H2N2V1, PubMed, Checkpoint, bibRecord, 000049

High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.

Identifieur interne : 000049 ( PubMed/Checkpoint ); précédent : 000048; suivant : 000050

High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.

Auteurs : Naomi Komadina [Australie] ; Sergio M. Qui Ones-Parra [Australie] ; Katherine Kedzierska [Australie] ; James M. Mccaw [Australie] ; Anne Kelso [Australie] ; Karin Leder [Australie] ; Jodie Mcvernon [Australie]

Source :

Journal of medical virology [ 1096-9071 ] ; 2016.

RBID : pubmed:26950895

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies, Viral (immunology), Cross Protection, Epitopes, T-Lymphocyte, Humans, Influenza A Virus, H1N1 Subtype (chemistry), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N2 Subtype (genetics), Influenza A Virus, H1N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Peptides (immunology), RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), T-Lymphocytes, Cytotoxic (immunology), Viral Core Proteins (genetics), Viral Core Proteins (immunology).
MESH :
- chemical , genetics : RNA-Binding Proteins, Viral Core Proteins.
- chemical , immunology : Antibodies, Viral, Peptides, RNA-Binding Proteins, Viral Core Proteins.
- chemistry : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- genetics : Influenza A Virus, H1N2 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H1N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Orthomyxoviridae Infections, T-Lymphocytes, Cytotoxic.
- virology : Orthomyxoviridae Infections.
- Animals, Cross Protection, Epitopes, T-Lymphocyte, Humans.

Abstract

Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8(+) T cell (CTL) mediated cross-protective immunity may offer a long-term alternative strategy. However, measuring pre- and existing levels of CTL cross-protection in humans is confounded by differences in infection histories across individuals. During 2000-2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed to the survival of the viruses. This study describes the immunogenic NP peptides of H1N1, H2N2, and H3N2 influenza viruses isolated from humans over the past century, 1918-2003, by comparing this historical dataset to reference NP peptides from H1N2 that circulated in humans during 2000-2003. Observed peptides sequences ranged from highly conserved (15%) to highly variable (12%), with variation unrelated to reported immunodominance. No unique NP peptides which were exclusive to the H1N2 viruses were noted. However, the virus had inherited the NP from a recently emerged H3N2 variant containing novel peptides, which may have assisted its persistence. Any advantage due to this novelty was subsequently lost with emergence of a newer H3N2 variant in 2003. Our approach has potential to provide insight into the population context in which influenza viruses emerge, and may help to inform immunogenic peptide selection for CTL-inducing influenza vaccines. J. Med. Virol. 88:1725-1732, 2016. © 2016 Wiley Periodicals, Inc.

DOI: 10.1002/jmv.24516
PubMed: 26950895

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8(+) T cell (CTL) mediated cross-protective immunity may offer a long-term alternative strategy. However, measuring pre- and existing levels of CTL cross-protection in humans is confounded by differences in infection histories across individuals. During 2000-2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed to the survival of the viruses. This study describes the immunogenic NP peptides of H1N1, H2N2, and H3N2 influenza viruses isolated from humans over the past century, 1918-2003, by comparing this historical dataset to reference NP peptides from H1N2 that circulated in humans during 2000-2003. Observed peptides sequences ranged from highly conserved (15%) to highly variable (12%), with variation unrelated to reported immunodominance. No unique NP peptides which were exclusive to the H1N2 viruses were noted. However, the virus had inherited the NP from a recently emerged H3N2 variant containing novel peptides, which may have assisted its persistence. Any advantage due to this novelty was subsequently lost with emergence of a newer H3N2 variant in 2003. Our approach has potential to provide insight into the population context in which influenza viruses emerge, and may help to inform immunogenic peptide selection for CTL-inducing influenza vaccines. J. Med. Virol. 88:1725-1732, 2016. © 2016 Wiley Periodicals, Inc.</div>
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<Abstract><AbstractText>Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8(+) T cell (CTL) mediated cross-protective immunity may offer a long-term alternative strategy. However, measuring pre- and existing levels of CTL cross-protection in humans is confounded by differences in infection histories across individuals. During 2000-2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed to the survival of the viruses. This study describes the immunogenic NP peptides of H1N1, H2N2, and H3N2 influenza viruses isolated from humans over the past century, 1918-2003, by comparing this historical dataset to reference NP peptides from H1N2 that circulated in humans during 2000-2003. Observed peptides sequences ranged from highly conserved (15%) to highly variable (12%), with variation unrelated to reported immunodominance. No unique NP peptides which were exclusive to the H1N2 viruses were noted. However, the virus had inherited the NP from a recently emerged H3N2 variant containing novel peptides, which may have assisted its persistence. Any advantage due to this novelty was subsequently lost with emergence of a newer H3N2 variant in 2003. Our approach has potential to provide insight into the population context in which influenza viruses emerge, and may help to inform immunogenic peptide selection for CTL-inducing influenza vaccines. J. Med. Virol. 88:1725-1732, 2016. © 2016 Wiley Periodicals, Inc.</AbstractText>
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</AffiliationInfo>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014758">Viral Core Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056738" MajorTopicYN="Y">Cross Protection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018984" MajorTopicYN="Y">Epitopes, T-Lymphocyte</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057221" MajorTopicYN="N">Influenza A Virus, H1N2 Subtype</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014758" MajorTopicYN="N">Viral Core Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">H1N2</Keyword>
<Keyword MajorTopicYN="Y">cross-protection</Keyword>
<Keyword MajorTopicYN="Y">immunogenic</Keyword>
<Keyword MajorTopicYN="Y">influenza</Keyword>
<Keyword MajorTopicYN="Y">peptides</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>03</Month>
<Day>02</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>3</Month>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26950895</ArticleId>
<ArticleId IdType="doi">10.1002/jmv.24516</ArticleId>
</ArticleIdList>
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</pubmed>
<affiliations><list><country><li>Australie</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Komadina, Naomi" sort="Komadina, Naomi" uniqKey="Komadina N" first="Naomi" last="Komadina">Naomi Komadina</name>
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<name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name>
<name sortKey="Kelso, Anne" sort="Kelso, Anne" uniqKey="Kelso A" first="Anne" last="Kelso">Anne Kelso</name>
<name sortKey="Leder, Karin" sort="Leder, Karin" uniqKey="Leder K" first="Karin" last="Leder">Karin Leder</name>
<name sortKey="Mccaw, James M" sort="Mccaw, James M" uniqKey="Mccaw J" first="James M" last="Mccaw">James M. Mccaw</name>
<name sortKey="Mcvernon, Jodie" sort="Mcvernon, Jodie" uniqKey="Mcvernon J" first="Jodie" last="Mcvernon">Jodie Mcvernon</name>
<name sortKey="Qui Ones Parra, Sergio M" sort="Qui Ones Parra, Sergio M" uniqKey="Qui Ones Parra S" first="Sergio M" last="Qui Ones-Parra">Sergio M. Qui Ones-Parra</name>
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</record>

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   |texte=   High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.
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	Serveur d'exploration H2N2
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Serveur d'exploration H2N2

High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.

High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.

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