Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants.
Identifieur interne : 000369 ( PubMed/Checkpoint ); précédent : 000368; suivant : 000370Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants.
Auteurs : A I Klimov [États-Unis] ; J R Romanova ; A Y Egorov ; I V Lukashok ; I V Kiseleva ; G I Alexandrova ; N J CoxSource :
- Virus genes [ 0920-8569 ] ; 1995.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Neuraminidase.
- chemical : DNA, Viral.
- enzymology : Influenza A virus.
- genetics : Influenza A virus, Reassortant Viruses.
- Amino Acid Sequence, Base Sequence, Genetic Variation, Humans, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data.
Abstract
The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.
DOI: 10.1007/bf01724302
PubMed: 7483295
Affiliations:
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scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>DNA, Viral</term><term>Genetic Variation</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A virus (enzymology)</term><term>Influenza A virus (genetics)</term><term>Molecular Sequence Data</term><term>Neuraminidase (genetics)</term><term>Reassortant Viruses (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Sialidase (génétique)</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Variation génétique</term><term>Virus de la grippe A (enzymologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus recombinants (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sialidase</term><term>Virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Genetic Variation</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7483295</PMID><DateCompleted><Year>1995</Year><Month>12</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0920-8569</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>1995</Year></PubDate></JournalIssue><Title>Virus genes</Title><ISOAbbreviation>Virus Genes</ISOAbbreviation></Journal><ArticleTitle>Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants.</ArticleTitle><Pagination><MedlinePgn>95-8</MedlinePgn></Pagination><Abstract><AbstractText>The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klimov</LastName><ForeName>A I</ForeName><Initials>AI</Initials><AffiliationInfo><Affiliation>Influenza Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romanova</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Egorov</LastName><ForeName>A Y</ForeName><Initials>AY</Initials></Author><Author ValidYN="Y"><LastName>Lukashok</LastName><ForeName>I V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Kiseleva</LastName><ForeName>I V</ForeName><Initials>IV</Initials></Author><Author ValidYN="Y"><LastName>Alexandrova</LastName><ForeName>G I</ForeName><Initials>GI</Initials></Author><Author ValidYN="Y"><LastName>Cox</LastName><ForeName>N J</ForeName><Initials>NJ</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>L37329</AccessionNumber><AccessionNumber>L37330</AccessionNumber><AccessionNumber>L37331</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virus Genes</MedlineTA><NlmUniqueID>8803967</NlmUniqueID><ISSNLinking>0920-8569</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7483295</ArticleId><ArticleId IdType="doi">10.1007/bf01724302</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Virology. 1992 Feb;186(2):795-7</Citation><ArticleIdList><ArticleId IdType="pubmed">1733114</ArticleId></ArticleIdList></Reference><Reference><Citation>Vopr Virusol. 1991 Mar-Apr;36(2):96-100</Citation><ArticleIdList><ArticleId IdType="pubmed">1882532</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1985 Aug;66 ( Pt 8):1697-704</Citation><ArticleIdList><ArticleId IdType="pubmed">2991435</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol Methods. 1995 Mar;52(1-2):41-9</Citation><ArticleIdList><ArticleId IdType="pubmed">7769038</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G I" last="Alexandrova">G I Alexandrova</name><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N J" last="Cox">N J Cox</name><name sortKey="Egorov, A Y" sort="Egorov, A Y" uniqKey="Egorov A" first="A Y" last="Egorov">A Y Egorov</name><name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name><name sortKey="Lukashok, I V" sort="Lukashok, I V" uniqKey="Lukashok I" first="I V" last="Lukashok">I V Lukashok</name><name sortKey="Romanova, J R" sort="Romanova, J R" uniqKey="Romanova J" first="J R" last="Romanova">J R Romanova</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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