Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants.
Identifieur interne : 000369 ( PubMed/Checkpoint ); précédent : 000368; suivant : 000370Nucleotide sequences of the neuraminidase genes of influenza A/Leningrad/134/57 (H2N2) virus and two of its live, attenuated, cold-adapted variants.
Auteurs : A I Klimov [États-Unis] ; J R Romanova ; A Y Egorov ; I V Lukashok ; I V Kiseleva ; G I Alexandrova ; N J CoxSource :
- Virus genes [ 0920-8569 ] ; 1995.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Neuraminidase.
- chemical : DNA, Viral.
- enzymology : Influenza A virus.
- genetics : Influenza A virus, Reassortant Viruses.
- Amino Acid Sequence, Base Sequence, Genetic Variation, Humans, Influenza A Virus, H2N2 Subtype, Molecular Sequence Data.
Abstract
The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.
DOI: 10.1007/bf01724302
PubMed: 7483295
Affiliations:
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<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Neuraminidase (genetics)</term>
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<term>Données de séquences moléculaires</term>
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<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus recombinants (génétique)</term>
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<term>Base Sequence</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Molecular Sequence Data</term>
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<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
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<front><div type="abstract" xml:lang="en">The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.</div>
</front>
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<Abstract><AbstractText>The nucleotide sequences of the neuraminidase (NA) genes of the A/Leningrad/134/57 (H2N2) wild-type (Len/wt) virus as well as two of its live attenuated, cold-adapted (ca) variants, A/Leningrad/134/17/57 (Len/17) and A/Leningrad/134/47/57 (Len/47), were determined. In comparison with Len/wt, one nucleotide change (C-225 to A) was found in the NA gene of Len/17. This change codes for a Thr-to-Asn substitution at position 69 of NA. The NA gene of the more attenuated Len/47 ca virus has one silent (T-814 to C) and two coding nucleotide substitutions, C-78 to T (Ala-20 to Val) and C-225 to A (Thr-69 to Asn). These sequence data were used to design a PCR-restriction technique to determine the origin of the NA gene in candidate live, attenuated vaccine reassortants made by reassorting these ca strains with current field viruses.</AbstractText>
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