Serveur d'exploration H2N2

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2

Identifieur interne : 000C04 ( Pmc/Curation ); précédent : 000C03; suivant : 000C05

Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2

Auteurs : Wei Wang [États-Unis] ; Christine M. Anderson [États-Unis] ; Christopher J. De Feo [États-Unis] ; Min Zhuang [États-Unis] ; Hong Yang [États-Unis] ; Russell Vassell [États-Unis] ; Hang Xie [États-Unis] ; Zhiping Ye [États-Unis] ; Dorothy Scott [États-Unis] ; Carol D. Weiss [États-Unis]

Source :

RBID : PMC:3111540

Abstract

Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from H1N1 strains that circulated in the past 50 years, but resembles the A/New Jersey/1976 H1N1 strain used in the 1976 swine influenza vaccine. We investigated whether sera from persons immunized with the 1976 swine influenza or recent seasonal influenza vaccines, or both, neutralize 2009 H1N1. Using retroviral pseudovirions bearing hemagglutinins on their surface (HA-pseudotypes), we found that 77% of the sera collected in 1976 after immunization with the A/New Jersey/1976 H1N1 swine influenza vaccine neutralized 2009 H1N1. Forty five percent also neutralized A/New Caledonia/20/1999 H1N1, a strain used in seasonal influenza vaccines during the 2000/01–2006/07 seasons. Among adults aged 48–64 who received the swine influenza vaccine in 1976 and recent seasonal influenza vaccines during the 2004/05–2008/09 seasons, 83% had sera that neutralized 2009 H1N1. However, 68% of age-matched subjects who received the same seasonal influenza vaccines, but did not receive the 1976 swine influenza vaccine, also had sera that neutralized 2009 H1N1. Sera from both 1976 and contemporary cohorts frequently had cross-neutralizing antibodies to 2009 H1N1 and A/New Caledonia/20/1999 that mapped to hemagglutinin subunit 2 (HA2). A conservative mutation in HA2 corresponding to a residue in the A/Solomon Islands/3/2006 and A/Brisbane/59/2007 H1N1 strains that circulated in the 2006/07 and 2007/08 influenza seasons, respectively, abrogated this neutralization. These findings highlight a cross-neutralization determinant influenced by a point mutation in HA2 and suggest that HA2 may be evolving under direct or indirect immune pressure.


