Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin.
Identifieur interne : 000236 ( PubMed/Checkpoint ); précédent : 000235; suivant : 000237Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin.
Auteurs : Manabu Igarashi [Japon] ; Kimihito Ito ; Hiroshi Kida ; Ayato TakadaSource :
- Virology [ 0042-6822 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (), Antigènes viraux (génétique), Antigènes viraux (métabolisme), Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Glycosylation, Grippe chez les oiseaux (virologie), Modèles moléculaires, Oiseaux, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (métabolisme), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (métabolisme), Sous-type H3N2 du virus de la grippe A (génétique), Variation des antigènes, Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
- MESH :
- génétique : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Virus de la grippe A.
- immunologie : Virus de la grippe A.
- métabolisme : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- virologie : Grippe chez les oiseaux.
- Animaux, Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Glycosylation, Modèles moléculaires, Oiseaux, Variation des antigènes.
English descriptors
- KwdEn :
- Animals, Antigenic Variation, Antigens, Viral (chemistry), Antigens, Viral (genetics), Antigens, Viral (metabolism), Birds, Glycosylation, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (metabolism), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (metabolism), Influenza A Virus, H3N2 Subtype (genetics), Influenza A virus (genetics), Influenza A virus (immunology), Influenza in Birds (virology), Models, Molecular.
- MESH :
- chemical , chemistry : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus.
- immunology : Influenza A virus.
- metabolism : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype.
- virology : Influenza in Birds.
- Animals, Antigenic Variation, Birds, Glycosylation, Models, Molecular.
Abstract
The addition of oligosaccharide side chains to influenza virus hemagglutinin (HA) is believed to facilitate viral escape from immune pressure in the human population. To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population.
DOI: 10.1016/j.virol.2008.03.036
PubMed: 18456302
Affiliations:
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To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18456302</PMID><DateCompleted><Year>2008</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2008</Year><Month>06</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>376</Volume><Issue>2</Issue><PubDate><Year>2008</Year><Month>Jul</Month><Day>05</Day></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin.</ArticleTitle><Pagination><MedlinePgn>323-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virol.2008.03.036</ELocationID><Abstract><AbstractText>The addition of oligosaccharide side chains to influenza virus hemagglutinin (HA) is believed to facilitate viral escape from immune pressure in the human population. To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Igarashi</LastName><ForeName>Manabu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0020, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ito</LastName><ForeName>Kimihito</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kida</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Takada</LastName><ForeName>Ayato</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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IdType="doi">10.1016/j.virol.2008.03.036</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><name sortKey="Takada, Ayato" sort="Takada, Ayato" uniqKey="Takada A" first="Ayato" last="Takada">Ayato Takada</name></noCountry><country name="Japon"><noRegion><name sortKey="Igarashi, Manabu" sort="Igarashi, Manabu" uniqKey="Igarashi M" first="Manabu" last="Igarashi">Manabu Igarashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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