[Evolution and infection biology of new influenza A viruses with pandemic potential].
Identifieur interne : 000103 ( PubMed/Checkpoint ); précédent : 000102; suivant : 000104[Evolution and infection biology of new influenza A viruses with pandemic potential].
Auteurs : H D Klenk [Allemagne]Source :
- Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz [ 1437-1588 ] ; 2013.
Descripteurs français
- KwdFr :
- Facteurs de risque, Facteurs de virulence (génétique), Grippe humaine (génétique), Grippe humaine (microbiologie), Grippe humaine (épidémiologie), Humains, Modèles génétiques, Pandémies (), Protéines virales (génétique), Prédisposition génétique à une maladie (génétique), Prédisposition génétique à une maladie (épidémiologie), Prévalence, Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité), Évolution moléculaire.
- MESH :
- génétique : Facteurs de virulence, Grippe humaine, Protéines virales, Prédisposition génétique à une maladie, Virus de la grippe A.
- microbiologie : Grippe humaine.
- pathogénicité : Virus de la grippe A.
- épidémiologie : Grippe humaine, Prédisposition génétique à une maladie.
- Facteurs de risque, Humains, Modèles génétiques, Pandémies, Prévalence, Évolution moléculaire.
English descriptors
- KwdEn :
- Evolution, Molecular, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Humans, Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (microbiology), Models, Genetic, Pandemics (prevention & control), Pandemics (statistics & numerical data), Prevalence, Risk Factors, Viral Proteins (genetics), Virulence Factors (genetics).
- MESH :
- chemical , genetics : Viral Proteins, Virulence Factors.
- epidemiology : Genetic Predisposition to Disease, Influenza, Human.
- genetics : Genetic Predisposition to Disease, Influenza A virus, Influenza, Human.
- microbiology : Influenza, Human.
- pathogenicity : Influenza A virus.
- prevention & control : Pandemics.
- statistics & numerical data : Pandemics.
- Evolution, Molecular, Humans, Models, Genetic, Prevalence, Risk Factors.
Abstract
Wild aquatic birds are natural hosts for a large variety of influenza A viruses. Occasionally, viruses are transmitted from this reservoir to other species, such as chickens, pigs, and man, and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics. The H5N1-, H7N7-, H9N2-, and H2N2-viruses are considered to have high pandemic potential, because of their pathogenicity in humans and because of the lack of immune protection in the human population. However, the unexpected outbreak of the H1N1 pandemic in 2009 demonstrates that the reliability of such predictions is limited. Host specificity, pathogenicity, and transmissibility are polygenic traits that depend on the interactions of viral proteins with host factors, among which receptor specificity and fusion activity of the hemagglutinin, nuclear transport of the polymerase, and interferon antagonism of the NS1 protein are of particular importance.
DOI: 10.1007/s00103-012-1584-2
PubMed: 23275951
Affiliations:
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type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term><term>Grippe humaine</term><term>Protéines virales</term><term>Prédisposition génétique à une maladie</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evolution, Molecular</term><term>Humans</term><term>Models, Genetic</term><term>Prevalence</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Humains</term><term>Modèles génétiques</term><term>Pandémies</term><term>Prévalence</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wild aquatic birds are natural hosts for a large variety of influenza A viruses. Occasionally, viruses are transmitted from this reservoir to other species, such as chickens, pigs, and man, and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics. The H5N1-, H7N7-, H9N2-, and H2N2-viruses are considered to have high pandemic potential, because of their pathogenicity in humans and because of the lack of immune protection in the human population. However, the unexpected outbreak of the H1N1 pandemic in 2009 demonstrates that the reliability of such predictions is limited. Host specificity, pathogenicity, and transmissibility are polygenic traits that depend on the interactions of viral proteins with host factors, among which receptor specificity and fusion activity of the hemagglutinin, nuclear transport of the polymerase, and interferon antagonism of the NS1 protein are of particular importance.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23275951</PMID><DateCompleted><Year>2013</Year><Month>11</Month><Day>25</Day></DateCompleted><DateRevised><Year>2016</Year><Month>07</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1437-1588</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz</Title><ISOAbbreviation>Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz</ISOAbbreviation></Journal><ArticleTitle>[Evolution and infection biology of new influenza A viruses with pandemic potential].</ArticleTitle><Pagination><MedlinePgn>15-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00103-012-1584-2</ELocationID><Abstract><AbstractText>Wild aquatic birds are natural hosts for a large variety of influenza A viruses. 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