H2N2V1, PubMed, Curation, bibRecord, 000068

Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Identifieur interne : 000068 ( PubMed/Curation ); précédent : 000067; suivant : 000069

Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Auteurs : Wei Wang ; Esmeralda Alvarado-Facundo ; Qiong Chen ; Christine M. Anderson [États-Unis] ; Dorothy Scott [États-Unis] ; Russell Vassell ; Carol D. Weiss

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2016.

RBID : pubmed:26243315

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Anticorps antiviraux (sang), Grippe humaine (), Grippe humaine (sang), Grippe humaine (virologie), Humains, Pandémies, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie).
MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- sang : Anticorps antiviraux, Grippe humaine.
- virologie : Grippe humaine.
- Adulte d'âge moyen, Grippe humaine, Humains, Pandémies.

English descriptors

KwdEn :
- Antibodies, Viral (blood), Humans, Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (blood), Influenza, Human (prevention & control), Influenza, Human (virology), Middle Aged, Pandemics.
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- blood : Influenza, Human.
- immunology : Influenza A virus, Influenza Vaccines.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Humans, Middle Aged, Pandemics.

Abstract

We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers >160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). Thirty-six percent to 0% had neutralization titers to various H5N1 strains. Titers to H9, H6, and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization.

DOI: 10.1093/infdis/jiv407
PubMed: 26243315

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Wei Wang

<affiliation><nlm:affiliation>Laboratory of Immunoregulation, Division of Viral Products.</nlm:affiliation>
<wicri:noCountry code="subField">Division of Viral Products</wicri:noCountry>
</affiliation>

Esmeralda Alvarado-Facundo

<affiliation><nlm:affiliation>Laboratory of Immunoregulation, Division of Viral Products.</nlm:affiliation>
<wicri:noCountry code="subField">Division of Viral Products</wicri:noCountry>
</affiliation>

Qiong Chen

<affiliation><nlm:affiliation>Laboratory of Immunoregulation, Division of Viral Products.</nlm:affiliation>
<wicri:noCountry code="subField">Division of Viral Products</wicri:noCountry>
</affiliation>

Russell Vassell

<affiliation><nlm:affiliation>Laboratory of Immunoregulation, Division of Viral Products.</nlm:affiliation>
<wicri:noCountry code="subField">Division of Viral Products</wicri:noCountry>
</affiliation>

Carol D. Weiss

<affiliation><nlm:affiliation>Laboratory of Immunoregulation, Division of Viral Products.</nlm:affiliation>
<wicri:noCountry code="subField">Division of Viral Products</wicri:noCountry>
</affiliation>

Le document en format XML

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<front><div type="abstract" xml:lang="en">We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/Hong Kong/SF4/01 (H6N1). None had titers >160 to A/Shanghai/2/13 (H7N9) or A/Netherlands/219/03 (H7N7). Thirty-six percent to 0% had neutralization titers to various H5N1 strains. Titers to H9, H6, and H5 HA-pseudoviruses correlated with each other, but not with H3N2v, suggesting group-specific cross-neutralization. </div>
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Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

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Abstract

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