Lethal Synergism between Influenza and Streptococcus pneumoniae
Identifieur interne : 000C67 ( Pmc/Curation ); précédent : 000C66; suivant : 000C68Lethal Synergism between Influenza and Streptococcus pneumoniae
Auteurs : Jennifer M. Rudd [États-Unis] ; Harshini K. Ashar [États-Unis] ; Vincent Tk Chow [Singapour] ; Narasaraju Teluguakula [États-Unis]Source :
- Journal of infectious pulmonary diseases [ 2470-3176 ] ; 2016.
Abstract
The devastating synergism of bacterial pneumonia with influenza viral infections left its mark on the world over the last century. Although the details of pathogenesis remain unclear, the synergism is related to a variety of factors including pulmonary epithelial barrier damage which exposes receptors that influence bacterial adherence and the triggering of an exaggerated innate immune response and cytokine storm, which further acts to worsen the injury. Several therapeutics and combination therapies of antibiotics, anti-inflammatories including corticosteroids and toll-like receptor modifiers, and anti-virals are being discussed. This mini review summarizes recent developments in unearthing the pathogenesis of the lethal synergism of pneumococcal co-infection following influenza, as well as addresses potential therapeutic options and combinations of therapies currently being evaluated.
Url:
PubMed: 27981251
PubMed Central: 5154682
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<front><div type="abstract" xml:lang="en"><p id="P1">The devastating synergism of bacterial pneumonia with influenza viral infections left its mark on the world over the last century. Although the details of pathogenesis remain unclear, the synergism is related to a variety of factors including pulmonary epithelial barrier damage which exposes receptors that influence bacterial adherence and the triggering of an exaggerated innate immune response and cytokine storm, which further acts to worsen the injury. Several therapeutics and combination therapies of antibiotics, anti-inflammatories including corticosteroids and toll-like receptor modifiers, and anti-virals are being discussed. This mini review summarizes recent developments in unearthing the pathogenesis of the lethal synergism of pneumococcal co-infection following influenza, as well as addresses potential therapeutic options and combinations of therapies currently being evaluated.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chertow, Ds" uniqKey="Chertow D">DS Chertow</name>
</author>
<author><name sortKey="Memoli, Mj" uniqKey="Memoli M">MJ Memoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Madhi, Sa" uniqKey="Madhi S">SA Madhi</name>
</author>
<author><name sortKey="Schoub, B" uniqKey="Schoub B">B Schoub</name>
</author>
<author><name sortKey="Klugman, Kp" uniqKey="Klugman K">KP Klugman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rynda Apple, A" uniqKey="Rynda Apple A">A Rynda-Apple</name>
</author>
<author><name sortKey="Robinson, Km" uniqKey="Robinson K">KM Robinson</name>
</author>
<author><name sortKey="Alcorn, Jf" uniqKey="Alcorn J">JF Alcorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
<author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
<author><name sortKey="Fuentes, R" uniqKey="Fuentes R">R Fuentes</name>
</author>
<author><name sortKey="Flores, J" uniqKey="Flores J">J Flores</name>
</author>
<author><name sortKey="Miller, Ma" uniqKey="Miller M">MA Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
<author><name sortKey="Grais, Rf" uniqKey="Grais R">RF Grais</name>
</author>
<author><name sortKey="Lafont, Ba" uniqKey="Lafont B">BA Lafont</name>
</author>
<author><name sortKey="Miller, Ma" uniqKey="Miller M">MA Miller</name>
</author>
<author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortiz, Jr" uniqKey="Ortiz J">JR Ortiz</name>
</author>
<author><name sortKey="Lafond, Ke" uniqKey="Lafond K">KE Lafond</name>
