Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.
Identifieur interne : 000143 ( PubMed/Corpus ); précédent : 000142; suivant : 000144Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.
Auteurs : Ivana D. Radojevi ; Zorica D. Petrovi ; Ljiljana R. Omi ; Dušica Simijonovi ; Vladimir P. Petrovi ; Dimitra Hadjipavlou-LitinaSource :
- Medicinal chemistry (Shariqah (United Arab Emirates)) [ 1875-6638 ] ; 2012.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Antifungal Agents (chemistry), Antifungal Agents (pharmacology), Antineoplastic Agents, Alkylating (chemistry), Antineoplastic Agents, Alkylating (pharmacology), Coordination Complexes (chemistry), Coordination Complexes (pharmacology), Fungi (drug effects), Fungi (growth & development), Gram-Negative Bacteria (drug effects), Gram-Negative Bacteria (growth & development), Gram-Positive Bacteria (drug effects), Gram-Positive Bacteria (growth & development), Lipoxygenase (chemistry), Lipoxygenase (metabolism), Mechlorethamine (chemistry), Microbial Sensitivity Tests, Platinum (chemistry), Prodrugs (chemistry), Prodrugs (pharmacology), Soybeans (chemistry), Soybeans (enzymology).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Alkylating, Coordination Complexes, Lipoxygenase, Mechlorethamine, Platinum, Prodrugs.
- chemical , metabolism : Lipoxygenase.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Alkylating, Coordination Complexes, Prodrugs.
- chemistry : Soybeans.
- drug effects : Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria.
- enzymology : Soybeans.
- growth & development : Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria.
- Microbial Sensitivity Tests.
Abstract
The reaction of K(2)PtCl(4) with anticancer-alkylating agent mechlorethamine hydrochloride (CH(3)NH(C(2)H(4)Cl)(2) x HCl = HN2×HCl), in the molar ratio 1 : 2, affords the complex [H2N2](2)[PtCl(4)]. In vitro antimicrobial and lipoxygenase inhibitory activities of the complex and its precursor were evaluated. Antimicrobial activity of the HN2×HCl and [H2N2](2)[PtCl(4)] complex was investigated against 29 species of microorganisms. Testing is performed by microdilution method. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of precursor and corresponding platinum(II) complex is noticed and the activity of the precursor was higher. Tested compounds demonstrated the high and significant antifungal activity and low to moderate antibacterial activity. It was shown that the gram-positive bacteria were more sensitive than the gram-negative. UV absorbance-based enzyme assays were performed with HN2×HCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also. Assay with LOX showed significantly greater inhibitory activity of the complex, than the precursor.
DOI: 10.2174/157340612802084315
PubMed: 22741794
Links to Exploration step
pubmed:22741794Le document en format XML
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Omi</name></author><author><name sortKey="Simijonovi, Dusica" sort="Simijonovi, Dusica" uniqKey="Simijonovi D" first="Dušica" last="Simijonovi">Dušica Simijonovi</name></author><author><name sortKey="Petrovi, Vladimir P" sort="Petrovi, Vladimir P" uniqKey="Petrovi V" first="Vladimir P" last="Petrovi">Vladimir P. Petrovi</name></author><author><name sortKey="Hadjipavlou Litina, Dimitra" sort="Hadjipavlou Litina, Dimitra" uniqKey="Hadjipavlou Litina D" first="Dimitra" last="Hadjipavlou-Litina">Dimitra Hadjipavlou-Litina</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22741794</idno><idno type="pmid">22741794</idno><idno type="doi">10.2174/157340612802084315</idno><idno type="wicri:Area/PubMed/Corpus">000143</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.</title><author><name sortKey="Radojevi, Ivana D" sort="Radojevi, Ivana D" uniqKey="Radojevi I" first="Ivana D" last="Radojevi">Ivana D. Radojevi</name><affiliation><nlm:affiliation>Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, P. O. Box 60, 34000 Kragujevac, Serbia. ivana@kg.ac.rs</nlm:affiliation></affiliation></author><author><name sortKey="Petrovi, Zorica D" sort="Petrovi, Zorica D" uniqKey="Petrovi Z" first="Zorica D" last="Petrovi">Zorica D. Petrovi</name></author><author><name sortKey=" Omi, Ljiljana R" sort=" Omi, Ljiljana R" uniqKey=" Omi L" first="Ljiljana R" last=" Omi">Ljiljana R. Omi</name></author><author><name sortKey="Simijonovi, Dusica" sort="Simijonovi, Dusica" uniqKey="Simijonovi D" first="Dušica" last="Simijonovi">Dušica Simijonovi</name></author><author><name sortKey="Petrovi, Vladimir P" sort="Petrovi, Vladimir P" uniqKey="Petrovi V" first="Vladimir P" last="Petrovi">Vladimir P. Petrovi</name></author><author><name sortKey="Hadjipavlou Litina, Dimitra" sort="Hadjipavlou Litina, Dimitra" uniqKey="Hadjipavlou Litina D" first="Dimitra" last="Hadjipavlou-Litina">Dimitra Hadjipavlou-Litina</name></author></analytic><series><title level="j">Medicinal chemistry (Shariqah (United Arab Emirates))</title><idno type="eISSN">1875-6638</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Antifungal Agents (chemistry)</term><term>Antifungal Agents (pharmacology)</term><term>Antineoplastic Agents, Alkylating (chemistry)</term><term>Antineoplastic Agents, Alkylating (pharmacology)</term><term>Coordination Complexes (chemistry)</term><term>Coordination Complexes (pharmacology)</term><term>Fungi (drug effects)</term><term>Fungi (growth & development)</term><term>Gram-Negative Bacteria (drug effects)</term><term>Gram-Negative Bacteria (growth & development)</term><term>Gram-Positive Bacteria (drug effects)</term><term>Gram-Positive Bacteria (growth & development)</term><term>Lipoxygenase (chemistry)</term><term>Lipoxygenase (metabolism)</term><term>Mechlorethamine (chemistry)</term><term>Microbial Sensitivity Tests</term><term>Platinum (chemistry)</term><term>Prodrugs (chemistry)</term><term>Prodrugs (pharmacology)</term><term>Soybeans (chemistry)</term><term>Soybeans (enzymology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Antineoplastic Agents, Alkylating</term><term>Coordination Complexes</term><term>Lipoxygenase</term><term>Mechlorethamine</term><term>Platinum</term><term>Prodrugs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lipoxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Antineoplastic Agents, Alkylating</term><term>Coordination Complexes</term><term>Prodrugs</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fungi</term><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Fungi</term><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The reaction of K(2)PtCl(4) with anticancer-alkylating agent mechlorethamine hydrochloride (CH(3)NH(C(2)H(4)Cl)(2) x HCl = HN2×HCl), in the molar ratio 1 : 2, affords the complex [H2N2](2)[PtCl(4)]. In vitro antimicrobial and lipoxygenase inhibitory activities of the complex and its precursor were evaluated. Antimicrobial activity of the HN2×HCl and [H2N2](2)[PtCl(4)] complex was investigated against 29 species of microorganisms. Testing is performed by microdilution method. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of precursor and corresponding platinum(II) complex is noticed and the activity of the precursor was higher. Tested compounds demonstrated the high and significant antifungal activity and low to moderate antibacterial activity. It was shown that the gram-positive bacteria were more sensitive than the gram-negative. UV absorbance-based enzyme assays were performed with HN2×HCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also. Assay with LOX showed significantly greater inhibitory activity of the complex, than the precursor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22741794</PMID><DateCompleted><Year>2012</Year><Month>12</Month><Day>26</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-6638</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Medicinal chemistry (Shariqah (United Arab Emirates))</Title><ISOAbbreviation>Med Chem</ISOAbbreviation></Journal><ArticleTitle>Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.</ArticleTitle><Pagination><MedlinePgn>947-52</MedlinePgn></Pagination><Abstract><AbstractText>The reaction of K(2)PtCl(4) with anticancer-alkylating agent mechlorethamine hydrochloride (CH(3)NH(C(2)H(4)Cl)(2) x HCl = HN2×HCl), in the molar ratio 1 : 2, affords the complex [H2N2](2)[PtCl(4)]. In vitro antimicrobial and lipoxygenase inhibitory activities of the complex and its precursor were evaluated. Antimicrobial activity of the HN2×HCl and [H2N2](2)[PtCl(4)] complex was investigated against 29 species of microorganisms. Testing is performed by microdilution method. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of precursor and corresponding platinum(II) complex is noticed and the activity of the precursor was higher. Tested compounds demonstrated the high and significant antifungal activity and low to moderate antibacterial activity. It was shown that the gram-positive bacteria were more sensitive than the gram-negative. UV absorbance-based enzyme assays were performed with HN2×HCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also. Assay with LOX showed significantly greater inhibitory activity of the complex, than the precursor.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Radojević</LastName><ForeName>Ivana D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, P. O. Box 60, 34000 Kragujevac, Serbia. ivana@kg.ac.rs</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrović</LastName><ForeName>Zorica D</ForeName><Initials>ZD</Initials></Author><Author ValidYN="Y"><LastName>Čomić</LastName><ForeName>Ljiljana R</ForeName><Initials>LR</Initials></Author><Author ValidYN="Y"><LastName>Simijonović</LastName><ForeName>Dušica</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Petrović</LastName><ForeName>Vladimir P</ForeName><Initials>VP</Initials></Author><Author ValidYN="Y"><LastName>Hadjipavlou-Litina</LastName><ForeName>Dimitra</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Med Chem</MedlineTA><NlmUniqueID>101240303</NlmUniqueID><ISSNLinking>1573-4064</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018906">Antineoplastic Agents, Alkylating</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D056831">Coordination Complexes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011355">Prodrugs</NameOfSubstance></Chemical><Chemical><RegistryNumber>49DFR088MY</RegistryNumber><NameOfSubstance UI="D010984">Platinum</NameOfSubstance></Chemical><Chemical><RegistryNumber>50D9XSG0VR</RegistryNumber><NameOfSubstance UI="D008466">Mechlorethamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.13.11.12</RegistryNumber><NameOfSubstance UI="D008084">Lipoxygenase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018906" MajorTopicYN="N">Antineoplastic Agents, Alkylating</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056831" MajorTopicYN="N">Coordination Complexes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006090" MajorTopicYN="N">Gram-Negative Bacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006094" MajorTopicYN="N">Gram-Positive Bacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008084" MajorTopicYN="N">Lipoxygenase</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008466" MajorTopicYN="N">Mechlorethamine</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010984" MajorTopicYN="N">Platinum</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011355" MajorTopicYN="N">Prodrugs</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22741794</ArticleId><ArticleId IdType="pii">MC-EPUB-20120625-19</ArticleId><ArticleId IdType="doi">10.2174/157340612802084315</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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