Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes.
Identifieur interne : 000383 ( PubMed/Curation ); précédent : 000382; suivant : 000384Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes.
Auteurs : S. Sambhara ; S. Woods ; R. Arpino ; A. Kurichh ; A. Tamane ; B. Underdown ; M. Klein ; K. Lövgren Bengtsson ; B. Morein ; D. BurtSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1998.
Descripteurs français
- KwdFr :
- Animaux, Complexes immunostimulants, Facteurs temps, Femelle, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (mortalité), Lymphocytes T cytotoxiques (immunologie), Relation dose-effet des médicaments, Réactions croisées, Souris, Souris de lignée BALB C, Vaccins antigrippaux, Virion (immunologie), Virus de la grippe A (), Virus de la grippe A (immunologie).
- MESH :
- immunologie : Infections à Orthomyxoviridae, Lymphocytes T cytotoxiques, Virion, Virus de la grippe A.
- mortalité : Infections à Orthomyxoviridae.
- Animaux, Complexes immunostimulants, Facteurs temps, Femelle, Infections à Orthomyxoviridae, Relation dose-effet des médicaments, Réactions croisées, Souris, Souris de lignée BALB C, Vaccins antigrippaux, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Cross Reactions, Dose-Response Relationship, Drug, Female, ISCOMs, Influenza A virus (classification), Influenza A virus (immunology), Influenza Vaccines, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (prevention & control), T-Lymphocytes, Cytotoxic (immunology), Time Factors, Virion (immunology).
- MESH :
- chemical : ISCOMs, Influenza Vaccines.
- classification : Influenza A virus.
- immunology : Influenza A virus, Orthomyxoviridae Infections, T-Lymphocytes, Cytotoxic, Virion.
- mortality : Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Cross Reactions, Dose-Response Relationship, Drug, Female, Mice, Mice, Inbred BALB C, Time Factors.
Abstract
Influenza immunostimulating complexes (flu-ISCOMs) and a monovalent subvirion vaccine prepared with an H1N1 strain of influenza virus were compared in mice for immunogenicity and protection against challenge with homologous and heterotypic influenza viruses. flu-ISCOMs but not subvirion vaccine fully protected mice against homologous virus challenge after one immunization as assessed by measurement of virus lung titers. The improved protection induced by flu-ISCOMs was associated with a 10-fold higher prechallenge serum hemagglutination inhibition titer. Furthermore, only flu-ISCOMs fully protected mice against mortality and reduced morbidity following challenge with an influenza virus of the serologically distinct H2N2 subtype. This cross-protection correlated with the induction of virus cross-reactive cytotoxic T lymphocytes that recognized a known major histocompatibility class I (H2-Kd)-restricted epitope within the hemagglutinin of influenza virus that is conserved among the H1 and H2 influenza virus subtypes. flu-ISCOMs may offer significant advantages over current commercial formulations as an improved influenza vaccine.
DOI: 10.1086/515285
PubMed: 9593011
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S. Sambhara<affiliation><nlm:affiliation>Department of Immunology, Research Center, Pasteur Mérieux Connaught Canada, Toronto.</nlm:affiliation>
<wicri:noCountry code="subField">Toronto</wicri:noCountry>
</affiliation>
Le document en format XML
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<term>Influenza A virus (classification)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines</term>
<term>Mice</term>
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<term>Complexes immunostimulants</term>
<term>Facteurs temps</term>
<term>Femelle</term>
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<term>Infections à Orthomyxoviridae (immunologie)</term>
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<front><div type="abstract" xml:lang="en">Influenza immunostimulating complexes (flu-ISCOMs) and a monovalent subvirion vaccine prepared with an H1N1 strain of influenza virus were compared in mice for immunogenicity and protection against challenge with homologous and heterotypic influenza viruses. flu-ISCOMs but not subvirion vaccine fully protected mice against homologous virus challenge after one immunization as assessed by measurement of virus lung titers. The improved protection induced by flu-ISCOMs was associated with a 10-fold higher prechallenge serum hemagglutination inhibition titer. Furthermore, only flu-ISCOMs fully protected mice against mortality and reduced morbidity following challenge with an influenza virus of the serologically distinct H2N2 subtype. This cross-protection correlated with the induction of virus cross-reactive cytotoxic T lymphocytes that recognized a known major histocompatibility class I (H2-Kd)-restricted epitope within the hemagglutinin of influenza virus that is conserved among the H1 and H2 influenza virus subtypes. flu-ISCOMs may offer significant advantages over current commercial formulations as an improved influenza vaccine.</div>
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