Age and secular distributions of virus-proven influenza patients in successive epidemics 1961-1976 in Cirencester: epidemiological significance discussed.
Identifieur interne : 000520 ( PubMed/Curation ); précédent : 000519; suivant : 000521Age and secular distributions of virus-proven influenza patients in successive epidemics 1961-1976 in Cirencester: epidemiological significance discussed.
Auteurs : R E Hope-SimpsonSource :
- The Journal of hygiene [ 0022-1724 ] ; 1984.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Angleterre, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Flambées de maladies (épidémiologie), Grippe humaine (microbiologie), Grippe humaine (transmission), Grippe humaine (épidémiologie), Humains, Nourrisson, Orthomyxoviridae (), Sujet âgé, Virus de la grippe A ().
- MESH :
- microbiologie : Grippe humaine.
- épidémiologie : Flambées de maladies, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Angleterre, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Humains, Nourrisson, Orthomyxoviridae, Sujet âgé, Virus de la grippe A.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Disease Outbreaks (epidemiology), England, Humans, Infant, Influenza A virus (classification), Influenza, Human (epidemiology), Influenza, Human (microbiology), Influenza, Human (transmission), Middle Aged, Orthomyxoviridae (classification).
- MESH :
- geographic : England.
- classification : Influenza A virus, Orthomyxoviridae.
- epidemiology : Disease Outbreaks, Influenza, Human.
- microbiology : Influenza, Human.
- transmission : Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Humans, Infant, Middle Aged.
Abstract
A general practice population of around 3900, under continuous clinical and laboratory surveillance, experienced 20 outbreaks of influenza between March 1960 and March 1976. Four epidemics were caused by subtype H2N2 type A viruses, seven by subtype H3N2 type A viruses and nine outbreaks by type B viruses. The age of every person proved virologically to have influenza is related to the age structure of the community and to the phase of the epidemic in which the virus-positive specimens were collected. Children 0-15 years old suffered a higher incidence rate than adults 16-90+. Pre-school children 0-4 suffered the highest rate of infection by viruses of both influenza A subtypes, whereas older schoolchildren 10-15 suffered the highest rate of type B infections. Despite these high incidence rates neither pre-school nor schoolchildren appear to have been the major disseminators of any of these influenza viruses in the community. Adults of all ages suffered a high rate of infection even into extreme old age, and the indiscriminate age distribution among adults was sustained in the successive epidemics. Such age-patterns are not those caused by a highly infectious immunizing virus surviving by means of direct transmissions from the sick, whose prompt development of the disease continues endless chains of transmissions. An alternative epidemic mechanism--whereby the virus does not spread from the sick but becomes latent in them, reactivating seasonally so that they later infect their companions--would produce age patterns similar to those recorded here for influenza patients. The suggested mechanism is illustrated by a simple conceptual model and the influenzal age patterns are discussed in relation to the recycling of influenza A subtypes.
DOI: 10.1017/s0022172400064548
PubMed: 6736641
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Four epidemics were caused by subtype H2N2 type A viruses, seven by subtype H3N2 type A viruses and nine outbreaks by type B viruses. The age of every person proved virologically to have influenza is related to the age structure of the community and to the phase of the epidemic in which the virus-positive specimens were collected. Children 0-15 years old suffered a higher incidence rate than adults 16-90+. Pre-school children 0-4 suffered the highest rate of infection by viruses of both influenza A subtypes, whereas older schoolchildren 10-15 suffered the highest rate of type B infections. Despite these high incidence rates neither pre-school nor schoolchildren appear to have been the major disseminators of any of these influenza viruses in the community. Adults of all ages suffered a high rate of infection even into extreme old age, and the indiscriminate age distribution among adults was sustained in the successive epidemics. Such age-patterns are not those caused by a highly infectious immunizing virus surviving by means of direct transmissions from the sick, whose prompt development of the disease continues endless chains of transmissions. An alternative epidemic mechanism--whereby the virus does not spread from the sick but becomes latent in them, reactivating seasonally so that they later infect their companions--would produce age patterns similar to those recorded here for influenza patients. The suggested mechanism is illustrated by a simple conceptual model and the influenzal age patterns are discussed in relation to the recycling of influenza A subtypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">6736641</PMID><DateCompleted><Year>1984</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1724</ISSN><JournalIssue CitedMedium="Print"><Volume>92</Volume><Issue>3</Issue><PubDate><Year>1984</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The Journal of hygiene</Title><ISOAbbreviation>J Hyg (Lond)</ISOAbbreviation></Journal><ArticleTitle>Age and secular distributions of virus-proven influenza patients in successive epidemics 1961-1976 in Cirencester: epidemiological significance discussed.