Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
Identifieur interne : 000466 ( PubMed/Curation ); précédent : 000465; suivant : 000467Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
Auteurs : M L Clements [États-Unis] ; S D Sears ; K. Christina ; B R Murphy ; M H SnyderSource :
- Journal of clinical microbiology [ 0095-1137 ] ; 1989.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Grippe humaine (), Gènes viraux, Humains, Relation dose-réponse (immunologie), Réplication virale, Sous-type H3N2 du virus de la grippe A, Test ELISA, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins atténués (effets indésirables), Vaccins atténués (immunologie), Vaccins synthétiques (effets indésirables), Vaccins synthétiques (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie), Électrophorèse sur gel de polyacrylamide.
- MESH :
- biosynthèse : Anticorps antiviraux.
- effets indésirables : Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques.
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- Animaux, Grippe humaine, Gènes viraux, Humains, Relation dose-réponse (immunologie), Réplication virale, Sous-type H3N2 du virus de la grippe A, Test ELISA, Tests d'inhibition de l'hémagglutination, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Dose-Response Relationship, Immunologic, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Viral, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Vaccines, Attenuated (adverse effects), Vaccines, Attenuated (immunology), Vaccines, Synthetic (adverse effects), Vaccines, Synthetic (immunology), Virus Replication.
- MESH :
- chemical , adverse effects : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Synthetic.
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Synthetic.
- physiology : Influenza A virus.
- prevention & control : Influenza, Human.
- Animals, Dose-Response Relationship, Immunologic, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Viral, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Virus Replication.
Abstract
We compared the abilities of the six internal RNA segments of two avian influenza viruses, A/Mallard/Alberta/88/76 (H3N8) and A/Mallard/NY/6750/78 (H2N2), to confer attenuation on wild-type human influenza A/Bethesda/1/85 (H3N2) virus in seronegative adult volunteers. Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.
PubMed: 2913033
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Christina</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author><author><name sortKey="Snyder, M H" sort="Snyder, M H" uniqKey="Snyder M" first="M H" last="Snyder">M H Snyder</name></author></analytic><series><title level="j">Journal of clinical microbiology</title><idno type="ISSN">0095-1137</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Dose-Response Relationship, Immunologic</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Genes, Viral</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (physiology)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Vaccines, Attenuated (adverse effects)</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Synthetic (adverse effects)</term><term>Vaccines, Synthetic (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Grippe humaine ()</term><term>Gènes viraux</term><term>Humains</term><term>Relation dose-réponse (immunologie)</term><term>Réplication virale</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Test ELISA</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (effets indésirables)</term><term>Vaccins atténués (immunologie)</term><term>Vaccins synthétiques (effets indésirables)</term><term>Vaccins synthétiques (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (physiologie)</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins synthétiques</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Immunologic</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Genes, Viral</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Grippe humaine</term><term>Gènes viraux</term><term>Humains</term><term>Relation dose-réponse (immunologie)</term><term>Réplication virale</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Test ELISA</term><term>Tests d'inhibition de l'hémagglutination</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the abilities of the six internal RNA segments of two avian influenza viruses, A/Mallard/Alberta/88/76 (H3N8) and A/Mallard/NY/6750/78 (H2N2), to confer attenuation on wild-type human influenza A/Bethesda/1/85 (H3N2) virus in seronegative adult volunteers. Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2913033</PMID><DateCompleted><Year>1989</Year><Month>03</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0095-1137</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>1</Issue><PubDate><Year>1989</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of clinical microbiology</Title><ISOAbbreviation>J. 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PubStatus="pubmed"><Year>1989</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2913033</ArticleId><ArticleId IdType="pmc">PMC267272</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Clin Microbiol. 1986 Sep;24(3):467-9</Citation><ArticleIdList><ArticleId IdType="pubmed">3760140</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1985 Jul;152(1):225-9</Citation><ArticleIdList><ArticleId IdType="pubmed">4008988</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1972 Aug;126(2):170-8</Citation><ArticleIdList><ArticleId 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