H2N2V1, PubMed, Checkpoint, bibRecord, 000106

Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.

Identifieur interne : 000106 ( PubMed/Checkpoint ); précédent : 000105; suivant : 000107

Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.

Auteurs : Cyrille Dreyfus [États-Unis] ; Damian C. Ekiert ; Ian A. Wilson

Source :

Journal of virology [ 1098-5514 ] ; 2013.

RBID : pubmed:23552413

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (chemistry), Antibodies, Neutralizing (immunology), Antibodies, Viral (chemistry), Antibodies, Viral (immunology), Cross Reactions, Crystallography, X-Ray, Epitopes (chemistry), Epitopes (immunology), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (immunology), Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (immunology), Influenza, Human (virology), Mice, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Pandemics.
MESH :
- chemical , chemistry : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus.
- classification : Influenza A virus.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A virus, Influenza, Human.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Cross Reactions, Crystallography, X-Ray, Humans, Mice, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Pandemics.

Abstract

We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.

DOI: 10.1128/JVI.02975-12
PubMed: 23552413

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000125
to stream PubMed, to step Curation: 000125

Links to Exploration step

pubmed:23552413

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.</title>
<author><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C" last="Ekiert">Damian C. Ekiert</name>
</author>
<author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23552413</idno>
<idno type="pmid">23552413</idno>
<idno type="doi">10.1128/JVI.02975-12</idno>
<idno type="wicri:Area/PubMed/Corpus">000125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000125</idno>
<idno type="wicri:Area/PubMed/Curation">000125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000125</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000106</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000106</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.</title>
<author><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C" last="Ekiert">Damian C. Ekiert</name>
</author>
<author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (chemistry)</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Neutralizing (chemistry)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (chemistry)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Cross Reactions</term>
<term>Crystallography, X-Ray</term>
<term>Epitopes (chemistry)</term>
<term>Epitopes (immunology)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A virus (classification)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux ()</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps monoclonaux ()</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps neutralisants ()</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Cristallographie aux rayons X</term>
<term>Données de séquences moléculaires</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Pandémies</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Séquence d'acides aminés</term>
<term>Tests de neutralisation</term>
<term>Virus de la grippe A ()</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Épitopes ()</term>
<term>Épitopes (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Epitopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Anticorps neutralisants</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cross Reactions</term>
<term>Crystallography, X-Ray</term>
<term>Humans</term>
<term>Mice</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Anticorps neutralisants</term>
<term>Cristallographie aux rayons X</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Pandémies</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Tests de neutralisation</term>
<term>Virus de la grippe A</term>
<term>Épitopes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23552413</PMID>
<DateCompleted><Year>2013</Year>
<Month>07</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>87</Volume>
<Issue>12</Issue>
<PubDate><Year>2013</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Journal of virology</Title>
<ISOAbbreviation>J. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.</ArticleTitle>
<Pagination><MedlinePgn>7149-54</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.02975-12</ELocationID>
<Abstract><AbstractText>We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dreyfus</LastName>
<ForeName>Cyrille</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ekiert</LastName>
<ForeName>Damian C</ForeName>
<Initials>DC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>Ian A</ForeName>
<Initials>IA</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>PDB</DataBankName>
<AccessionNumberList><AccessionNumber>4HLZ</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>P41RR001209</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R56 AI099275</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI099275</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P41 RR001209</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI058113</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 AI058113</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>04</Month>
<Day>03</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000939">Epitopes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003429" MajorTopicYN="N">Cross Reactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018360" MajorTopicYN="N">Crystallography, X-Ray</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>7</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23552413</ArticleId>
<ArticleId IdType="pii">JVI.02975-12</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.02975-12</ArticleId>
<ArticleId IdType="pmc">PMC3676097</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2008 Jan;82(2):596-601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17942553</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20383002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Aug 12;333(6044):850-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21798894</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19461840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20057044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2010 Dec;88(3):249-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20849879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1994 May 20;238(5):777-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8182748</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Immunol. 2008 Aug;45(14):3832-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18614234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17175-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19805083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Sep 14;337(6100):1343-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22878502</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Biotechnol. 2012 Jun;30(6):543-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22634563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 May;67(5):2552-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7682624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Feb;84(4):1715-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20007271</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1987 Sep 20;197(2):273-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3681996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Apr 10;324(5924):246-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19251591</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2010;6(7):e1000990</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20628565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20124702</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Sep 6;449(7158):101-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17805298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2012 Sep 27;489(7417):526-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22982990</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004;32(5):1792-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15034147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2009 Mar;16(3):265-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19234466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13701-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20615991</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2000;145(8):1733-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11003481</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 May 13;332(6031):816-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21566186</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Virol. 1999 Aug;43(4):237-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10749369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2011 Jan 17;208(1):181-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21220454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20124692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Aug 12;333(6044):843-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21737702</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><noCountry><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C" last="Ekiert">Damian C. Ekiert</name>
<name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000106 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000106 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:23552413
   |texte=   Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:23552413" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.

Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki