H2N2V1, PubMed, Curation, bibRecord, 000037

Three mutations switch H7N9 influenza to human-type receptor specificity.

Identifieur interne : 000037 ( PubMed/Curation ); précédent : 000036; suivant : 000038

Three mutations switch H7N9 influenza to human-type receptor specificity.

Auteurs : Robert P. De Vries [États-Unis] ; Wenjie Peng [États-Unis] ; Oliver C. Grant [États-Unis] ; Andrew J. Thompson [États-Unis] ; Xueyong Zhu [États-Unis] ; Kim M. Bouwman [Pays-Bas] ; Alba T Torrents De La Pena [Pays-Bas] ; Marielle J. Van Breemen [Pays-Bas] ; Iresha N. Ambepitiya Wickramasinghe [Pays-Bas] ; Cornelis A M. De Haan [Pays-Bas] ; Wenli Yu [États-Unis] ; Ryan Mcbride [États-Unis] ; Rogier W. Sanders [Pays-Bas] ; Robert J. Woods [États-Unis] ; Monique H. Verheije [Pays-Bas] ; Ian A. Wilson [États-Unis] ; James C. Paulson [États-Unis]

Source :

PLoS pathogens [ 1553-7374 ] ; 2017.

RBID : pubmed:28617868

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Host Specificity, Humans, Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (metabolism), Influenza A Virus, H7N9 Subtype (chemistry), Influenza A Virus, H7N9 Subtype (genetics), Influenza A Virus, H7N9 Subtype (metabolism), Influenza in Birds (genetics), Influenza in Birds (metabolism), Influenza in Birds (virology), Influenza, Human (genetics), Influenza, Human (metabolism), Influenza, Human (virology), Molecular Sequence Data, Mutation, Poultry, Poultry Diseases (genetics), Poultry Diseases (metabolism), Poultry Diseases (virology), Protein Binding, Receptors, Virus (genetics), Receptors, Virus (metabolism), Sequence Alignment.
MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- chemistry : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype.
- genetics : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype, Influenza in Birds, Influenza, Human, Poultry Diseases.
- metabolism : Influenza A Virus, H3N2 Subtype, Influenza A Virus, H7N9 Subtype, Influenza in Birds, Influenza, Human, Poultry Diseases.
- virology : Influenza in Birds, Influenza, Human, Poultry Diseases.
- Amino Acid Sequence, Animals, Host Specificity, Humans, Molecular Sequence Data, Mutation, Poultry, Protein Binding, Sequence Alignment.

Abstract

The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans. To determine if the H7 HA was capable of acquiring human-type receptor specificity, we conducted mutation analyses. Remarkably, three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human H1 pandemic virus, and promoted binding to human trachea epithelial cells.

DOI: 10.1371/journal.ppat.1006390
PubMed: 28617868

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</affiliation>
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<author><name sortKey="De La Pena, Alba T Torrents" sort="De La Pena, Alba T Torrents" uniqKey="De La Pena A" first="Alba T Torrents" last="De La Pena">Alba T Torrents De La Pena</name>
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<author><name sortKey="Van Breemen, Marielle J" sort="Van Breemen, Marielle J" uniqKey="Van Breemen M" first="Marielle J" last="Van Breemen">Marielle J. Van Breemen</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ambepitiya Wickramasinghe, Iresha N" sort="Ambepitiya Wickramasinghe, Iresha N" uniqKey="Ambepitiya Wickramasinghe I" first="Iresha N" last="Ambepitiya Wickramasinghe">Iresha N. Ambepitiya Wickramasinghe</name>
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<author><name sortKey="De Haan, Cornelis A M" sort="De Haan, Cornelis A M" uniqKey="De Haan C" first="Cornelis A M" last="De Haan">Cornelis A M. De Haan</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Mcbride, Ryan" sort="Mcbride, Ryan" uniqKey="Mcbride R" first="Ryan" last="Mcbride">Ryan Mcbride</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<author><name sortKey="Sanders, Rogier W" sort="Sanders, Rogier W" uniqKey="Sanders R" first="Rogier W" last="Sanders">Rogier W. Sanders</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam</wicri:regionArea>
</affiliation>
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<author><name sortKey="Woods, Robert J" sort="Woods, Robert J" uniqKey="Woods R" first="Robert J" last="Woods">Robert J. Woods</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<author><name sortKey="Verheije, Monique H" sort="Verheije, Monique H" uniqKey="Verheije M" first="Monique H" last="Verheije">Monique H. Verheije</name>
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<author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C" last="Paulson">James C. Paulson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
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<term>Animals</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term>
<term>Host Specificity</term>
<term>Humans</term>
<term>Influenza A Virus, H3N2 Subtype (chemistry)</term>
<term>Influenza A Virus, H3N2 Subtype (genetics)</term>
<term>Influenza A Virus, H3N2 Subtype (metabolism)</term>
<term>Influenza A Virus, H7N9 Subtype (chemistry)</term>
<term>Influenza A Virus, H7N9 Subtype (genetics)</term>
<term>Influenza A Virus, H7N9 Subtype (metabolism)</term>
<term>Influenza in Birds (genetics)</term>
<term>Influenza in Birds (metabolism)</term>
<term>Influenza in Birds (virology)</term>
<term>Influenza, Human (genetics)</term>
<term>Influenza, Human (metabolism)</term>
<term>Influenza, Human (virology)</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Poultry</term>
<term>Poultry Diseases (genetics)</term>
<term>Poultry Diseases (metabolism)</term>
<term>Poultry Diseases (virology)</term>
<term>Protein Binding</term>
<term>Receptors, Virus (genetics)</term>
<term>Receptors, Virus (metabolism)</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Glycoprotéine hémagglutinine du virus influenza ()</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term>
<term>Grippe chez les oiseaux (génétique)</term>
<term>Grippe chez les oiseaux (métabolisme)</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (métabolisme)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Maladies de la volaille (génétique)</term>
<term>Maladies de la volaille (métabolisme)</term>
<term>Maladies de la volaille (virologie)</term>
<term>Mutation</term>
<term>Récepteurs viraux (génétique)</term>
<term>Récepteurs viraux (métabolisme)</term>
<term>Sous-type H3N2 du virus de la grippe A ()</term>
<term>Sous-type H3N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H3N2 du virus de la grippe A (métabolisme)</term>
<term>Sous-type H7N9 du virus de la grippe A ()</term>
<term>Sous-type H7N9 du virus de la grippe A (génétique)</term>
<term>Sous-type H7N9 du virus de la grippe A (métabolisme)</term>
<term>Spécificité d'hôte</term>
<term>Séquence d'acides aminés</term>
<term>Volaille</term>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Receptors, Virus</term>
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<term>Receptors, Virus</term>
</keywords>
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<term>Influenza A Virus, H7N9 Subtype</term>
</keywords>
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<term>Influenza A Virus, H7N9 Subtype</term>
<term>Influenza in Birds</term>
<term>Influenza, Human</term>
<term>Poultry Diseases</term>
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<term>Grippe humaine</term>
<term>Maladies de la volaille</term>
<term>Récepteurs viraux</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
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<term>Influenza A Virus, H7N9 Subtype</term>
<term>Influenza in Birds</term>
<term>Influenza, Human</term>
<term>Poultry Diseases</term>
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<term>Grippe chez les oiseaux</term>
<term>Grippe humaine</term>
<term>Maladies de la volaille</term>
<term>Récepteurs viraux</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
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<term>Grippe humaine</term>
<term>Maladies de la volaille</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term>
<term>Influenza, Human</term>
<term>Poultry Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Host Specificity</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Poultry</term>
<term>Protein Binding</term>
<term>Sequence Alignment</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Mutation</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Sous-type H7N9 du virus de la grippe A</term>
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<front><div type="abstract" xml:lang="en">The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans. To determine if the H7 HA was capable of acquiring human-type receptor specificity, we conducted mutation analyses. Remarkably, three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human H1 pandemic virus, and promoted binding to human trachea epithelial cells.</div>
</front>
</TEI>
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<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1553-7374</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>6</Issue>
<PubDate><Year>2017</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>PLoS pathogens</Title>
<ISOAbbreviation>PLoS Pathog.</ISOAbbreviation>
</Journal>
<ArticleTitle>Three mutations switch H7N9 influenza to human-type receptor specificity.</ArticleTitle>
<Pagination><MedlinePgn>e1006390</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.ppat.1006390</ELocationID>
<Abstract><AbstractText>The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans. To determine if the H7 HA was capable of acquiring human-type receptor specificity, we conducted mutation analyses. Remarkably, three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human H1 pandemic virus, and promoted binding to human trachea epithelial cells.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Vries</LastName>
<ForeName>Robert P</ForeName>
<Initials>RP</Initials>
<AffiliationInfo><Affiliation>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, CG Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Wenjie</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5093-7115</Identifier>
<AffiliationInfo><Affiliation>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grant</LastName>
<ForeName>Oliver C</ForeName>
<Initials>OC</Initials>
<AffiliationInfo><Affiliation>Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Xueyong</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouwman</LastName>
<ForeName>Kim M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de la Pena</LastName>
<ForeName>Alba T Torrents</ForeName>
<Initials>ATT</Initials>
<AffiliationInfo><Affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Breemen</LastName>
<ForeName>Marielle J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ambepitiya Wickramasinghe</LastName>
<ForeName>Iresha N</ForeName>
<Initials>IN</Initials>
<AffiliationInfo><Affiliation>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Haan</LastName>
<ForeName>Cornelis A M</ForeName>
<Initials>CAM</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4459-9874</Identifier>
<AffiliationInfo><Affiliation>Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1,CL Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Wenli</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McBride</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-8616-1910</Identifier>
<AffiliationInfo><Affiliation>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanders</LastName>
<ForeName>Rogier W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo><Affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Weil Medical College of Cornell University, New York, NY, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Woods</LastName>
<ForeName>Robert J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verheije</LastName>
<ForeName>Monique H</ForeName>
<Initials>MH</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1274-2987</Identifier>
<AffiliationInfo><Affiliation>Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>Ian A</ForeName>
<Initials>IA</Initials>
<AffiliationInfo><Affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paulson</LastName>
<ForeName>James C</ForeName>
<Initials>JC</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-4589-5322</Identifier>
<AffiliationInfo><Affiliation>Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI114730</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P41 GM103390</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R56 AI117675</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01 CA207824</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM100058</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>06</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Pathog</MedlineTA>
<NlmUniqueID>101238921</NlmUniqueID>
<ISSNLinking>1553-7366</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058507" MajorTopicYN="N">Host Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D064766" MajorTopicYN="N">Influenza A Virus, H7N9 Subtype</DescriptorName>
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<MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011200" MajorTopicYN="N">Poultry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011201" MajorTopicYN="N">Poultry Diseases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
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Three mutations switch H7N9 influenza to human-type receptor specificity.

Three mutations switch H7N9 influenza to human-type receptor specificity.

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