The age distribution of mortality due to influenza: pandemic and peri-pandemic.
Identifieur interne : 000132 ( PubMed/Corpus ); précédent : 000131; suivant : 000133The age distribution of mortality due to influenza: pandemic and peri-pandemic.
Auteurs : Tom Reichert ; Gerardo Chowell ; Jonathan A. MccullersSource :
- BMC medicine [ 1741-7015 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Influenza, Human.
- mortality : Influenza, Human.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Developed Countries, Female, Humans, Infant, Male, Middle Aged, Pandemics, Young Adult.
Abstract
Pandemic influenza is said to 'shift mortality' to younger age groups; but also to spare a subpopulation of the elderly population. Does one of these effects dominate? Might this have important ramifications?
DOI: 10.1186/1741-7015-10-162
PubMed: 23234604
Links to Exploration step
pubmed:23234604Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The age distribution of mortality due to influenza: pandemic and peri-pandemic.</title><author><name sortKey="Reichert, Tom" sort="Reichert, Tom" uniqKey="Reichert T" first="Tom" last="Reichert">Tom Reichert</name><affiliation><nlm:affiliation>Entropy Research Institute, 345 S, Great Road, Lincoln, 01773, Massachusetts, USA. treichert@entropyresearch.org</nlm:affiliation></affiliation></author><author><name sortKey="Chowell, Gerardo" sort="Chowell, Gerardo" uniqKey="Chowell G" first="Gerardo" last="Chowell">Gerardo Chowell</name></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23234604</idno><idno type="pmid">23234604</idno><idno type="doi">10.1186/1741-7015-10-162</idno><idno type="wicri:Area/PubMed/Corpus">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The age distribution of mortality due to influenza: pandemic and peri-pandemic.</title><author><name sortKey="Reichert, Tom" sort="Reichert, Tom" uniqKey="Reichert T" first="Tom" last="Reichert">Tom Reichert</name><affiliation><nlm:affiliation>Entropy Research Institute, 345 S, Great Road, Lincoln, 01773, Massachusetts, USA. treichert@entropyresearch.org</nlm:affiliation></affiliation></author><author><name sortKey="Chowell, Gerardo" sort="Chowell, Gerardo" uniqKey="Chowell G" first="Gerardo" last="Chowell">Gerardo Chowell</name></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A" last="Mccullers">Jonathan A. Mccullers</name></author></analytic><series><title level="j">BMC medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Developed Countries</term><term>Female</term><term>Humans</term><term>Infant</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (mortality)</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Developed Countries</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pandemic influenza is said to 'shift mortality' to younger age groups; but also to spare a subpopulation of the elderly population. Does one of these effects dominate? Might this have important ramifications?</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23234604</PMID><DateCompleted><Year>2013</Year><Month>06</Month><Day>03</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1741-7015</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><PubDate><Year>2012</Year><Month>Dec</Month><Day>12</Day></PubDate></JournalIssue><Title>BMC medicine</Title><ISOAbbreviation>BMC Med</ISOAbbreviation></Journal><ArticleTitle>The age distribution of mortality due to influenza: pandemic and peri-pandemic.</ArticleTitle><Pagination><MedlinePgn>162</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1741-7015-10-162</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pandemic influenza is said to 'shift mortality' to younger age groups; but also to spare a subpopulation of the elderly population. Does one of these effects dominate? Might this have important ramifications?</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We estimated age-specific excess mortality rates for all-years for which data were available in the 20th century for Australia, Canada, France, Japan, the UK, and the USA for people older than 44 years of age. We modeled variation with age, and standardized estimates to allow direct comparison across age groups and countries. Attack rate data for four pandemics were assembled.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For nearly all seasons, an exponential model characterized mortality data extremely well. For seasons of emergence and a variable number of seasons following, however, a subpopulation above a threshold age invariably enjoyed reduced mortality. 'Immune escape', a stepwise increase in mortality among the oldest elderly, was observed a number of seasons after both the A(H2N2) and A(H3N2) pandemics. The number of seasons from emergence to escape varied by country. For the latter pandemic, mortality rates in four countries increased for younger age groups but only in the season following that of emergence. Adaptation to both emergent viruses was apparent as a progressive decrease in mortality rates, which, with two exceptions, was seen only in younger age groups. Pandemic attack rate variation with age was estimated to be similar across four pandemics with very different mortality impact.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In all influenza pandemics of the 20th century, emergent viruses resembled those that had circulated previously within the lifespan of then-living people. Such individuals were relatively immune to the emergent strain, but this immunity waned with mutation of the emergent virus. An immune subpopulation complicates and may invalidate vaccine trials. Pandemic influenza does not 'shift' mortality to younger age groups; rather, the mortality level is reset by the virulence of the emerging virus and is moderated by immunity of past experience. In this study, we found that after immune escape, older age groups showed no further mortality reduction, despite their being the principal target of conventional influenza vaccines. Vaccines incorporating variants of pandemic viruses seem to provide little benefit to those previously immune. If attack rates truly are similar across pandemics, it must be the case that immunity to the pandemic virus does not prevent infection, but only mitigates the consequences.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reichert</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Entropy Research Institute, 345 S, Great Road, Lincoln, 01773, Massachusetts, USA. treichert@entropyresearch.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chowell</LastName><ForeName>Gerardo</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>McCullers</LastName><ForeName>Jonathan A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>12</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Med</MedlineTA><NlmUniqueID>101190723</NlmUniqueID><ISSNLinking>1741-7015</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019049" MajorTopicYN="N">Developed Countries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>12</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>6</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23234604</ArticleId><ArticleId IdType="pii">1741-7015-10-162</ArticleId><ArticleId IdType="doi">10.1186/1741-7015-10-162</ArticleId><ArticleId IdType="pmc">PMC3554498</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Bull World Health Organ. 1999;77(10):820-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10593030</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2008 May 29;453(7195):667-71</Citation><ArticleIdList><ArticleId IdType="pubmed">18449194</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12</Citation><ArticleIdList><ArticleId IdType="pubmed">19597152</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):674-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19564633</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2009 Sep 1;183(5):3294-301</Citation><ArticleIdList><ArticleId IdType="pubmed">19648276</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2009;14(33). pii: 19309</Citation><ArticleIdList><ArticleId IdType="pubmed">19712643</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2010;10:5</Citation><ArticleIdList><ArticleId IdType="pubmed">20059763</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2010 Aug 15;202(4):567-75</Citation><ArticleIdList><ArticleId IdType="pubmed">20594109</ArticleId></ArticleIdList></Reference><Reference><Citation>Health Technol Assess. 2010 Dec;14(55):115-92</Citation><ArticleIdList><ArticleId IdType="pubmed">21208549</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2011 Mar 15;183(6):767-73</Citation><ArticleIdList><ArticleId IdType="pubmed">20935106</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2011 Jul 22;29 Suppl 2:B42-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21757103</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2012 Jan;18(1):48-56</Citation><ArticleIdList><ArticleId IdType="pubmed">22257780</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2012;8(7):e1002802</Citation><ArticleIdList><ArticleId IdType="pubmed">22829765</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(8):e42328</Citation><ArticleIdList><ArticleId IdType="pubmed">22876316</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13751-6</Citation><ArticleIdList><ArticleId IdType="pubmed">22869731</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2006 Jun;18(3):255-64</Citation><ArticleIdList><ArticleId IdType="pubmed">16632337</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2001 Mar 22;344(12):889-96</Citation><ArticleIdList><ArticleId IdType="pubmed">11259722</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jan 8;289(2):179-86</Citation><ArticleIdList><ArticleId IdType="pubmed">12517228</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 2004 Sep 1;160(5):492-502</Citation><ArticleIdList><ArticleId IdType="pubmed">15321847</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2004 Oct 10;328(1):101-19</Citation><ArticleIdList><ArticleId IdType="pubmed">15380362</ArticleId></ArticleIdList></Reference><Reference><Citation>Bull World Health Organ. 1969;41(3):361-6</Citation><ArticleIdList><ArticleId IdType="pubmed">5309440</ArticleId></ArticleIdList></Reference><Reference><Citation>Bull World Health Organ. 1969;41(3):461-8</Citation><ArticleIdList><ArticleId IdType="pubmed">5309456</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1970 Oct;92(4):240-7</Citation><ArticleIdList><ArticleId IdType="pubmed">5458216</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Soc Exp Biol Med. 1972 Mar;139(3):825-6</Citation><ArticleIdList><ArticleId IdType="pubmed">5023771</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1973 Aug;98(2):96-103</Citation><ArticleIdList><ArticleId IdType="pubmed">4125129</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1975 Mar;72(3):1012-6</Citation><ArticleIdList><ArticleId IdType="pubmed">48247</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 1976 Feb;103(2):166-73</Citation><ArticleIdList><ArticleId IdType="pubmed">1251831</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1978 Sep;89(2):613-7</Citation><ArticleIdList><ArticleId IdType="pubmed">716220</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1980 Aug 21;286(5775):771-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7402351</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 1993;11(10):1055-60</Citation><ArticleIdList><ArticleId IdType="pubmed">8212827</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1994 May;169(5):1125-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8169406</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1998 Jul;178(1):53-60</Citation><ArticleIdList><ArticleId IdType="pubmed">9652423</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1998 Jul 30;394(6692):482-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9697771</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1958 Apr 19;1(7025):814-8</Citation><ArticleIdList><ArticleId IdType="pubmed">13526280</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Dec;78(23):12817-28</Citation><ArticleIdList><ArticleId IdType="pubmed">15542634</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2005 Feb 3;23(11):1414-25</Citation><ArticleIdList><ArticleId IdType="pubmed">15661391</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Intern Med. 2005 Feb 14;165(3):265-72</Citation><ArticleIdList><ArticleId IdType="pubmed">15710788</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Jul 15;192(2):233-48</Citation><ArticleIdList><ArticleId IdType="pubmed">15962218</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 2005 Jul;150(7):1327-38</Citation><ArticleIdList><ArticleId IdType="pubmed">15789269</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11059-63</Citation><ArticleIdList><ArticleId IdType="pubmed">16046546</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2005 Oct 1;366(9492):1165-74</Citation><ArticleIdList><ArticleId IdType="pubmed">16198765</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2005 Nov 15;192(10):1858-60; author reply 1860-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16235189</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Feb 20;24(8):1159-69</Citation><ArticleIdList><ArticleId IdType="pubmed">16213065</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Mar 24;24(14):2451-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16417956</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Rev. 2006 Jun;211:310-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16824138</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Prev Med. 2006 Sep;31(3):252-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16905037</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2007 Oct;7(10):658-66</Citation><ArticleIdList><ArticleId IdType="pubmed">17897608</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2007 Nov;8(11):1188-93</Citation><ArticleIdList><ArticleId IdType="pubmed">17952044</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2008 Jan 15;197(2):270-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18194088</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2008 Mar 25;5(3):e74</Citation><ArticleIdList><ArticleId IdType="pubmed">18366252</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2008 Feb 15;4(2):e1000012</Citation><ArticleIdList><ArticleId IdType="pubmed">18463694</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2008 May 29;453(7195):615-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18418375</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Jun 18;360(25):2595-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19423872</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000132 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000132 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:23234604
|texte= The age distribution of mortality due to influenza: pandemic and peri-pandemic.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:23234604" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |