Influenza A virus transfectants with chimeric hemagglutinins containing epitopes from different subtypes.
Identifieur interne : 000439 ( PubMed/Corpus ); précédent : 000438; suivant : 000440Influenza A virus transfectants with chimeric hemagglutinins containing epitopes from different subtypes.
Auteurs : S Q Li ; J L Schulman ; T. Moran ; C. Bona ; P. PaleseSource :
- Journal of virology [ 0022-538X ] ; 1992.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Viral (immunology), Base Sequence, Cell Line, Chimera, DNA, Viral, Epitopes (genetics), Epitopes (immunology), Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Influenza A virus (genetics), Influenza A virus (immunology), Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutagenesis, Site-Directed, Transfection.
- MESH :
- chemical , genetics : Epitopes, Hemagglutinins, Viral.
- chemical , immunology : Antibodies, Viral, Epitopes, Hemagglutinins, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- Amino Acid Sequence, Animals, Base Sequence, Cell Line, Chimera, DNA, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutagenesis, Site-Directed, Transfection.
Abstract
Influenza virus transfectants with chimeric hemagglutinins were constructed by using a ribonucleoprotein transfection method. Transfectants W(H1)-H2 and W(H1)-H3 contained A/WSN/33(H1N1) (WSN) hemagglutinins in which the six-amino-acid loop (contained in antigenic site B) was replaced by the corresponding structures of influenza viruses A/Japan/57(H2N2) and A/Hong Kong/8/68(H3N2) (HK), respectively. Serological analysis indicated that the W(H1)-H3 transfectant virus reacted with antibodies against both the WSN and HK viruses in hemagglutination inhibition and plaque neutralization assays. Furthermore, mice immunized with W(H1)-H3 transfectant virus produced antibodies to the WSN and HK viruses. The results demonstrate that influenza virus transfectants can be engineered to express epitopes of different subtypes on their hemagglutinins.
PubMed: 1370088
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pubmed:1370088Le document en format XML
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<author><name sortKey="Li, S Q" sort="Li, S Q" uniqKey="Li S" first="S Q" last="Li">S Q Li</name>
<affiliation><nlm:affiliation>Department of Microbiology, Mt. Sinai School of Medicine, New York, New York 10029.</nlm:affiliation>
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<author><name sortKey="Schulman, J L" sort="Schulman, J L" uniqKey="Schulman J" first="J L" last="Schulman">J L Schulman</name>
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<author><name sortKey="Moran, T" sort="Moran, T" uniqKey="Moran T" first="T" last="Moran">T. Moran</name>
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<author><name sortKey="Bona, C" sort="Bona, C" uniqKey="Bona C" first="C" last="Bona">C. Bona</name>
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<author><name sortKey="Palese, P" sort="Palese, P" uniqKey="Palese P" first="P" last="Palese">P. Palese</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza A virus transfectants with chimeric hemagglutinins containing epitopes from different subtypes.</title>
<author><name sortKey="Li, S Q" sort="Li, S Q" uniqKey="Li S" first="S Q" last="Li">S Q Li</name>
<affiliation><nlm:affiliation>Department of Microbiology, Mt. Sinai School of Medicine, New York, New York 10029.</nlm:affiliation>
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<author><name sortKey="Moran, T" sort="Moran, T" uniqKey="Moran T" first="T" last="Moran">T. Moran</name>
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<author><name sortKey="Bona, C" sort="Bona, C" uniqKey="Bona C" first="C" last="Bona">C. Bona</name>
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<term>Animals</term>
<term>Antibodies, Viral (immunology)</term>
<term>Base Sequence</term>
<term>Cell Line</term>
<term>Chimera</term>
<term>DNA, Viral</term>
<term>Epitopes (genetics)</term>
<term>Epitopes (immunology)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Hemagglutinins, Viral (genetics)</term>
<term>Hemagglutinins, Viral (immunology)</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Molecular Sequence Data</term>
<term>Mutagenesis, Site-Directed</term>
<term>Transfection</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cell Line</term>
<term>Chimera</term>
<term>DNA, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<front><div type="abstract" xml:lang="en">Influenza virus transfectants with chimeric hemagglutinins were constructed by using a ribonucleoprotein transfection method. Transfectants W(H1)-H2 and W(H1)-H3 contained A/WSN/33(H1N1) (WSN) hemagglutinins in which the six-amino-acid loop (contained in antigenic site B) was replaced by the corresponding structures of influenza viruses A/Japan/57(H2N2) and A/Hong Kong/8/68(H3N2) (HK), respectively. Serological analysis indicated that the W(H1)-H3 transfectant virus reacted with antibodies against both the WSN and HK viruses in hemagglutination inhibition and plaque neutralization assays. Furthermore, mice immunized with W(H1)-H3 transfectant virus produced antibodies to the WSN and HK viruses. The results demonstrate that influenza virus transfectants can be engineered to express epitopes of different subtypes on their hemagglutinins.</div>
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<Abstract><AbstractText>Influenza virus transfectants with chimeric hemagglutinins were constructed by using a ribonucleoprotein transfection method. Transfectants W(H1)-H2 and W(H1)-H3 contained A/WSN/33(H1N1) (WSN) hemagglutinins in which the six-amino-acid loop (contained in antigenic site B) was replaced by the corresponding structures of influenza viruses A/Japan/57(H2N2) and A/Hong Kong/8/68(H3N2) (HK), respectively. Serological analysis indicated that the W(H1)-H3 transfectant virus reacted with antibodies against both the WSN and HK viruses in hemagglutination inhibition and plaque neutralization assays. Furthermore, mice immunized with W(H1)-H3 transfectant virus produced antibodies to the WSN and HK viruses. The results demonstrate that influenza virus transfectants can be engineered to express epitopes of different subtypes on their hemagglutinins.</AbstractText>
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