[Leading role of genes coding polymerase complex in attenuation of domestic donor viruses for A and B live influenza vaccine].
Identifieur interne : 000176 ( PubMed/Corpus ); précédent : 000175; suivant : 000177[Leading role of genes coding polymerase complex in attenuation of domestic donor viruses for A and B live influenza vaccine].
Auteurs : I V Kiseleva ; N V Larionova ; J T M. Voeten ; L C P. Teley ; S K M. Drieszen-Van Der Cruijsen ; J G M. Heldens ; J F Van Den Bosch ; L G RudenkoSource :
- Zhurnal mikrobiologii, epidemiologii, i immunobiologii [ 0372-9311 ]
English descriptors
- KwdEn :
- Amino Acid Substitution, Animals, Cell Line, Chick Embryo, Dogs, Influenza A virus (genetics), Influenza A virus (immunology), Influenza B virus (genetics), Influenza B virus (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), RNA Replicase (genetics), RNA Replicase (immunology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Serial Passage, Temperature, Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Viral Proteins (genetics), Viral Proteins (immunology), Virus Replication.
- MESH :
- chemical , genetics : Influenza Vaccines, RNA Replicase, Vaccines, Attenuated, Viral Proteins.
- genetics : Influenza A virus, Influenza B virus, Reassortant Viruses.
- immunology : Influenza A virus, Influenza B virus, Influenza Vaccines, RNA Replicase, Reassortant Viruses, Vaccines, Attenuated, Viral Proteins.
- Amino Acid Substitution, Animals, Cell Line, Chick Embryo, Dogs, Serial Passage, Temperature, Virus Replication.
Abstract
To identify the genes that are responsible for attenuation of donor viruses for live influenza vaccine. MATERIALS AND METHODS. Analysis of phenotypical properties of reassortants of wild type A and B influenza viruses with A/Leningrad/134/17/57 (H2N2) (A17) and B/USSR/60/69 (B60) master donor viruses was performed by comparison of their capability to grow at different temperatures in chicken eggs or/and MDCK cells.
PubMed: 21381376
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pubmed:21381376Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Leading role of genes coding polymerase complex in attenuation of domestic donor viruses for A and B live influenza vaccine].</title><author><name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name></author><author><name sortKey="Larionova, N V" sort="Larionova, N V" uniqKey="Larionova N" first="N V" last="Larionova">N V Larionova</name></author><author><name sortKey="Voeten, J T M" sort="Voeten, J T M" uniqKey="Voeten J" first="J T M" last="Voeten">J T M. Voeten</name></author><author><name sortKey="Teley, L C P" sort="Teley, L C P" uniqKey="Teley L" first="L C P" last="Teley">L C P. Teley</name></author><author><name sortKey="Drieszen Van Der Cruijsen, S K M" sort="Drieszen Van Der Cruijsen, S K M" uniqKey="Drieszen Van Der Cruijsen S" first="S K M" last="Drieszen-Van Der Cruijsen">S K M. Drieszen-Van Der Cruijsen</name></author><author><name sortKey="Heldens, J G M" sort="Heldens, J G M" uniqKey="Heldens J" first="J G M" last="Heldens">J G M. Heldens</name></author><author><name sortKey="Van Den Bosch, J F" sort="Van Den Bosch, J F" uniqKey="Van Den Bosch J" first="J F" last="Van Den Bosch">J F Van Den Bosch</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2010 Nov-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:21381376</idno><idno type="pmid">21381376</idno><idno type="wicri:Area/PubMed/Corpus">000176</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000176</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Leading role of genes coding polymerase complex in attenuation of domestic donor viruses for A and B live influenza vaccine].</title><author><name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name></author><author><name sortKey="Larionova, N V" sort="Larionova, N V" uniqKey="Larionova N" first="N V" last="Larionova">N V Larionova</name></author><author><name sortKey="Voeten, J T M" sort="Voeten, J T M" uniqKey="Voeten J" first="J T M" last="Voeten">J T M. Voeten</name></author><author><name sortKey="Teley, L C P" sort="Teley, L C P" uniqKey="Teley L" first="L C P" last="Teley">L C P. Teley</name></author><author><name sortKey="Drieszen Van Der Cruijsen, S K M" sort="Drieszen Van Der Cruijsen, S K M" uniqKey="Drieszen Van Der Cruijsen S" first="S K M" last="Drieszen-Van Der Cruijsen">S K M. Drieszen-Van Der Cruijsen</name></author><author><name sortKey="Heldens, J G M" sort="Heldens, J G M" uniqKey="Heldens J" first="J G M" last="Heldens">J G M. Heldens</name></author><author><name sortKey="Van Den Bosch, J F" sort="Van Den Bosch, J F" uniqKey="Van Den Bosch J" first="J F" last="Van Den Bosch">J F Van Den Bosch</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></analytic><series><title level="j">Zhurnal mikrobiologii, epidemiologii, i immunobiologii</title><idno