Url:
DOI: 10.1371/journal.ppat.1002081
PubMed: 21695241
PubMed Central: 3111540

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:3111540

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2</title>
<author>
<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Anderson, Christine M" sort="Anderson, Christine M" uniqKey="Anderson C" first="Christine M." last="Anderson">Christine M. Anderson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Feo, Christopher J" sort="De Feo, Christopher J" uniqKey="De Feo C" first="Christopher J." last="De Feo">Christopher J. De Feo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhuang, Min" sort="Zhuang, Min" uniqKey="Zhuang M" first="Min" last="Zhuang">Min Zhuang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vassell, Russell" sort="Vassell, Russell" uniqKey="Vassell R" first="Russell" last="Vassell">Russell Vassell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Xie, Hang" sort="Xie, Hang" uniqKey="Xie H" first="Hang" last="Xie">Hang Xie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ye, Zhiping" sort="Ye, Zhiping" uniqKey="Ye Z" first="Zhiping" last="Ye">Zhiping Ye</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, Dorothy" sort="Scott, Dorothy" uniqKey="Scott D" first="Dorothy" last="Scott">Dorothy Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weiss, Carol D" sort="Weiss, Carol D" uniqKey="Weiss C" first="Carol D." last="Weiss">Carol D. Weiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">21695241</idno>
<idno type="pmc">3111540</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111540</idno>
<idno type="RBID">PMC:3111540</idno>
<idno type="doi">10.1371/journal.ppat.1002081</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000C04</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C04</idno>
<idno type="wicri:Area/Pmc/Curation">000C04</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C04</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2</title>
<author>
<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Anderson, Christine M" sort="Anderson, Christine M" uniqKey="Anderson C" first="Christine M." last="Anderson">Christine M. Anderson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Feo, Christopher J" sort="De Feo, Christopher J" uniqKey="De Feo C" first="Christopher J." last="De Feo">Christopher J. De Feo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhuang, Min" sort="Zhuang, Min" uniqKey="Zhuang M" first="Min" last="Zhuang">Min Zhuang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vassell, Russell" sort="Vassell, Russell" uniqKey="Vassell R" first="Russell" last="Vassell">Russell Vassell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Xie, Hang" sort="Xie, Hang" uniqKey="Xie H" first="Hang" last="Xie">Hang Xie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ye, Zhiping" sort="Ye, Zhiping" uniqKey="Ye Z" first="Zhiping" last="Ye">Zhiping Ye</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, Dorothy" sort="Scott, Dorothy" uniqKey="Scott D" first="Dorothy" last="Scott">Dorothy Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<addr-line>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weiss, Carol D" sort="Weiss, Carol D" uniqKey="Weiss C" first="Carol D." last="Weiss">Carol D. Weiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">PLoS Pathogens</title>
<idno type="ISSN">1553-7366</idno>
<idno type="eISSN">1553-7374</idno>
<imprint>
<date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from H1N1 strains that circulated in the past 50 years, but resembles the A/New Jersey/1976 H1N1 strain used in the 1976 swine influenza vaccine. We investigated whether sera from persons immunized with the 1976 swine influenza or recent seasonal influenza vaccines, or both, neutralize 2009 H1N1. Using retroviral pseudovirions bearing hemagglutinins on their surface (HA-pseudotypes), we found that 77% of the sera collected in 1976 after immunization with the A/New Jersey/1976 H1N1 swine influenza vaccine neutralized 2009 H1N1. Forty five percent also neutralized A/New Caledonia/20/1999 H1N1, a strain used in seasonal influenza vaccines during the 2000/01–2006/07 seasons. Among adults aged 48–64 who received the swine influenza vaccine in 1976 and recent seasonal influenza vaccines during the 2004/05–2008/09 seasons, 83% had sera that neutralized 2009 H1N1. However, 68% of age-matched subjects who received the same seasonal influenza vaccines, but did not receive the 1976 swine influenza vaccine, also had sera that neutralized 2009 H1N1. Sera from both 1976 and contemporary cohorts frequently had cross-neutralizing antibodies to 2009 H1N1 and A/New Caledonia/20/1999 that mapped to hemagglutinin subunit 2 (HA2). A conservative mutation in HA2 corresponding to a residue in the A/Solomon Islands/3/2006 and A/Brisbane/59/2007 H1N1 strains that circulated in the 2006/07 and 2007/08 influenza seasons, respectively, abrogated this neutralization. These findings highlight a cross-neutralization determinant influenced by a point mutation in HA2 and suggest that HA2 may be evolving under direct or indirect immune pressure.</p>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author>
