Influenza and Memory T Cells: How to Awake the Force
Identifieur interne : 000E20 ( Pmc/Curation ); précédent : 000E19; suivant : 000E21Influenza and Memory T Cells: How to Awake the Force
Auteurs : Jan Spitaels [Belgique] ; Kenny Roose [Belgique] ; Xavier Saelens [Belgique]Source :
- Vaccines [ 2076-393X ] ; 2016.
Abstract
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus.
Url:
DOI: 10.3390/vaccines4040033
PubMed: 27754364
PubMed Central: 5192353
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza and Memory T Cells: How to Awake the Force</title><author><name sortKey="Spitaels, Jan" sort="Spitaels, Jan" uniqKey="Spitaels J" first="Jan" last="Spitaels">Jan Spitaels</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea></affiliation></author><author><name sortKey="Roose, Kenny" sort="Roose, Kenny" uniqKey="Roose K" first="Kenny" last="Roose">Kenny Roose</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea></affiliation></author><author><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country 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first="Jan" last="Spitaels">Jan Spitaels</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea></affiliation></author><author><name sortKey="Roose, Kenny" sort="Roose, Kenny" uniqKey="Roose K" first="Kenny" last="Roose">Kenny Roose</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea></affiliation></author><author><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name><affiliation><nlm:aff id="af1-vaccines-04-00033">Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-vaccines-04-00033">Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000</wicri:regionArea></affiliation></author></analytic><series><title level="j">Vaccines</title><idno type="eISSN">2076-393X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccines (Basel)</journal-id><journal-id journal-id-type="iso-abbrev">Vaccines (Basel)</journal-id><journal-id journal-id-type="publisher-id">vaccines</journal-id><journal-title-group><journal-title>Vaccines</journal-title></journal-title-group><issn pub-type="epub">2076-393X</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27754364</article-id><article-id pub-id-type="pmc">5192353</article-id><article-id pub-id-type="doi">10.3390/vaccines4040033</article-id><article-id pub-id-type="publisher-id">vaccines-04-00033</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Influenza and Memory T Cells: How to Awake the Force</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Spitaels</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="af1-vaccines-04-00033">1</xref><xref ref-type="aff" rid="af2-vaccines-04-00033">2</xref></contrib><contrib contrib-type="author"><name><surname>Roose</surname><given-names>Kenny</given-names></name><xref ref-type="aff" rid="af1-vaccines-04-00033">1</xref><xref ref-type="aff" rid="af2-vaccines-04-00033">2</xref></contrib><contrib contrib-type="author"><name><surname>Saelens</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="af1-vaccines-04-00033">1</xref><xref ref-type="aff" rid="af2-vaccines-04-00033">2</xref><xref rid="c1-vaccines-04-00033" ref-type="corresp">*</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Todryk</surname><given-names>Stephen</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-vaccines-04-00033"><label>1</label>Medical Biotechnology Center, VIB, Ghent 9000, Belgium;<email>jan.spitaels@vib-ugent.be</email> (J.S.);<email>kenny.roose@vib-ugent.be</email> (K.R.)</aff><aff id="af2-vaccines-04-00033"><label>2</label>Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium</aff><author-notes><corresp id="c1-vaccines-04-00033"><label>*</label>Correspondence: <email>xavier.saelens@vib-ugent.be</email>; Tel.: +32-331-3620</corresp></author-notes><pub-date pub-type="epub"><day>13</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="collection"><month>12</month><year>2016</year></pub-date><volume>4</volume><issue>4</issue><elocation-id>33</elocation-id><history><date date-type="received"><day>18</day><month>7</month><year>2016</year></date><date date-type="accepted"><day>27</day><month>9</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2016</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals. The past few years, the importance of cellular immunity, and especially memory T cells, in long-lived protection against influenza virus has become clear. To overcome the shortcomings of current influenza vaccines, eliciting both humoral and cellular immunity is imperative. Today, several new vaccines such as infection-permissive and recombinant T cell inducing vaccines, are being developed and show promising results. These vaccines will allow us to stay several steps ahead of the constantly evolving influenza virus.</p></abstract><kwd-group><kwd>influenza</kwd><kwd>vaccines</kwd><kwd>cellular immunity</kwd><kwd>memory T cells</kwd></kwd-group></article-meta></front><floats-group><fig id="vaccines-04-00033-f001" position="float"><label>Figure 1</label><caption><p>Innate immunity against influenza virus infection. (<bold>A</bold>) The first barrier that the influenza virus has to overcome, is the mucus layer that lines the respiratory tract. To cross this barrier, influenza viruses rely on the enzymatic activity of the neuraminidase glycoprotein; (<bold>B</bold>) The second barrier consists of carbohydrate-binding proteins called lectins. Surfactant proteins A (SP-A) and D (SP-D) are the main two lectins involved in anti-influenza activity. SP-A acts as a decoy receptor for influenza virus, and SP-D binds to oligosaccharides on influenza hemagglutinin (HA) and neuraminidase (NA) proteins; (<bold>C</bold>) Once influenza virions have reached respiratory epithelial cells they recognize sialic acid-containing host cell receptors by the HA glycoprotein. This is followed by endocytosis of the influenza virus and the virion particle ends up in the early endosomes. After acidification of the endosome and subsequent membrane fusion, the genomic RNA segments of the influenza virus are released into the cytosol. The two major PRRs that are responsible for the cytoplasmic sensing of influenza virus infection are retinoic acid inducible gene-I (RIG-I) and NOD-like receptor family pyrin domain containing 3 (NLRP3) protein. Activation of RIG-I—by interaction with 5′ triphosphorylated RNA (5′ ppp-RNA)—results in the production of proinflammatory cytokines and type I interferons (IFNs), which in turn induce the expression of interferon-stimulated genes (ISGs). NLRP3 is a part of the NLRP3 inflammasome, which becomes activated by the proton gating activity of influenza A virus M2. This leads to the conversion of pro-IL-1β to IL-1β, which is a proinflammatory cytokine that is involved in the induction of Th17 cells and the expansion of CD4<sup>+</sup> T cells.</p></caption><graphic xlink:href="vaccines-04-00033-g001"></graphic></fig><fig id="vaccines-04-00033-f002" position="float"><label>Figure 2</label><caption><p>Adaptive immunity against influenza virus infection. (<bold>A</bold>) Alveolar macrophages (AMs) reside in the alveolar lumen and are considered the first immune cell type to encounter respiratory pathogens. Activated AMs produce nitric oxide synthase 2 (NOS2) and tumor necrosis factor (TNF), by which they also contribute to lung pathology upon influenza virus infection; (<bold>B</bold>) Dendritic cells (DCs) are professional antigen-presenting cells (APCs). The conventional DCs (cDCs), which are located underneath the airway epithelium barrier and above the basal membrane, continuously monitor the airway lumen with their dendrites. Once the cDCs acquired viral antigen, they migrate to the draining lymph nodes (DLNs) via a CCL19 and CCL21 chemokine gradient along the afferent lymphatic system. In the LNs, DCs present processed antigen to naïve T cells. The DC degrades viral proteins, and the resulting peptides (antigens) are presented by MHC class I or II proteins for specific CD8<sup>+</sup> and CD4<sup>+</sup> T cells respectively. The T cells that are specific for the antigen become activated and expand clonally. The newly activated T cells begin to acquire effector functions, and migrate from the LNs to the site of infection; (<bold>C</bold>) CD8<sup>+</sup> T cells can kill infected respiratory epithelial cells, and, by this, clear the virus from the lungs. This is done by exocytosis of granules that contain perforins and granzymes. CD4<sup>+</sup> T cells on the other hand mainly provide help to other immune cells, and regulate the immune response by producing a vast array of cytokines.</p></caption><graphic xlink:href="vaccines-04-00033-g002"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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