</author>
<author><name sortKey="Wong, Ta" uniqKey="Wong T">TA Wong</name>
</author>
<author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Rk" uniqKey="Gupta R">RK Gupta</name>
</author>
<author><name sortKey="George, R" uniqKey="George R">R George</name>
</author>
<author><name sortKey="Nguyen Van Tam, Js" uniqKey="Nguyen Van Tam J">JS Nguyen-Van-Tam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Xy" uniqKey="Wang X">XY Wang</name>
</author>
<author><name sortKey="Kilgore, Pe" uniqKey="Kilgore P">PE Kilgore</name>
</author>
<author><name sortKey="Lim, Ka" uniqKey="Lim K">KA Lim</name>
</author>
<author><name sortKey="Wang, Sm" uniqKey="Wang S">SM Wang</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herzog, H" uniqKey="Herzog H">H Herzog</name>
</author>
<author><name sortKey="Staub, H" uniqKey="Staub H">H Staub</name>
</author>
<author><name sortKey="Richterich, R" uniqKey="Richterich R">R Richterich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
<author><name sortKey="Mcauley, Jl" uniqKey="Mcauley J">JL McAuley</name>
</author>
<author><name sortKey="Browall, S" uniqKey="Browall S">S Browall</name>
</author>
<author><name sortKey="Iverson, Ar" uniqKey="Iverson A">AR Iverson</name>
</author>
<author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dockrell, Dh" uniqKey="Dockrell D">DH Dockrell</name>
</author>
<author><name sortKey="Whyte, Mk" uniqKey="Whyte M">MK Whyte</name>
</author>
<author><name sortKey="Mitchell, Tj" uniqKey="Mitchell T">TJ Mitchell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moorthy, An" uniqKey="Moorthy A">AN Moorthy</name>
</author>
<author><name sortKey="Rai, P" uniqKey="Rai P">P Rai</name>
</author>
<author><name sortKey="Jiao, H" uniqKey="Jiao H">H Jiao</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Tan, Kb" uniqKey="Tan K">KB Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, Am" uniqKey="Levine A">AM LeVine</name>
</author>
<author><name sortKey="Koeningsknecht, V" uniqKey="Koeningsknecht V">V Koeningsknecht</name>
</author>
<author><name sortKey="Stark, Jm" uniqKey="Stark J">JM Stark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loosli, Cg" uniqKey="Loosli C">CG Loosli</name>
</author>
<author><name sortKey="Stinson, Sf" uniqKey="Stinson S">SF Stinson</name>
</author>
<author><name sortKey="Ryan, Dp" uniqKey="Ryan D">DP Ryan</name>
</author>
<author><name sortKey="Hertweck, Ms" uniqKey="Hertweck M">MS Hertweck</name>
</author>
<author><name sortKey="Hardy, Jd" uniqKey="Hardy J">JD Hardy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
<author><name sortKey="Walters, Ka" uniqKey="Walters K">KA Walters</name>
</author>
<author><name sortKey="Davis, As" uniqKey="Davis A">AS Davis</name>
</author>
<author><name sortKey="Sandouk, A" uniqKey="Sandouk A">A Sandouk</name>
</author>
<author><name sortKey="Schwartzman, Lm" uniqKey="Schwartzman L">LM Schwartzman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Florescu, Df" uniqKey="Florescu D">DF Florescu</name>
</author>
<author><name sortKey="Kalil, Ac" uniqKey="Kalil A">AC Kalil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nita Lazar, M" uniqKey="Nita Lazar M">M Nita-Lazar</name>
</author>
<author><name sortKey="Banerjee, A" uniqKey="Banerjee A">A Banerjee</name>
</author>
<author><name sortKey="Feng, C" uniqKey="Feng C">C Feng</name>
</author>
<author><name sortKey="Amin, Mn" uniqKey="Amin M">MN Amin</name>
</author>
<author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
<author><name sortKey="Rehg, Je" uniqKey="Rehg J">JE Rehg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feldman, C" uniqKey="Feldman C">C Feldman</name>
</author>
<author><name sortKey="Anderson, R" uniqKey="Anderson R">R Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcnamee, La" uniqKey="Mcnamee L">LA McNamee</name>
</author>
