Dimensionality of Parkinsonian Signs in Aging and Alzheimer's Disease
Identifieur interne : 000391 ( Istex/Corpus ); précédent : 000390; suivant : 000392Dimensionality of Parkinsonian Signs in Aging and Alzheimer's Disease
Auteurs : David Bennett ; Kathleen Shannon ; Laurel Beckett ; Robert WilsonSource :
- Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences [ 1079-5006 ] ; 1999-04.
Abstract
Background. Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously. Methods. The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race. Results. A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor. Conclusions. The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. The results provide an empirical basis for summarizing the principal motoric manifestations of parkinsonism.
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DOI: 10.1093/gerona/54.4.M191
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Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously. Methods. The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race. Results. A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor. Conclusions. The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. The results provide an empirical basis for summarizing the principal motoric manifestations of parkinsonism.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>David A. Bennett</name><affiliations><json:string>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</json:string><json:string>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</json:string></affiliations></json:item><json:item><name>Kathleen M. Shannon</name><affiliations><json:string>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</json:string></affiliations></json:item><json:item><name>Laurel A. Beckett</name><affiliations><json:string>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</json:string></affiliations></json:item><json:item><name>Robert S. Wilson</name><affiliations><json:string>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</json:string><json:string>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Articles</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background. Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously. Methods. The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race. Results. A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor. Conclusions. The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. 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Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously. Methods. The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race. Results. A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor. Conclusions. The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. The results provide an empirical basis for summarizing the principal motoric manifestations of parkinsonism.</p></abstract><textClass><keywords scheme="keyword"><list><head>heading</head><item><term>Articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-04">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-1-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/7A7C937DA5622F748C96FDC222D0297DB495A750/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">gerona</journal-id><journal-id journal-id-type="publisher-id">gerona</journal-id><journal-title>Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences</journal-title><abbrev-journal-title>Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences</abbrev-journal-title><issn pub-type="ppub">1079-5006</issn><issn pub-type="epub">1758-535X</issn><publisher><publisher-name>The Gerontological Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/gerona/54.4.M191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Dimensionality of Parkinsonian Signs in Aging and Alzheimer's Disease</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Bennett</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="AU1">1</xref><xref ref-type="aff" rid="AU2">2</xref></contrib><contrib contrib-type="author"><name><surname>Shannon</surname><given-names>Kathleen M.</given-names></name><xref ref-type="aff" rid="AU2">2</xref></contrib><contrib contrib-type="author"><name><surname>Beckett</surname><given-names>Laurel A.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Robert S.</given-names></name><xref ref-type="aff" rid="AU1">1</xref><xref ref-type="aff" rid="AU2">2</xref></contrib><aff id="AU1"><label>1</label><institution>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging</institution>, <addr-line>Chicago</addr-line></aff><aff id="AU2"><label>2</label><institution>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center</institution>, <addr-line>Chicago</addr-line></aff></contrib-group><pub-date pub-type="ppub"><month>4</month><year>1999</year></pub-date><volume>54</volume><issue>4</issue><fpage>M191</fpage><lpage>M196</lpage><history><date date-type="received"><day>30</day><month>10</month><year>1997</year></date><date date-type="accepted"><day>7</day><month>6</month><year>1998</year></date></history><copyright-statement>Copyright 1999 by The Gerontological Society of America</copyright-statement><copyright-year>1999</copyright-year><abstract><p><bold><italic>Background.</italic></bold> Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously.</p><p><bold><italic>Methods.</italic></bold> The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race.</p><p><bold><italic>Results.</italic></bold> A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor.</p><p><bold><italic>Conclusions.</italic></bold> The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. The results provide an empirical basis for summarizing the principal motoric manifestations of parkinsonism.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Dimensionality of Parkinsonian Signs in Aging and Alzheimer's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Dimensionality of Parkinsonian Signs in Aging and Alzheimer's Disease</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">David A.</namePart><namePart type="family">Bennett</namePart><affiliation>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</affiliation><affiliation>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathleen M.</namePart><namePart type="family">Shannon</namePart><affiliation>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laurel A.</namePart><namePart type="family">Beckett</namePart><affiliation>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert S.</namePart><namePart type="family">Wilson</namePart><affiliation>The Rush Alzheimer's Disease Center and Rush Institute for Healthy Aging, Chicago</affiliation><affiliation>Department of Neurological Sciences, Rush University, and Rush Presbyterian-St. Luke's Medical Center, Chicago</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article">research-article</genre><subject><genre>heading</genre><topic>Articles</topic></subject><originInfo><publisher>The Gerontological Society of America</publisher><dateIssued encoding="w3cdtf">1999-04</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background. Parkinsonian signs are commonly found on the neurologic examination of older persons and are associated with morbidity and mortality. The extent to which parkinsonian signs in aging and Alzheimer's disease cluster in groups typical of Parkinson's disease has not been investigated previously. Methods. The motor portion of the Unified Parkinson's Disease Rating Scale (UPDRS), or a version with minor modifications, was administered to more than 2,800 persons in three cohorts: (a) 637 older persons with a wide range of neurologic conditions participating in the Chicago Health and Aging Project, a study of common health problems of a random sample of older persons from a geographically defined biracial community population; (b) 638 relatively healthy and highly educated older persons from 25 Catholic religious communities participating in the Religious Orders Study, a longitudinal clinical—pathologic study of aging; and (c) 1,546 older persons undergoing evaluation for possible dementia at the Rush Alzheimer's Disease Center, an urban, tertiary care center that evaluates persons for possible dementia. Separate factor analyses were performed on each data set. Additional analyses examined the factor structure in subsets by gender and race. Results. A similar grouping of items emerged in each cohort and did not differ substantially by gender or race. The factors corresponded closely with the traditional grouping of parkinsonian signs into bradykinesia, gait disturbance, rigidity, and tremor. Conclusions. The grouping of parkinsonian signs is consistent in diverse samples of older persons and does not vary substantially across gender or race. 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