Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.
Identifieur interne : 000232 ( PubMed/Curation ); précédent : 000231; suivant : 000233Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.
Auteurs : Olive T W. Li [République populaire de Chine] ; Michael C W. Chan ; Cynthia S W. Leung ; Renee W Y. Chan ; Yi Guan ; John M. Nicholls ; Leo L M. PoonSource :
- PloS one [ 1932-6203 ] ; 2009.
Descripteurs français
- KwdFr :
- Adaptation biologique, Animaux, Chiens, Cytokines (métabolisme), Grippe chez les oiseaux (enzymologie), Gènes viraux, Humains, Lignée cellulaire, Luciferases (métabolisme), Mammifères (virologie), Mutation (génétique), Médiateurs de l'inflammation (métabolisme), Oiseaux, Passage en série, Poulets, Protéines virales (métabolisme), RNA replicase (métabolisme), Sous-unités de protéines (métabolisme), Sélection génétique, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique).
- MESH :
- enzymologie : Grippe chez les oiseaux, Virus de la grippe A.
- génétique : Mutation, Virus de la grippe A.
- métabolisme : Cytokines, Luciferases, Médiateurs de l'inflammation, Protéines virales, RNA replicase, Sous-unités de protéines.
- virologie : Mammifères.
- Adaptation biologique, Animaux, Chiens, Gènes viraux, Humains, Lignée cellulaire, Oiseaux, Passage en série, Poulets, Sélection génétique.
English descriptors
- KwdEn :
- Adaptation, Biological, Animals, Birds, Cell Line, Chickens, Cytokines (metabolism), Dogs, Genes, Viral, Humans, Inflammation Mediators (metabolism), Influenza A virus (enzymology), Influenza A virus (genetics), Influenza in Birds (enzymology), Luciferases (metabolism), Mammals (virology), Mutation (genetics), Protein Subunits (metabolism), RNA Replicase (metabolism), Selection, Genetic, Serial Passage, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Inflammation Mediators, Luciferases, Protein Subunits, RNA Replicase, Viral Proteins.
- enzymology : Influenza A virus, Influenza in Birds.
- genetics : Influenza A virus, Mutation.
- virology : Mammals.
- Adaptation, Biological, Animals, Birds, Cell Line, Chickens, Dogs, Genes, Viral, Humans, Selection, Genetic, Serial Passage.
Abstract
Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play roles for interspecies transmission. To test this hypothesis, we tested the compatibility between PB2, PB1, PA and NP derived from a H5N1 virus and a mammalian H1N1 virus. All 16 possible combinations of avian-mammalian chimeric viral ribonucleoproteins (vRNPs) were characterized. We showed that recombinant vRNPs with a mammalian PB2 and an avian PB1 had the strongest polymerase activities in human cells at all studied temperature. In addition, viruses with this specific PB2-PB1 combination could grow efficiently in cell cultures, especially at a high incubation temperature. These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes. Viruses with this specific PB2-PB1 combination were also found to be more capable to generate adaptive mutations under a new selection pressure. These results suggested that the viral polymerase activity might be relevant for the genesis of influenza viruses of human health concern.
DOI: 10.1371/journal.pone.0005658
PubMed: 19462010
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000232
Links to Exploration step
pubmed:19462010Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.</title>
<author><name sortKey="Li, Olive T W" sort="Li, Olive T W" uniqKey="Li O" first="Olive T W" last="Li">Olive T W. Li</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
</author>
<author><name sortKey="Leung, Cynthia S W" sort="Leung, Cynthia S W" uniqKey="Leung C" first="Cynthia S W" last="Leung">Cynthia S W. Leung</name>
</author>
<author><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W Y" last="Chan">Renee W Y. Chan</name>
</author>
<author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
</author>
<author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
</author>
<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19462010</idno>
<idno type="pmid">19462010</idno>
<idno type="doi">10.1371/journal.pone.0005658</idno>
<idno type="wicri:Area/PubMed/Corpus">000232</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000232</idno>
<idno type="wicri:Area/PubMed/Curation">000232</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000232</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.</title>
<author><name sortKey="Li, Olive T W" sort="Li, Olive T W" uniqKey="Li O" first="Olive T W" last="Li">Olive T W. Li</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name>
</author>
<author><name sortKey="Leung, Cynthia S W" sort="Leung, Cynthia S W" uniqKey="Leung C" first="Cynthia S W" last="Leung">Cynthia S W. Leung</name>
</author>
<author><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W Y" last="Chan">Renee W Y. Chan</name>
</author>
<author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name>
</author>
<author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name>
</author>
<author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Biological</term>
<term>Animals</term>
<term>Birds</term>
<term>Cell Line</term>
<term>Chickens</term>
<term>Cytokines (metabolism)</term>
<term>Dogs</term>
<term>Genes, Viral</term>
<term>Humans</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza in Birds (enzymology)</term>
<term>Luciferases (metabolism)</term>
<term>Mammals (virology)</term>
<term>Mutation (genetics)</term>
<term>Protein Subunits (metabolism)</term>
<term>RNA Replicase (metabolism)</term>
<term>Selection, Genetic</term>
<term>Serial Passage</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation biologique</term>
<term>Animaux</term>
<term>Chiens</term>
<term>Cytokines (métabolisme)</term>
<term>Grippe chez les oiseaux (enzymologie)</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Luciferases (métabolisme)</term>
<term>Mammifères (virologie)</term>
<term>Mutation (génétique)</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Oiseaux</term>
<term>Passage en série</term>
<term>Poulets</term>
<term>Protéines virales (métabolisme)</term>
<term>RNA replicase (métabolisme)</term>
<term>Sous-unités de protéines (métabolisme)</term>
<term>Sélection génétique</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Inflammation Mediators</term>
<term>Luciferases</term>
<term>Protein Subunits</term>
<term>RNA Replicase</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Grippe chez les oiseaux</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Luciferases</term>
<term>Médiateurs de l'inflammation</term>
<term>Protéines virales</term>
<term>RNA replicase</term>
<term>Sous-unités de protéines</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Mammifères</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Mammals</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Biological</term>
<term>Animals</term>
<term>Birds</term>
<term>Cell Line</term>
<term>Chickens</term>
<term>Dogs</term>
<term>Genes, Viral</term>
<term>Humans</term>
<term>Selection, Genetic</term>
<term>Serial Passage</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adaptation biologique</term>
<term>Animaux</term>
<term>Chiens</term>
<term>Gènes viraux</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Oiseaux</term>
<term>Passage en série</term>
<term>Poulets</term>
<term>Sélection génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play roles for interspecies transmission. To test this hypothesis, we tested the compatibility between PB2, PB1, PA and NP derived from a H5N1 virus and a mammalian H1N1 virus. All 16 possible combinations of avian-mammalian chimeric viral ribonucleoproteins (vRNPs) were characterized. We showed that recombinant vRNPs with a mammalian PB2 and an avian PB1 had the strongest polymerase activities in human cells at all studied temperature. In addition, viruses with this specific PB2-PB1 combination could grow efficiently in cell cultures, especially at a high incubation temperature. These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes. Viruses with this specific PB2-PB1 combination were also found to be more capable to generate adaptive mutations under a new selection pressure. These results suggested that the viral polymerase activity might be relevant for the genesis of influenza viruses of human health concern.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19462010</PMID>
