Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
Identifieur interne : 001490 ( Main/Curation ); précédent : 001489; suivant : 001491Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
Auteurs : Sofia Oliveira [États-Unis] ; William Scott [États-Unis] ; Martha Nance [États-Unis] ; Ray Watts [États-Unis] ; Jean Hubble [États-Unis] ; William Koller [États-Unis] ; Kelly Lyons [États-Unis] ; Rajesh Pahwa [États-Unis] ; Matthew Stern [États-Unis] ; Bradley Hiner [États-Unis] ; Joseph Jankovic [États-Unis] ; William Ondo [États-Unis] ; Fred Allen [États-Unis] ; Burton Scott [États-Unis] ; Christopher Goetz [États-Unis] ; Gary Small [États-Unis] ; Frank Mastaglia [Australie] ; Jeffrey Stajich [États-Unis] ; FENGYU ZHANG [États-Unis] ; Michael Booze [États-Unis] ; Joshua Reaves [États-Unis] ; Lefkos Middleton [Royaume-Uni] ; Jonathan Haines [États-Unis] ; Margaret Pericak [États-Unis] ; Jeffery Vance [États-Unis] ; Eden Martin [États-Unis]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Allele, Alleles, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Human, Humans, Idiopathic, Ligases (genetics), Male, Middle Aged, Parkinson Disease (genetics), Parkinson disease, Polymerase Chain Reaction, Polymerase chain reaction, Polymorphism, Single Nucleotide (genetics), Risk factor, Single nucleotide polymorphism, Ubiquitin-Protein Ligases.
- MESH :
- chemical , genetics : Ligases.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Adolescent, Adult, Aged, Alleles, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymerase Chain Reaction, Ubiquitin-Protein Ligases.
Abstract
Background: Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD. Objective: To investigate the association of 7 previously studied Parkin single-nucleotide polymorphisms (SNPs) throughout the promoter and most of the open reading frame with PD in a large cohort of patients with primarily late-onset PD. Methods: One promoter, 3 intronic, and 3 exonic Parkin SNPs were genotyped in 1580 individuals belonging to 397 families, and their association with PD was evaluated using family-based association tests. Results: No significant association (P>.05) between PD and any Parkin SNP allele or genotype was detected. Haplotype analysis and stratification by age at onset or family history also failed to produce significant results. Conclusions: These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD.
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Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Allen, Fred H Jr" sort="Allen, Fred H Jr" uniqKey="Allen F" first="Fred" last="Allen">Fred Allen</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Carolina Neurologic Clinic</s1><s2>Charlotte, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region 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type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey Stajich</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Fengyu Zhang" sort="Fengyu Zhang" uniqKey="Fengyu Zhang" last="Fengyu">FENGYU ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua Reaves</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>GlaxoSmithKline Research and Development, Green-ford</s1><s2>Middlesex</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Middlesex</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Human Genetics, Vanderbilt University Medical Center</s1><s2>Nashville, Tenn</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Nashville, Tenn</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0469596</idno><date 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type="wicri:Area/Main/Curation">001490</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association study of Parkin gene polymorphisms with idiopathic Parkinson disease</title><author><name sortKey="Oliveira, Sofia A" sort="Oliveira, Sofia A" uniqKey="Oliveira S" first="Sofia" last="Oliveira">Sofia Oliveira</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William" last="Scott">William Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Struthers Parkinson Center</s1><s2>Golden Valley, Minn</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Struthers Parkinson Center</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Emory University School of Medicine</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Ga</wicri:noRegion></affiliation></author><author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean" last="Hubble">Jean Hubble</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly Lyons</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Kansas City</wicri:noRegion></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Pennsylvania HealthSystem</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia</wicri:noRegion></affiliation></author><author><name sortKey="Hiner, Bradley C" sort="Hiner, Bradley C" uniqKey="Hiner B" first="Bradley" last="Hiner">Bradley Hiner</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Marshfield Clinic</s1><s2>Marshfield, Wis</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Marshfield, Wis</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Allen, Fred H Jr" sort="Allen, Fred H Jr" uniqKey="Allen F" first="Fred" last="Allen">Fred Allen</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Carolina Neurologic Clinic</s1><s2>Charlotte, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher Goetz</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurological Sciences, Rush-Presbyterian-St Luke's Hospital</s1><s2>Chicago, Ill</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chicago, Ill</wicri:noRegion></affiliation></author><author><name sortKey="Small, Gary W" sort="Small, Gary W" uniqKey="Small G" first="Gary" last="Small">Gary Small</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Psychiatry and Biobehavioral Sciences, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey Stajich</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Fengyu Zhang" sort="Fengyu Zhang" uniqKey="Fengyu Zhang" last="Fengyu">FENGYU ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua Reaves</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>GlaxoSmithKline Research and Development, Green-ford</s1><s2>Middlesex</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Middlesex</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Human Genetics, Vanderbilt University Medical Center</s1><s2>Nashville, Tenn</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Nashville, Tenn</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Allele</term><term>Alleles</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Human</term><term>Humans</term><term>Idiopathic</term><term>Ligases (genetics)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Polymerase Chain Reaction</term><term>Polymerase chain reaction</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk factor</term><term>Single nucleotide polymorphism</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Alleles</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymerase Chain Reaction</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Idiopathique</term><term>Allèle</term><term>Génotype</term><term>Polymorphisme mononucléotide</term><term>Réaction chaîne polymérase</term><term>Facteur risque</term><term>Homme</term><term>Gène Parkin</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD. Objective: To investigate the association of 7 previously studied Parkin single-nucleotide polymorphisms (SNPs) throughout the promoter and most of the open reading frame with PD in a large cohort of patients with primarily late-onset PD. Methods: One promoter, 3 intronic, and 3 exonic Parkin SNPs were genotyped in 1580 individuals belonging to 397 families, and their association with PD was evaluated using family-based association tests. Results: No significant association (P>.05) between PD and any Parkin SNP allele or genotype was detected. Haplotype analysis and stratification by age at onset or family history also failed to produce significant results. Conclusions: These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD.</div></front></TEI><double idat="0003-9942:2003:Oliveira S:association:study:of"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association study of Parkin gene polymorphisms with idiopathic Parkinson disease</title><author><name sortKey="Oliveira, Sofia A" sort="Oliveira, Sofia A" uniqKey="Oliveira S" first="Sofia" last="Oliveira">Sofia Oliveira</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William" last="Scott">William Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Struthers Parkinson Center</s1><s2>Golden Valley, Minn</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Struthers Parkinson Center</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Emory University School of Medicine</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Ga</wicri:noRegion></affiliation></author><author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean" last="Hubble">Jean Hubble</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly Lyons</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Kansas City</wicri:noRegion></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Pennsylvania HealthSystem</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia</wicri:noRegion></affiliation></author><author><name sortKey="Hiner, Bradley C" sort="Hiner, Bradley C" uniqKey="Hiner B" first="Bradley" last="Hiner">Bradley Hiner</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Marshfield Clinic</s1><s2>Marshfield, Wis</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Marshfield, Wis</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Allen, Fred H Jr" sort="Allen, Fred H Jr" uniqKey="Allen F" first="Fred" last="Allen">Fred Allen</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Carolina Neurologic Clinic</s1><s2>Charlotte, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher Goetz</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurological Sciences, Rush-Presbyterian-St Luke's Hospital</s1><s2>Chicago, Ill</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chicago, Ill</wicri:noRegion></affiliation></author><author><name sortKey="Small, Gary W" sort="Small, Gary W" uniqKey="Small G" first="Gary" last="Small">Gary Small</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Psychiatry and Biobehavioral Sciences, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey Stajich</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Fengyu Zhang" sort="Fengyu Zhang" uniqKey="Fengyu Zhang" last="Fengyu">FENGYU ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua Reaves</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>GlaxoSmithKline Research and Development, Green-ford</s1><s2>Middlesex</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Middlesex</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Human Genetics, Vanderbilt University Medical Center</s1><s2>Nashville, Tenn</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Nashville, Tenn</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0469596</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0469596 INIST</idno><idno type="RBID">Pascal:03-0469596</idno><idno type="wicri:Area/PascalFrancis/Corpus">000106</idno><idno type="wicri:Area/PascalFrancis/Curation">000060</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000109</idno><idno type="wicri:doubleKey">0003-9942:2003:Oliveira S:association:study:of</idno><idno type="wicri:Area/Main/Merge">001546</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association study of Parkin gene polymorphisms with idiopathic Parkinson disease</title><author><name sortKey="Oliveira, Sofia A" sort="Oliveira, Sofia A" uniqKey="Oliveira S" first="Sofia" last="Oliveira">Sofia Oliveira</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William" last="Scott">William Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Struthers Parkinson Center</s1><s2>Golden Valley, Minn</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Struthers Parkinson Center</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Emory University School of Medicine</s1><s2>Atlanta, Ga</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, Ga</wicri:noRegion></affiliation></author><author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean" last="Hubble">Jean Hubble</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly Lyons</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>Miami, Fla</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Miami, Fla</wicri:noRegion></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Kansas City</wicri:noRegion></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew" last="Stern">Matthew Stern</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Pennsylvania HealthSystem</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia</wicri:noRegion></affiliation></author><author><name sortKey="Hiner, Bradley C" sort="Hiner, Bradley C" uniqKey="Hiner B" first="Bradley" last="Hiner">Bradley Hiner</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Marshfield Clinic</s1><s2>Marshfield, Wis</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Marshfield, Wis</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, Tex</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Allen, Fred H Jr" sort="Allen, Fred H Jr" uniqKey="Allen F" first="Fred" last="Allen">Fred Allen</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Carolina Neurologic Clinic</s1><s2>Charlotte, NC</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher Goetz</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurological Sciences, Rush-Presbyterian-St Luke's Hospital</s1><s2>Chicago, Ill</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chicago, Ill</wicri:noRegion></affiliation></author><author><name sortKey="Small, Gary W" sort="Small, Gary W" uniqKey="Small G" first="Gary" last="Small">Gary Small</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Psychiatry and Biobehavioral Sciences, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey Stajich</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Fengyu Zhang" sort="Fengyu Zhang" uniqKey="Fengyu Zhang" last="Fengyu">FENGYU ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua Reaves</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>GlaxoSmithKline Research and Development, Green-ford</s1><s2>Middlesex</s2><s3>GBR</s3><sZ>22 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Middlesex</wicri:noRegion></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Human Genetics, Vanderbilt University Medical Center</s1><s2>Nashville, Tenn</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Nashville, Tenn</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allele</term><term>Genotype</term><term>Human</term><term>Idiopathic</term><term>Parkinson disease</term><term>Polymerase chain reaction</term><term>Risk factor</term><term>Single nucleotide polymorphism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Idiopathique</term><term>Allèle</term><term>Génotype</term><term>Polymorphisme mononucléotide</term><term>Réaction chaîne polymérase</term><term>Facteur risque</term><term>Homme</term><term>Gène Parkin</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD. Objective: To investigate the association of 7 previously studied Parkin single-nucleotide polymorphisms (SNPs) throughout the promoter and most of the open reading frame with PD in a large cohort of patients with primarily late-onset PD. Methods: One promoter, 3 intronic, and 3 exonic Parkin SNPs were genotyped in 1580 individuals belonging to 397 families, and their association with PD was evaluated using family-based association tests. Results: No significant association (P>.05) between PD and any Parkin SNP allele or genotype was detected. Haplotype analysis and stratification by age at onset or family history also failed to produce significant results. Conclusions: These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD.</div></front></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association study of Parkin gene polymorphisms with idiopathic Parkinson disease.</title><author><name sortKey="Oliveira, Sofia A" sort="Oliveira, Sofia A" uniqKey="Oliveira S" first="Sofia" last="Oliveira">Sofia. Oliveira</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William" last="Scott">William. Scott</name></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha" last="Nance">Martha. Nance</name></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray. Watts</name></author><author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean" last="Hubble">Jean. Hubble</name></author><author><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William" last="Koller">William. Koller</name></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly. Lyons</name></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew" last="Stern">Matthew. Stern</name></author><author><name sortKey="Hiner, Bradley C" sort="Hiner, Bradley C" uniqKey="Hiner B" first="Bradley" last="Hiner">Bradley. Hiner</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William. Ondo</name></author><author><name sortKey="Allen, Fred H" sort="Allen, Fred H" uniqKey="Allen F" first="Fred" last="Allen">Fred. Allen</name></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton. Scott</name></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher. Goetz</name></author><author><name sortKey="Small, Gary W" sort="Small, Gary W" uniqKey="Small G" first="Gary" last="Small">Gary. Small</name></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank. Mastaglia</name></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey. Stajich</name></author><author><name sortKey="Zhang, Fengyu" sort="Zhang, Fengyu" uniqKey="Zhang F" first="Fengyu" last="Zhang">Fengyu Zhang</name></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael. Booze</name></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua. Reaves</name></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos. Middleton</name></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan. Haines</name></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret. Pericak</name></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery. Vance</name></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden. Martin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12873854</idno><idno type="pmid">12873854</idno><idno type="doi">10.1001/archneur.60.7.975</idno><idno type="wicri:Area/PubMed/Corpus">000218</idno><idno type="wicri:Area/PubMed/Curation">000218</idno><idno type="wicri:Area/PubMed/Checkpoint">000221</idno><idno type="wicri:Area/Ncbi/Merge">000061</idno><idno type="wicri:Area/Ncbi/Curation">000061</idno><idno type="wicri:Area/Ncbi/Checkpoint">000061</idno><idno type="wicri:doubleKey">0003-9942:2003:Oliveira S:association:study:of</idno><idno type="wicri:Area/Main/Merge">001370</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association study of Parkin gene polymorphisms with idiopathic Parkinson disease.</title><author><name sortKey="Oliveira, Sofia A" sort="Oliveira, Sofia A" uniqKey="Oliveira S" first="Sofia" last="Oliveira">Sofia. Oliveira</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William" last="Scott">William. Scott</name></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha" last="Nance">Martha. Nance</name></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray. Watts</name></author><author><name sortKey="Hubble, Jean P" sort="Hubble, Jean P" uniqKey="Hubble J" first="Jean" last="Hubble">Jean. Hubble</name></author><author><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William" last="Koller">William. Koller</name></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly. Lyons</name></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew" last="Stern">Matthew. Stern</name></author><author><name sortKey="Hiner, Bradley C" sort="Hiner, Bradley C" uniqKey="Hiner B" first="Bradley" last="Hiner">Bradley. Hiner</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William" last="Ondo">William. Ondo</name></author><author><name sortKey="Allen, Fred H" sort="Allen, Fred H" uniqKey="Allen F" first="Fred" last="Allen">Fred. Allen</name></author><author><name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton" last="Scott">Burton. Scott</name></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher. Goetz</name></author><author><name sortKey="Small, Gary W" sort="Small, Gary W" uniqKey="Small G" first="Gary" last="Small">Gary. Small</name></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank" last="Mastaglia">Frank. Mastaglia</name></author><author><name sortKey="Stajich, Jeffrey M" sort="Stajich, Jeffrey M" uniqKey="Stajich J" first="Jeffrey" last="Stajich">Jeffrey. Stajich</name></author><author><name sortKey="Zhang, Fengyu" sort="Zhang, Fengyu" uniqKey="Zhang F" first="Fengyu" last="Zhang">Fengyu Zhang</name></author><author><name sortKey="Booze, Michael W" sort="Booze, Michael W" uniqKey="Booze M" first="Michael" last="Booze">Michael. Booze</name></author><author><name sortKey="Reaves, Joshua A" sort="Reaves, Joshua A" uniqKey="Reaves J" first="Joshua" last="Reaves">Joshua. Reaves</name></author><author><name sortKey="Middleton, Lefkos T" sort="Middleton, Lefkos T" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos. Middleton</name></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan. Haines</name></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret" last="Pericak">Margaret. Pericak</name></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery" last="Vance">Jeffery. Vance</name></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden" last="Martin">Eden. Martin</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Alleles</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Ligases (genetics)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Alleles</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymerase Chain Reaction</term><term>Ubiquitin-Protein Ligases</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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