</ArticleTitle><Pagination><MedlinePgn>303-36</MedlinePgn></Pagination><Abstract><AbstractText>A general practice population of around 3900, under continuous clinical and laboratory surveillance, experienced 20 outbreaks of influenza between March 1960 and March 1976. Four epidemics were caused by subtype H2N2 type A viruses, seven by subtype H3N2 type A viruses and nine outbreaks by type B viruses. The age of every person proved virologically to have influenza is related to the age structure of the community and to the phase of the epidemic in which the virus-positive specimens were collected. Children 0-15 years old suffered a higher incidence rate than adults 16-90+. Pre-school children 0-4 suffered the highest rate of infection by viruses of both influenza A subtypes, whereas older schoolchildren 10-15 suffered the highest rate of type B infections. Despite these high incidence rates neither pre-school nor schoolchildren appear to have been the major disseminators of any of these influenza viruses in the community. Adults of all ages suffered a high rate of infection even into extreme old age, and the indiscriminate age distribution among adults was sustained in the successive epidemics. Such age-patterns are not those caused by a highly infectious immunizing virus surviving by means of direct transmissions from the sick, whose prompt development of the disease continues endless chains of transmissions. An alternative epidemic mechanism--whereby the virus does not spread from the sick but becomes latent in them, reactivating seasonally so that they later infect their companions--would produce age patterns similar to those recorded here for influenza patients. The suggested mechanism is illustrated by a simple conceptual model and the influenzal age patterns are discussed in relation to the recycling of influenza A subtypes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hope-Simpson</LastName><ForeName>R E</ForeName><Initials>RE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Hyg (Lond)</MedlineTA><NlmUniqueID>0375374</NlmUniqueID><ISSNLinking>0022-1724</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age 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IdType="pubmed">5827480</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Microbiol Immunol. 1977;164(1-3):69-76</Citation><ArticleIdList><ArticleId IdType="pubmed">74794</ArticleId></ArticleIdList></Reference><Reference><Citation>Prog Med Virol. 1969;11:354-407</Citation><ArticleIdList><ArticleId IdType="pubmed">4313720</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1980 Jan;111(1):13-22</Citation><ArticleIdList><ArticleId IdType="pubmed">7352453</ArticleId></ArticleIdList></Reference><Reference><Citation>J Theor Biol. 1979 Jan 21;76(2):157-65</Citation><ArticleIdList><ArticleId IdType="pubmed">431093</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hyg (Lond). 1983 Jun;90(3):397-402</Citation><ArticleIdList><ArticleId IdType="pubmed">6863911</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hyg (Lond). 1979 Aug;83(1):11-26</Citation><ArticleIdList><ArticleId IdType="pubmed">458138</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hyg. 1961 Mar;73:123-37</Citation><ArticleIdList><ArticleId IdType="pubmed">13735254</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 1978 Mar 16;298(11):587-92</Citation><ArticleIdList><ArticleId IdType="pubmed">628375</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1952 Sep 20;2(6734):549-54</Citation><ArticleIdList><ArticleId IdType="pubmed">12981903</ArticleId></ArticleIdList></Reference><Reference><Citation>Br Med J. 1972 Nov 25;4(5838):490-1</Citation><ArticleIdList><ArticleId IdType="pubmed">4653894</ArticleId></ArticleIdList></Reference><Reference><Citation>Dtsch Med Wochenschr. 1976 Jan 23;101(4):130-2</Citation><ArticleIdList><ArticleId IdType="pubmed">1245171</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1954 Apr 3;266(6814):721-6</Citation><ArticleIdList><ArticleId IdType="pubmed">13143763</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1973 Jan;97(1):44-9</Citation><ArticleIdList><ArticleId IdType="pubmed">4684066</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1982 Oct;116(4):589-98</Citation><ArticleIdList><ArticleId IdType="pubmed">7137146</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1978 Jul 27;274(5669):334-9</Citation><ArticleIdList><ArticleId IdType="pubmed">672956</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hyg (Lond). 1981 Feb;86(1):35-47</Citation><ArticleIdList><ArticleId IdType="pubmed">7462597</ArticleId></ArticleIdList></Reference><Reference><Citation>Br Med J. 1970 Jul 11;3(5714):74-7</Citation><ArticleIdList><ArticleId IdType="pubmed">5428780</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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