A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.
Identifieur interne : 000049 ( PubMed/Curation ); précédent : 000048; suivant : 000050A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.
Auteurs : Sergio M. Qui Ones-Parra [Australie] ; E Bridie Clemens [Australie] ; Zhongfang Wang [Australie] ; Hayley A. Croom [Australie] ; Lukasz Kedzierski [Australie] ; Jodie Mcvernon [Australie] ; Dhanasekaran Vijaykrishna [Singapour] ; Katherine Kedzierska [Australie]Source :
- Journal of virology [ 1098-5514 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Déterminants antigéniques des lymphocytes T (immunologie), Enfant, Femelle, Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Lymphocytes B (immunologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T cytotoxiques (immunologie), Orthomyxoviridae (immunologie), Pandémies, Phylogénie, Protection croisée, Souris, Évolution moléculaire.
- MESH :
- immunologie : Déterminants antigéniques des lymphocytes T, Grippe humaine, Infections à Orthomyxoviridae, Lymphocytes B, Lymphocytes T CD8+, Lymphocytes T cytotoxiques, Orthomyxoviridae.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- Adulte, Animaux, Enfant, Femelle, Humains, Pandémies, Phylogénie, Protection croisée, Souris, Évolution moléculaire.
English descriptors
- KwdEn :
- Adult, Animals, B-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Child, Cross Protection, Epitopes, T-Lymphocyte (immunology), Evolution, Molecular, Female, Humans, Influenza, Human (immunology), Influenza, Human (virology), Mice, Orthomyxoviridae (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Pandemics, Phylogeny, T-Lymphocytes, Cytotoxic (immunology).
- MESH :
- chemical , immunology : Epitopes, T-Lymphocyte.
- immunology : B-Lymphocytes, CD8-Positive T-Lymphocytes, Influenza, Human, Orthomyxoviridae, Orthomyxoviridae Infections, T-Lymphocytes, Cytotoxic.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Adult, Animals, Child, Cross Protection, Evolution, Molecular, Female, Humans, Mice, Pandemics, Phylogeny.
Abstract
Novel influenza viruses often cause differential infection patterns across different age groups, an effect that is defined as heterogeneous demographic susceptibility. This occurred during the A/H2N2 pandemic, when children experienced higher influenza attack rates than adults. Since the recognition of conserved epitopes across influenza subtypes by CD8(+) cytotoxic T lymphocytes (CTLs) limit influenza disease, we hypothesized that conservation of CTL antigenic peptides (Ag-p) in viruses circulating before the pH2N2-1957 may have resulted in differential CTL immunity. We compared viruses isolated in the years preceding the pandemic (1941 to 1957) to which children and adults were exposed to viruses circulating decades earlier (1918 to 1940), which could infect adults only. Consistent with phylogenetic models, influenza viruses circulating from 1941 to 1957, which infected children, shared with pH2N2 the majority (∼89%) of the CTL peptides within the most immunogenic nucleoprotein, matrix 1, and polymerase basic 1, thus providing evidence for minimal pH2N2 CTL escape in children. Our study, however, identified potential CTL immune evasion from pH2N2 irrespective of age, within HLA-A*03:01(+) individuals for PB1471-L473V/N476I variants and HLA-B*15:01(+) population for NP404-414-V408I mutant. Further experiments using the murine model of B-cell-deficient mice showed that multiple influenza infections resulted in superior protection from influenza-induced morbidity, coinciding with accumulation of tissue-resident memory CD8(+) T cells in the lung. Our study suggests that protection against H2N2-1957 pandemic influenza was most likely linked to the number of influenza virus infections prior to the pandemic challenge rather than differential preexisting CTL immunity. Thus, the regimen of a CTL-based vaccine/vaccine-component may benefit from periodic boosting to achieve fully protective, asymptomatic influenza infection.
DOI: 10.1128/JVI.00349-16
PubMed: 27226365
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000049
Links to Exploration step
pubmed:27226365Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.</title><author><name sortKey="Qui Ones Parra, Sergio M" sort="Qui Ones Parra, Sergio M" uniqKey="Qui Ones Parra S" first="Sergio M" last="Qui Ones-Parra">Sergio M. Qui Ones-Parra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Clemens, E Bridie" sort="Clemens, E Bridie" uniqKey="Clemens E" first="E Bridie" last="Clemens">E Bridie Clemens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhongfang" sort="Wang, Zhongfang" uniqKey="Wang Z" first="Zhongfang" last="Wang">Zhongfang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Croom, Hayley A" sort="Croom, Hayley A" uniqKey="Croom H" first="Hayley A" last="Croom">Hayley A. Croom</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kedzierski, Lukasz" sort="Kedzierski, Lukasz" uniqKey="Kedzierski L" first="Lukasz" last="Kedzierski">Lukasz Kedzierski</name><affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, The University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Mcvernon, Jodie" sort="Mcvernon, Jodie" uniqKey="Mcvernon J" first="Jodie" last="Mcvernon">Jodie Mcvernon</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Vijaykrishna, Dhanasekaran" sort="Vijaykrishna, Dhanasekaran" uniqKey="Vijaykrishna D" first="Dhanasekaran" last="Vijaykrishna">Dhanasekaran Vijaykrishna</name><affiliation wicri:level="1"><nlm:affiliation>Duke-NUS Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia kkedz@unimelb.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27226365</idno><idno type="pmid">27226365</idno><idno type="doi">10.1128/JVI.00349-16</idno><idno type="wicri:Area/PubMed/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000049</idno><idno type="wicri:Area/PubMed/Curation">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.</title><author><name sortKey="Qui Ones Parra, Sergio M" sort="Qui Ones Parra, Sergio M" uniqKey="Qui Ones Parra S" first="Sergio M" last="Qui Ones-Parra">Sergio M. Qui Ones-Parra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Clemens, E Bridie" sort="Clemens, E Bridie" uniqKey="Clemens E" first="E Bridie" last="Clemens">E Bridie Clemens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhongfang" sort="Wang, Zhongfang" uniqKey="Wang Z" first="Zhongfang" last="Wang">Zhongfang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Croom, Hayley A" sort="Croom, Hayley A" uniqKey="Croom H" first="Hayley A" last="Croom">Hayley A. Croom</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Kedzierski, Lukasz" sort="Kedzierski, Lukasz" uniqKey="Kedzierski L" first="Lukasz" last="Kedzierski">Lukasz Kedzierski</name><affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, The University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Mcvernon, Jodie" sort="Mcvernon, Jodie" uniqKey="Mcvernon J" first="Jodie" last="Mcvernon">Jodie Mcvernon</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Vijaykrishna, Dhanasekaran" sort="Vijaykrishna, Dhanasekaran" uniqKey="Vijaykrishna D" first="Dhanasekaran" last="Vijaykrishna">Dhanasekaran Vijaykrishna</name><affiliation wicri:level="1"><nlm:affiliation>Duke-NUS Medical School, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS Medical School</wicri:regionArea></affiliation></author><author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia kkedz@unimelb.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>B-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Child</term><term>Cross Protection</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Evolution, Molecular</term><term>Female</term><term>Humans</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Orthomyxoviridae (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Pandemics</term><term>Phylogeny</term><term>T-Lymphocytes, Cytotoxic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Enfant</term><term>Femelle</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Orthomyxoviridae (immunologie)</term><term>Pandémies</term><term>Phylogénie</term><term>Protection croisée</term><term>Souris</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes T</term><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Lymphocytes B</term><term>Lymphocytes T CD8+</term><term>Lymphocytes T cytotoxiques</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Influenza, Human</term><term>Orthomyxoviridae</term><term>Orthomyxoviridae Infections</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Child</term><term>Cross Protection</term><term>Evolution, Molecular</term><term>Female</term><term>Humans</term><term>Mice</term><term>Pandemics</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Pandémies</term><term>Phylogénie</term><term>Protection croisée</term><term>Souris</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Novel influenza viruses often cause differential infection patterns across different age groups, an effect that is defined as heterogeneous demographic susceptibility. This occurred during the A/H2N2 pandemic, when children experienced higher influenza attack rates than adults. Since the recognition of conserved epitopes across influenza subtypes by CD8(+) cytotoxic T lymphocytes (CTLs) limit influenza disease, we hypothesized that conservation of CTL antigenic peptides (Ag-p) in viruses circulating before the pH2N2-1957 may have resulted in differential CTL immunity. We compared viruses isolated in the years preceding the pandemic (1941 to 1957) to which children and adults were exposed to viruses circulating decades earlier (1918 to 1940), which could infect adults only. Consistent with phylogenetic models, influenza viruses circulating from 1941 to 1957, which infected children, shared with pH2N2 the majority (∼89%) of the CTL peptides within the most immunogenic nucleoprotein, matrix 1, and polymerase basic 1, thus providing evidence for minimal pH2N2 CTL escape in children. Our study, however, identified potential CTL immune evasion from pH2N2 irrespective of age, within HLA-A*03:01(+) individuals for PB1471-L473V/N476I variants and HLA-B*15:01(+) population for NP404-414-V408I mutant. Further experiments using the murine model of B-cell-deficient mice showed that multiple influenza infections resulted in superior protection from influenza-induced morbidity, coinciding with accumulation of tissue-resident memory CD8(+) T cells in the lung. Our study suggests that protection against H2N2-1957 pandemic influenza was most likely linked to the number of influenza virus infections prior to the pandemic challenge rather than differential preexisting CTL immunity. Thus, the regimen of a CTL-based vaccine/vaccine-component may benefit from periodic boosting to achieve fully protective, asymptomatic influenza infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27226365</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>02</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>90</Volume><Issue>15</Issue><PubDate><Year>2016</Year><Month>08</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.</ArticleTitle><Pagination><MedlinePgn>6936-6947</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.00349-16</ELocationID><Abstract><AbstractText Label="UNLABELLED">Novel influenza viruses often cause differential infection patterns across different age groups, an effect that is defined as heterogeneous demographic susceptibility. This occurred during the A/H2N2 pandemic, when children experienced higher influenza attack rates than adults. Since the recognition of conserved epitopes across influenza subtypes by CD8(+) cytotoxic T lymphocytes (CTLs) limit influenza disease, we hypothesized that conservation of CTL antigenic peptides (Ag-p) in viruses circulating before the pH2N2-1957 may have resulted in differential CTL immunity. We compared viruses isolated in the years preceding the pandemic (1941 to 1957) to which children and adults were exposed to viruses circulating decades earlier (1918 to 1940), which could infect adults only. Consistent with phylogenetic models, influenza viruses circulating from 1941 to 1957, which infected children, shared with pH2N2 the majority (∼89%) of the CTL peptides within the most immunogenic nucleoprotein, matrix 1, and polymerase basic 1, thus providing evidence for minimal pH2N2 CTL escape in children. Our study, however, identified potential CTL immune evasion from pH2N2 irrespective of age, within HLA-A*03:01(+) individuals for PB1471-L473V/N476I variants and HLA-B*15:01(+) population for NP404-414-V408I mutant. Further experiments using the murine model of B-cell-deficient mice showed that multiple influenza infections resulted in superior protection from influenza-induced morbidity, coinciding with accumulation of tissue-resident memory CD8(+) T cells in the lung. Our study suggests that protection against H2N2-1957 pandemic influenza was most likely linked to the number of influenza virus infections prior to the pandemic challenge rather than differential preexisting CTL immunity. Thus, the regimen of a CTL-based vaccine/vaccine-component may benefit from periodic boosting to achieve fully protective, asymptomatic influenza infection.</AbstractText><AbstractText Label="IMPORTANCE">Due to a lack of cross-reactive neutralizing antibodies, children are particularly susceptible to influenza infections caused by novel viral strains. Preexisting T cell immunity directed at conserved viral regions, however, can provide protection against influenza viruses, promote rapid recovery and better clinical outcomes. When we asked whether high susceptibility of children (compared to adults) to the pandemic H2N2 influenza strain was associated with immune evasion from T-cell immunity, we found high conservation within T-cell antigenic regions in pandemic H2N2. However, the number of influenza infections prior to the challenge was linked to protective, asymptomatic infections and establishment of tissue-resident memory T cells. Our study supports development of vaccines that prime and boost T cells to elicit cross-strain protective T cells, especially tissue-resident memory T cells, for lifelong immunity against distinct influenza viruses.</AbstractText><CopyrightInformation>Copyright © 2016, American Society for Microbiology. All Rights Reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Quiñones-Parra</LastName><ForeName>Sergio M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clemens</LastName><ForeName>E Bridie</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhongfang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Croom</LastName><ForeName>Hayley A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kedzierski</LastName><ForeName>Lukasz</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McVernon</LastName><ForeName>Jodie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vijaykrishna</LastName><ForeName>Dhanasekaran</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Duke-NUS Medical School, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kedzierska</LastName><ForeName>Katherine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia kkedz@unimelb.