[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].
Identifieur interne : 000237 ( PubMed/Corpus ); précédent : 000236; suivant : 000238[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].
Auteurs : Iu A. Desheva ; T A Smolonogina ; M V Sergeeva ; A R Rekstin ; D. Swayne ; A I Klimov ; L G RudenkoSource :
- Zhurnal mikrobiologii, epidemiologii, i immunobiologii [ 0372-9311 ]
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (analysis), Chickens, Cold Temperature, Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Mice, Mice, Inbred BALB C, Nasal Mucosa (immunology), Nasal Mucosa (virology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reassortant Viruses (pathogenicity), Virus Replication.
- MESH :
- chemical , analysis : Antibodies, Viral.
- genetics : Influenza A virus, Influenza Vaccines, Reassortant Viruses.
- immunology : Influenza A virus, Influenza Vaccines, Nasal Mucosa, Reassortant Viruses.
- pathogenicity : Influenza A virus, Reassortant Viruses.
- prevention & control : Influenza, Human.
- virology : Nasal Mucosa.
- Animals, Chickens, Cold Temperature, Humans, Mice, Mice, Inbred BALB C, Virus Replication.
Abstract
For the development of live attenuated influenza vaccine (LAIV) against influenza virus strains with pandemic potential, method of classic genetic reassortment of donor of attenuation A/Leningrad/134/17/57 (H2N2) [Len/17] with avian apathogenic influenza viruses of different subtypes was used. Strain with genome formula 6:2, which contains HA and NA genes from avian apathogenic virus A/wild duck/Netherlands/12/00 (H7N3) [N7N3-wt] and 6 other genes--from Len/17, was studied. Reassortant strain A/17/ wild duck/Netherlands/00/84 (H7N3) [Lenl7/ H7] exhibited ts- and ca- phenotype specific for cold-adapted strains. Reassortant was identical on antigenic profile to parent avian virus H7N3-wt. Like cold-adapted donor strain Len/17, Len17/H7 was attenuated for chickens, whereas wild-type parent strain was lethal in 60% of birds after its intravenous challenge. Reassortant strain Len17/H7 was attenuated during intranasal inoculation of 6 EID50 to white mice, which was confirmed by absence of its isolation from the lungs, actively reproduced on nasal mucosa and stimulated specific systemic and local antibody response.
PubMed: 19340965
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pubmed:19340965Le document en format XML
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Swayne</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2009 Jan-Feb</MedlineDate></PubDate></date><idno type="RBID">pubmed:19340965</idno><idno type="pmid">19340965</idno><idno type="wicri:Area/PubMed/Corpus">000237</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].</title><author><name sortKey="Desheva, Iu A" sort="Desheva, Iu A" uniqKey="Desheva I" first="Iu A" last="Desheva">Iu A. Desheva</name></author><author><name sortKey="Smolonogina, T A" sort="Smolonogina, T A" uniqKey="Smolonogina T" first="T A" last="Smolonogina">T A Smolonogina</name></author><author><name sortKey="Sergeeva, M V" sort="Sergeeva, M V" uniqKey="Sergeeva M" first="M V" last="Sergeeva">M V Sergeeva</name></author><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name></author><author><name sortKey="Swayne, D" sort="Swayne, D" uniqKey="Swayne D" first="D" last="Swayne">D. Swayne</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></analytic><series><title level="j">Zhurnal mikrobiologii, epidemiologii, i immunobiologii</title><idno type="ISSN">0372-9311</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (analysis)</term><term>Chickens</term><term>Cold Temperature</term><term>Humans</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nasal Mucosa (immunology)</term><term>Nasal Mucosa (virology)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Reassortant Viruses (pathogenicity)</term><term>Virus Replication</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term><term>Nasal Mucosa</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasal Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Cold Temperature</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Virus Replication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For the development of live attenuated influenza vaccine (LAIV) against influenza virus strains with pandemic potential, method of classic genetic reassortment of donor of attenuation A/Leningrad/134/17/57 (H2N2) [Len/17] with avian apathogenic influenza viruses of different subtypes was used. Strain with genome formula 6:2, which contains HA and NA genes from avian apathogenic virus A/wild duck/Netherlands/12/00 (H7N3) [N7N3-wt] and 6 other genes--from Len/17, was studied. Reassortant strain A/17/ wild duck/Netherlands/00/84 (H7N3) [Lenl7/ H7] exhibited ts- and ca- phenotype specific for cold-adapted strains. Reassortant was identical on antigenic profile to parent avian virus H7N3-wt. Like cold-adapted donor strain Len/17, Len17/H7 was attenuated for chickens, whereas wild-type parent strain was lethal in 60% of birds after its intravenous challenge. Reassortant strain Len17/H7 was attenuated during intranasal inoculation of 6 EID50 to white mice, which was confirmed by absence of its isolation from the lungs, actively reproduced on nasal mucosa and stimulated specific systemic and local antibody response.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19340965</PMID><DateCompleted><Year>2009</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2009</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0372-9311</ISSN><JournalIssue CitedMedium="Print"><Issue>1</Issue><PubDate><MedlineDate>2009 Jan-Feb</MedlineDate></PubDate></JournalIssue><Title>Zhurnal mikrobiologii, epidemiologii, i immunobiologii</Title><ISOAbbreviation>Zh. Mikrobiol. Epidemiol. Immunobiol.</ISOAbbreviation></Journal><ArticleTitle>[Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3].</ArticleTitle><Pagination><MedlinePgn>31-6</MedlinePgn></Pagination><Abstract><AbstractText>For the development of live attenuated influenza vaccine (LAIV) against influenza virus strains with pandemic potential, method of classic genetic reassortment of donor of attenuation A/Leningrad/134/17/57 (H2N2) [Len/17] with avian apathogenic influenza viruses of different subtypes was used. Strain with genome formula 6:2, which contains HA and NA genes from avian apathogenic virus A/wild duck/Netherlands/12/00 (H7N3) [N7N3-wt] and 6 other genes--from Len/17, was studied. Reassortant strain A/17/ wild duck/Netherlands/00/84 (H7N3) [Lenl7/ H7] exhibited ts- and ca- phenotype specific for cold-adapted strains. Reassortant was identical on antigenic profile to parent avian virus H7N3-wt. Like cold-adapted donor strain Len/17, Len17/H7 was attenuated for chickens, whereas wild-type parent strain was lethal in 60% of birds after its intravenous challenge. Reassortant strain Len17/H7 was attenuated during intranasal inoculation of 6 EID50 to white mice, which was confirmed by absence of its isolation from the lungs, actively reproduced on nasal mucosa and stimulated specific systemic and local antibody response.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Desheva</LastName><ForeName>Iu A</ForeName><Initials>IuA</Initials></Author><Author ValidYN="Y"><LastName>Smolonogina</LastName><ForeName>T A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Sergeeva</LastName><ForeName>M V</ForeName><Initials>MV</Initials></Author><Author ValidYN="Y"><LastName>Rekstin</LastName><ForeName>A R</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Swayne</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Klimov</LastName><ForeName>A I</ForeName><Initials>AI</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>L G</ForeName><Initials>LG</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Zh Mikrobiol Epidemiol Immunobiol</MedlineTA><NlmUniqueID>0415217</NlmUniqueID><ISSNLinking>0372-9311</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003080" MajorTopicYN="N">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009297" MajorTopicYN="N">Nasal Mucosa</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>4</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>4</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>5</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19340965</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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