<name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author>
<name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
<author>
<name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author>
<name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Dowdle, Wr" uniqKey="Dowdle W">WR Dowdle</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name>
</author>
<author>
<name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name>
</author>
<author>
<name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author>
<name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name>
</author>
<author>
<name sortKey="Butler, En" uniqKey="Butler E">EN Butler</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Johns, Mc" uniqKey="Johns M">MC Johns</name>
</author>
<author>
<name sortKey="Eick, Aa" uniqKey="Eick A">AA Eick</name>
</author>
<author>
<name sortKey="Blazes, Dl" uniqKey="Blazes D">DL Blazes</name>
</author>
<author>
<name sortKey="Lee, Se" uniqKey="Lee S">SE Lee</name>
</author>
<author>
<name sortKey="Perdue, Cl" uniqKey="Perdue C">CL Perdue</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Labrosse, B" uniqKey="Labrosse B">B Labrosse</name>
</author>
<author>
<name sortKey="Tourdjman, M" uniqKey="Tourdjman M">M Tourdjman</name>
</author>
<author>
<name sortKey="Porcher, R" uniqKey="Porcher R">R Porcher</name>
</author>
<author>
<name sortKey="Legoff, J" uniqKey="Legoff J">J LeGoff</name>
</author>
<author>
<name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lee, Vj" uniqKey="Lee V">VJ Lee</name>
</author>
<author>
<name sortKey="Tay, Jk" uniqKey="Tay J">JK Tay</name>
</author>
<author>
<name sortKey="Chen, Mi" uniqKey="Chen M">MI Chen</name>
</author>
<author>
<name sortKey="Phoon, Mc" uniqKey="Phoon M">MC Phoon</name>
</author>
<author>
<name sortKey="Xie, Ml" uniqKey="Xie M">ML Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
<author>
<name sortKey="Van De Velde, La" uniqKey="Van De Velde L">LA Van De Velde</name>
</author>
<author>
<name sortKey="Allison, Kj" uniqKey="Allison K">KJ Allison</name>
</author>
<author>
<name sortKey="Branum, Kc" uniqKey="Branum K">KC Branum</name>
</author>
<author>
<name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
<author>
<name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="White, Jm" uniqKey="White J">JM White</name>
</author>
<author>
<name sortKey="Delos, Se" uniqKey="Delos S">SE Delos</name>
</author>
<author>
<name sortKey="Brecher, M" uniqKey="Brecher M">M Brecher</name>
</author>
<author>
<name sortKey="Schornberg, K" uniqKey="Schornberg K">K Schornberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name>
</author>
<author>
<name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
<author>
<name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Caton, Aj" uniqKey="Caton A">AJ Caton</name>
</author>
<author>
<name sortKey="Brownlee, Gg" uniqKey="Brownlee G">GG Brownlee</name>
</author>
<author>
<name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name>
</author>
<author>
<name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name>
</author>
<author>
<name sortKey="Isegawa, Y" uniqKey="Isegawa Y">Y Isegawa</name>
</author>
<author>
<name sortKey="Sasao, F" uniqKey="Sasao F">F Sasao</name>
</author>
<author>
<name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kashyap, Ak" uniqKey="Kashyap A">AK Kashyap</name>
</author>
<author>
<name sortKey="Steel, J" uniqKey="Steel J">J Steel</name>
</author>
<author>
<name sortKey="Oner, Af" uniqKey="Oner A">AF Oner</name>
</author>
<author>
<name sortKey="Dillon, Ma" uniqKey="Dillon M">MA Dillon</name>
</author>
<author>
<name sortKey="Swale, Re" uniqKey="Swale R">RE Swale</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Throsby, M" uniqKey="Throsby M">M Throsby</name>
</author>
<author>
<name sortKey="Van Den Brink, E" uniqKey="Van Den Brink E">E van den Brink</name>
</author>
<author>
<name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name>
</author>
<author>
<name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author>
<name sortKey="Alard, P" uniqKey="Alard P">P Alard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name>
</author>
<author>
<name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name>
</author>
<author>
<name sortKey="Elsliger, Ma" uniqKey="Elsliger M">MA Elsliger</name>
</author>
<author>
<name sortKey="Friesen, Rh" uniqKey="Friesen R">RH Friesen</name>
</author>
<author>
<name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
</author>
<author>
<name sortKey="Hwang, Wc" uniqKey="Hwang W">WC Hwang</name>
</author>
<author>
<name sortKey="Perez, S" uniqKey="Perez S">S Perez</name>
</author>
<author>
<name sortKey="Wei, G" uniqKey="Wei G">G Wei</name>
</author>
<author>
<name sortKey="Aird, D" uniqKey="Aird D">D Aird</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Corti, D" uniqKey="Corti D">D Corti</name>
</author>
<author>
<name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name>
</author>
<author>
<name sortKey="Pinna, D" uniqKey="Pinna D">D Pinna</name>
</author>
<author>
<name sortKey="Silacci, C" uniqKey="Silacci C">C Silacci</name>
</author>
<author>
<name sortKey="Fernandez Rodriguez, Bm" uniqKey="Fernandez Rodriguez B">BM Fernandez-Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
<author>
<name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name>
</author>
<author>
<name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author>
<name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author>
<name sortKey="Petersen, E" uniqKey="Petersen E">E Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author>
<name sortKey="Butler, En" uniqKey="Butler E">EN Butler</name>
</author>
<author>
<name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name>
</author>
<author>
<name sortKey="Vassell, R" uniqKey="Vassell R">R Vassell</name>
</author>
<author>
<name sortKey="Thomas, Jt" uniqKey="Thomas J">JT Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Dolin, R" uniqKey="Dolin R">R Dolin</name>
</author>
<author>
<name sortKey="Wise, Tg" uniqKey="Wise T">TG Wise</name>
</author>
<author>
<name sortKey="Mazur, Mh" uniqKey="Mazur M">MH Mazur</name>
</author>
<author>
<name sortKey="Tuazon, Cu" uniqKey="Tuazon C">CU Tuazon</name>
</author>
<author>
<name sortKey="Ennis, Fa" uniqKey="Ennis F">FA Ennis</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author>
<name sortKey="Xie, H" uniqKey="Xie H">H Xie</name>
</author>
<author>
<name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name>
</author>
<author>
<name sortKey="Vassell, R" uniqKey="Vassell R">R Vassell</name>
</author>
<author>
<name sortKey="Weiss, Cd" uniqKey="Weiss C">CD Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author>
<name sortKey="Castelan Vega, Ja" uniqKey="Castelan Vega J">JA Castelan-Vega</name>
</author>
<author>
<name sortKey="Jimenez Alberto, A" uniqKey="Jimenez Alberto A">A Jimenez-Alberto</name>
</author>
<author>
<name sortKey="Vassell, R" uniqKey="Vassell R">R Vassell</name>
</author>
<author>
<name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kelly, H" uniqKey="Kelly H">H Kelly</name>
</author>
<author>
<name sortKey="Grant, K" uniqKey="Grant K">K Grant</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Garcia Garcia, L" uniqKey="Garcia Garcia L">L Garcia-Garcia</name>
</author>
<author>
<name sortKey="Valdespino Gomez, Jl" uniqKey="Valdespino Gomez J">JL Valdespino-Gomez</name>
</author>
<author>
<name sortKey="Lazcano Ponce, E" uniqKey="Lazcano Ponce E">E Lazcano-Ponce</name>
</author>
<author>
<name sortKey="Jimenez Corona, A" uniqKey="Jimenez Corona A">A Jimenez-Corona</name>
</author>
<author>
<name sortKey="Higuera Iglesias, A" uniqKey="Higuera Iglesias A">A Higuera-Iglesias</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tang, Jw" uniqKey="Tang J">JW Tang</name>
</author>
<author>
<name sortKey="Tambyah, Pa" uniqKey="Tambyah P">PA Tambyah</name>
</author>
<author>
<name sortKey="Wilder Smith, A" uniqKey="Wilder Smith A">A Wilder-Smith</name>
</author>
<author>
<name sortKey="Puong, Ky" uniqKey="Puong K">KY Puong</name>
</author>
<author>
<name sortKey="Shaw, R" uniqKey="Shaw R">R Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B Manicassamy</name>
</author>
<author>
<name sortKey="Medina, Ra" uniqKey="Medina R">RA Medina</name>
</author>
<author>
<name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author>
<name sortKey="Tsibane, T" uniqKey="Tsibane T">T Tsibane</name>
</author>
<author>
<name sortKey="Stertz, S" uniqKey="Stertz S">S Stertz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ellebedy, Ah" uniqKey="Ellebedy A">AH Ellebedy</name>
</author>
<author>
<name sortKey="Ducatez, Mf" uniqKey="Ducatez M">MF Ducatez</name>
</author>
<author>
<name sortKey="Duan, S" uniqKey="Duan S">S Duan</name>
</author>
<author>
<name sortKey="Stigger Rosser, E" uniqKey="Stigger Rosser E">E Stigger-Rosser</name>
</author>
<author>
<name sortKey="Rubrum, Am" uniqKey="Rubrum A">AM Rubrum</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kashyap, Ak" uniqKey="Kashyap A">AK Kashyap</name>
</author>
<author>
<name sortKey="Steel, J" uniqKey="Steel J">J Steel</name>
</author>
<author>
<name sortKey="Rubrum, A" uniqKey="Rubrum A">A Rubrum</name>
</author>
<author>
<name sortKey="Estelles, A" uniqKey="Estelles A">A Estelles</name>
</author>
<author>
<name sortKey="Briante, R" uniqKey="Briante R">R Briante</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wrammert, J" uniqKey="Wrammert J">J Wrammert</name>
</author>
<author>
<name sortKey="Koutsonanos, D" uniqKey="Koutsonanos D">D Koutsonanos</name>
</author>
<author>
<name sortKey="Li, Gm" uniqKey="Li G">GM Li</name>
</author>
<author>
<name sortKey="Edupuganti, S" uniqKey="Edupuganti S">S Edupuganti</name>
</author>
<author>
<name sortKey="Sui, J" uniqKey="Sui J">J Sui</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Bullough, Pa" uniqKey="Bullough P">PA Bullough</name>
</author>
<author>
<name sortKey="Hughson, Fm" uniqKey="Hughson F">FM Hughson</name>
</author>
<author>
<name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
<author>
<name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Temperton, Nj" uniqKey="Temperton N">NJ Temperton</name>
</author>
<author>
<name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name>
</author>
<author>
<name sortKey="Major, D" uniqKey="Major D">D Major</name>
</author>
<author>
<name sortKey="Nicolson, C" uniqKey="Nicolson C">C Nicolson</name>
</author>
<author>
<name sortKey="Manvell, R" uniqKey="Manvell R">R Manvell</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Alberini, I" uniqKey="Alberini I">I Alberini</name>
</author>
<author>
<name sortKey="Del Tordello, E" uniqKey="Del Tordello E">E Del Tordello</name>
</author>
<author>
<name sortKey="Fasolo, A" uniqKey="Fasolo A">A Fasolo</name>
</author>
<author>
<name sortKey="Temperton, Nj" uniqKey="Temperton N">NJ Temperton</name>
</author>
<author>
<name sortKey="Galli, G" uniqKey="Galli G">G Galli</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kwong, Pd" uniqKey="Kwong P">PD Kwong</name>
</author>
<author>
<name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sakabe, S" uniqKey="Sakabe S">S Sakabe</name>
</author>
<author>
<name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K Iwatsuki-Horimoto</name>
</author>
<author>
<name sortKey="Horimoto, T" uniqKey="Horimoto T">T Horimoto</name>
</author>
<author>
<name sortKey="Nidom, Ca" uniqKey="Nidom C">CA Nidom</name>
</author>
<author>
<name sortKey="Le, Mq" uniqKey="Le M">MQ Le</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lambert, Lc" uniqKey="Lambert L">LC Lambert</name>
</author>
<author>
<name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wei, Cj" uniqKey="Wei C">CJ Wei</name>
</author>
<author>
<name sortKey="Boyington, Jc" uniqKey="Boyington J">JC Boyington</name>
</author>
<author>
<name sortKey="Mctamney, Pm" uniqKey="Mctamney P">PM McTamney</name>
</author>
<author>
<name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name>
</author>
<author>
<name sortKey="Pearce, Mb" uniqKey="Pearce M">MB Pearce</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
<author>
<name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name>
</author>
<author>
<name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author>
<name sortKey="Pica, N" uniqKey="Pica N">N Pica</name>
</author>
<author>
<name sortKey="Ngai, L" uniqKey="Ngai L">L Ngai</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author>
<name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name>
</author>
<author>
<name sortKey="Krause, Jc" uniqKey="Krause J">JC Krause</name>
</author>
<author>
<name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author>
<name sortKey="Crowe, Je" uniqKey="Crowe J">JE Crowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Weis, Wi" uniqKey="Weis W">WI Weis</name>
</author>
<author>
<name sortKey="Brunger, At" uniqKey="Brunger A">AT Brunger</name>
</author>
<author>
<name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
<author>
<name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
<author>
<name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name>
</author>
<author>
<name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Naldini, L" uniqKey="Naldini L">L Naldini</name>
</author>
<author>
<name sortKey="Blomer, U" uniqKey="Blomer U">U Blomer</name>
</author>
<author>
<name sortKey="Gallay, P" uniqKey="Gallay P">P Gallay</name>
</author>
<author>
<name sortKey="Ory, D" uniqKey="Ory D">D Ory</name>
</author>
<author>
<name sortKey="Mulligan, R" uniqKey="Mulligan R">R Mulligan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zufferey, R" uniqKey="Zufferey R">R Zufferey</name>
</author>
<author>
<name sortKey="Nagy, D" uniqKey="Nagy D">D Nagy</name>
</author>
<author>
<name sortKey="Mandel, Rj" uniqKey="Mandel R">RJ Mandel</name>
</author>
<author>
<name sortKey="Naldini, L" uniqKey="Naldini L">L Naldini</name>
</author>
<author>
<name sortKey="Trono, D" uniqKey="Trono D">D Trono</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Pettersen, Ef" uniqKey="Pettersen E">EF Pettersen</name>
</author>
<author>
<name sortKey="Goddard, Td" uniqKey="Goddard T">TD Goddard</name>
</author>
<author>
<name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name>
</author>
<author>
<name sortKey="Couch, Gs" uniqKey="Couch G">GS Couch</name>
</author>
<author>
<name sortKey="Greenblatt, Dm" uniqKey="Greenblatt D">DM Greenblatt</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">PLoS Pathog</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS Pathog</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plospath</journal-id>
<journal-title-group>
<journal-title>PLoS Pathogens</journal-title>
</journal-title-group>
<issn pub-type="ppub">1553-7366</issn>
<issn pub-type="epub">1553-7374</issn>
<publisher>
<publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">21695241</article-id>
<article-id pub-id-type="pmc">3111540</article-id>
<article-id pub-id-type="publisher-id">PPATHOGENS-D-11-00117</article-id>
