Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
Identifieur interne : 000030 ( PubMed/Corpus ); précédent : 000029; suivant : 000031Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
Auteurs : Mizuho Suzuki ; Masatoshi Okamatsu ; Takahiro Hiono ; Keita Matsuno ; Yoshihiro SakodaSource :
- The Journal of veterinary medical science [ 1347-7439 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Cross Reactions (immunology), Female, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza Vaccines (pharmacology), Mice, Mice, Inbred BALB C, Neutralization Tests (veterinary), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Phylogeny, Sequence Analysis, DNA, Vaccines, Inactivated (immunology), Vaccines, Inactivated (pharmacology).
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Inactivated.
- genetics : Influenza A virus.
- immunology : Cross Reactions, Influenza A virus, Orthomyxoviridae Infections.
- chemical , pharmacology : Influenza Vaccines, Vaccines, Inactivated.
- prevention & control : Orthomyxoviridae Infections.
- veterinary : Neutralization Tests.
- virology : Orthomyxoviridae Infections.
- Animals, Female, Mice, Mice, Inbred BALB C, Phylogeny, Sequence Analysis, DNA.
Abstract
H2N2 influenza virus caused a pandemic starting in 1957 but has not been detected in humans since 1968. Thus, most people are immunologically naive to viruses of the H2 subtype. In contrast, H2 influenza viruses are continually isolated from wild birds, and H2N3 viruses were isolated from pigs in 2006. H2 influenza viruses could cause a pandemic if re-introduced into humans. In the present study, a vaccine against H2 influenza was prepared as an effective control measure against a future human pandemic. A/duck/Hokkaido/162/2013 (H2N1), which showed broad antigenic cross-reactivity, was selected from the candidate H2 influenza viruses recently isolated from wild birds in Asian countries. Sufficient neutralizing antibodies against homologous and heterologous viruses were induced in mice after two subcutaneous injections of the inactivated whole virus particle vaccine. The inactivated vaccine induced protective immunity sufficient to reduce the impact of challenges with A/swine/Missouri/2124514/2006 (H2N3). This study demonstrates that the inactivated whole virus particle vaccine prepared from an influenza virus library would be useful against a future H2 influenza pandemic.
DOI: 10.1292/jvms.17-0312
PubMed: 28993601
Links to Exploration step
pubmed:28993601Le document en format XML
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<front><div type="abstract" xml:lang="en">H2N2 influenza virus caused a pandemic starting in 1957 but has not been detected in humans since 1968. Thus, most people are immunologically naive to viruses of the H2 subtype. In contrast, H2 influenza viruses are continually isolated from wild birds, and H2N3 viruses were isolated from pigs in 2006. H2 influenza viruses could cause a pandemic if re-introduced into humans. In the present study, a vaccine against H2 influenza was prepared as an effective control measure against a future human pandemic. A/duck/Hokkaido/162/2013 (H2N1), which showed broad antigenic cross-reactivity, was selected from the candidate H2 influenza viruses recently isolated from wild birds in Asian countries. Sufficient neutralizing antibodies against homologous and heterologous viruses were induced in mice after two subcutaneous injections of the inactivated whole virus particle vaccine. The inactivated vaccine induced protective immunity sufficient to reduce the impact of challenges with A/swine/Missouri/2124514/2006 (H2N3). This study demonstrates that the inactivated whole virus particle vaccine prepared from an influenza virus library would be useful against a future H2 influenza pandemic.</div>
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