Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson’s Disease
Identifieur interne : 000029 ( Main/Exploration ); précédent : 000028; suivant : 000030Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson’s Disease
Auteurs : Na Ko [États-Unis] ; Christopher Laine [États-Unis] ; Beth Fisher [États-Unis] ; Francisco Valero [États-Unis]Source :
- Frontiers in Aging Neuroscience ; 2015.
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting about 1–2% of the population over the age of 65. Individuals with PD experience gradual deterioration of dexterous manipulation for activities of daily living; however, current clinical evaluations are mostly subjective and do not quantify changes in dynamic control of fingertip force that is critical for manual dexterity. Thus, there is a need to develop clinical measures to quantify those changes with aging and disease progression. We investigated the dynamic control of fingertip forces in both hands of 20 individuals with PD (69.0 ± 7.4 years) using the Strength–Dexterity test. The test requires low forces (<3 N) to compress a compliant and slender spring prone to buckling. A maximal level of sustained compression is informative of the greatest instability the person can control, and thus is indicative of the integrity of the neuromuscular system for dexterous manipulation. Miniature sensors recorded fingertip force (F) during maximal sustained compressions. The force variability during sustained compression was quantified in two frequency bands: low (<4 Hz, F_LF) and high (4–12 Hz, F_HF). F_LF characterizes variability in voluntary fluctuations, while F_HF characterizes variability in involuntary fluctuations including tremor. The more-affected hand exhibited significantly lower F and lower F_LF than those in the less-affected hand. The more-affected hand showed significant negative correlations between F_LF and the Unified Parkinson’s Disease Rating Scale motor scores for both total and hand-only, suggesting that greater force variability in the voluntary range was associated with less clinical motor impairment. We conclude the nature of force variability in the voluntary range during this dynamic and dexterous task may be a biomarker of greater motor capability/flexibility/adaptability in PD. This approach may provide a more quantitative clinical assessment of changes of sensorimotor control in individuals with PD.
Url:
DOI: 10.3389/fnagi.2015.00151
PubMed: 26321947
PubMed Central: 4530309
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson’s Disease</title><author><name sortKey="Ko, Na Hyeon" sort="Ko, Na Hyeon" uniqKey="Ko N" first="Na" last="Ko">Na Ko</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Neuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laine, Christopher M" sort="Laine, Christopher M" uniqKey="Laine C" first="Christopher" last="Laine">Christopher Laine</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fisher, Beth E" sort="Fisher, Beth E" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Neuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valero Cuevas, Francisco J" sort="Valero Cuevas, Francisco J" uniqKey="Valero Cuevas F" first="Francisco" last="Valero">Francisco Valero</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26321947</idno><idno type="pmc">4530309</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530309</idno><idno type="RBID">PMC:4530309</idno><idno type="doi">10.3389/fnagi.2015.00151</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000014</idno><idno type="wicri:Area/Pmc/Curation">000014</idno><idno type="wicri:Area/Pmc/Checkpoint">000015</idno><idno type="wicri:Area/Ncbi/Merge">000514</idno><idno type="wicri:Area/Ncbi/Curation">000514</idno><idno type="wicri:Area/Ncbi/Checkpoint">000514</idno><idno type="wicri:Area/Main/Merge">000029</idno><idno type="wicri:Area/Main/Curation">000029</idno><idno type="wicri:Area/Main/Exploration">000029</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Force Variability during Dexterous Manipulation in Individuals with Mild to Moderate Parkinson’s Disease</title><author><name sortKey="Ko, Na Hyeon" sort="Ko, Na Hyeon" uniqKey="Ko N" first="Na" last="Ko">Na Ko</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Neuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laine, Christopher M" sort="Laine, Christopher M" uniqKey="Laine C" first="Christopher" last="Laine">Christopher Laine</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fisher, Beth E" sort="Fisher, Beth E" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Neuroplasticity and Neuroimaging Laboratory, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Valero Cuevas, Francisco J" sort="Valero Cuevas, Francisco J" uniqKey="Valero Cuevas F" first="Francisco" last="Valero">Francisco Valero</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Brain-Body Dynamics Laboratory, Department of Biomechanical Engineering, Division of Biokinesiology and Physical Therapy, University of Southern California Los Angeles</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="e-ISSN">1663-4365</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting about 1–2% of the population over the age of 65. Individuals with PD experience gradual deterioration of dexterous manipulation for activities of daily living; however, current clinical evaluations are mostly subjective and do not quantify changes in dynamic control of fingertip force that is critical for manual dexterity. Thus, there is a need to develop clinical measures to quantify those changes with aging and disease progression. We investigated the dynamic control of fingertip forces in both hands of 20 individuals with PD (69.0 ± 7.4 years) using the Strength–Dexterity test. The test requires low forces (<3 N) to compress a compliant and slender spring prone to buckling. A maximal level of sustained compression is informative of the greatest instability the person can control, and thus is indicative of the integrity of the neuromuscular system for dexterous manipulation. Miniature sensors recorded fingertip force (F) during maximal sustained compressions. The force variability during sustained compression was quantified in two frequency bands: low (<4 Hz, F_LF) and high (4–12 Hz, F_HF). F_LF characterizes variability in voluntary fluctuations, while F_HF characterizes variability in involuntary fluctuations including tremor. The more-affected hand exhibited significantly lower F and lower F_LF than those in the less-affected hand. The more-affected hand showed significant negative correlations between F_LF and the Unified Parkinson’s Disease Rating Scale motor scores for both total and hand-only, suggesting that greater force variability in the voluntary range was associated with less clinical motor impairment. We conclude the nature of force variability in the voluntary range during this dynamic and dexterous task may be a biomarker of greater motor capability/flexibility/adaptability in PD. This approach may provide a more quantitative clinical assessment of changes of sensorimotor control in individuals with PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cody, F" uniqKey="Cody F">F. Cody</name></author><author><name sortKey="Macdermott, N" uniqKey="Macdermott N">N. Macdermott</name></author><author><name sortKey="Matthews, P" uniqKey="Matthews P">P. Matthews</name></author><author><name sortKey="Richardson, H C" uniqKey="Richardson H">H. C. Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cole, K J" uniqKey="Cole K">K. J. Cole</name></author><author><name sortKey="Abbs, J H" uniqKey="Abbs J">J. H. Abbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooke, J" uniqKey="Cooke J">J. Cooke</name></author><author><name sortKey="Brown, J" uniqKey="Brown J">J. Brown</name></author><author><name sortKey="Brooks, V" uniqKey="Brooks V">V. 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Newell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valero Cuevas, F J" uniqKey="Valero Cuevas F">F. J. Valero-Cuevas</name></author><author><name sortKey="Smaby, N" uniqKey="Smaby N">N. Smaby</name></author><author><name sortKey="Venkadesan, M" uniqKey="Venkadesan M">M. Venkadesan</name></author><author><name sortKey="Peterson, M" uniqKey="Peterson M">M. Peterson</name></author><author><name sortKey="Wright, T" uniqKey="Wright T">T. Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valero Cuevas, F J" uniqKey="Valero Cuevas F">F. J. Valero-Cuevas</name></author><author><name sortKey="Zajac, F E" uniqKey="Zajac F">F. E. Zajac</name></author><author><name sortKey="Burgar, C G" uniqKey="Burgar C">C. G. Burgar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkadesan, M" uniqKey="Venkadesan M">M. Venkadesan</name></author><author><name sortKey="Guckenheimer, J" uniqKey="Guckenheimer J">J. Guckenheimer</name></author><author><name sortKey="Valero Cuevas, F J" uniqKey="Valero Cuevas F">F. J. Valero-Cuevas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vereijken, B" uniqKey="Vereijken B">B. Vereijken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vollmer, B" uniqKey="Vollmer B">B. Vollmer</name></author><author><name sortKey="Holmstrom, L" uniqKey="Holmstrom L">L. Holmström</name></author><author><name sortKey="Forsman, L" uniqKey="Forsman L">L. Forsman</name></author><author><name sortKey="Krumlinde Sundholm, L" uniqKey="Krumlinde Sundholm L">L. Krumlinde-Sundholm</name></author><author><name sortKey="Valero Cuevas, F J" uniqKey="Valero Cuevas F">F. J. Valero-Cuevas</name></author><author><name sortKey="Forssberg, H" uniqKey="Forssberg H">H. Forssberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weintraub, D" uniqKey="Weintraub D">D. Weintraub</name></author><author><name sortKey="Comella, C L" uniqKey="Comella C">C. L. Comella</name></author><author><name sortKey="Horn, S" uniqKey="Horn S">S. Horn</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Ko, Na Hyeon" sort="Ko, Na Hyeon" uniqKey="Ko N" first="Na" last="Ko">Na Ko</name></noRegion><name sortKey="Fisher, Beth E" sort="Fisher, Beth E" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Ko, Na Hyeon" sort="Ko, Na Hyeon" uniqKey="Ko N" first="Na" last="Ko">Na Ko</name><name sortKey="Laine, Christopher M" sort="Laine, Christopher M" uniqKey="Laine C" first="Christopher" last="Laine">Christopher Laine</name><name sortKey="Valero Cuevas, Francisco J" sort="Valero Cuevas, Francisco J" uniqKey="Valero Cuevas F" first="Francisco" last="Valero">Francisco Valero</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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