<DateCompleted><Year>2009</Year>
<Month>07</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>4</Volume>
<Issue>5</Issue>
<PubDate><Year>2009</Year>
<Month>May</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.</ArticleTitle>
<Pagination><MedlinePgn>e5658</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0005658</ELocationID>
<Abstract><AbstractText>Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play roles for interspecies transmission. To test this hypothesis, we tested the compatibility between PB2, PB1, PA and NP derived from a H5N1 virus and a mammalian H1N1 virus. All 16 possible combinations of avian-mammalian chimeric viral ribonucleoproteins (vRNPs) were characterized. We showed that recombinant vRNPs with a mammalian PB2 and an avian PB1 had the strongest polymerase activities in human cells at all studied temperature. In addition, viruses with this specific PB2-PB1 combination could grow efficiently in cell cultures, especially at a high incubation temperature. These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes. Viruses with this specific PB2-PB1 combination were also found to be more capable to generate adaptive mutations under a new selection pressure. These results suggested that the viral polymerase activity might be relevant for the genesis of influenza viruses of human health concern.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Olive T W</ForeName>
<Initials>OT</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Michael C W</ForeName>
<Initials>MC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leung</LastName>
<ForeName>Cynthia S W</ForeName>
<Initials>CS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Renee W Y</ForeName>
<Initials>RW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guan</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nicholls</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Poon</LastName>
<ForeName>Leo L M</ForeName>
<Initials>LL</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>HHSN266200700005C</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HHSN266200700005C</GrantID>
<Agency>PHS HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2009</Year>
<Month>05</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C057027">PB2 protein, Influenzavirus A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D021122">Protein Subunits</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C077346">influenza virus polymerase basic protein 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.13.12.-</RegistryNumber>
<NameOfSubstance UI="D008156">Luciferases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber>
<NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000220" MajorTopicYN="Y">Adaptation, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001717" MajorTopicYN="N">Birds</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008156" MajorTopicYN="N">Luciferases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008322" MajorTopicYN="N">Mammals</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021122" MajorTopicYN="N">Protein Subunits</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012324" MajorTopicYN="N">RNA Replicase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012641" MajorTopicYN="N">Selection, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012692" MajorTopicYN="N">Serial Passage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year>
<Month>02</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2009</Year>
<Month>04</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2009</Year>
<Month>7</Month>
<Day>21</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">19462010</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0005658</ArticleId>
<ArticleId IdType="pmc">PMC2680953</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2005 Sep;79(18):11788-800</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16140756</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2005 Oct 6;437(7060):889-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16208372</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Nov;79(21):13811-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16227302</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16339318</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2005;6:135</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16283933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2006 Mar 20;203(3):689-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16533883</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Jun;80(12):5976-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16731936</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Avian Pathol. 2006 Jun;35(3):189-205</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16753610</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2006 Jul 20;351(1):210-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16624367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Med Virol. 2006 Sep-Oct;16(5):329-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16933365</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2006 Oct;12(10):1203-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16964257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Dec;80(24):11911-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17005651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Feb;81(3):1339-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17121807</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Cells. 2007 Feb;12(2):133-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17295834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 May;81(10):5315-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17344288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Dec;82(23):11880-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18815312</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008 May;4(5):e1000072</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18497857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proteomics. 2008 May;8(10):2077-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18491320</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Jul;135(1):161-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18455827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Sep;136(1-2):91-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18550190</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2008 Sep;79(3):166-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18547656</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2007 Jun 5;362(2):271-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17270230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2007 Aug;88(Pt 8):2297-306</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17622635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Aug;81(16):8515-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17553873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Sep;81(17):9601-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17567688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2007 Sep;128(1-2):159-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17521765</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antivir Ther. 2007;12(4 Pt B):603-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17944268</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2007 Oct 5;3(10):1414-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17922571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2007 Nov 13;581(27):5300-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17967456</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3064-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18287069</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2008 Apr;9(4):267-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18319742</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 May;82(9):4544-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18305037</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Immunol. 2008 Apr;52(4):216-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18426396</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008 Feb 8;4(2):e11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18248089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2008;153(6):1149-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18414973</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1989 Jul;171(1):162-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2741339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008;4(8):e1000115</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18670648</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Aug 28;454(7208):1123-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18615018</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Aug 28;454(7208):1127-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18660801</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Microbiol. 2008;62:403-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18785841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Chem. 2008 Oct;389(10):1299-305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18713015</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 May;81(Pt 5):1283-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10769071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 May 23;97(11):6108-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10801978</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2746-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11226311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Jun;75(11):5398-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11333924</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2001 Sep;77(1):3-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11451482</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Sep 7;293(5536):1840-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11546875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2001 Dec;7(12):1306-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11726970</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2001 Dec;146(12):2275-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11811679</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Immunol. 2002;46(3):167-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12008925</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2002 Jul;13(7):2461-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12134083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2002 Sep;8(9):950-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12195436</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2002 Dec 7;360(9348):1831-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12480361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2002 Nov 25;303(2):240-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12490387</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 2003 Oct;270(19):3859-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14511368</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3166-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14963236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Mar 15;320(2):258-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15016548</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2004 Jul;103(1-2):107-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15163498</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Sep;78(17):9144-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15308710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Sep;78(17):9568-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15308750</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1977 Dec 15;270(5638):617-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">593388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 1986 Jul;5(1):27-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3751286</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1987 Sep;61(9):2857-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2441080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1989 Nov;63(11):4603-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2795713</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Feb;67(2):759-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8419645</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Apr;67(4):1761-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8445709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 1993 Sep;29(3):321</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8237114</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1994 Nov;68(11):6900-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7933070</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Nov;69(11):6932-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7474111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1996 Sep;77 ( Pt 9):2149-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8811014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1996 Nov 15;24(22):4456-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8948635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1997 Mar 21;275(5307):1793-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9065404</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Immunol Med Microbiol. 1997 Aug;18(4):275-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9348163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Occup Med (Lond). 1998 Feb;48(2):85-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9614766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1999 Jul;80 ( Pt 7):1635-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10423131</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Nov;73(11):9679-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10516084</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 1963 Jun 15;1(7294):1301-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13983945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Mar;79(5):2814-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15709000</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Mar;79(6):3766-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15731270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 May;79(9):5812-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15827195</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2005 May;86(Pt 5):1447-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15831957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2005 May 15;19(10):1227-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15905410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jul;79(13):8669-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15956611</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2005 Jun 17;121(6):913-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15960978</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Aug 19;309(5738):1206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16000410</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000232 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000232 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:19462010 |texte= Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:19462010" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |