Serveur d'exploration H2N2

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[COLD-ADAPTED A/KRASNODAR/101/35/59 (H2N2) STRAIN--A PROMISING STRAIN-DONOR OF ATTENUATION FOR PROCURATION OF LIVE INFLUENZA VACCINES].

Identifieur interne : 000583 ( PubMed/Checkpoint ); précédent : 000582; suivant : 000584

[COLD-ADAPTED A/KRASNODAR/101/35/59 (H2N2) STRAIN--A PROMISING STRAIN-DONOR OF ATTENUATION FOR PROCURATION OF LIVE INFLUENZA VACCINES].

Auteurs : S G Markushin ; T M Tsfasman ; A V Terekhov ; K V Lisovskaya ; I I Akopova

Source :

RBID : pubmed:26829850

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English descriptors

Abstract

Study of ts, ca, att phenotype, immunogenicity and protective effectiveness of reassortants obtained by a way of recombination of a new influenza cold-adapted (ca) strain donor of attenuation A/Krasnodar/101/35/59 (H2N2) and virulent strain of influenza virus.

PubMed: 26829850


Affiliations:


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pubmed:26829850

Le document en format XML

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<title xml:lang="en">[COLD-ADAPTED A/KRASNODAR/101/35/59 (H2N2) STRAIN--A PROMISING STRAIN-DONOR OF ATTENUATION FOR PROCURATION OF LIVE INFLUENZA VACCINES].</title>
<author>
<name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name>
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<name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name>
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<name sortKey="Terekhov, A V" sort="Terekhov, A V" uniqKey="Terekhov A" first="A V" last="Terekhov">A V Terekhov</name>
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<author>
<name sortKey="Lisovskaya, K V" sort="Lisovskaya, K V" uniqKey="Lisovskaya K" first="K V" last="Lisovskaya">K V Lisovskaya</name>
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<name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name>
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<term>Immunization</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (pathogenicity)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
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<term>Vaccines, Attenuated (therapeutic use)</term>
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<term>Animaux</term>
<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Souris</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (pathogénicité)</term>
<term>Vaccins antigrippaux (immunologie)</term>
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<term>Vaccins atténués (usage thérapeutique)</term>
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<term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
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<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en">
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr">
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
</keywords>
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<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
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<term>Grippe humaine</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Influenza, Human</term>
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<term>Animals</term>
<term>Chick Embryo</term>
<term>Cold Temperature</term>
<term>Humans</term>
<term>Immunization</term>
<term>Mice</term>
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<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Grippe humaine</term>
<term>Humains</term>
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<front>
<div type="abstract" xml:lang="en">Study of ts, ca, att phenotype, immunogenicity and protective effectiveness of reassortants obtained by a way of recombination of a new influenza cold-adapted (ca) strain donor of attenuation A/Krasnodar/101/35/59 (H2N2) and virulent strain of influenza virus.</div>
</front>
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<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">26829850</PMID>
<DateCompleted>
<Year>2016</Year>
<Month>02</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised>
<Year>2016</Year>
<Month>02</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Print">0372-9311</ISSN>
<JournalIssue CitedMedium="Print">
<Issue>5</Issue>
<PubDate>
<MedlineDate>2015 Sep-Oct</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Zhurnal mikrobiologii, epidemiologii, i immunobiologii</Title>
<ISOAbbreviation>Zh. Mikrobiol. Epidemiol. Immunobiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>[COLD-ADAPTED A/KRASNODAR/101/35/59 (H2N2) STRAIN--A PROMISING STRAIN-DONOR OF ATTENUATION FOR PROCURATION OF LIVE INFLUENZA VACCINES].</ArticleTitle>
<Pagination>
<MedlinePgn>27-32</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">Study of ts, ca, att phenotype, immunogenicity and protective effectiveness of reassortants obtained by a way of recombination of a new influenza cold-adapted (ca) strain donor of attenuation A/Krasnodar/101/35/59 (H2N2) and virulent strain of influenza virus.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Viruses were used: ca strain A/Krasnodar/101/35.59 (H2N2), virulent strains: A/Kumamoto/102/02 (H3N2) and A/Bern/07/95. For determination of ts and ca phenotype, titration of viruses in chicken embryos was carried out simultaneously at optimal, decreased and increased temperature. Protective effect of immunization was evaluated during intranasal infection of mice with a virulent strain of influenza virus.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All the obtained reassortants possessed 6 internal genes from strain-donor of attenuation and 2 genes, coding HA and NA-proteins from virulent strains. Ca reassortants were characterized by ts and ca phenotype, had antigenic specificity and good immunogenicity, had high protective effectiveness.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The data obtained indicate on the perspectiveness of ca strain A/Krasnodar/101/35/59 (H2N2)as a donor of attenuation for live influenza vaccines.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
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<LastName>Markushin</LastName>
<ForeName>S G</ForeName>
<Initials>SG</Initials>
</Author>
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<LastName>Tsfasman</LastName>
<ForeName>T M</ForeName>
<Initials>TM</Initials>
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<LastName>Terekhov</LastName>
<ForeName>A V</ForeName>
<Initials>AV</Initials>
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<LastName>Lisovskaya</LastName>
<ForeName>K V</ForeName>
<Initials>KV</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Akopova</LastName>
<ForeName>I I</ForeName>
<Initials>II</Initials>
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<DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
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<MeshHeading>
<DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
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<Hour>6</Hour>
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<name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name>
<name sortKey="Lisovskaya, K V" sort="Lisovskaya, K V" uniqKey="Lisovskaya K" first="K V" last="Lisovskaya">K V Lisovskaya</name>
<name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name>
<name sortKey="Terekhov, A V" sort="Terekhov, A V" uniqKey="Terekhov A" first="A V" last="Terekhov">A V Terekhov</name>
<name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name>
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