JankovicV1, Main, Curation, bibRecord, 000015

Redox implications in adipose tissue (dys)function—A new look at old acquaintances

Identifieur interne : 000015 ( Main/Curation ); précédent : 000014; suivant : 000016

Redox implications in adipose tissue (dys)function—A new look at old acquaintances

Auteurs : Aleksandra Jankovic [Serbie] ; Aleksandra Korac [Serbie] ; Biljana Buzadzic [Serbie] ; Vesna Otasevic [Serbie] ; Ana Stancic [Serbie] ; Andreas Daiber [Allemagne] ; Bato Korac [Serbie]

Source :

Redox Biology ; 2015.

RBID : PMC:4511633

Abstract

Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to “adipocyte dysfunction”, rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511633

DOI: 10.1016/j.redox.2015.06.018
PubMed: 26177468
PubMed Central: 4511633

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PMC:4511633

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to “adipocyte dysfunction”, rather than fat mass accretion <italic>per se</italic>
, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.</p>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ristow, M" uniqKey="Ristow M">M. Ristow</name>
</author>
<author><name sortKey="Zarse, K" uniqKey="Zarse K">K. Zarse</name>
</author>
<author><name sortKey="Oberbach, A" uniqKey="Oberbach A">A. Oberbach</name>
</author>
<author><name sortKey="Kloting, N" uniqKey="Kloting N">N. Klöting</name>
</author>
<author><name sortKey="Birringer, M" uniqKey="Birringer M">M. Birringer</name>
</author>
<author><name sortKey="Kiehntopf, M" uniqKey="Kiehntopf M">M. Kiehntopf</name>
</author>
<author><name sortKey="Stumvoll, M" uniqKey="Stumvoll M">M. Stumvoll</name>
</author>
<author><name sortKey="Kahn, C R" uniqKey="Kahn C">C.R. Kahn</name>
</author>
<author><name sortKey="Bluher, M" uniqKey="Bluher M">M. Blüher</name>
</author>
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<biblStruct><analytic><author><name sortKey="Gomez Cabrera, M C" uniqKey="Gomez Cabrera M">M.C. Gomez-Cabrera</name>
</author>
<author><name sortKey="Ristow, M" uniqKey="Ristow M">M. Ristow</name>
</author>
<author><name sortKey="Vi A, J" uniqKey="Vi A J">J. Viña</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abdali, D" uniqKey="Abdali D">D. Abdali</name>
</author>
<author><name sortKey="Samson, S E" uniqKey="Samson S">S.E. Samson</name>
</author>
<author><name sortKey="Grover, A K" uniqKey="Grover A">A.K. Grover</name>
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	Serveur d'exploration autour de Joseph Jankovic
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Serveur d'exploration autour de Joseph Jankovic

Redox implications in adipose tissue (dys)function—A new look at old acquaintances

Redox implications in adipose tissue (dys)function—A new look at old acquaintances

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