahdavi, Reza" uniqKey="Mahdavi R" first="Reza" last="Mahdavi">Reza Mahdavi</name></noRegion><name sortKey="Malakouti, Seyed Kazem" sort="Malakouti, Seyed Kazem" uniqKey="Malakouti S" first="Seyed" last="Malakouti">Seyed Malakouti</name><name sortKey="Parvaresh Rizi, Mansour" sort="Parvaresh Rizi, Mansour" uniqKey="Parvaresh Rizi M" first="Mansour" last="Parvaresh">Mansour Parvaresh</name><name sortKey="Shahidi, Gholam Ali" sort="Shahidi, Gholam Ali" uniqKey="Shahidi G" first="Gholam" last="Shahidi">Gholam Shahidi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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