Influenza A(H1N1): a widening spectrum?
Identifieur interne : 000398 ( PubMed/Checkpoint ); précédent : 000397; suivant : 000399Influenza A(H1N1): a widening spectrum?
Auteurs : P W Gill ; A M Murphy ; A L CunninghamSource :
- The Medical journal of Australia [ 0025-729X ] ; 1991.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (analyse), Antigènes viraux (analyse), Australie (épidémiologie), Flambées de maladies, Grippe humaine (microbiologie), Grippe humaine (épidémiologie), Humains, Prévalence, Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Virus de la grippe A (enzymologie), Virus de la grippe A (immunologie), Études prospectives.
- MESH :
- analyse : Anticorps antiviraux, Antigènes viraux.
- enzymologie : Virus de la grippe A.
- immunologie : Sialidase, Virus de la grippe A.
- microbiologie : Grippe humaine.
- épidémiologie : Australie, Grippe humaine.
- Flambées de maladies, Humains, Prévalence, Sous-type H1N1 du virus de la grippe A, Tests d'inhibition de l'hémagglutination, Études prospectives.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Antigens, Viral (analysis), Australia (epidemiology), Disease Outbreaks, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Influenza A virus (enzymology), Influenza A virus (immunology), Influenza, Human (epidemiology), Influenza, Human (microbiology), Neuraminidase (immunology), Prevalence, Prospective Studies.
- MESH :
- chemical , analysis : Antibodies, Viral, Antigens, Viral.
- geographic , epidemiology : Australia.
- enzymology : Influenza A virus.
- epidemiology : Influenza, Human.
- immunology : Influenza A virus, Neuraminidase.
- microbiology : Influenza, Human.
- Disease Outbreaks, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Prevalence, Prospective Studies.
Abstract
To study the incidence of H1N1 influenza from 1977 to 1988 in unvaccinated volunteers and the effects of continuing minor antigenic change (antigenic drift) in the virus.
PubMed: 1921782
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza A(H1N1): a widening spectrum?</title><author><name sortKey="Gill, P W" sort="Gill, P W" uniqKey="Gill P" first="P W" last="Gill">P W Gill</name><affiliation><nlm:affiliation>Department of Virology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW.</nlm:affiliation><wicri:noCountry code="subField">NSW</wicri:noCountry></affiliation></author><author><name sortKey="Murphy, A M" sort="Murphy, A M" uniqKey="Murphy A" first="A M" last="Murphy">A M Murphy</name></author><author><name sortKey="Cunningham, A L" sort="Cunningham, A L" uniqKey="Cunningham A" first="A L" last="Cunningham">A L Cunningham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1921782</idno><idno type="pmid">1921782</idno><idno type="wicri:Area/PubMed/Corpus">000441</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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A" first="A L" last="Cunningham">A L Cunningham</name></author></analytic><series><title level="j">The Medical journal of Australia</title><idno type="ISSN">0025-729X</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (analysis)</term><term>Antigens, Viral (analysis)</term><term>Australia (epidemiology)</term><term>Disease Outbreaks</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A virus (enzymology)</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (microbiology)</term><term>Neuraminidase (immunology)</term><term>Prevalence</term><term>Prospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (analyse)</term><term>Antigènes viraux (analyse)</term><term>Australie (épidémiologie)</term><term>Flambées de maladies</term><term>Grippe humaine (microbiologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Prévalence</term><term>Sialidase (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Tests d'inhibition de l'hémagglutination</term><term>Virus de la grippe A (enzymologie)</term><term>Virus de la grippe A (immunologie)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Australia</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sialidase</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Australie</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Outbreaks</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Prevalence</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Flambées de maladies</term><term>Humains</term><term>Prévalence</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Tests d'inhibition de l'hémagglutination</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the incidence of H1N1 influenza from 1977 to 1988 in unvaccinated volunteers and the effects of continuing minor antigenic change (antigenic drift) in the virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1921782</PMID><DateCompleted><Year>1991</Year><Month>10</Month><Day>29</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0025-729X</ISSN><JournalIssue CitedMedium="Print"><Volume>155</Volume><Issue>6</Issue><PubDate><Year>1991</Year><Month>Sep</Month><Day>16</Day></PubDate></JournalIssue><Title>The Medical journal of Australia</Title><ISOAbbreviation>Med. J. Aust.</ISOAbbreviation></Journal><ArticleTitle>Influenza A(H1N1): a widening spectrum?</ArticleTitle><Pagination><MedlinePgn>362-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the incidence of H1N1 influenza from 1977 to 1988 in unvaccinated volunteers and the effects of continuing minor antigenic change (antigenic drift) in the virus.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective study by a group of general practitioners, backed up by virological findings.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Mainly patients of the general practitioner group, also some doctors and members of staff. There were 287 participants during 1977-1981, and 207 at the end of 1988.</AbstractText><AbstractText Label="INTERVENTION" NlmCategory="METHODS">Any participant deemed to be "at risk" was encouraged to be vaccinated and to withdraw from the study.</AbstractText><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In 1957, H1N1 subtype influenza had been displaced by H2N2 (Asian) subtype. In 1968, H2N2 was displaced by H3N2 (Hong Kong) subtype. During 1977, H1N1 influenza unexpectedly reappeared in Asia, and spread widely. The resurgent strain, designated A/USSR/90/77(H1N1), caused world pandemics, attacking (almost exclusively) persons who had been born since the 1950-1951 northern winter and causing negligible mortality. It did not displace the current H3N2 strain, and strains of both subtypes have continued to emerge independently.</AbstractText><AbstractText Label="HYPOTHESIS" NlmCategory="OBJECTIVE">Antigens of A/USSR resembled closely those of the 1950-1951 H1N1 strain, which apparently was rendered antigenically inert between 1951 and 1976 (possibly frozen) and was reactivated during 1977. Antigenic drift was then resumed.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURE" NlmCategory="METHODS">The A/USSR/90/77 strain and its close successor, A/Brazil/11/78, attacked mainly the young, whose previous exposure to H1N1 antigens had been minimal or zero. Mortality during the A/USSR pandemics was negligible because death from influenza in people aged less than 30 years is rare. Would continuing antigenic drift ultimately widen the H1N1 spectrum of attack?</AbstractText><AbstractText Label="RESULT" NlmCategory="RESULTS">During the epidemic of 1988, A/Taiwan/1/86(H1N1) attacked a wider range of age groups than had A/USSR or A/Brazil.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Assuming that H1N1 viruses continue to undergo further antigenic drift, an ever widening age spectrum of H1N1 attack may be expected.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gill</LastName><ForeName>P W</ForeName><Initials>PW</Initials><AffiliationInfo><Affiliation>Department of Virology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murphy</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Cunningham</LastName><ForeName>A L</ForeName><Initials>AL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Med J Aust</MedlineTA><NlmUniqueID>0400714</NlmUniqueID><ISSNLinking>0025-729X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001315" MajorTopicYN="N" Type="Geographic">Australia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="Y">Influenza A virus</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>9</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>9</Month><Day>16</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>9</Month><Day>16</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1921782</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Cunningham, A L" sort="Cunningham, A L" uniqKey="Cunningham A" first="A L" last="Cunningham">A L Cunningham</name><name sortKey="Gill, P W" sort="Gill, P W" uniqKey="Gill P" first="P W" last="Gill">P W Gill</name><name sortKey="Murphy, A M" sort="Murphy, A M" uniqKey="Murphy A" first="A M" last="Murphy">A M Murphy</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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