Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.
Identifieur interne : 000406 ( PubMed/Checkpoint ); précédent : 000405; suivant : 000407Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.
Auteurs : B V Migunova ; A Z Plusnin ; N A Petrov ; M I Rivkin ; E B Grinbaum ; L V Obuchova ; O K KuznetzovSource :
- Acta virologica [ 0001-723X ] ; 1990.
Descripteurs français
- KwdFr :
- ADN viral (), Données de séquences moléculaires, Fréquence d'allèle, Glycoprotéine hémagglutinine du virus influenza, Gènes viraux, Humains, Hémagglutinines virales (génétique), Mutation, Orthomyxoviridae (génétique), Séquence d'acides aminés, Séquence nucléotidique, Variation des antigènes (génétique), Évolution biologique.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA, Viral.
- genetics : Antigenic Variation, Hemagglutinins, Viral, Orthomyxoviridae.
- Amino Acid Sequence, Base Sequence, Biological Evolution, Gene Frequency, Genes, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Molecular Sequence Data, Mutation.
Abstract
Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at position 51 of HA1 gene) caused an antigenic drift. One silent mutation was detected (nucleotide 428 of HA1 gene) which points at the relatedness of strains A/Leningrad/385/80 with A/Bangkok/2/79 and with other more recent strains. These data allowed to determine the position of the strain A/Leningrad/385/80 HA gene regarding to the evolutionary relationships of HA genes of influenza A (H3N2 subtype) viruses. The branch leading to the above-mentioned strain is supposed to start from a point common for strains isolated following A/Bangkok/1/79. The mutations of HA genes presented in this subgroup were analysed supporting the notion on limited evolutionary potential of the subtype H3N2 influenza viruses.
PubMed: 1980394
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.</title><author><name sortKey="Migunova, B V" sort="Migunova, B V" uniqKey="Migunova B" first="B V" last="Migunova">B V Migunova</name><affiliation><nlm:affiliation>Research Institute of Vaccines, Sera Minmedbioprom U.S.S.R., Leningrad.</nlm:affiliation><wicri:noCountry code="subField">Leningrad</wicri:noCountry></affiliation></author><author><name sortKey="Plusnin, A Z" sort="Plusnin, A Z" uniqKey="Plusnin A" first="A Z" last="Plusnin">A Z Plusnin</name></author><author><name sortKey="Petrov, N A" sort="Petrov, N A" uniqKey="Petrov N" first="N A" last="Petrov">N A Petrov</name></author><author><name sortKey="Rivkin, M I" sort="Rivkin, M I" uniqKey="Rivkin M" first="M I" last="Rivkin">M I Rivkin</name></author><author><name sortKey="Grinbaum, E B" sort="Grinbaum, E B" uniqKey="Grinbaum E" first="E B" last="Grinbaum">E B Grinbaum</name></author><author><name sortKey="Obuchova, L V" sort="Obuchova, L V" uniqKey="Obuchova L" first="L V" last="Obuchova">L V Obuchova</name></author><author><name sortKey="Kuznetzov, O K" sort="Kuznetzov, O K" uniqKey="Kuznetzov O" first="O K" last="Kuznetzov">O K Kuznetzov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:1980394</idno><idno type="pmid">1980394</idno><idno type="wicri:Area/PubMed/Corpus">000453</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000453</idno><idno type="wicri:Area/PubMed/Curation">000453</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000453</idno><idno type="wicri:Area/PubMed/Checkpoint">000406</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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Rivkin</name></author><author><name sortKey="Grinbaum, E B" sort="Grinbaum, E B" uniqKey="Grinbaum E" first="E B" last="Grinbaum">E B Grinbaum</name></author><author><name sortKey="Obuchova, L V" sort="Obuchova, L V" uniqKey="Obuchova L" first="L V" last="Obuchova">L V Obuchova</name></author><author><name sortKey="Kuznetzov, O K" sort="Kuznetzov, O K" uniqKey="Kuznetzov O" first="O K" last="Kuznetzov">O K Kuznetzov</name></author></analytic><series><title level="j">Acta virologica</title><idno type="ISSN">0001-723X</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Antigenic Variation (genetics)</term><term>Base Sequence</term><term>Biological Evolution</term><term>DNA, Viral (chemistry)</term><term>Gene Frequency</term><term>Genes, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Hemagglutinins, Viral (genetics)</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Orthomyxoviridae (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral ()</term><term>Données de séquences moléculaires</term><term>Fréquence d'allèle</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Gènes viraux</term><term>Humains</term><term>Hémagglutinines virales (génétique)</term><term>Mutation</term><term>Orthomyxoviridae (génétique)</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Variation des antigènes (génétique)</term><term>Évolution biologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antigenic Variation</term><term>Hemagglutinins, Viral</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Orthomyxoviridae</term><term>Variation des antigènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Biological Evolution</term><term>Gene Frequency</term><term>Genes, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Données de séquences moléculaires</term><term>Fréquence d'allèle</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Gènes viraux</term><term>Humains</term><term>Mutation</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at position 51 of HA1 gene) caused an antigenic drift. One silent mutation was detected (nucleotide 428 of HA1 gene) which points at the relatedness of strains A/Leningrad/385/80 with A/Bangkok/2/79 and with other more recent strains. These data allowed to determine the position of the strain A/Leningrad/385/80 HA gene regarding to the evolutionary relationships of HA genes of influenza A (H3N2 subtype) viruses. The branch leading to the above-mentioned strain is supposed to start from a point common for strains isolated following A/Bangkok/1/79. The mutations of HA genes presented in this subgroup were analysed supporting the notion on limited evolutionary potential of the subtype H3N2 influenza viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1980394</PMID><DateCompleted><Year>1991</Year><Month>02</Month><Day>26</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-723X</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>3</Issue><PubDate><Year>1990</Year><Month>May</Month></PubDate></JournalIssue><Title>Acta virologica</Title><ISOAbbreviation>Acta Virol.</ISOAbbreviation></Journal><ArticleTitle>Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.</ArticleTitle><Pagination><MedlinePgn>209-19</MedlinePgn></Pagination><Abstract><AbstractText>Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at position 51 of HA1 gene) caused an antigenic drift. One silent mutation was detected (nucleotide 428 of HA1 gene) which points at the relatedness of strains A/Leningrad/385/80 with A/Bangkok/2/79 and with other more recent strains. These data allowed to determine the position of the strain A/Leningrad/385/80 HA gene regarding to the evolutionary relationships of HA genes of influenza A (H3N2 subtype) viruses. The branch leading to the above-mentioned strain is supposed to start from a point common for strains isolated following A/Bangkok/1/79. The mutations of HA genes presented in this subgroup were analysed supporting the notion on limited evolutionary potential of the subtype H3N2 influenza viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Migunova</LastName><ForeName>B V</ForeName><Initials>BV</Initials><AffiliationInfo><Affiliation>Research Institute of Vaccines, Sera Minmedbioprom U.S.S.R., Leningrad.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plusnin</LastName><ForeName>A Z</ForeName><Initials>AZ</Initials></Author><Author ValidYN="Y"><LastName>Petrov</LastName><ForeName>N A</ForeName><Initials>NA</Initials></Author><Author ValidYN="Y"><LastName>Rivkin</LastName><ForeName>M I</ForeName><Initials>MI</Initials></Author><Author ValidYN="Y"><LastName>Grinbaum</LastName><ForeName>E B</ForeName><Initials>EB</Initials></Author><Author ValidYN="Y"><LastName>Obuchova</LastName><ForeName>L V</ForeName><Initials>LV</Initials></Author><Author ValidYN="Y"><LastName>Kuznetzov</LastName><ForeName>O K</ForeName><Initials>OK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Slovakia</Country><MedlineTA>Acta Virol</MedlineTA><NlmUniqueID>0370401</NlmUniqueID><ISSNLinking>0001-723X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000940" MajorTopicYN="N">Antigenic Variation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="Y">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="Y">Genes, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1980394</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Grinbaum, E B" sort="Grinbaum, E B" uniqKey="Grinbaum E" first="E B" last="Grinbaum">E B Grinbaum</name><name sortKey="Kuznetzov, O K" sort="Kuznetzov, O K" uniqKey="Kuznetzov O" first="O K" last="Kuznetzov">O K Kuznetzov</name><name sortKey="Migunova, B V" sort="Migunova, B V" uniqKey="Migunova B" first="B V" last="Migunova">B V Migunova</name><name sortKey="Obuchova, L V" sort="Obuchova, L V" uniqKey="Obuchova L" first="L V" last="Obuchova">L V Obuchova</name><name sortKey="Petrov, N A" sort="Petrov, N A" uniqKey="Petrov N" first="N A" last="Petrov">N A Petrov</name><name sortKey="Plusnin, A Z" sort="Plusnin, A Z" uniqKey="Plusnin A" first="A Z" last="Plusnin">A Z Plusnin</name><name sortKey="Rivkin, M I" sort="Rivkin, M I" uniqKey="Rivkin M" first="M I" last="Rivkin">M I Rivkin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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