Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).
Identifieur interne : 000160 ( PubMed/Corpus ); précédent : 000159; suivant : 000161Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).
Auteurs : Alexandra S. Gambaryan ; Natalia F. Lomakina ; Elizaveta Y. Boravleva ; Ekaterina A. Kropotkina ; Vadim V. Mashin ; Igor V. Krasilnikov ; Alexander I. Klimov ; Larisa G. RudenkoSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), Chickens, Hemagglutinin Glycoproteins, Influenza Virus (adverse effects), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (adverse effects), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Influenza in Birds (virology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Mice, Mice, Inbred BALB C, Vaccines, Attenuated (adverse effects), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Vaccines, Inactivated (adverse effects), Vaccines, Inactivated (genetics), Vaccines, Inactivated (immunology).
- MESH :
- chemical , adverse effects : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- chemical , immunology : Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- genetics : Influenza A Virus, H5N1 Subtype.
- immunology : Influenza A Virus, H5N1 Subtype, Influenza in Birds, Influenza, Human.
- prevention & control : Influenza in Birds, Influenza, Human.
- virology : Influenza in Birds, Influenza, Human.
- Animals, Chickens, Humans, Mice, Mice, Inbred BALB C.
Abstract
Parallel testing of inactivated (split and whole virion) and live vaccine was conducted to compare the immunogenicity and protective efficacy against homologous and heterosubtypic challenge by H5N1 highly pathogenic avian influenza virus.
DOI: 10.1111/j.1750-2659.2011.00291.x
PubMed: 21951678
Links to Exploration step
pubmed:21951678Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).</title><author><name sortKey="Gambaryan, Alexandra S" sort="Gambaryan, Alexandra S" uniqKey="Gambaryan A" first="Alexandra S" last="Gambaryan">Alexandra S. Gambaryan</name><affiliation><nlm:affiliation>M P Chumakov Institute of Poliomyelitis and Viral Encephalitides, RAMS, Moscow, Russia. alexandra.gambaryan@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Lomakina, Natalia F" sort="Lomakina, Natalia F" uniqKey="Lomakina N" first="Natalia F" last="Lomakina">Natalia F. Lomakina</name></author><author><name sortKey="Boravleva, Elizaveta Y" sort="Boravleva, Elizaveta Y" uniqKey="Boravleva E" first="Elizaveta Y" last="Boravleva">Elizaveta Y. Boravleva</name></author><author><name sortKey="Kropotkina, Ekaterina A" sort="Kropotkina, Ekaterina A" uniqKey="Kropotkina E" first="Ekaterina A" last="Kropotkina">Ekaterina A. Kropotkina</name></author><author><name sortKey="Mashin, Vadim V" sort="Mashin, Vadim V" uniqKey="Mashin V" first="Vadim V" last="Mashin">Vadim V. Mashin</name></author><author><name sortKey="Krasilnikov, Igor V" sort="Krasilnikov, Igor V" uniqKey="Krasilnikov I" first="Igor V" last="Krasilnikov">Igor V. Krasilnikov</name></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21951678</idno><idno type="pmid">21951678</idno><idno type="doi">10.1111/j.1750-2659.2011.00291.x</idno><idno type="wicri:Area/PubMed/Corpus">000160</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000160</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).</title><author><name sortKey="Gambaryan, Alexandra S" sort="Gambaryan, Alexandra S" uniqKey="Gambaryan A" first="Alexandra S" last="Gambaryan">Alexandra S. Gambaryan</name><affiliation><nlm:affiliation>M P Chumakov Institute of Poliomyelitis and Viral Encephalitides, RAMS, Moscow, Russia. alexandra.gambaryan@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Lomakina, Natalia F" sort="Lomakina, Natalia F" uniqKey="Lomakina N" first="Natalia F" last="Lomakina">Natalia F. Lomakina</name></author><author><name sortKey="Boravleva, Elizaveta Y" sort="Boravleva, Elizaveta Y" uniqKey="Boravleva E" first="Elizaveta Y" last="Boravleva">Elizaveta Y. Boravleva</name></author><author><name sortKey="Kropotkina, Ekaterina A" sort="Kropotkina, Ekaterina A" uniqKey="Kropotkina E" first="Ekaterina A" last="Kropotkina">Ekaterina A. Kropotkina</name></author><author><name sortKey="Mashin, Vadim V" sort="Mashin, Vadim V" uniqKey="Mashin V" first="Vadim V" last="Mashin">Vadim V. Mashin</name></author><author><name sortKey="Krasilnikov, Igor V" sort="Krasilnikov, Igor V" uniqKey="Krasilnikov I" first="Igor V" last="Krasilnikov">Igor