Attenuated ts-recombinants of influenza A/USSR/77 (H1N1) virus obtained by crossing with the cold-adapted donor A/Leningrad/134/57 (H2N2) virus.
Identifieur interne : 000491 ( PubMed/Checkpoint ); précédent : 000490; suivant : 000492Attenuated ts-recombinants of influenza A/USSR/77 (H1N1) virus obtained by crossing with the cold-adapted donor A/Leningrad/134/57 (H2N2) virus.
Auteurs : F I Polezhaev ; L M Garmashova ; T A Koval ; G P Taranova ; N V Topuriya ; G I AleksandrovaSource :
- Acta virologica [ 0001-723X ] ; 1982.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Anticorps antiviraux (analyse), Humains, Hémagglutinines virales (analyse), Immunisation, Recombinaison génétique, Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Température, Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- analyse : Anticorps antiviraux, Hémagglutinines virales.
- génétique : Virus de la grippe A.
- immunologie : Sialidase, Vaccins antigrippaux, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- Adolescent, Adulte, Humains, Immunisation, Recombinaison génétique, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Température.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (analysis), Hemagglutinins, Viral (analysis), Humans, Immunization, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza Vaccines (immunology), Neuraminidase (immunology), Recombination, Genetic, Temperature.
- MESH :
- chemical , analysis : Antibodies, Viral, Hemagglutinins, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines, Neuraminidase.
- pathogenicity : Influenza A virus.
- Adolescent, Adult, Humans, Immunization, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Recombination, Genetic, Temperature.
Abstract
Conditions of obtaining attenuated influenza virus recombinants by crossing of a cold-adapted donor with A (H1N1) influenza virus that reappeared in 1977 were studied. Temperature-sensitive recombinants suitable for intranasal immunization of adults with low titres of anti-haemagglutinin and anti-neuraminidase antibodies, and possessing sufficiently high immunogenicity were obtained by crossing of native parent strains and cross-reactivation techniques. It was confirmed that the cold-adapted A/Leningrad/134/17/57 (H2N2) influenza virus variant is a prospective donor of attenuation for obtaining recombinants--candidates for live influenza vaccine strains.
PubMed: 6127928
Affiliations:
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pubmed:6127928Le document en format XML
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<author><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name>
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<author><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name>
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<author><name sortKey="Koval, T A" sort="Koval, T A" uniqKey="Koval T" first="T A" last="Koval">T A Koval</name>
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<author><name sortKey="Taranova, G P" sort="Taranova, G P" uniqKey="Taranova G" first="G P" last="Taranova">G P Taranova</name>
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<author><name sortKey="Topuriya, N V" sort="Topuriya, N V" uniqKey="Topuriya N" first="N V" last="Topuriya">N V Topuriya</name>
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<author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name>
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<author><name sortKey="Taranova, G P" sort="Taranova, G P" uniqKey="Taranova G" first="G P" last="Taranova">G P Taranova</name>
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<series><title level="j">Acta virologica</title>
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<term>Adult</term>
<term>Antibodies, Viral (analysis)</term>
<term>Hemagglutinins, Viral (analysis)</term>
<term>Humans</term>
<term>Immunization</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Neuraminidase (immunology)</term>
<term>Recombination, Genetic</term>
<term>Temperature</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Humains</term>
<term>Hémagglutinines virales (analyse)</term>
<term>Immunisation</term>
<term>Recombinaison génétique</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Température</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term>
<term>Hemagglutinins, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Hémagglutinines virales</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sialidase</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
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<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Humans</term>
<term>Immunization</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Recombination, Genetic</term>
<term>Temperature</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Recombinaison génétique</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Température</term>
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<front><div type="abstract" xml:lang="en">Conditions of obtaining attenuated influenza virus recombinants by crossing of a cold-adapted donor with A (H1N1) influenza virus that reappeared in 1977 were studied. Temperature-sensitive recombinants suitable for intranasal immunization of adults with low titres of anti-haemagglutinin and anti-neuraminidase antibodies, and possessing sufficiently high immunogenicity were obtained by crossing of native parent strains and cross-reactivation techniques. It was confirmed that the cold-adapted A/Leningrad/134/17/57 (H2N2) influenza virus variant is a prospective donor of attenuation for obtaining recombinants--candidates for live influenza vaccine strains.</div>
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<Month>12</Month>
<Day>21</Day>
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<DateRevised><Year>2005</Year>
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<Day>05</Day>
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<JournalIssue CitedMedium="Print"><Volume>26</Volume>
<Issue>4</Issue>
<PubDate><Year>1982</Year>
<Month>Jul</Month>
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<Title>Acta virologica</Title>
<ISOAbbreviation>Acta Virol.</ISOAbbreviation>
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<ArticleTitle>Attenuated ts-recombinants of influenza A/USSR/77 (H1N1) virus obtained by crossing with the cold-adapted donor A/Leningrad/134/57 (H2N2) virus.</ArticleTitle>
<Pagination><MedlinePgn>221-6</MedlinePgn>
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<Abstract><AbstractText>Conditions of obtaining attenuated influenza virus recombinants by crossing of a cold-adapted donor with A (H1N1) influenza virus that reappeared in 1977 were studied. Temperature-sensitive recombinants suitable for intranasal immunization of adults with low titres of anti-haemagglutinin and anti-neuraminidase antibodies, and possessing sufficiently high immunogenicity were obtained by crossing of native parent strains and cross-reactivation techniques. It was confirmed that the cold-adapted A/Leningrad/134/17/57 (H2N2) influenza virus variant is a prospective donor of attenuation for obtaining recombinants--candidates for live influenza vaccine strains.</AbstractText>
</Abstract>
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<tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name>
<name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name>
<name sortKey="Koval, T A" sort="Koval, T A" uniqKey="Koval T" first="T A" last="Koval">T A Koval</name>
<name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name>
<name sortKey="Taranova, G P" sort="Taranova, G P" uniqKey="Taranova G" first="G P" last="Taranova">G P Taranova</name>
<name sortKey="Topuriya, N V" sort="Topuriya, N V" uniqKey="Topuriya N" first="N V" last="Topuriya">N V Topuriya</name>
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