Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?
Identifieur interne : 001F16 ( Main/Curation ); précédent : 001F15; suivant : 001F17Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?
Auteurs : B. Pillon [France] ; B. Dubois [France] ; G. Cusimano [France] ; A Bonnet [France] ; F. Lhermitte [France] ; Y. Agid [France]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 1989-02.
Abstract
In order to investigate the neuronal basis of cognitive disorders in Parkinson's disease, the neuropsychological performance of 120 patients with idiopathic Parkinson's disease was analysed in relation to motor symptoms as a function of their response to levodopa. Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. The correlations suggest that much of the cognitive impairment in Parkinson's disease results from the dysfunction of non-dopaminergic neuronal systems.
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- https://api.istex.fr/document/C3251A1FA229A2D74258EB10D0085E0901E386D8/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032506
DOI: 10.1136/jnnp.52.2.201
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Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. 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Agid</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Clinique de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="1989-02">1989-02</date><biblScope unit="volume">52</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="201">201</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">C3251A1FA229A2D74258EB10D0085E0901E386D8</idno><idno type="DOI">10.1136/jnnp.52.2.201</idno><idno type="href">jnnp-52-201.pdf</idno><idno type="PMID">2703838</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to investigate the neuronal basis of cognitive disorders in Parkinson's disease, the neuropsychological performance of 120 patients with idiopathic Parkinson's disease was analysed in relation to motor symptoms as a function of their response to levodopa. Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. The correlations suggest that much of the cognitive impairment in Parkinson's disease results from the dysfunction of non-dopaminergic neuronal systems.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?</title><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author><author><name sortKey="Cusimano, G" sort="Cusimano, G" uniqKey="Cusimano G" first="G" last="Cusimano">G. Cusimano</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A" last="Bonnet">A Bonnet</name></author><author><name sortKey="Lhermitte, F" sort="Lhermitte, F" uniqKey="Lhermitte F" first="F" last="Lhermitte">F. Lhermitte</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Y. Agid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2703838</idno><idno type="pmc">1032506</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1032506</idno><idno type="RBID">PMC:1032506</idno><date when="1989">1989</date><idno type="wicri:Area/Pmc/Corpus">000065</idno><idno type="wicri:Area/Pmc/Curation">000065</idno><idno type="wicri:Area/Pmc/Checkpoint">000320</idno><idno type="wicri:Area/Ncbi/Merge">000538</idno><idno type="wicri:Area/Ncbi/Curation">000538</idno><idno type="wicri:Area/Ncbi/Checkpoint">000538</idno><idno type="wicri:doubleKey">0022-3050:1989:Pillon B:does:cognitive:impairment</idno><idno type="wicri:Area/Main/Merge">002063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?</title><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name></author><author><name sortKey="Cusimano, G" sort="Cusimano, G" uniqKey="Cusimano G" first="G" last="Cusimano">G. Cusimano</name></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A" last="Bonnet">A Bonnet</name></author><author><name sortKey="Lhermitte, F" sort="Lhermitte, F" uniqKey="Lhermitte F" first="F" last="Lhermitte">F. Lhermitte</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Y. Agid</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="e-ISSN">1468-330X</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In order to investigate the neuronal basis of cognitive disorders in Parkinson's disease, the neuropsychological performance of 120 patients with idiopathic Parkinson's disease was analysed in relation to motor symptoms as a function of their response to levodopa. Cognitive impairment was poorly correlated with akinesia and rigidity, symptoms which respond well to levodopa treatment, and was not correlated at all with that part of the patients' motor score that could be improved by the drug. In contrast, strong correlations were found between all neuropsychological test scores and axial symptoms such as gait disorder and dysarthria, which respond little if at all to levodopa treatment. The neuropsychological test scores were also strongly correlated with the motor score of patients estimated when clinical improvement was maximal under levodopa treatment. This score is assumed to represent residual non-dopaminergic motor dysfunctions. The correlations suggest that much of the cognitive impairment in Parkinson's disease results from the dysfunction of non-dopaminergic neuronal systems.</p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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