type="ISSN">0372-9311</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Substitution</term><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Dogs</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza B virus (genetics)</term><term>Influenza B virus (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>RNA Replicase (genetics)</term><term>RNA Replicase (immunology)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Serial Passage</term><term>Temperature</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Influenza Vaccines</term><term>RNA Replicase</term><term>Vaccines, Attenuated</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>RNA Replicase</term><term>Reassortant Viruses</term><term>Vaccines, Attenuated</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Dogs</term><term>Serial Passage</term><term>Temperature</term><term>Virus Replication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify the genes that are responsible for attenuation of donor viruses for live influenza vaccine. MATERIALS AND METHODS. Analysis of phenotypical properties of reassortants of wild type A and B influenza viruses with A/Leningrad/134/17/57 (H2N2) (A17) and B/USSR/60/69 (B60) master donor viruses was performed by comparison of their capability to grow at different temperatures in chicken eggs or/and MDCK cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21381376</PMID><DateCompleted><Year>2011</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2011</Year><Month>03</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0372-9311</ISSN><JournalIssue CitedMedium="Print"><Issue>6</Issue><PubDate><MedlineDate>2010 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Zhurnal mikrobiologii, epidemiologii, i immunobiologii</Title><ISOAbbreviation>Zh. Mikrobiol. Epidemiol. Immunobiol.</ISOAbbreviation></Journal><ArticleTitle>[Leading role of genes coding polymerase complex in attenuation of domestic donor viruses for A and B live influenza vaccine].</ArticleTitle><Pagination><MedlinePgn>41-7</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To identify the genes that are responsible for attenuation of donor viruses for live influenza vaccine. MATERIALS AND METHODS. Analysis of phenotypical properties of reassortants of wild type A and B influenza viruses with A/Leningrad/134/17/57 (H2N2) (A17) and B/USSR/60/69 (B60) master donor viruses was performed by comparison of their capability to grow at different temperatures in chicken eggs or/and MDCK cells.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Ts phenotype of 178 reassortants of A17 with current non-ts influenza A wild type viruses and 33 reassortants of B60 with current non-ts influenza B wild type viruses were evaluated. Reassortants inherited two polymerase genes PB2 and PA or PB 1 from A17 regularly demonstrated ts phenotype. The polymerase PA and PB2 gene segments of B60 independently controlled manifestation of ts phenotype of B60 based reassortants. The other nonpolymerase genes played no role in manifestation of ts phenotype of reassortants A17 and B60 viruses.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The molecular basis for the development ts phenotype of both A and B influenza vaccine reassortant viruses determined by polymerase genes complex.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kiseleva</LastName><ForeName>I V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Larionova</LastName><ForeName>N V</ForeName><Initials>NV</Initials></Author><Author ValidYN="Y"><LastName>Voeten</LastName><ForeName>J T M</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Teley</LastName><ForeName>L C P</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Drieszen-van der Cruijsen</LastName><ForeName>S K M</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Heldens</LastName><ForeName>J G M</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>van den Bosch</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>L G</ForeName><Initials>LG</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Zh Mikrobiol Epidemiol Immunobiol</MedlineTA><NlmUniqueID>0415217</NlmUniqueID><ISSNLinking>0372-9311</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C061290">PA protein, influenza viruses</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502893">PB2 protein, influenza virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C077346">influenza virus polymerase basic protein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber><NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012324" MajorTopicYN="N">RNA Replicase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012692" MajorTopicYN="N">Serial Passage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013696" MajorTopicYN="N">Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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