[Restriction analysis of genome composition of live influenza vaccine].
Identifieur interne : 000167 ( PubMed/Corpus ); précédent : 000166; suivant : 000168[Restriction analysis of genome composition of live influenza vaccine].
Auteurs : I V Kiseleva ; N V Larionova ; L C P. Teley ; L G RudenkoSource :
- Voprosy virusologii [ 0507-4088 ]
English descriptors
- KwdEn :
- Adaptation, Physiological (genetics), Animals, Biological Assay, Chick Embryo, Cold Temperature, DNA Primers (chemistry), DNA Primers (metabolism), DNA Restriction Enzymes (metabolism), Genome, Viral, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza B virus (genetics), Influenza B virus (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (genetics), Influenza, Human (immunology), Influenza, Human (virology), Pandemics, Phenotype, Polymorphism, Restriction Fragment Length, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Russia, Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , chemistry : DNA Primers.
- chemical , genetics : Vaccines, Attenuated.
- chemical , immunology : Vaccines, Attenuated.
- geographic : Russia.
- genetics : Adaptation, Physiological, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Reassortant Viruses.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Reassortant Viruses.
- chemical , metabolism : DNA Primers, DNA Restriction Enzymes.
- virology : Influenza, Human.
- Animals, Biological Assay, Chick Embryo, Cold Temperature, Genome, Viral, Hemagglutination Inhibition Tests, Humans, Pandemics, Phenotype, Polymorphism, Restriction Fragment Length, Virus Replication.
Abstract
Live attenuated cold-adapted influenza vaccine (LIV) has been used in Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on influenza AILeningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (att), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (HINI) and A (H3N2) viruses and wt influenza B virus. The ca/ts/att phenotype of these viruses limits replication in the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.
PubMed: 21786624
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pubmed:21786624Le document en format XML
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Teley</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2011 May-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:21786624</idno><idno type="pmid">21786624</idno><idno type="wicri:Area/PubMed/Corpus">000167</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000167</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Restriction analysis of genome composition of live influenza vaccine].</title><author><name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name></author><author><name sortKey="Larionova, N V" sort="Larionova, N V" uniqKey="Larionova N" first="N V" last="Larionova">N V Larionova</name></author><author><name sortKey="Teley, L C P" sort="Teley, L C P" uniqKey="Teley L" first="L C P" last="Teley">L C P. Teley</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term><term>Animals</term><term>Biological Assay</term><term>Chick Embryo</term><term>Cold Temperature</term><term>DNA Primers (chemistry)</term><term>DNA Primers (metabolism)</term><term>DNA Restriction Enzymes (metabolism)</term><term>Genome, Viral</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza B virus (genetics)</term><term>Influenza B virus (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (genetics)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Pandemics</term><term>Phenotype</term><term>Polymorphism, Restriction Fragment Length</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Russia</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Russia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza B virus</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA Primers</term><term>DNA Restriction Enzymes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Assay</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Genome, Viral</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Pandemics</term><term>Phenotype</term><term>Polymorphism, Restriction Fragment Length</term><term>Virus Replication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Live attenuated cold-adapted influenza vaccine (LIV) has been used in Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on influenza AILeningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (att), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (HINI) and A (H3N2) viruses and wt influenza B virus. The ca/ts/att phenotype of these viruses limits replication in the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21786624</PMID><DateCompleted><Year>2011</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0507-4088</ISSN><JournalIssue CitedMedium="Print"><Volume>56</Volume><Issue>3</Issue><PubDate><MedlineDate>2011 May-Jun</MedlineDate></PubDate></JournalIssue><Title>Voprosy virusologii</Title><ISOAbbreviation>Vopr. Virusol.</ISOAbbreviation></Journal><ArticleTitle>[Restriction analysis of genome composition of live influenza vaccine].</ArticleTitle><Pagination><MedlinePgn>28-32</MedlinePgn></Pagination><Abstract><AbstractText>Live attenuated cold-adapted influenza vaccine (LIV) has been used in Russia for over 50 years and proved to be safe and effective. Currently, Russian reassortant LAIV is based on influenza AILeningrad/134/17/57 (H2N2) and B/USSR/60/69 Master Donor Viruses (MDVs) which are cold-adapted (ca), temperature-sensitive (ts), and attenuated (att), respectively. The MDVs are used to generate attenuated reassortant vaccine viruses containing the surface antigens of current wild type (wt) influenza A (HINI) and A (H3N2) viruses and wt influenza B virus. The ca/ts/att phenotype of these viruses limits replication in the upper respiratory tract. Reassortment typically yields numerous viruses with different genome constellations, rapid screening is needed to select proper vaccine viruses. In this study, screening of reassortant vaccine strains for live attenuated influenza vaccine generated from currently circulating influenza A and B viruses by RFLP assay is described.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kiseleva</LastName><ForeName>I V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Larionova</LastName><ForeName>N V</ForeName><Initials>NV</Initials></Author><Author ValidYN="Y"><LastName>Teley</LastName><ForeName>L C P</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>L G</ForeName><Initials>LG</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Vopr 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