H2N2V1, PubMed, Curation, bibRecord, 000468

Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).

Identifieur interne : 000468 ( PubMed/Curation ); précédent : 000467; suivant : 000469

Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).

Auteurs : N J Cox [États-Unis] ; F. Kitame ; A P Kendal ; H F Maassab ; C. Naeve

Source :

Virology [ 0042-6822 ] ; 1988.

RBID : pubmed:2974219

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Base Sequence, Capsid (genetics), Cold Temperature, DNA-Directed RNA Polymerases (genetics), Genes, Viral, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza Vaccines (genetics), Molecular Sequence Data, RNA, Messenger (genetics), RNA, Viral (genetics), Ribonucleoproteins (genetics), Vaccines, Attenuated (genetics), Viral Core Proteins (genetics), Viral Matrix Proteins (genetics), Viral Nonstructural Proteins, Viral Proteins (genetics).
MESH :
- chemical , genetics : DNA-Directed RNA Polymerases, Influenza Vaccines, RNA, Messenger, RNA, Viral, Ribonucleoproteins, Vaccines, Attenuated, Viral Core Proteins, Viral Matrix Proteins, Viral Proteins.
- genetics : Capsid, Influenza A virus.
- Amino Acid Sequence, Base Sequence, Cold Temperature, Genes, Viral, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data, Viral Nonstructural Proteins.

Abstract

Nucleotide sequences have been obtained for RNA segments encoding the PB2, PB1, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses.

PubMed: 2974219

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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
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<wicri:cityArea>Division of Viral Diseases, Centers for Disease Control, Atlanta</wicri:cityArea>
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<author><name sortKey="Kitame, F" sort="Kitame, F" uniqKey="Kitame F" first="F" last="Kitame">F. Kitame</name>
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<term>Base Sequence</term>
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<term>Cold Temperature</term>
<term>DNA-Directed RNA Polymerases (genetics)</term>
<term>Genes, Viral</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Molecular Sequence Data</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Viral (genetics)</term>
<term>Ribonucleoproteins (genetics)</term>
<term>Vaccines, Attenuated (genetics)</term>
<term>Viral Core Proteins (genetics)</term>
<term>Viral Matrix Proteins (genetics)</term>
<term>Viral Nonstructural Proteins</term>
<term>Viral Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN viral (génétique)</term>
<term>Basse température</term>
<term>Capside (génétique)</term>
<term>DNA-directed RNA polymerases (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines du core viral (génétique)</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales non structurales</term>
<term>Ribonucléoprotéines (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins atténués (génétique)</term>
<term>Virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Directed RNA Polymerases</term>
<term>Influenza Vaccines</term>
<term>RNA, Messenger</term>
<term>RNA, Viral</term>
<term>Ribonucleoproteins</term>
<term>Vaccines, Attenuated</term>
<term>Viral Core Proteins</term>
<term>Viral Matrix Proteins</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Capsid</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>ARN viral</term>
<term>Capside</term>
<term>DNA-directed RNA polymerases</term>
<term>Protéines de la matrice virale</term>
<term>Protéines du core viral</term>
<term>Protéines virales</term>
<term>Ribonucléoprotéines</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Base Sequence</term>
<term>Cold Temperature</term>
<term>Genes, Viral</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Molecular Sequence Data</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Basse température</term>
<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Protéines virales non structurales</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en">Nucleotide sequences have been obtained for RNA segments encoding the PB2, PB1, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses.</div>
</front>
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<Abstract><AbstractText>Nucleotide sequences have been obtained for RNA segments encoding the PB2, PB1, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses.</AbstractText>
</Abstract>
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Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).

Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).

Source :

Descripteurs français

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Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki