H2 influenza viruses: designing vaccines against future H2 pandemics.
Identifieur interne : 000011 ( PubMed/Corpus ); précédent : 000010; suivant : 000012H2 influenza viruses: designing vaccines against future H2 pandemics.
Auteurs : Z Beau Reneer ; Ted M. RossSource :
- Biochemical Society transactions [ 1470-8752 ] ; 2019.
English descriptors
- KwdEn :
- Animals, Binding Sites, Birds, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (biosynthesis), Influenza in Birds (epidemiology), Influenza in Birds (prevention & control), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (transmission), N-Acetylneuraminic Acid (metabolism), Pandemics (prevention & control), Swine.
- MESH :
- chemical , biosynthesis : Influenza Vaccines.
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, N-Acetylneuraminic Acid.
- epidemiology : Influenza in Birds.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza, Human.
- prevention & control : Influenza in Birds, Influenza, Human, Pandemics.
- transmission : Influenza, Human.
- Animals, Binding Sites, Birds, Humans, Swine.
Abstract
Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'Asian Flu' pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world's population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.
DOI: 10.1042/BST20180602
PubMed: 30647144
Links to Exploration step
pubmed:30647144Le document en format XML
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Ross</name><affiliation><nlm:affiliation>Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A. tedross@uga.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30647144</idno><idno type="pmid">30647144</idno><idno type="doi">10.1042/BST20180602</idno><idno type="wicri:Area/PubMed/Corpus">000011</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">H2 influenza viruses: designing vaccines against future H2 pandemics.</title><author><name sortKey="Reneer, Z Beau" sort="Reneer, Z Beau" uniqKey="Reneer Z" first="Z Beau" last="Reneer">Z Beau Reneer</name><affiliation><nlm:affiliation>Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A.</nlm:affiliation></affiliation></author><author><name sortKey="Ross, Ted M" sort="Ross, Ted M" uniqKey="Ross T" first="Ted M" last="Ross">Ted M. Ross</name><affiliation><nlm:affiliation>Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A. tedross@uga.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biochemical Society transactions</title><idno type="eISSN">1470-8752</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>Birds</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza Vaccines (biosynthesis)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (prevention & control)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (transmission)</term><term>N-Acetylneuraminic Acid (metabolism)</term><term>Pandemics (prevention & control)</term><term>Swine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>N-Acetylneuraminic Acid</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Binding Sites</term><term>Birds</term><term>Humans</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'Asian Flu' pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world's population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30647144</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1470-8752</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>02</Month><Day>28</Day></PubDate></JournalIssue><Title>Biochemical Society transactions</Title><ISOAbbreviation>Biochem. Soc. Trans.</ISOAbbreviation></Journal><ArticleTitle>H2 influenza viruses: designing vaccines against future H2 pandemics.</ArticleTitle><Pagination><MedlinePgn>251-264</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1042/BST20180602</ELocationID><Abstract><AbstractText>Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'Asian Flu' pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world's population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.</AbstractText><CopyrightInformation>© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reneer</LastName><ForeName>Z Beau</ForeName><Initials>ZB</Initials><AffiliationInfo><Affiliation>Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Ted M</ForeName><Initials>TM</Initials><Identifier Source="ORCID">0000-0003-1947-7469</Identifier><AffiliationInfo><Affiliation>Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, U.S.A. tedross@uga.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Infectious Diseases, University of Georgia, Athens, GA 30602, U.S.A.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019158" MajorTopicYN="N">N-Acetylneuraminic Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">H2N2</Keyword><Keyword MajorTopicYN="Y">influenza</Keyword><Keyword MajorTopicYN="Y">pandemic</Keyword><Keyword MajorTopicYN="Y">vaccine</Keyword><Keyword MajorTopicYN="Y">virus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>08</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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