<author><name sortKey="Harmsen, Ag" uniqKey="Harmsen A">AG Harmsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Damjanovic, D" uniqKey="Damjanovic D">D Damjanovic</name>
</author>
<author><name sortKey="Lai, R" uniqKey="Lai R">R Lai</name>
</author>
<author><name sortKey="Jeyanathan, M" uniqKey="Jeyanathan M">M Jeyanathan</name>
</author>
<author><name sortKey="Hogaboam, Cm" uniqKey="Hogaboam C">CM Hogaboam</name>
</author>
<author><name sortKey="Xing, Z" uniqKey="Xing Z">Z Xing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okumura, Cy" uniqKey="Okumura C">CY Okumura</name>
</author>
<author><name sortKey="Nizet, V" uniqKey="Nizet V">V Nizet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, K" uniqKey="Sun K">K Sun</name>
</author>
<author><name sortKey="Metzger, Dw" uniqKey="Metzger D">DW Metzger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robinson, Km" uniqKey="Robinson K">KM Robinson</name>
</author>
<author><name sortKey="Kolls, Jk" uniqKey="Kolls J">JK Kolls</name>
</author>
<author><name sortKey="Alcorn, Jf" uniqKey="Alcorn J">JF Alcorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narasaraju, T" uniqKey="Narasaraju T">T Narasaraju</name>
</author>
<author><name sortKey="Yang, E" uniqKey="Yang E">E Yang</name>
</author>
<author><name sortKey="Samy, Rp" uniqKey="Samy R">RP Samy</name>
</author>
<author><name sortKey="Ng, Hh" uniqKey="Ng H">HH Ng</name>
</author>
<author><name sortKey="Poh, Wp" uniqKey="Poh W">WP Poh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brinkmann, V" uniqKey="Brinkmann V">V Brinkmann</name>
</author>
<author><name sortKey="Reichard, U" uniqKey="Reichard U">U Reichard</name>
</author>
<author><name sortKey="Goosmann, C" uniqKey="Goosmann C">C Goosmann</name>
</author>
<author><name sortKey="Fauler, B" uniqKey="Fauler B">B Fauler</name>
</author>
<author><name sortKey="Uhlemann, Y" uniqKey="Uhlemann Y">Y Uhlemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saffarzadeh, M" uniqKey="Saffarzadeh M">M Saffarzadeh</name>
</author>
<author><name sortKey="Juenemann, C" uniqKey="Juenemann C">C Juenemann</name>
</author>
<author><name sortKey="Queisser, Ma" uniqKey="Queisser M">MA Queisser</name>
</author>
<author><name sortKey="Lochnit, G" uniqKey="Lochnit G">G Lochnit</name>
</author>
<author><name sortKey="Barreto, G" uniqKey="Barreto G">G Barreto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narayana Moorthy, A" uniqKey="Narayana Moorthy A">A Narayana Moorthy</name>
</author>
<author><name sortKey="Narasaraju, T" uniqKey="Narasaraju T">T Narasaraju</name>
</author>
<author><name sortKey="Rai, P" uniqKey="Rai P">P Rai</name>
</author>
<author><name sortKey="Perumalsamy, R" uniqKey="Perumalsamy R">R Perumalsamy</name>
</author>
<author><name sortKey="Tan, Kb" uniqKey="Tan K">KB Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abrams, St" uniqKey="Abrams S">ST Abrams</name>
</author>
<author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name>
</author>
<author><name sortKey="Manson, J" uniqKey="Manson J">J Manson</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Dart, C" uniqKey="Dart C">C Dart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Short, Kr" uniqKey="Short K">KR Short</name>
</author>
<author><name sortKey="Von Kockritz Blickwede, M" uniqKey="Von Kockritz Blickwede M">M von Köckritz-Blickwede</name>
</author>
<author><name sortKey="Langereis, Jd" uniqKey="Langereis J">JD Langereis</name>
</author>
<author><name sortKey="Chew, Ky" uniqKey="Chew K">KY Chew</name>
</author>
<author><name sortKey="Job, Er" uniqKey="Job E">ER Job</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Czaikoski, Pg" uniqKey="Czaikoski P">PG Czaikoski</name>
</author>
<author><name sortKey="Mota, Jm" uniqKey="Mota J">JM Mota</name>
</author>
<author><name sortKey="Nascimento, Dc" uniqKey="Nascimento D">DC Nascimento</name>
</author>
<author><name sortKey="Sonego, F" uniqKey="Sonego F">F Sônego</name>