V. Krasilnikov</name></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G" last="Rudenko">Larisa G. Rudenko</name></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>Chickens</term><term>Hemagglutinin Glycoproteins, Influenza Virus (adverse effects)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (prevention & control)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Vaccines, Attenuated (adverse effects)</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Inactivated (adverse effects)</term><term>Vaccines, Inactivated (genetics)</term><term>Vaccines, Inactivated (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parallel testing of inactivated (split and whole virion) and live vaccine was conducted to compare the immunogenicity and protective efficacy against homologous and heterosubtypic challenge by H5N1 highly pathogenic avian influenza virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21951678</PMID><DateCompleted><Year>2012</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).</ArticleTitle><Pagination><MedlinePgn>188-95</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1750-2659.2011.00291.x</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Parallel testing of inactivated (split and whole virion) and live vaccine was conducted to compare the immunogenicity and protective efficacy against homologous and heterosubtypic challenge by H5N1 highly pathogenic avian influenza virus.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Four experimental live vaccines based on two H5N1 influenza virus strains were tested; two of them had hemagglutinin (HA) of A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site, and two others had hemagglutinins from attenuated H5N1 virus A/Chicken/Kurgan/3/05, with amino acid substitutions of Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2 while maintaining the polybasic HA cleavage site. The neuraminidase and non-glycoprotein genes of the experimental live vaccines were from H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/Gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). Inactivated H5N1 and H1N1 and live H1N1 vaccine were used for comparison. All vaccines were applied in a single dose. Safety, immunogenicity, and protectivity against the challenge with HPAI H5N1 virus A/Chicken/Kurgan/3/05 were estimated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">All experimental live H5 vaccines tested were apathogenic as determined by weight loss and conferred more than 90% protection against lethal challenge with A/Chicken/Kurgan/3/05 infection. Inactivated H1N1 vaccine in mice offered no protection against challenge with H5N1 virus, while live cold-adapted H1N1 vaccine reduced the mortality near to zero level.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The high yield, safety, and protectivity of VN-Len and Ku-Len made them promising strains for the production of inactivated and live vaccines against H5N1 viruses.</AbstractText><CopyrightInformation>© 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gambaryan</LastName><ForeName>Alexandra S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>M P Chumakov Institute of Poliomyelitis and Viral Encephalitides, RAMS, Moscow, Russia. alexandra.gambaryan@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lomakina</LastName><ForeName>Natalia F</ForeName><Initials>NF</Initials></Author><Author ValidYN="Y"><LastName>Boravleva</LastName><ForeName>Elizaveta Y</ForeName><Initials>EY</Initials></Author><Author ValidYN="Y"><LastName>Kropotkina</LastName><ForeName>Ekaterina A</ForeName><Initials>EA</Initials></Author><Author ValidYN="Y"><LastName>Mashin</LastName><ForeName>Vadim V</ForeName><Initials>VV</Initials></Author><Author ValidYN="Y"><LastName>Krasilnikov</LastName><ForeName>Igor V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Klimov</LastName><ForeName>Alexander I</ForeName><Initials>AI</Initials></Author><Author ValidYN="Y"><LastName>Rudenko</LastName><ForeName>Larisa G</ForeName><Initials>LG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Influenza Other Respir Viruses</MedlineTA><NlmUniqueID>101304007</NlmUniqueID><ISSNLinking>1750-2640</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015164" MajorTopicYN="N">Vaccines, Inactivated</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21951678</ArticleId><ArticleId IdType="doi">10.1111/j.1750-2659.2011.00291.x</ArticleId><ArticleId IdType="pmc">PMC4941668</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Vaccine. 2007 Jan 8;25(4):612-20</Citation><ArticleIdList><ArticleId IdType="pubmed">17005299</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2006 Sep;3(9):e360</Citation><ArticleIdList><ArticleId IdType="pubmed">16968127</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Feb 13;26(7):874-81</Citation><ArticleIdList><ArticleId IdType="pubmed">18207290</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Nov;80(22):11009-18</Citation><ArticleIdList><ArticleId IdType="pubmed">16943300</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Nov 19;25(47):7999-8009</Citation><ArticleIdList><ArticleId IdType="pubmed">17933442</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Nov 10;24(44-46):6585-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16839650</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Jul 4;26(29-30):3580-6</Citation><ArticleIdList><ArticleId IdType="pubmed">18539366</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Immunol Infect. 2006 Aug;39(4):292-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16926974</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 1995 Dec;39(2-3):105-18</Citation><ArticleIdList><ArticleId IdType="pubmed">8837878</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 May 12;312(5775):879-82</Citation><ArticleIdList><ArticleId IdType="pubmed">16690858</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1982 Dec 24;218(4579):1330-2</Citation><ArticleIdList><ArticleId IdType="pubmed">6183749</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Nanomedicine. 2011;6:835-42</Citation><ArticleIdList><ArticleId IdType="pubmed">21589651</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Nov 17;24(47-48):6859-66</Citation><ArticleIdList><ArticleId IdType="pubmed">17050041</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1988 Aug;62(8):3020-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2969057</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Feb;83(4):1742-53</Citation><ArticleIdList><ArticleId IdType="pubmed">19073731</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Nov;82(21):10580-90</Citation><ArticleIdList><ArticleId IdType="pubmed">18768976</ArticleId></ArticleIdList></Reference><Reference><Citation>Avian Pathol. 2003 Feb;32(1):47-55</Citation><ArticleIdList><ArticleId IdType="pubmed">12745380</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Apr;83(8):3568-80</Citation><ArticleIdList><ArticleId IdType="pubmed">19193808</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Feb;84(3):1527-35</Citation><ArticleIdList><ArticleId IdType="pubmed">19923184</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2005 Dec;68(3):116-23</Citation><ArticleIdList><ArticleId IdType="pubmed">16214231</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 1984 Jun;44(3):734-9</Citation><ArticleIdList><ArticleId IdType="pubmed">6724695</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1999 Sep;73(9):7357-67</Citation><ArticleIdList><ArticleId IdType="pubmed">10438825</ArticleId></ArticleIdList></Reference><Reference><Citation>Avian Dis. 2010 Mar;54(1 Suppl):297-301</Citation><ArticleIdList><ArticleId IdType="pubmed">20521649</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2009 Dec 20;395(2):280-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19833372</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Feb 13;26(7):956-65</Citation><ArticleIdList><ArticleId IdType="pubmed">18164519</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2001 Sep 7;293(5536):1840-2</Citation><ArticleIdList><ArticleId IdType="pubmed">11546875</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16339318</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2008 Jul 24;5:85</Citation><ArticleIdList><ArticleId IdType="pubmed">18652681</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6883-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11371620</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1999 Nov;73(11):9679-82</Citation><ArticleIdList><ArticleId IdType="pubmed">10516084</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2003 Jan 5;305(1):192-200</Citation><ArticleIdList><ArticleId IdType="pubmed">12504552</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000160 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000160 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:21951678
|texte= Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:21951678" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |