Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.
Identifieur interne : 000229 ( PubMed/Curation ); précédent : 000228; suivant : 000230Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.
Auteurs : Jodi Mcgill [États-Unis] ; David K. Meyerholz ; Michelle Edsen-Moore ; Betty Young ; Ruth A. Coleman ; Annette J. Schlueter ; Thomas J. Waldschmidt ; Robert T. Cook ; Kevin L. LeggeSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Effets différés de l'exposition prénatale aux facteurs de risque, Facteurs temps, Femelle, Grossesse, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Lymphocytes B (cytologie), Lymphocytes B (immunologie), Modèles animaux de maladie humaine, Numération des lymphocytes, Souris, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Taux de survie, Troubles du spectre de l'alcoolisation foetale (immunologie), Éthanol (pharmacologie).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae.
- cytologie : Lymphocytes B.
- immunologie : Infections à Orthomyxoviridae, Lymphocytes B, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Troubles du spectre de l'alcoolisation foetale.
- pharmacologie : Éthanol.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Effets différés de l'exposition prénatale aux facteurs de risque, Facteurs temps, Femelle, Grossesse, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Numération des lymphocytes, Souris, Taux de survie.
English descriptors
- KwdEn :
- Animals, B-Lymphocytes (cytology), B-Lymphocytes (immunology), Disease Models, Animal, Ethanol (pharmacology), Female, Fetal Alcohol Spectrum Disorders (immunology), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Lymphocyte Count, Mice, Orthomyxoviridae Infections (complications), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Pregnancy, Prenatal Exposure Delayed Effects, Survival Rate, Time Factors.
- MESH :
- chemical , pharmacology : Ethanol.
- complications : Orthomyxoviridae Infections.
- cytology : B-Lymphocytes.
- immunology : B-Lymphocytes, Fetal Alcohol Spectrum Disorders, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Orthomyxoviridae Infections.
- pathology : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Female, Lymphocyte Count, Mice, Pregnancy, Prenatal Exposure Delayed Effects, Survival Rate, Time Factors.
Abstract
Alcohol use by pregnant women is a significant public health issue despite well-described risks to the fetus including physical and intellectual growth retardation and malformations. Although clinical studies are limited, they suggest that in utero alcohol exposure also results in significant immune deficiencies in naive neonates. However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effects of FAE on disease susceptibility and the adult immune system, we infected FAE adult mice with influenza virus. In this study, we demonstrate that mice exposed to ethanol during gestation and nursing exhibit enhanced disease severity as well as increased and sustained pulmonary viral titers following influenza virus infection. Secondary exposure to alcohol as an adult further exacerbates these effects. Moreover, we demonstrate that FAE mice have impaired adaptive immune responses, including decreased numbers of virus-specific pulmonary CD8 T cells, a decreased size and frequency of pulmonary B cell foci, and reduced production of influenza-specific Ab following influenza infection. Together, our results suggest that FAE induces significant and long-term defects in immunity and susceptibility to influenza virus infection and that FAE individuals could be at increased risk for severe and fatal respiratory infections.
DOI: 10.4049/jimmunol.0803881
PubMed: 19494304
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Although clinical studies are limited, they suggest that in utero alcohol exposure also results in significant immune deficiencies in naive neonates. However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effects of FAE on disease susceptibility and the adult immune system, we infected FAE adult mice with influenza virus. In this study, we demonstrate that mice exposed to ethanol during gestation and nursing exhibit enhanced disease severity as well as increased and sustained pulmonary viral titers following influenza virus infection. Secondary exposure to alcohol as an adult further exacerbates these effects. Moreover, we demonstrate that FAE mice have impaired adaptive immune responses, including decreased numbers of virus-specific pulmonary CD8 T cells, a decreased size and frequency of pulmonary B cell foci, and reduced production of influenza-specific Ab following influenza infection. Together, our results suggest that FAE induces significant and long-term defects in immunity and susceptibility to influenza virus infection and that FAE individuals could be at increased risk for severe and fatal respiratory infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19494304</PMID><DateCompleted><Year>2009</Year><Month>06</Month><Day>25</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN><JournalIssue CitedMedium="Internet"><Volume>182</Volume><Issue>12</Issue><PubDate><Year>2009</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.</ArticleTitle><Pagination><MedlinePgn>7803-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.0803881</ELocationID><Abstract><AbstractText>Alcohol use by pregnant women is a significant public health issue despite well-described risks to the fetus including physical and intellectual growth retardation and malformations. Although clinical studies are limited, they suggest that in utero alcohol exposure also results in significant immune deficiencies in naive neonates. However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effects of FAE on disease susceptibility and the adult immune system, we infected FAE adult mice with influenza virus. In this study, we demonstrate that mice exposed to ethanol during gestation and nursing exhibit enhanced disease severity as well as increased and sustained pulmonary viral titers following influenza virus infection. Secondary exposure to alcohol as an adult further exacerbates these effects. Moreover, we demonstrate that FAE mice have impaired adaptive immune responses, including decreased numbers of virus-specific pulmonary CD8 T cells, a decreased size and frequency of pulmonary B cell foci, and reduced production of influenza-specific Ab following influenza infection. Together, our results suggest that FAE induces significant and long-term defects in immunity and susceptibility to influenza virus infection and that FAE individuals could be at increased risk for severe and fatal respiratory infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McGill</LastName><ForeName>Jodi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyerholz</LastName><ForeName>David K</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><LastName>Edsen-Moore</LastName><ForeName>Michelle</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Betty</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Coleman</LastName><ForeName>Ruth A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Schlueter</LastName><ForeName>Annette J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Waldschmidt</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials></Author><Author ValidYN="Y"><LastName>Cook</LastName><ForeName>Robert T</ForeName><Initials>RT</Initials></Author><Author ValidYN="Y"><LastName>Legge</LastName><ForeName>Kevin L</ForeName><Initials>KL</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AA014405</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AA014405-05</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AA-014405</GrantID><Acronym>AA</Acronym><Agency>NIAAA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063647" MajorTopicYN="N">Fetal Alcohol Spectrum Disorders</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018655" MajorTopicYN="N">Lymphocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011297" MajorTopicYN="Y">Prenatal Exposure Delayed Effects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time 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