</author>
<author><name sortKey="Castanheira, Fv" uniqKey="Castanheira F">FV Castanheira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, Y" uniqKey="Mori Y">Y Mori</name>
</author>
<author><name sortKey="Yamaguchi, M" uniqKey="Yamaguchi M">M Yamaguchi</name>
</author>
<author><name sortKey="Terao, Y" uniqKey="Terao Y">Y Terao</name>
</author>
<author><name sortKey="Hamada, S" uniqKey="Hamada S">S Hamada</name>
</author>
<author><name sortKey="Ooshima, T" uniqKey="Ooshima T">T Ooshima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name>
</author>
<author><name sortKey="Kuang, Z" uniqKey="Kuang Z">Z Kuang</name>
</author>
<author><name sortKey="Wilson, Ba" uniqKey="Wilson B">BA Wilson</name>
</author>
<author><name sortKey="Lau, Gw" uniqKey="Lau G">GW Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ellis, Gt" uniqKey="Ellis G">GT Ellis</name>
</author>
<author><name sortKey="Davidson, S" uniqKey="Davidson S">S Davidson</name>
</author>
<author><name sortKey="Crotta, S" uniqKey="Crotta S">S Crotta</name>
</author>
<author><name sortKey="Branzk, N" uniqKey="Branzk N">N Branzk</name>
</author>
<author><name sortKey="Papayannopoulos, V" uniqKey="Papayannopoulos V">V Papayannopoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engelich, G" uniqKey="Engelich G">G Engelich</name>
</author>
<author><name sortKey="White, M" uniqKey="White M">M White</name>
</author>
<author><name sortKey="Hartshorn, Kl" uniqKey="Hartshorn K">KL Hartshorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richard, Al" uniqKey="Richard A">AL Richard</name>
</author>
<author><name sortKey="Siegel, Sj" uniqKey="Siegel S">SJ Siegel</name>
</author>
<author><name sortKey="Erikson, J" uniqKey="Erikson J">J Erikson</name>
</author>
<author><name sortKey="Weiser, Jn" uniqKey="Weiser J">JN Weiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshimura, A" uniqKey="Yoshimura A">A Yoshimura</name>
</author>
<author><name sortKey="Lien, E" uniqKey="Lien E">E Lien</name>
</author>
<author><name sortKey="Ingalls, Rr" uniqKey="Ingalls R">RR Ingalls</name>
</author>
<author><name sortKey="Tuomanen, E" uniqKey="Tuomanen E">E Tuomanen</name>
</author>
<author><name sortKey="Dziarski, R" uniqKey="Dziarski R">R Dziarski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spelmink, L" uniqKey="Spelmink L">L Spelmink</name>
</author>
<author><name sortKey="Sender, V" uniqKey="Sender V">V Sender</name>
</author>
<author><name sortKey="Hentrich, K" uniqKey="Hentrich K">K Hentrich</name>
</author>
<author><name sortKey="Kuri, T" uniqKey="Kuri T">T Kuri</name>
</author>
<author><name sortKey="Plant, L" uniqKey="Plant L">L Plant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name>
</author>
<author><name sortKey="Xu, F" uniqKey="Xu F">F Xu</name>
</author>
<author><name sortKey="Lung, Wy" uniqKey="Lung W">WY Lung</name>
</author>
<author><name sortKey="Meyerson, C" uniqKey="Meyerson C">C Meyerson</name>
</author>
<author><name sortKey="Ghaffari, Aa" uniqKey="Ghaffari A">AA Ghaffari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Moltedo, B" uniqKey="Moltedo B">B Moltedo</name>
</author>
<author><name sortKey="Moran, Tm" uniqKey="Moran T">TM Moran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shahangian, A" uniqKey="Shahangian A">A Shahangian</name>
</author>
<author><name sortKey="Chow, Ek" uniqKey="Chow E">EK Chow</name>
</author>
<author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name>
</author>
<author><name sortKey="Kang, Jr" uniqKey="Kang J">JR Kang</name>
</author>
<author><name sortKey="Ghaffari, A" uniqKey="Ghaffari A">A Ghaffari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Rien, Rl" uniqKey="O Rien R">RL O’Brien</name>
</author>
<author><name sortKey="Roark, Cl" uniqKey="Roark C">CL Roark</name>
</author>
<author><name sortKey="Jin, N" uniqKey="Jin N">N Jin</name>
</author>
<author><name sortKey="Aydintug, Mk" uniqKey="Aydintug M">MK Aydintug</name>
</author>
<author><name sortKey="French, Jd" uniqKey="French J">JD French</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Negishi, H" uniqKey="Negishi H">H Negishi</name>
</author>
<author><name sortKey="Yanai, H" uniqKey="Yanai H">H Yanai</name>
</author>
<author><name sortKey="Nakajima, A" uniqKey="Nakajima A">A Nakajima</name>
</author>
<author><name sortKey="Koshiba, R" uniqKey="Koshiba R">R Koshiba</name>
</author>
<author><name sortKey="Atarashi, K" uniqKey="Atarashi K">K Atarashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malley, R" uniqKey="Malley R">R Malley</name>
</author>
<author><name sortKey="Henneke, P" uniqKey="Henneke P">P Henneke</name>
</author>
<author><name sortKey="Morse, Sc" uniqKey="Morse S">SC Morse</name>
</author>
<author><name sortKey="Cieslewicz, Mj" uniqKey="Cieslewicz M">MJ Cieslewicz</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlstrom, A" uniqKey="Karlstrom A">A Karlström</name>
</author>
<author><name sortKey="Heston, Sm" uniqKey="Heston S">SM Heston</name>
</author>
<author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name>
</author>
<author><name sortKey="Tuomanen, Ei" uniqKey="Tuomanen E">EI Tuomanen</name>
</author>
<author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waterer, Gw" uniqKey="Waterer G">GW Waterer</name>
</author>
<author><name sortKey="Somes, Gw" uniqKey="Somes G">GW Somes</name>
</author>
<author><name sortKey="Wunderink, Rg" uniqKey="Wunderink R">RG Wunderink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watkins, Rr" uniqKey="Watkins R">RR Watkins</name>
</author>
<author><name sortKey="Lemonovich, Tl" uniqKey="Lemonovich T">TL Lemonovich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Majhi, A" uniqKey="Majhi A">A Majhi</name>
</author>
<author><name sortKey="Adhikary, R" uniqKey="Adhikary R">R Adhikary</name>
</author>
<author><name sortKey="Bhattacharyya, A" uniqKey="Bhattacharyya A">A Bhattacharyya</name>
</author>
<author><name sortKey="Mahanti, S" uniqKey="Mahanti S">S Mahanti</name>
</author>
<author><name sortKey="Bishayi, B" uniqKey="Bishayi B">B Bishayi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlstrom, A" uniqKey="Karlstrom A">A Karlström</name>
</author>
<author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name>
</author>
<author><name sortKey="English, Bk" uniqKey="English B">BK English</name>
</author>
<author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Majhi, A" uniqKey="Majhi A">A Majhi</name>
</author>
<author><name sortKey="Kundu, K" uniqKey="Kundu K">K Kundu</name>
</author>
<author><name sortKey="Adhikary, R" uniqKey="Adhikary R">R Adhikary</name>
</author>
<author><name sortKey="Banerjee, M" uniqKey="Banerjee M">M Banerjee</name>
</author>
<author><name sortKey="Mahanti, S" uniqKey="Mahanti S">S Mahanti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luxameechanporn, T" uniqKey="Luxameechanporn T">T Luxameechanporn</name>
</author>
<author><name sortKey="Blair, C" uniqKey="Blair C">C Blair</name>
</author>
<author><name sortKey="Kirtsreesakul, V" uniqKey="Kirtsreesakul V">V Kirtsreesakul</name>
</author>
<author><name sortKey="Thompson, K" uniqKey="Thompson K">K Thompson</name>
</author>
<author><name sortKey="Naclerio, Rm" uniqKey="Naclerio R">RM Naclerio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldstein, Lh" uniqKey="Goldstein L">LH Goldstein</name>
</author>
<author><name sortKey="Gabin, A" uniqKey="Gabin A">A Gabin</name>
</author>
<author><name sortKey="Fawaz, A" uniqKey="Fawaz A">A Fawaz</name>
</author>
<author><name sortKey="Freedberg, Na" uniqKey="Freedberg N">NA Freedberg</name>
</author>
<author><name sortKey="Schwartz, N" uniqKey="Schwartz N">N Schwartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ke, Han" uniqKey="Ke H">Han Ke</name>
</author>
<author><name sortKey="Ma, Huilai" uniqKey="Ma H">Huilai Ma</name>
</author>
<author><name sortKey="An, Xiangdong" uniqKey="An X">Xiangdong An</name>
</author>
<author><name sortKey="Su, Yang" uniqKey="Su Y">Yang Su</name>
</author>
<author><name sortKey="Chen, Jing" uniqKey="Chen J">Jing Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mifsud, Ej" uniqKey="Mifsud E">EJ Mifsud</name>
</author>
<author><name sortKey="Tan, Ac" uniqKey="Tan A">AC Tan</name>
</author>
<author><name sortKey="Short, Kr" uniqKey="Short K">KR Short</name>
</author>
<author><name sortKey="Brown, Le" uniqKey="Brown L">LE Brown</name>
</author>
<author><name sortKey="Chua, By" uniqKey="Chua B">BY Chua</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reppe, K" uniqKey="Reppe K">K Reppe</name>
</author>
<author><name sortKey="Radunzel, P" uniqKey="Radunzel P">P Radünzel</name>
</author>
<author><name sortKey="Dietert, K" uniqKey="Dietert K">K Dietert</name>
</author>
<author><name sortKey="Tschernig, T" uniqKey="Tschernig T">T Tschernig</name>
</author>
<author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Porte, R" uniqKey="Porte R">R Porte</name>
</author>
<author><name sortKey="Fougeron, D" uniqKey="Fougeron D">D Fougeron</name>
</author>
<author><name sortKey="Mu Oz Wolf, N" uniqKey="Mu Oz Wolf N">N Muñoz-Wolf</name>
</author>
<author><name sortKey="Tabareau, J" uniqKey="Tabareau J">J Tabareau</name>
</author>
<author><name sortKey="Georgel, Af" uniqKey="Georgel A">AF Georgel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tanaka, A" uniqKey="Tanaka A">A Tanaka</name>
</author>
<author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name>
</author>
<author><name sortKey="Seki, M" uniqKey="Seki M">M Seki</name>
</author>
<author><name sortKey="Fukudome, K" uniqKey="Fukudome K">K Fukudome</name>
</author>
<author><name sortKey="Iwanaga, N" uniqKey="Iwanaga N">N Iwanaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Guo, S" uniqKey="Guo S">S Guo</name>
</author>
<author><name sortKey="Wu, L" uniqKey="Wu L">L Wu</name>
</author>
<author><name sortKey="Hao, C" uniqKey="Hao C">C Hao</name>
</author>
<author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Onishi, M" uniqKey="Onishi M">M Onishi</name>
</author>
<author><name sortKey="Kitano, M" uniqKey="Kitano M">M Kitano</name>
</author>
<author><name sortKey="Taniguchi, K" uniqKey="Taniguchi K">K Taniguchi</name>
</author>
<author><name sortKey="Homma, T" uniqKey="Homma T">T Homma</name>
</author>
<author><name sortKey="Kobayashi, M" uniqKey="Kobayashi M">M Kobayashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walther, E" uniqKey="Walther E">E Walther</name>
</author>
<author><name sortKey="Richter, M" uniqKey="Richter M">M Richter</name>
</author>
<author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
<author><name sortKey="Kramer, C" uniqKey="Kramer C">C Kramer</name>
</author>
<author><name sortKey="Von Grafenstein, S" uniqKey="Von Grafenstein S">S von Grafenstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Armstrong, Sm" uniqKey="Armstrong S">SM Armstrong</name>
</author>
<author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S Mubareka</name>
</author>
<author><name sortKey="Lee, Wl" uniqKey="Lee W">WL Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathieu, C" uniqKey="Mathieu C">C Mathieu</name>
</author>
<author><name sortKey="Rioux, G" uniqKey="Rioux G">G Rioux</name>
</author>
<author><name sortKey="Dumas, Mc" uniqKey="Dumas M">MC Dumas</name>
</author>
<author><name sortKey="Leclerc, D" uniqKey="Leclerc D">D Leclerc</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Metzger, Dw" uniqKey="Metzger D">DW Metzger</name>
</author>
<author><name sortKey="Furuya, Y" uniqKey="Furuya Y">Y Furuya</name>
</author>
<author><name sortKey="Salmon, Sl" uniqKey="Salmon S">SL Salmon</name>
</author>
<author><name sortKey="Roberts, S" uniqKey="Roberts S">S Roberts</name>
</author>
