Molecular diagnostics of neurodegenerative disorders
Identifieur interne : 000023 ( Main/Exploration ); précédent : 000022; suivant : 000024Molecular diagnostics of neurodegenerative disorders
Auteurs : Megha Agrawal [États-Unis] ; Abhijit Biswas [États-Unis]Source :
- Frontiers in Molecular Biosciences ; 2015.
Abstract
Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.
Url:
DOI: 10.3389/fmolb.2015.00054
PubMed: 26442283
PubMed Central: 4585189
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular diagnostics of neurodegenerative disorders</title><author><name sortKey="Agrawal, Megha" sort="Agrawal, Megha" uniqKey="Agrawal M" first="Megha" last="Agrawal">Megha Agrawal</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biology, University of Arkansas at Little Rock</institution><country>Little Rock, AR, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Biswas, Abhijit" sort="Biswas, Abhijit" uniqKey="Biswas A" first="Abhijit" last="Biswas">Abhijit Biswas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical Engineering, Center for Nano Science and Technology, University of Notre Dame</institution><country>Notre Dame, IN, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26442283</idno><idno type="pmc">4585189</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585189</idno><idno type="RBID">PMC:4585189</idno><idno type="doi">10.3389/fmolb.2015.00054</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000020</idno><idno type="wicri:Area/Pmc/Curation">000020</idno><idno type="wicri:Area/Pmc/Checkpoint">000014</idno><idno type="wicri:Area/Ncbi/Merge">000517</idno><idno type="wicri:Area/Ncbi/Curation">000517</idno><idno type="wicri:Area/Ncbi/Checkpoint">000517</idno><idno type="wicri:Area/Main/Merge">000023</idno><idno type="wicri:Area/Main/Curation">000023</idno><idno type="wicri:Area/Main/Exploration">000023</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular diagnostics of neurodegenerative disorders</title><author><name sortKey="Agrawal, Megha" sort="Agrawal, Megha" uniqKey="Agrawal M" first="Megha" last="Agrawal">Megha Agrawal</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Biology, University of Arkansas at Little Rock</institution><country>Little Rock, AR, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Biswas, Abhijit" sort="Biswas, Abhijit" uniqKey="Biswas A" first="Abhijit" last="Biswas">Abhijit Biswas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Electrical Engineering, Center for Nano Science and Technology, University of Notre Dame</institution><country>Notre Dame, IN, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Molecular Biosciences</title><idno type="e-ISSN">2296-889X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alvarez Erviti, L" uniqKey="Alvarez Erviti L">L. 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Tjian</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Agrawal, Megha" sort="Agrawal, Megha" uniqKey="Agrawal M" first="Megha" last="Agrawal">Megha Agrawal</name></noRegion><name sortKey="Biswas, Abhijit" sort="Biswas, Abhijit" uniqKey="Biswas A" first="Abhijit" last="Biswas">Abhijit Biswas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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