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN272201400006C</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018984">Epitopes, T-Lymphocyte</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056738" MajorTopicYN="N">Cross Protection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018984" MajorTopicYN="N">Epitopes, T-Lymphocyte</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27226365</ArticleId><ArticleId IdType="pii">JVI.00349-16</ArticleId><ArticleId IdType="doi">10.1128/JVI.00349-16</ArticleId><ArticleId IdType="pmc">PMC4944292</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Commun. 2013;4:2663</Citation><ArticleIdList><ArticleId IdType="pubmed">24173108</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2013 Dec;14(12):1294-301</Citation><ArticleIdList><ArticleId IdType="pubmed">24162776</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2007 Feb;88(Pt 2):530-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17251571</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2000 Aug;74(15):6800-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10888619</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Jul 15;192(2):233-48</Citation><ArticleIdList><ArticleId IdType="pubmed">15962218</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2014 Jun 1;192(11):5039-49</Citation><ArticleIdList><ArticleId IdType="pubmed">24778446</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Jun;82(11):5161-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18353950</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1991 Apr 4;350(6317):423-6</Citation><ArticleIdList><ArticleId IdType="pubmed">1901381</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2014 Feb;95(2):215-24</Citation><ArticleIdList><ArticleId IdType="pubmed">24006506</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Sep;86(18):10258; author reply1259-60</Citation><ArticleIdList><ArticleId IdType="pubmed">22923812</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Cell Biol. 2013 Feb;91(2):184-94</Citation><ArticleIdList><ArticleId IdType="pubmed">23399741</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1999 Dec;80 ( Pt 12):3167-71</Citation><ArticleIdList><ArticleId IdType="pubmed">10567648</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2006 Jan 1;193(1):49-53</Citation><ArticleIdList><ArticleId IdType="pubmed">16323131</ArticleId></ArticleIdList></Reference><Reference><Citation>Epidemiol Rev. 1996;18(1):64-76</Citation><ArticleIdList><ArticleId IdType="pubmed">8877331</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Feb;89(4):2442-7</Citation><ArticleIdList><ArticleId IdType="pubmed">25505070</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2015 May 13;6:6833</Citation><ArticleIdList><ArticleId IdType="pubmed">25967273</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hyg. 1948 Mar;47(2):142-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18908909</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1951 Feb 3;1(6649):264-5</Citation><ArticleIdList><ArticleId IdType="pubmed">14795845</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2008 Feb 29;4(2):e1000012</Citation><ArticleIdList><ArticleId IdType="pubmed">18463694</ArticleId></ArticleIdList></Reference><Reference><Citation>Bull World Health Organ. 1952;6(3):287-315</Citation><ArticleIdList><ArticleId IdType="pubmed">12988024</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11143-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12954978</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Nov;89(22):11275-83</Citation><ArticleIdList><ArticleId IdType="pubmed">26311880</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2014 Oct 3;346(6205):101-5</Citation><ArticleIdList><ArticleId IdType="pubmed">25278612</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1978 May 18;273(5659):238-9</Citation><ArticleIdList><ArticleId IdType="pubmed">306072</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 1983 Jul 7;309(1):13-7</Citation><ArticleIdList><ArticleId IdType="pubmed">6602294</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Microbiol. 2014 Jun 12;5:285</Citation><ArticleIdList><ArticleId IdType="pubmed">24971078</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Jun 28;25(27):5086-96</Citation><ArticleIdList><ArticleId IdType="pubmed">17544181</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Feb;88(3):1684-93</Citation><ArticleIdList><ArticleId IdType="pubmed">24257602</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Nov 04;90(2):1009-22</Citation><ArticleIdList><ArticleId IdType="pubmed">26537686</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Dec;82(24):12241-51</Citation><ArticleIdList><ArticleId IdType="pubmed">18842709</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2004 Feb 15;172(4):2453-60</Citation><ArticleIdList><ArticleId IdType="pubmed">14764717</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2013 Jul 29;210(8):1493-500</Citation><ArticleIdList><ArticleId IdType="pubmed">23857983</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Virol. 1992 Mar;36(2):113-20</Citation><ArticleIdList><ArticleId IdType="pubmed">1279962</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2012 Feb 29;483(7388):227-31</Citation><ArticleIdList><ArticleId IdType="pubmed">22388819</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2002 Mar;76(5):2567-72</Citation><ArticleIdList><ArticleId IdType="pubmed">11836437</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Nov 15;192(10):1858-60; author reply 1860-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16235189</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1990 Aug 16;346(6285):629-33</Citation><ArticleIdList><ArticleId IdType="pubmed">1696684</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 May;79(9):5721-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15827187</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2011 May 31;108(22):9178-83</Citation><ArticleIdList><ArticleId IdType="pubmed">21562214</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1997 Aug;176 Suppl 1:S14-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9240688</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12599-604</Citation><ArticleIdList><ArticleId IdType="pubmed">20616031</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2013 Oct;19(10 ):1305-12</Citation><ArticleIdList><ArticleId IdType="pubmed">24056771</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2002 May 24;296(5572):1439-43</Citation><ArticleIdList><ArticleId IdType="pubmed">12029127</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2015 Jul;21(7):688-97</Citation><ArticleIdList><ArticleId IdType="pubmed">26121195</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Jun 18;459(7249):931-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19525932</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12</Citation><ArticleIdList><ArticleId IdType="pubmed">19597152</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Jun 18;10(6):e0129768</Citation><ArticleIdList><ArticleId IdType="pubmed">26086392</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2015 Jun 19;348(6241):aaa8205</Citation><ArticleIdList><ArticleId IdType="pubmed">26089520</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Cell Biol. 2007 Feb-Mar;85(2):85-92</Citation><ArticleIdList><ArticleId IdType="pubmed">17213831</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10748-52</Citation><ArticleIdList><ArticleId IdType="pubmed">12136133</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2011 May 27;34(5):781-93</Citation><ArticleIdList><ArticleId IdType="pubmed">21549619</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 May 16;368(20):1862-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23577629</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1945-52</Citation><ArticleIdList><ArticleId IdType="pubmed">19745214</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Microbiol. 2015 Apr;23(4):212-24</Citation><ArticleIdList><ArticleId IdType="pubmed">25613992</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2014 Oct 3;346(6205):93-8</Citation><ArticleIdList><ArticleId IdType="pubmed">25170048</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 1992 Apr 1;175(4):1143-5</Citation><ArticleIdList><ArticleId IdType="pubmed">1552285</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2000 Dec;74(24):11690-6</Citation><ArticleIdList><ArticleId IdType="pubmed">11090168</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2009 Oct 23;27(45):6363-5</Citation><ArticleIdList><ArticleId IdType="pubmed">19840674</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2013 Mar;14(3):238-45</Citation><ArticleIdList><ArticleId IdType="pubmed">23354485</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1998 Jan 1;160(1):322-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9551987</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2004 Jul;103(1-2):97-100</Citation><ArticleIdList><ArticleId IdType="pubmed">15163496</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2006 Apr;12(4):661-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16704816</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2010 Jul 23;33(1):128-40</Citation><ArticleIdList><ArticleId IdType="pubmed">20619696</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2008 Sep 1;181(5):3486-94</Citation><ArticleIdList><ArticleId IdType="pubmed">18714021</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2014 Oct 3;346(6205):98-101</Citation><ArticleIdList><ArticleId IdType="pubmed">25170049</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2015 Jun 15;191(12):1422-31</Citation><ArticleIdList><ArticleId IdType="pubmed">25844934</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2006 Jul 15;177(2):831-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16818737</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Jan;88(2):1175-88</Citation><ArticleIdList><ArticleId IdType="pubmed">24227848</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2006 Jul 6;355(1):31-40</Citation><ArticleIdList><ArticleId IdType="pubmed">16822994</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2012 Apr 4;4(128):128ra42</Citation><ArticleIdList><ArticleId IdType="pubmed">22491952</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Cell. 2010 Jan;1(1):9-13</Citation><ArticleIdList><ArticleId IdType="pubmed">21203993</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2015 Apr;16(4):406-14</Citation><ArticleIdList><ArticleId IdType="pubmed">25706747</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2013 Nov 14;39(5):939-48</Citation><ArticleIdList><ArticleId IdType="pubmed">24238342</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2008 Oct;118(10 ):3478-90</Citation><ArticleIdList><ArticleId IdType="pubmed">18802496</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1049-54</Citation><ArticleIdList><ArticleId IdType="pubmed">24395804</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000049 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000049 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27226365
|texte= A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27226365" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |