An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
Identifieur interne : 000C63 ( Pmc/Curation ); précédent : 000C62; suivant : 000C64An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
Auteurs : Louis M. Schwartzman ; Andrea L. Cathcart ; Lindsey M. Pujanauski ; Li Qi ; John C. Kash ; Jeffery K. TaubenbergerSource :
- mBio [ 2150-7511 ] ; 2015.
Abstract
Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine each year against specific circulating virus strains. Because these vaccines are unlikely to protect against an antigenically divergent strain or a new pandemic virus with a novel hemagglutinin (HA) subtype, there is a critical need for vaccines that protect against all influenza A viruses, a so-called “universal” vaccine. Here we show that mice were broadly protected against challenge with a wide variety of lethal influenza A virus infections (94% aggregate survival following vaccination) with a virus-like particle (VLP) vaccine cocktail. The vaccine consisted of a mixture of VLPs individually displaying H1, H3, H5, or H7 HAs, and vaccinated mice showed significant protection following challenge with influenza viruses expressing 1918 H1, 1957 H2, and avian H5, H6, H7, H10, and H11 hemagglutinin subtypes. These experiments suggest a promising and practical strategy for developing a broadly protective “universal” influenza vaccine.
Url:
DOI: 10.1128/mBio.01044-15
PubMed: 26199334
PubMed Central: 4513078
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C63
Links to Exploration step
PMC:4513078Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus</title><author><name sortKey="Schwartzman, Louis M" sort="Schwartzman, Louis M" uniqKey="Schwartzman L" first="Louis M." last="Schwartzman">Louis M. Schwartzman</name></author><author><name sortKey="Cathcart, Andrea L" sort="Cathcart, Andrea L" uniqKey="Cathcart A" first="Andrea L." last="Cathcart">Andrea L. Cathcart</name></author><author><name sortKey="Pujanauski, Lindsey M" sort="Pujanauski, Lindsey M" uniqKey="Pujanauski L" first="Lindsey M." last="Pujanauski">Lindsey M. Pujanauski</name></author><author><name sortKey="Qi, Li" sort="Qi, Li" uniqKey="Qi L" first="Li" last="Qi">Li Qi</name></author><author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26199334</idno><idno type="pmc">4513078</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513078</idno><idno type="RBID">PMC:4513078</idno><idno type="doi">10.1128/mBio.01044-15</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C63</idno><idno type="wicri:Area/Pmc/Curation">000C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus</title><author><name sortKey="Schwartzman, Louis M" sort="Schwartzman, Louis M" uniqKey="Schwartzman L" first="Louis M." last="Schwartzman">Louis M. Schwartzman</name></author><author><name sortKey="Cathcart, Andrea L" sort="Cathcart, Andrea L" uniqKey="Cathcart A" first="Andrea L." last="Cathcart">Andrea L. Cathcart</name></author><author><name sortKey="Pujanauski, Lindsey M" sort="Pujanauski, Lindsey M" uniqKey="Pujanauski L" first="Lindsey M." last="Pujanauski">Lindsey M. Pujanauski</name></author><author><name sortKey="Qi, Li" sort="Qi, Li" uniqKey="Qi L" first="Li" last="Qi">Li Qi</name></author><author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine each year against specific circulating virus strains. Because these vaccines are unlikely to protect against an antigenically divergent strain or a new pandemic virus with a novel hemagglutinin (HA) subtype, there is a critical need for vaccines that protect against all influenza A viruses, a so-called “universal” vaccine. Here we show that mice were broadly protected against challenge with a wide variety of lethal influenza A virus infections (94% aggregate survival following vaccination) with a virus-like particle (VLP) vaccine cocktail. The vaccine consisted of a mixture of VLPs individually displaying H1, H3, H5, or H7 HAs, and vaccinated mice showed significant protection following challenge with influenza viruses expressing 1918 H1, 1957 H2, and avian H5, H6, H7, H10, and H11 hemagglutinin subtypes. These experiments suggest a promising and practical strategy for developing a broadly protective “universal” influenza vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaw, Ml" uniqKey="Shaw M">ML Shaw</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malik Peiris, Js" uniqKey="Malik Peiris J">JS Malik Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, Mt" uniqKey="Osterholm M">MT Osterholm</name></author><author><name sortKey="Kelley, Ns" uniqKey="Kelley N">NS Kelley</name></author><author><name sortKey="Sommer, A" uniqKey="Sommer A">A Sommer</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascua, Pn" uniqKey="Pascua P">PN Pascua</name></author><author><name sortKey="Choi, Yk" uniqKey="Choi Y">YK Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockman, S" uniqKey="Rockman S">S Rockman</name></author><author><name sortKey="Brown, L" uniqKey="Brown L">L Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slepushkin, Va" uniqKey="Slepushkin V">VA Slepushkin</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Black, Ra" uniqKey="Black R">RA Black</name></author><author><name sortKey="Gamble, Wc" uniqKey="Gamble W">WC Gamble</name></author><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author><author><name sortKey="De Filette, M" uniqKey="De Filette M">M De Filette</name></author><author><name sortKey="Birkett, A" uniqKey="Birkett A">A Birkett</name></author><author><name sortKey="Neirynck, S" uniqKey="Neirynck S">S Neirynck</name></author><author><name sortKey="Min Jou, W" uniqKey="Min Jou W">W Min Jou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogra, Pl" uniqKey="Ogra P">PL Ogra</name></author><author><name sortKey="Chow, T" uniqKey="Chow T">T Chow</name></author><author><name sortKey="Beutner, Kr" uniqKey="Beutner K">KR Beutner</name></author><author><name sortKey="Rubi, E" uniqKey="Rubi E">E Rubi</name></author><author><name sortKey="Strussenberg, J" uniqKey="Strussenberg J">J Strussenberg</name></author><author><name sortKey="Demello, S" uniqKey="Demello S">S DeMello</name></author><author><name sortKey="Rizzone, C" uniqKey="Rizzone C">C Rizzone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Easterbrook, Jd" uniqKey="Easterbrook J">JD Easterbrook</name></author><author><name sortKey="Schwartzman, Lm" uniqKey="Schwartzman L">LM Schwartzman</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Couzens, L" uniqKey="Couzens L">L Couzens</name></author><author><name sortKey="Wan, H" uniqKey="Wan H">H Wan</name></author><author><name sortKey="Eichelberger, Mc" uniqKey="Eichelberger M">MC Eichelberger</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Yt" uniqKey="Lee Y">YT Lee</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Ko, Ej" uniqKey="Ko E">EJ Ko</name></author><author><name sortKey="Lee, Yn" uniqKey="Lee Y">YN Lee</name></author><author><name sortKey="Kim, Mc" uniqKey="Kim M">MC Kim</name></author><author><name sortKey="Kwon, Ym" uniqKey="Kwon Y">YM Kwon</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Cho, Mk" uniqKey="Cho M">MK Cho</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qui Ones Parra, S" uniqKey="Qui Ones Parra S">S Quiñones-Parra</name></author><author><name sortKey="Loh, L" uniqKey="Loh L">L Loh</name></author><author><name sortKey="Brown, Le" uniqKey="Brown L">LE Brown</name></author><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laursen, Ns" uniqKey="Laursen N">NS Laursen</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Bu, F" uniqKey="Bu F">F Bu</name></author><author><name sortKey="Knell, J" uniqKey="Knell J">J Knell</name></author><author><name sortKey="Robinson, R" uniqKey="Robinson R">R Robinson</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name></author><author><name sortKey="Carter, Dm" uniqKey="Carter D">DM Carter</name></author><author><name sortKey="Daniluk, S" uniqKey="Daniluk S">S Daniluk</name></author><author><name sortKey="Toapanta, Fr" uniqKey="Toapanta F">FR Toapanta</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author><author><name sortKey="Gavrilov, V" uniqKey="Gavrilov V">V Gavrilov</name></author><author><name sortKey="Massare, M" uniqKey="Massare M">M Massare</name></author><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Mytle, N" uniqKey="Mytle N">N Mytle</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author><author><name sortKey="Ross, Tm" uniqKey="Ross T">TM Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Van Hoeven, N" uniqKey="Van Hoeven N">N Van Hoeven</name></author><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Robinson, R" uniqKey="Robinson R">R Robinson</name></author><author><name sortKey="Nathan, M" uniqKey="Nathan M">M Nathan</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author><author><name sortKey="Wright, Dc" uniqKey="Wright D">DC Wright</name></author><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author><author><name sortKey="Song, Jm" uniqKey="Song J">JM Song</name></author><author><name sortKey="Quan, Fs" uniqKey="Quan F">FS Quan</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author><author><name sortKey="Yoo, Dg" uniqKey="Yoo D">DG Yoo</name></author><author><name sortKey="Lipatov, As" uniqKey="Lipatov A">AS Lipatov</name></author><author><name sortKey="Song, Jm" uniqKey="Song J">JM Song</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Quan, Fs" uniqKey="Quan F">FS Quan</name></author><author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name></author><author><name sortKey="Donis, Ro" uniqKey="Donis R">RO Donis</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quan, Fs" uniqKey="Quan F">FS Quan</name></author><author><name sortKey="Yoo, Dg" uniqKey="Yoo D">DG Yoo</name></author><author><name sortKey="Song, Jm" uniqKey="Song J">JM Song</name></author><author><name sortKey="Clements, Jd" uniqKey="Clements J">JD Clements</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lua, Lh" uniqKey="Lua L">LH Lua</name></author><author><name sortKey="Connors, Nk" uniqKey="Connors N">NK Connors</name></author><author><name sortKey="Sainsbury, F" uniqKey="Sainsbury F">F Sainsbury</name></author><author><name sortKey="Chuan, Yp" uniqKey="Chuan Y">YP Chuan</name></author><author><name sortKey="Wibowo, N" uniqKey="Wibowo N">N Wibowo</name></author><author><name sortKey="Middelberg, Ap" uniqKey="Middelberg A">AP Middelberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diazgranados, Ca" uniqKey="Diazgranados C">CA DiazGranados</name></author><author><name sortKey="Dunning, Aj" uniqKey="Dunning A">AJ Dunning</name></author><author><name sortKey="Kimmel, M" uniqKey="Kimmel M">M Kimmel</name></author><author><name sortKey="Kirby, D" uniqKey="Kirby D">D Kirby</name></author><author><name sortKey="Treanor, J" uniqKey="Treanor J">J Treanor</name></author><author><name sortKey="Collins, A" uniqKey="Collins A">A Collins</name></author><author><name sortKey="Pollak, R" uniqKey="Pollak R">R Pollak</name></author><author><name sortKey="Christoff, J" uniqKey="Christoff J">J Christoff</name></author><author><name sortKey="Earl, J" uniqKey="Earl J">J Earl</name></author><author><name sortKey="Landolfi, V" uniqKey="Landolfi V">V Landolfi</name></author><author><name sortKey="Martin, E" uniqKey="Martin E">E Martin</name></author><author><name sortKey="Gurunathan, S" uniqKey="Gurunathan S">S Gurunathan</name></author><author><name sortKey="Nathan, R" uniqKey="Nathan R">R Nathan</name></author><author><name sortKey="Greenberg, Dp" uniqKey="Greenberg D">DP Greenberg</name></author><author><name sortKey="Tornieporth, Ng" uniqKey="Tornieporth N">NG Tornieporth</name></author><author><name sortKey="Decker, Md" uniqKey="Decker M">MD Decker</name></author><author><name sortKey="Talbot, Hk" uniqKey="Talbot H">HK Talbot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, H" uniqKey="Jang H">H Jang</name></author><author><name sortKey="Boltz, D" uniqKey="Boltz D">D Boltz</name></author><author><name sortKey="Sturm Ramirez, K" uniqKey="Sturm Ramirez K">K Sturm-Ramirez</name></author><author><name sortKey="Shepherd, Kr" uniqKey="Shepherd K">KR Shepherd</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Webster, R" uniqKey="Webster R">R Webster</name></author><author><name sortKey="Smeyne, Rj" uniqKey="Smeyne R">RJ Smeyne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grebe, Km" uniqKey="Grebe K">KM Grebe</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckinstry, Kk" uniqKey="Mckinstry K">KK McKinstry</name></author><author><name sortKey="Strutt, Tm" uniqKey="Strutt T">TM Strutt</name></author><author><name sortKey="Swain, Sl" uniqKey="Swain S">SL Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author><author><name sortKey="Pearce, Mb" uniqKey="Pearce M">MB Pearce</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author><author><name sortKey="Tretyakova, I" uniqKey="Tretyakova I">I Tretyakova</name></author><author><name sortKey="Smith, G" uniqKey="Smith G">G Smith</name></author><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tretyakova, I" uniqKey="Tretyakova