Cognitive impairment in Parkinson’s disease
Identifieur interne : 000E44 ( Main/Curation ); précédent : 000E43; suivant : 000E45Cognitive impairment in Parkinson’s disease
Auteurs : D. Verbaan [Pays-Bas] ; J. Marinus [Pays-Bas] ; M. Visser [Pays-Bas] ; S Van [Pays-Bas] ; A Stiggelbout [Pays-Bas] ; H. Middelkoop [Pays-Bas] ; J Van [Pays-Bas]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2007-11.
Abstract
Background: Cognitive impairment plays a role in Parkinson’s disease (PD) and has important consequences for patient management. However, many aspects of cognitive impairment in PD remain unclear because of the use of different and often invalid measurement instruments. In this study, a reliable and valid instrument, the SCales for Outcomes in PArkinson’s disease-COGnition (SCOPA-COG), was used. Aim: To evaluate cognitive functioning in a large cohort of patients with Parkinson’s disease and to assess the relations with demographic, disease related and clinical variables. Methods: A cohort of 400 patients with PD was evaluated for cognition, motor and non-motor domains, as well as for demographic and disease related characteristics. Results were compared with 150 controls matched for overall age, sex and education distribution. Results: Patients with PD scored significantly lower on all cognitive subdomains compared with controls, with the largest differences for executive functioning and memory. After correction for age and years of education, 22% of patients had impaired cognition, as measured by the total SCOPA-COG score, compared with controls. Across all patients, more severe cognitive impairment was associated with significantly more impairment in motor, autonomic, depressive and psychotic domains. Patients with the postural instability gait difficulty (PIGD) dominant phenotype showed more cognitive impairment compared with patients with the tremor dominant phenotype. Contrary to tremor scores, PIGD scores significantly worsened with increasing disease severity. Conclusions: Cognition is an important domain of the clinical spectrum of PD and poorer cognitive performance is associated with greater impairment in motor and non-motor domains in PD. The difference in cognitive scores between PIGD dominant patients and tremor dominant patients likely reflects more advanced disease.
Url:
- https://api.istex.fr/document/284662A000740BA5009BA0DB2525DD680BA48A47/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117586
DOI: 10.1136/jnnp.2006.112367
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000215
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000215
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A79
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000091
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000091
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000251
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000141
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000141
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000141
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000E71
Links to Exploration step
ISTEX:284662A000740BA5009BA0DB2525DD680BA48A47Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cognitive impairment in Parkinson’s disease</title>
<author><name sortKey="Verbaan, D" sort="Verbaan, D" uniqKey="Verbaan D" first="D" last="Verbaan">D. Verbaan</name>
</author>
<author><name sortKey="Marinus, J" sort="Marinus, J" uniqKey="Marinus J" first="J" last="Marinus">J. Marinus</name>
</author>
<author><name sortKey="Visser, M" sort="Visser, M" uniqKey="Visser M" first="M" last="Visser">M. Visser</name>
</author>
<author><name sortKey="Van Rooden, S M" sort="Van Rooden, S M" uniqKey="Van Rooden S" first="S" last="Van">S Van</name>
</author>
<author><name sortKey="Stiggelbout, A M" sort="Stiggelbout, A M" uniqKey="Stiggelbout A" first="A" last="Stiggelbout">A Stiggelbout</name>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H" last="Middelkoop">H. Middelkoop</name>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J" last="Van">J Van</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:284662A000740BA5009BA0DB2525DD680BA48A47</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1136/jnnp.2006.112367</idno>
<idno type="url">https://api.istex.fr/document/284662A000740BA5009BA0DB2525DD680BA48A47/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000215</idno>
<idno type="wicri:Area/Istex/Curation">000215</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A79</idno>
<idno type="wicri:doubleKey">0022-3050:2007:Verbaan D:cognitive:impairment:in</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117586</idno>
<idno type="RBID">PMC:2117586</idno>
<idno type="wicri:Area/Pmc/Corpus">000091</idno>
<idno type="wicri:Area/Pmc/Curation">000091</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000251</idno>
<idno type="wicri:Area/Ncbi/Merge">000141</idno>
<idno type="wicri:Area/Ncbi/Curation">000141</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000141</idno>
<idno type="wicri:doubleKey">0022-3050:2007:Verbaan D:cognitive:impairment:in</idno>
<idno type="wicri:Area/Main/Merge">000E71</idno>
<idno type="wicri:Area/Main/Curation">000E44</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cognitive impairment in Parkinson’s disease</title>
<author><name sortKey="Verbaan, D" sort="Verbaan, D" uniqKey="Verbaan D" first="D" last="Verbaan">D. Verbaan</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marinus, J" sort="Marinus, J" uniqKey="Marinus J" first="J" last="Marinus">J. Marinus</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Visser, M" sort="Visser, M" uniqKey="Visser M" first="M" last="Visser">M. Visser</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Rooden, S M" sort="Van Rooden, S M" uniqKey="Van Rooden S" first="S" last="Van">S Van</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stiggelbout, A M" sort="Stiggelbout, A M" uniqKey="Stiggelbout A" first="A" last="Stiggelbout">A Stiggelbout</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Decision Making, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H" last="Middelkoop">H. Middelkoop</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neuropsychology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J" last="Van">J Van</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title>
<title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><publisher>BMJ Publishing Group Ltd</publisher>
<date type="published" when="2007-11">2007-11</date>
<biblScope unit="volume">78</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1182">1182</biblScope>
</imprint>
<idno type="ISSN">0022-3050</idno>
</series>
<idno type="istex">284662A000740BA5009BA0DB2525DD680BA48A47</idno>
<idno type="DOI">10.1136/jnnp.2006.112367</idno>
<idno type="href">jnnp-78-1182.pdf</idno>
<idno type="ArticleID">jn112367</idno>
<idno type="PMID">17442759</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3050</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">Background: Cognitive impairment plays a role in Parkinson’s disease (PD) and has important consequences for patient management. However, many aspects of cognitive impairment in PD remain unclear because of the use of different and often invalid measurement instruments. In this study, a reliable and valid instrument, the SCales for Outcomes in PArkinson’s disease-COGnition (SCOPA-COG), was used. Aim: To evaluate cognitive functioning in a large cohort of patients with Parkinson’s disease and to assess the relations with demographic, disease related and clinical variables. Methods: A cohort of 400 patients with PD was evaluated for cognition, motor and non-motor domains, as well as for demographic and disease related characteristics. Results were compared with 150 controls matched for overall age, sex and education distribution. Results: Patients with PD scored significantly lower on all cognitive subdomains compared with controls, with the largest differences for executive functioning and memory. After correction for age and years of education, 22% of patients had impaired cognition, as measured by the total SCOPA-COG score, compared with controls. Across all patients, more severe cognitive impairment was associated with significantly more impairment in motor, autonomic, depressive and psychotic domains. Patients with the postural instability gait difficulty (PIGD) dominant phenotype showed more cognitive impairment compared with patients with the tremor dominant phenotype. Contrary to tremor scores, PIGD scores significantly worsened with increasing disease severity. Conclusions: Cognition is an important domain of the clinical spectrum of PD and poorer cognitive performance is associated with greater impairment in motor and non-motor domains in PD. The difference in cognitive scores between PIGD dominant patients and tremor dominant patients likely reflects more advanced disease.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000E44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= JankovicV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:284662A000740BA5009BA0DB2525DD680BA48A47 |texte= Cognitive impairment in Parkinson’s disease }}
![]() | This area was generated with Dilib version V0.6.19. | ![]() |