The VPS35 gene and Parkinson's disease.
Identifieur interne : 000097 ( Main/Curation ); précédent : 000096; suivant : 000098The VPS35 gene and Parkinson's disease.
Auteurs : Hao Deng [République populaire de Chine] ; Kai Gao ; Joseph Jankovic [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Transcription Factors, Vesicular Transport Proteins.
- genetics : Mutation, Parkinson Disease.
- Animals, Female, Genetic Predisposition to Disease, Humans, Male.
Abstract
Parkinson's disease (PD), the second most common age-related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder.
DOI: 10.1002/mds.25430
PubMed: 23536430
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000044
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000044
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000041
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000403
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000403
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000403
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000097
Links to Exploration step
pubmed:23536430Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The VPS35 gene and Parkinson's disease.</title>
<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China. hdeng008@yahoo.com</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha</wicri:regionArea>
<wicri:noRegion>Changsha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Kai" sort="Gao, Kai" uniqKey="Gao K" first="Kai" last="Gao">Kai Gao</name>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="doi">10.1002/mds.25430</idno>
<idno type="RBID">pubmed:23536430</idno>
<idno type="pmid">23536430</idno>
<idno type="wicri:Area/PubMed/Corpus">000044</idno>
<idno type="wicri:Area/PubMed/Curation">000044</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000041</idno>
<idno type="wicri:Area/Ncbi/Merge">000403</idno>
<idno type="wicri:Area/Ncbi/Curation">000403</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000403</idno>
<idno type="wicri:Area/Main/Merge">000097</idno>
<idno type="wicri:Area/Main/Curation">000097</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The VPS35 gene and Parkinson's disease.</title>
<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China. hdeng008@yahoo.com</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha</wicri:regionArea>
<wicri:noRegion>Changsha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Kai" sort="Gao, Kai" uniqKey="Gao K" first="Kai" last="Gao">Kai Gao</name>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university" n="3">Baylor College of Medicine</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="e-ISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Mutation (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Transcription Factors (genetics)</term>
<term>Vesicular Transport Proteins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Transcription Factors</term>
<term>Vesicular Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD), the second most common age-related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000097 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000097 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= JankovicV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:23536430 |texte= The VPS35 gene and Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:23536430" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a JankovicV1
![]() | This area was generated with Dilib version V0.6.19. | ![]() |