I">I Tretyakova</name></author><author><name sortKey="Pearce, Mb" uniqKey="Pearce M">MB Pearce</name></author><author><name sortKey="Florese, R" uniqKey="Florese R">R Florese</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Pushko, P" uniqKey="Pushko P">P Pushko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crevar, Cj" uniqKey="Crevar C">CJ Crevar</name></author><author><name sortKey="Carter, Dm" uniqKey="Carter D">DM Carter</name></author><author><name sortKey="Lee, Ky" uniqKey="Lee K">KY Lee</name></author><author><name sortKey="Ross, Tm" uniqKey="Ross T">TM Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johansson, Be" uniqKey="Johansson B">BE Johansson</name></author><author><name sortKey="Moran, Tm" uniqKey="Moran T">TM Moran</name></author><author><name sortKey="Bona, Ca" uniqKey="Bona C">CA Bona</name></author><author><name sortKey="Popple, Sw" uniqKey="Popple S">SW Popple</name></author><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hopkins, R" uniqKey="Hopkins R">R Hopkins</name></author><author><name sortKey="Esposito, D" uniqKey="Esposito D">D Esposito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillette, Wk" uniqKey="Gillette W">WK Gillette</name></author><author><name sortKey="Esposito, D" uniqKey="Esposito D">D Esposito</name></author><author><name sortKey="Taylor, Te" uniqKey="Taylor T">TE Taylor</name></author><author><name sortKey="Hopkins, Rf" uniqKey="Hopkins R">RF Hopkins</name></author><author><name sortKey="Bagni, Rk" uniqKey="Bagni R">RK Bagni</name></author><author><name sortKey="Hartley, Jl" uniqKey="Hartley J">JL Hartley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, L" uniqKey="Qi L">L Qi</name></author><author><name sortKey="Pujanauski, Lm" uniqKey="Pujanauski L">LM Pujanauski</name></author><author><name sortKey="Davis, As" uniqKey="Davis A">AS Davis</name></author><author><name sortKey="Schwartzman, Lm" uniqKey="Schwartzman L">LM Schwartzman</name></author><author><name sortKey="Chertow, Ds" uniqKey="Chertow D">DS Chertow</name></author><author><name sortKey="Baxter, D" uniqKey="Baxter D">D Baxter</name></author><author><name sortKey="Scherler, K" uniqKey="Scherler K">K Scherler</name></author><author><name sortKey="Hartshorn, Kl" uniqKey="Hartshorn K">KL Hartshorn</name></author><author><name sortKey="Slemons, Rd" uniqKey="Slemons R">RD Slemons</name></author><author><name sortKey="Walters, Ka" uniqKey="Walters K">KA Walters</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, L" uniqKey="Qi L">L Qi</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Dugan, Vg" uniqKey="Dugan V">VG Dugan</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name></author><author><name sortKey="Cunningham, Re" uniqKey="Cunningham R">RE Cunningham</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Easterbrook, Jd" uniqKey="Easterbrook J">JD Easterbrook</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Sheng, Zm" uniqKey="Sheng Z">ZM Sheng</name></author><author><name sortKey="Qi, L" uniqKey="Qi L">L Qi</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author><author><name sortKey="Eichelberger, Mc" uniqKey="Eichelberger M">MC Eichelberger</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name></author><author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">mBio</journal-id><journal-id journal-id-type="iso-abbrev">MBio</journal-id><journal-id journal-id-type="hwp">mbio</journal-id><journal-id journal-id-type="pmc">mbio</journal-id><journal-id journal-id-type="publisher-id">mBio</journal-id><journal-title-group><journal-title>mBio</journal-title></journal-title-group><issn pub-type="epub">2150-7511</issn><publisher><publisher-name>American Society of Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26199334</article-id><article-id pub-id-type="pmc">4513078</article-id><article-id pub-id-type="publisher-id">mBio01044-15</article-id><article-id pub-id-type="doi">10.1128/mBio.01044-15</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus</article-title><alt-title alt-title-type="running-head">Broad Protection from an Influenza VLP Vaccine in Mice</alt-title><alt-title alt-title-type="short-authors">Schwartzman et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schwartzman</surname><given-names>Louis M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cathcart</surname><given-names>Andrea L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pujanauski</surname><given-names>Lindsey M.</given-names></name><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Li</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kash</surname><given-names>John C.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Taubenberger</surname><given-names>Jeffery K.</given-names></name></contrib><aff id="aff1"><addr-line>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</addr-line></aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Dermody</surname><given-names>Terence S.</given-names></name><role>Editor</role><aff>Vanderbilt University School of Medicine</aff></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to Jeffery K. Taubenberger, <email>taubenbergerj@niaid.nih.gov</email>.</corresp><fn id="fn1" fn-type="present-address"><label>*</label><p>Present address: Lindsey M. Pujanauski, The American Association of Immunologists, Bethesda, Maryland, USA.</p></fn><fn fn-type="equal"><p>L.M.S., A.L.C., and L.M.P. contributed equally to this article.</p></fn><fn fn-type="other"><p>This article is a direct contribution from a Fellow of the American Academy of Microbiology.</p></fn></author-notes><pub-date pub-type="epub"><day>21</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="collection"><season>Jul-Aug</season><year>2015</year></pub-date><volume>6</volume><issue>4</issue><elocation-id>e01044-15</elocation-id><history><date date-type="received"><day>19</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>26</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Schwartzman et al.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Schwartzman et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/">Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license</ext-link>, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="mbo004152406001.pdf"></self-uri><abstract><title>ABSTRACT</title><p>Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine each year against specific circulating virus strains. Because these vaccines are unlikely to protect against an antigenically divergent strain or a new pandemic virus with a novel hemagglutinin (HA) subtype, there is a critical need for vaccines that protect against all influenza A viruses, a so-called “universal” vaccine. Here we show that mice were broadly protected against challenge with a wide variety of lethal influenza A virus infections (94% aggregate survival following vaccination) with a virus-like particle (VLP) vaccine cocktail. The vaccine consisted of a mixture of VLPs individually displaying H1, H3, H5, or H7 HAs, and vaccinated mice showed significant protection following challenge with influenza viruses expressing 1918 H1, 1957 H2, and avian H5, H6, H7, H10, and H11 hemagglutinin subtypes. These experiments suggest a promising and practical strategy for developing a broadly protective “universal” influenza vaccine.</p></abstract><abstract abstract-type="executive-summary"><title>IMPORTANCE</title><p>The rapid and unpredictable nature of influenza A virus evolution requires new vaccines to be produced annually to match circulating strains. Human infections with influenza viruses derived from animals can cause outbreaks that may be associated with high mortality, and such strains may also adapt to humans to cause a future pandemic. Thus, there is a large public health need to create broadly protective, or “universal,” influenza vaccines that could prevent disease from a wide variety of human and animal influenza A viruses. In this study, a noninfectious virus-like particle (VLP) vaccine was shown to offer significant protection against a variety of influenza A viruses in mice, suggesting a practical strategy to develop a universal influenza vaccine.</p></abstract><counts><count count-type="supplementary-material" count="0"></count><fig-count count="4"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="45"></ref-count><page-count count="9"></page-count><word-count count="6765"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>July/August 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C63 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000C63 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4513078
|texte= An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26199334" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |