Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China.
Identifieur interne : 000002 ( PubMed/Corpus ); précédent : 000001; suivant : 000003Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China.
Auteurs : Yafen Song ; Yong Zhang ; Bing Zhang ; Ling Chen ; Min Zhang ; Jingwen Wang ; Ying Jiang ; Chenghuai Yang ; Taozhen JiangSource :
- Viruses [ 1999-4915 ] ; 2020.
Abstract
Swine influenza virus causes a substantial disease burden to swine populations worldwide and poses an imminent threat to the swine industry and humans. Given its importance, we characterized two swine influenza viruses isolated from Shandong, China. The homology and phylogenetic analyses showed that all eight gene segments of A/swine/Shandong/AV1522/2011(H1N1) were closely related to A/Maryland/12/1991(H1N1) circulating in North America. The HA, NA, M, and NS genes of the isolate were also confirmed to have a high homology to A/swine/Hubei/02/2008(H1N1) which appeared in China in 2008, and the virus was clustered into the classical swine lineage. The gene segments of A/swine/Shandong/AV1523/2011(H1N1) were highly homologous to the early human H1N1 and H2N2 influenza viruses, except for the HA gene, and the virus was a reassortant H1N1 virus containing genes from the classical swine (HA) and human (NA, PB2, PB1, PA, NP, M, and NS) lineages. Both the viruses could cause lethal infection and replicate efficiently in the lungs, brains, spleens, and kidneys of mice. Histopathological examinations showed that AV1522 and AV1523 viruses caused a spectrum of marked pneumonia and meningoencephalitis according to the duration of infection, demonstrating a progression of respiratory disease and neurological disease over the course of infection that ultimately resulted in lethality for the infected mice. The changes in the pathogenicity of swine influenza viruses to mammals, accompanied with the continuous reassortment and evolution of the viruses, highlights the importance of ongoing epidemiological investigation.
DOI: 10.3390/v12010055
PubMed: 31906591
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China.</title><author><name sortKey="Song, Yafen" sort="Song, Yafen" uniqKey="Song Y" first="Yafen" last="Song">Yafen Song</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Min" sort="Zhang, Min" uniqKey="Zhang M" first="Min" last="Zhang">Min Zhang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jingwen" sort="Wang, Jingwen" uniqKey="Wang J" first="Jingwen" last="Wang">Jingwen Wang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Ying" sort="Jiang, Ying" uniqKey="Jiang Y" first="Ying" last="Jiang">Ying Jiang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Chenghuai" sort="Yang, Chenghuai" uniqKey="Yang C" first="Chenghuai" last="Yang">Chenghuai Yang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Taozhen" sort="Jiang, Taozhen" uniqKey="Jiang T" first="Taozhen" last="Jiang">Taozhen Jiang</name><affiliation><nlm:affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Swine influenza virus causes a substantial disease burden to swine populations worldwide and poses an imminent threat to the swine industry and humans. Given its importance, we characterized two swine influenza viruses isolated from Shandong, China. The homology and phylogenetic analyses showed that all eight gene segments of A/swine/Shandong/AV1522/2011(H1N1) were closely related to A/Maryland/12/1991(H1N1) circulating in North America. The HA, NA, M, and NS genes of the isolate were also confirmed to have a high homology to A/swine/Hubei/02/2008(H1N1) which appeared in China in 2008, and the virus was clustered into the classical swine lineage. The gene segments of A/swine/Shandong/AV1523/2011(H1N1) were highly homologous to the early human H1N1 and H2N2 influenza viruses, except for the HA gene, and the virus was a reassortant H1N1 virus containing genes from the classical swine (HA) and human (NA, PB2, PB1, PA, NP, M, and NS) lineages. Both the viruses could cause lethal infection and replicate efficiently in the lungs, brains, spleens, and kidneys of mice. Histopathological examinations showed that AV1522 and AV1523 viruses caused a spectrum of marked pneumonia and meningoencephalitis according to the duration of infection, demonstrating a progression of respiratory disease and neurological disease over the course of infection that ultimately resulted in lethality for the infected mice. The changes in the pathogenicity of swine influenza viruses to mammals, accompanied with the continuous reassortment and evolution of the viruses, highlights the importance of ongoing epidemiological investigation.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31906591</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jan</Month><Day>02</Day></PubDate></JournalIssue><Title>Viruses</Title><ISOAbbreviation>Viruses</ISOAbbreviation></Journal><ArticleTitle>Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E55</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/v12010055</ELocationID><Abstract><AbstractText>Swine influenza virus causes a substantial disease burden to swine populations worldwide and poses an imminent threat to the swine industry and humans. Given its importance, we characterized two swine influenza viruses isolated from Shandong, China. The homology and phylogenetic analyses showed that all eight gene segments of A/swine/Shandong/AV1522/2011(H1N1) were closely related to A/Maryland/12/1991(H1N1) circulating in North America. The HA, NA, M, and NS genes of the isolate were also confirmed to have a high homology to A/swine/Hubei/02/2008(H1N1) which appeared in China in 2008, and the virus was clustered into the classical swine lineage. The gene segments of A/swine/Shandong/AV1523/2011(H1N1) were highly homologous to the early human H1N1 and H2N2 influenza viruses, except for the HA gene, and the virus was a reassortant H1N1 virus containing genes from the classical swine (HA) and human (NA, PB2, PB1, PA, NP, M, and NS) lineages. Both the viruses could cause lethal infection and replicate efficiently in the lungs, brains, spleens, and kidneys of mice. Histopathological examinations showed that AV1522 and AV1523 viruses caused a spectrum of marked pneumonia and meningoencephalitis according to the duration of infection, demonstrating a progression of respiratory disease and neurological disease over the course of infection that ultimately resulted in lethality for the infected mice. The changes in the pathogenicity of swine influenza viruses to mammals, accompanied with the continuous reassortment and evolution of the viruses, highlights the importance of ongoing epidemiological investigation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Yafen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jingwen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Chenghuai</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Taozhen</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Veterinary Culture Collection, China Institute of Veterinary Drug Control, 8 Nandajie, Zhongguancun, Haidian District, Beijing 100081, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>2016YFC1201603</GrantID><Agency>the National Key Research and Development Program of the People's Republic of China</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Viruses</MedlineTA><NlmUniqueID>101509722</NlmUniqueID><ISSNLinking>1999-4915</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList 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