<author><name sortKey="Sun, K" uniqKey="Sun K">K Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klugman, Kp" uniqKey="Klugman K">KP Klugman</name>
</author>
<author><name sortKey="Chien, Yw" uniqKey="Chien Y">YW Chien</name>
</author>
<author><name sortKey="Madhi, Sa" uniqKey="Madhi S">SA Madhi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101682673</journal-id>
<journal-id journal-id-type="pubmed-jr-id">45264</journal-id>
<journal-id journal-id-type="nlm-ta">J Infect Pulm Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">J Infect Pulm Dis</journal-id>
<journal-title-group><journal-title>Journal of infectious pulmonary diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">2470-3176</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27981251</article-id>
<article-id pub-id-type="pmc">5154682</article-id>
<article-id pub-id-type="manuscript">NIHMS784378</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Lethal Synergism between Influenza and <italic>Streptococcus pneumoniae</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rudd</surname>
<given-names>Jennifer M</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ashar</surname>
<given-names>Harshini K</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chow</surname>
<given-names>Vincent TK</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teluguakula</surname>
<given-names>Narasaraju</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Center for Veterinary Health Sciences, Oklahoma State University, OK, USA</aff>
<aff id="A2"><label>2</label>
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>Corresponding author:</bold>
Narasaraju Teluguakula, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA, <email>narasa@okstate.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>19</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>2</volume>
<issue>2</issue>
<elocation-id>10.16966/2470-3176.114</elocation-id>
<permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><p id="P1">The devastating synergism of bacterial pneumonia with influenza viral infections left its mark on the world over the last century. Although the details of pathogenesis remain unclear, the synergism is related to a variety of factors including pulmonary epithelial barrier damage which exposes receptors that influence bacterial adherence and the triggering of an exaggerated innate immune response and cytokine storm, which further acts to worsen the injury. Several therapeutics and combination therapies of antibiotics, anti-inflammatories including corticosteroids and toll-like receptor modifiers, and anti-virals are being discussed. This mini review summarizes recent developments in unearthing the pathogenesis of the lethal synergism of pneumococcal co-infection following influenza, as well as addresses potential therapeutic options and combinations of therapies currently being evaluated.</p>
</abstract>
<kwd-group><kwd>Bacterial co-infection</kwd>
<kwd>Influenza</kwd>
<kwd><italic>Streptococcus pneumoniae</italic>
</kwd>
<kwd>Pathogenesis</kwd>
<kwd>Therapeutics</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><title>Neutrophils are key players in co-infection pathogenesis</title>
<p id="P18">(A) Influenza damages airway epithelium and exposes receptors priming for bacterial adherence; <italic>S. pneumoniae</italic>
adheres to damaged epithelium and is able to migrate through pulmonary epithelium. (B) Sentinel cells detect pathogens and damaged cells and recruit neutrophils through a chemotactic gradient for phagocytosis and bacterial killing; Neutrophils contribute to immunopathology through a variety of mechanisms as illustrated. (C) Worsened epithelial and endothelial damage due to coinfection results in bacteremia.</p>
</caption>
<graphic xlink:href="nihms784378f1"></graphic>
</fig>
</floats-group>
</pmc>
</record>
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