[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].
Identifieur interne : 000276 ( PubMed/Corpus ); précédent : 000275; suivant : 000277[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].
Auteurs : Iu A. Desheva ; Kh Lu ; A R Rekstin ; D M Kats ; L G Rudenko ; A I KlimovSource :
- Voprosy virusologii [ 0507-4088 ]
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Viral (blood), Cold Temperature, Cross Reactions, Female, Hemagglutinins, Viral (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N2 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Neuraminidase (genetics), Neutralization Tests, Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses, Vaccination, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Viral Proteins (genetics).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase, Vaccines, Attenuated, Viral Proteins.
- blood : Orthomyxoviridae Infections.
- immunology : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Administration, Intranasal, Animals, Cold Temperature, Cross Reactions, Female, Mice, Mice, Inbred BALB C, Neutralization Tests, Reassortant Viruses, Vaccination.
Abstract
Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA) gene from the nonpathogenic avian virus A/Duck/Potsdam/ 1402-6186 (H5N2) and the genes of neuraminidase (NA) and non-glycated proteins from the ca attenuation donor A/Leningrad/134/17/57 (H2N2). All experiments were performed under increased biological protection (BSV-3+). The reassortant and parent H5N2 virus were non-pathogenic to Balb/c mice, the reassortant replication in the murine nasal passages (3.5 Ig EID50/ml) being higher than that in the lung (2.1 lg EID50/ml). Intranasal inoculation of mice with reassortant A/17/Duck/Potsdam/86/92 caused an immune response to both homological H5N2 virus and antigenically differing variants of influenza A (H5N1) virus isolated from humans in 1997 and 2003. The mice intranasally immunized with the ca reassortant were protected against fatal infection with the highly pathogenic A/Hong Kong/483/9797 (H5N1) virus and against infection with A/Hong Kong/213/03(H5N1) virus (80 and 100%, respectively).
PubMed: 17722607
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pubmed:17722607Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].</title><author><name sortKey="Desheva, Iu A" sort="Desheva, Iu A" uniqKey="Desheva I" first="Iu A" last="Desheva">Iu A. Desheva</name></author><author><name sortKey="Lu, Kh" sort="Lu, Kh" uniqKey="Lu K" first="Kh" last="Lu">Kh Lu</name></author><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name></author><author><name sortKey="Kats, D M" sort="Kats, D M" uniqKey="Kats D" first="D M" last="Kats">D M Kats</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2007 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:17722607</idno><idno type="pmid">17722607</idno><idno type="wicri:Area/PubMed/Corpus">000276</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000276</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].</title><author><name sortKey="Desheva, Iu A" sort="Desheva, Iu A" uniqKey="Desheva I" first="Iu A" last="Desheva">Iu A. Desheva</name></author><author><name sortKey="Lu, Kh" sort="Lu, Kh" uniqKey="Lu K" first="Kh" last="Lu">Kh Lu</name></author><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name></author><author><name sortKey="Kats, D M" sort="Kats, D M" uniqKey="Kats D" first="D M" last="Kats">D M Kats</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Cold Temperature</term><term>Cross Reactions</term><term>Female</term><term>Hemagglutinins, Viral (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza A Virus, H5N2 Subtype (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neuraminidase (genetics)</term><term>Neutralization Tests</term><term>Orthomyxoviridae Infections (blood)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Reassortant Viruses</term><term>Vaccination</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (genetics)</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Influenza Vaccines</term><term>Neuraminidase</term><term>Vaccines, Attenuated</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cold Temperature</term><term>Cross Reactions</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Reassortant Viruses</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA) gene from the nonpathogenic avian virus A/Duck/Potsdam/ 1402-6186 (H5N2) and the genes of neuraminidase (NA) and non-glycated proteins from the ca attenuation donor A/Leningrad/134/17/57 (H2N2). All experiments were performed under increased biological protection (BSV-3+). The reassortant and parent H5N2 virus were non-pathogenic to Balb/c mice, the reassortant replication in the murine nasal passages (3.5 Ig EID50/ml) being higher than that in the lung (2.1 lg EID50/ml). Intranasal inoculation of mice with reassortant A/17/Duck/Potsdam/86/92 caused an immune response to both homological H5N2 virus and antigenically differing variants of influenza A (H5N1) virus isolated from humans in 1997 and 2003. The mice intranasally immunized with the ca reassortant were protected against fatal infection with the highly pathogenic A/Hong Kong/483/9797 (H5N1) virus and against infection with A/Hong Kong/213/03(H5N1) virus (80 and 100%, respectively).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17722607</PMID><DateCompleted><Year>2007</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0507-4088</ISSN><JournalIssue CitedMedium="Print"><Volume>52</Volume><Issue>4</Issue><PubDate><MedlineDate>2007 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Voprosy virusologii</Title><ISOAbbreviation>Vopr. Virusol.</ISOAbbreviation></Journal><ArticleTitle>[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].</ArticleTitle><Pagination><MedlinePgn>27-30</MedlinePgn></Pagination><Abstract><AbstractText>Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA) gene from the nonpathogenic avian virus A/Duck/Potsdam/ 1402-6186 (H5N2) and the genes of neuraminidase (NA) and non-glycated proteins from the ca attenuation donor A/Leningrad/134/17/57 (H2N2). All experiments were performed under increased biological protection (BSV-3+). The reassortant and parent H5N2 virus were non-pathogenic to Balb/c mice, the reassortant replication in the murine nasal passages (3.5 Ig EID50/ml) being higher than that in the lung (2.1 lg EID50/ml). Intranasal inoculation of mice with reassortant A/17/Duck/Potsdam/86/92 caused an immune response to both homological H5N2 virus and antigenically differing variants of influenza A (H5N1) virus isolated from humans in 1997 and 2003. The mice intranasally immunized with the ca reassortant were protected against fatal infection with the highly pathogenic A/Hong Kong/483/9797 (H5N1) virus and against infection with A/Hong Kong/213/03(H5N1) virus (80 and 100%, respectively).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Desheva</LastName><ForeName>Iu A</ForeName><Initials>IuA</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Kh</ForeName><Initials>Kh</Initials></Author><Author ValidYN="Y"><LastName>Rekstin</LastName><ForeName>A R</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Kats</LastName><ForeName>D M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>L G</ForeName><Initials>LG</Initials></Author><Author ValidYN="Y"><LastName>Klimov</LastName><ForeName>A I</ForeName><Initials>AI</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Vopr Virusol</MedlineTA><NlmUniqueID>0417337</NlmUniqueID><ISSNLinking>0507-4088</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000281" MajorTopicYN="N">Administration, Intranasal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003080" MajorTopicYN="N">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" 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C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="Y">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000235" 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