Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.
Identifieur interne : 000266 ( PubMed/Corpus ); précédent : 000265; suivant : 000267Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.
Auteurs : Michelle Roti ; Junbao Yang ; Deanna Berger ; Laurie Huston ; Eddie A. James ; William W. KwokSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2008.
English descriptors
- KwdEn :
- Amino Acid Sequence, CD4-Positive T-Lymphocytes (immunology), Cross Reactions, Epitopes, T-Lymphocyte (chemistry), Epitopes, T-Lymphocyte (immunology), Female, Hemagglutinins, Viral (chemistry), Hemagglutinins, Viral (immunology), Humans, Influenza A Virus, H5N1 Subtype (immunology), Influenza, Human (immunology), Male, Molecular Sequence Data, Viral Proteins (chemistry), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Epitopes, T-Lymphocyte, Hemagglutinins, Viral, Viral Proteins.
- immunology : CD4-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Hemagglutinins, Viral, Influenza A Virus, H5N1 Subtype, Influenza, Human, Viral Proteins.
- Amino Acid Sequence, Cross Reactions, Female, Humans, Male, Molecular Sequence Data.
Abstract
It is commonly perceived that the human immune system is naive to the newly emerged H5N1 virus. In contrast, most adults have been exposed to influenza A H1N1 and H3N2 viruses through vaccination or infection. Adults born before 1968 have likely been exposed to H2N2 viruses. We hypothesized that CD4(+) T cells generated in response to H1N1, H3N2, and H2N2 influenza A viruses also recognize H5N1 epitopes. Tetramer-guided epitope mapping and Ag-specific class II tetramers were used to identify H5N1-specific T cell epitopes and detect H5N1-specific T cell responses. Fifteen of 15 healthy subjects tested had robust CD4(+) T cell responses against matrix protein, nucleoprotein, and neuraminidase of the influenza A/Viet Nam/1203/2004 (H5N1) virus. These results are not surprising, because the matrix protein and nucleoprotein of influenza A viruses are conserved while the neuraminidase of the H5N1 virus is of the same subtype as that of the circulating H1N1 influenza strain. However, H5N1 hemagglutinin-reactive CD4(+) T cells were also detected in 14 of 14 subjects examined despite the fact that hemagglutinin is less conserved. Most were cross-reactive to H1, H2, or H3 hemagglutinin epitopes. H5N1-reactive T cells were also detected ex vivo, exhibited a memory phenotype, and were capable of secreting IFN-gamma, TNF-alpha, IL-5, and IL-13. These data demonstrate the presence of H5N1 cross-reactive T cells in healthy Caucasian subjects, implying that exposure to influenza A H1N1, H3N2, or H2N2 viruses through either vaccination or infection may provide partial immunity to the H5N1 virus.
DOI: 10.4049/jimmunol.180.3.1758
PubMed: 18209073
Links to Exploration step
pubmed:18209073Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.</title><author><name sortKey="Roti, Michelle" sort="Roti, Michelle" uniqKey="Roti M" first="Michelle" last="Roti">Michelle Roti</name><affiliation><nlm:affiliation>Benaroya Research Institute at Virginia Mason, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Junbao" sort="Yang, Junbao" uniqKey="Yang J" first="Junbao" last="Yang">Junbao Yang</name></author><author><name sortKey="Berger, Deanna" sort="Berger, Deanna" uniqKey="Berger D" first="Deanna" last="Berger">Deanna Berger</name></author><author><name sortKey="Huston, Laurie" sort="Huston, Laurie" uniqKey="Huston L" first="Laurie" last="Huston">Laurie Huston</name></author><author><name sortKey="James, Eddie A" sort="James, Eddie A" uniqKey="James E" first="Eddie A" last="James">Eddie A. James</name></author><author><name sortKey="Kwok, William W" sort="Kwok, William W" uniqKey="Kwok W" first="William W" last="Kwok">William W. Kwok</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18209073</idno><idno type="pmid">18209073</idno><idno type="doi">10.4049/jimmunol.180.3.1758</idno><idno type="wicri:Area/PubMed/Corpus">000266</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.</title><author><name sortKey="Roti, Michelle" sort="Roti, Michelle" uniqKey="Roti M" first="Michelle" last="Roti">Michelle Roti</name><affiliation><nlm:affiliation>Benaroya Research Institute at Virginia Mason, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Junbao" sort="Yang, Junbao" uniqKey="Yang J" first="Junbao" last="Yang">Junbao Yang</name></author><author><name sortKey="Berger, Deanna" sort="Berger, Deanna" uniqKey="Berger D" first="Deanna" last="Berger">Deanna Berger</name></author><author><name sortKey="Huston, Laurie" sort="Huston, Laurie" uniqKey="Huston L" first="Laurie" last="Huston">Laurie Huston</name></author><author><name sortKey="James, Eddie A" sort="James, Eddie A" uniqKey="James E" first="Eddie A" last="James">Eddie A. James</name></author><author><name sortKey="Kwok, William W" sort="Kwok, William W" uniqKey="Kwok W" first="William W" last="Kwok">William W. Kwok</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Cross Reactions</term><term>Epitopes, T-Lymphocyte (chemistry)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Female</term><term>Hemagglutinins, Viral (chemistry)</term><term>Hemagglutinins, Viral (immunology)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza, Human (immunology)</term><term>Male</term><term>Molecular Sequence Data</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Hemagglutinins, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Epitopes, T-Lymphocyte</term><term>Hemagglutinins, Viral</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza, Human</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Cross Reactions</term><term>Female</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is commonly perceived that the human immune system is naive to the newly emerged H5N1 virus. In contrast, most adults have been exposed to influenza A H1N1 and H3N2 viruses through vaccination or infection. Adults born before 1968 have likely been exposed to H2N2 viruses. We hypothesized that CD4(+) T cells generated in response to H1N1, H3N2, and H2N2 influenza A viruses also recognize H5N1 epitopes. Tetramer-guided epitope mapping and Ag-specific class II tetramers were used to identify H5N1-specific T cell epitopes and detect H5N1-specific T cell responses. Fifteen of 15 healthy subjects tested had robust CD4(+) T cell responses against matrix protein, nucleoprotein, and neuraminidase of the influenza A/Viet Nam/1203/2004 (H5N1) virus. These results are not surprising, because the matrix protein and nucleoprotein of influenza A viruses are conserved while the neuraminidase of the H5N1 virus is of the same subtype as that of the circulating H1N1 influenza strain. However, H5N1 hemagglutinin-reactive CD4(+) T cells were also detected in 14 of 14 subjects examined despite the fact that hemagglutinin is less conserved. Most were cross-reactive to H1, H2, or H3 hemagglutinin epitopes. H5N1-reactive T cells were also detected ex vivo, exhibited a memory phenotype, and were capable of secreting IFN-gamma, TNF-alpha, IL-5, and IL-13. These data demonstrate the presence of H5N1 cross-reactive T cells in healthy Caucasian subjects, implying that exposure to influenza A H1N1, H3N2, or H2N2 viruses through either vaccination or infection may provide partial immunity to the H5N1 virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18209073</PMID><DateCompleted><Year>2008</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1767</ISSN><JournalIssue CitedMedium="Print"><Volume>180</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.</ArticleTitle><Pagination><MedlinePgn>1758-68</MedlinePgn></Pagination><Abstract><AbstractText>It is commonly perceived that the human immune system is naive to the newly emerged H5N1 virus. In contrast, most adults have been exposed to influenza A H1N1 and H3N2 viruses through vaccination or infection. Adults born before 1968 have likely been exposed to H2N2 viruses. We hypothesized that CD4(+) T cells generated in response to H1N1, H3N2, and H2N2 influenza A viruses also recognize H5N1 epitopes. Tetramer-guided epitope mapping and Ag-specific class II tetramers were used to identify H5N1-specific T cell epitopes and detect H5N1-specific T cell responses. Fifteen of 15 healthy subjects tested had robust CD4(+) T cell responses against matrix protein, nucleoprotein, and neuraminidase of the influenza A/Viet Nam/1203/2004 (H5N1) virus. These results are not surprising, because the matrix protein and nucleoprotein of influenza A viruses are conserved while the neuraminidase of the H5N1 virus is of the same subtype as that of the circulating H1N1 influenza strain. However, H5N1 hemagglutinin-reactive CD4(+) T cells were also detected in 14 of 14 subjects examined despite the fact that hemagglutinin is less conserved. Most were cross-reactive to H1, H2, or H3 hemagglutinin epitopes. H5N1-reactive T cells were also detected ex vivo, exhibited a memory phenotype, and were capable of secreting IFN-gamma, TNF-alpha, IL-5, and IL-13. These data demonstrate the presence of H5N1 cross-reactive T cells in healthy Caucasian subjects, implying that exposure to influenza A H1N1, H3N2, or H2N2 viruses through either vaccination or infection may provide partial immunity to the H5N1 virus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roti</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Benaroya Research Institute at Virginia Mason, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Junbao</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>DeAnna</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Huston</LastName><ForeName>Laurie</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Eddie A</ForeName><Initials>EA</Initials></Author><Author 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UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018984" MajorTopicYN="N">Epitopes, T-Lymphocyte</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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