<article-id pub-id-type="doi">10.1371/journal.ppat.1002081</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Biology</subject>
<subj-group>
<subject>Microbiology</subject>
<subj-group>
<subject>Immunity</subject>
<subj-group>
<subject>Adaptive Immunity</subject>
<subject>Immunizations</subject>
</subj-group>
</subj-group>
<subj-group>
<subject>Virology</subject>
<subj-group>
<subject>Viral Structure</subject>
<subj-group>
<subject>Viral Envelope</subject>
</subj-group>
</subj-group>
<subj-group>
<subject>Emerging Viral Diseases</subject>
<subject>Viral Immune Evasion</subject>
<subject>Viral Vaccines</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Medicine</subject>
<subj-group>
<subject>Infectious Diseases</subject>
<subj-group>
<subject>Infectious Disease Control</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2</article-title>
<alt-title alt-title-type="running-head">Cross-Neutralizing 2009 H1N1 Antibodies</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Anderson</surname>
<given-names>Christine M.</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>De Feo</surname>
<given-names>Christopher J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhuang</surname>
<given-names>Min</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yang</surname>
<given-names>Hong</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vassell</surname>
<given-names>Russell</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Xie</surname>
<given-names>Hang</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ye</surname>
<given-names>Zhiping</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Scott</surname>
<given-names>Dorothy</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Weiss</surname>
<given-names>Carol D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">
<sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<label>1</label>
<addr-line>Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff2">
<label>2</label>
<addr-line>Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff3">
<label>3</label>
<addr-line>Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</aff>
<aff id="aff4">
<label>4</label>
<addr-line>Laboratory of Pediatric and Respiratory Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</aff>
<contrib-group>
<contrib contrib-type="editor">
<name>
<surname>Pekosz</surname>
<given-names>Andrew</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">Johns Hopkins University - Bloomberg School of Public Health, United States of America</aff>
<author-notes>
<corresp id="cor1">* E-mail:
<email>carol.weiss@fda.hhs.gov</email>
</corresp>
<fn fn-type="con">
<p>Conceived and designed the experiments: WW CDW. Performed the experiments: WW MZ. Analyzed the data: WW CJD HY CDW. Contributed reagents/materials/analysis tools: WW CMA DS RV HX ZY CDW. Wrote the paper: WW CJD CDW.</p>
</fn>
</author-notes>
<pub-date pub-type="collection">
<month>6</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>9</day>
<month>6</month>
<year>2011</year>
</pub-date>
<volume>7</volume>
<issue>6</issue>
<elocation-id>e1002081</elocation-id>
<history>
<date date-type="received">
<day>13</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>8</day>
<month>4</month>
<year>2011</year>
</date>
</history>
<permissions>
<copyright-statement>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</copyright-statement>
<copyright-year>2011</copyright-year>
<license xlink:href="https://creativecommons.org/publicdomain/zero/1.0/">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.</license-p>
</license>
</permissions>
<abstract>
<p>Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from H1N1 strains that circulated in the past 50 years, but resembles the A/New Jersey/1976 H1N1 strain used in the 1976 swine influenza vaccine. We investigated whether sera from persons immunized with the 1976 swine influenza or recent seasonal influenza vaccines, or both, neutralize 2009 H1N1. Using retroviral pseudovirions bearing hemagglutinins on their surface (HA-pseudotypes), we found that 77% of the sera collected in 1976 after immunization with the A/New Jersey/1976 H1N1 swine influenza vaccine neutralized 2009 H1N1. Forty five percent also neutralized A/New Caledonia/20/1999 H1N1, a strain used in seasonal influenza vaccines during the 2000/01–2006/07 seasons. Among adults aged 48–64 who received the swine influenza vaccine in 1976 and recent seasonal influenza vaccines during the 2004/05–2008/09 seasons, 83% had sera that neutralized 2009 H1N1. However, 68% of age-matched subjects who received the same seasonal influenza vaccines, but did not receive the 1976 swine influenza vaccine, also had sera that neutralized 2009 H1N1. Sera from both 1976 and contemporary cohorts frequently had cross-neutralizing antibodies to 2009 H1N1 and A/New Caledonia/20/1999 that mapped to hemagglutinin subunit 2 (HA2). A conservative mutation in HA2 corresponding to a residue in the A/Solomon Islands/3/2006 and A/Brisbane/59/2007 H1N1 strains that circulated in the 2006/07 and 2007/08 influenza seasons, respectively, abrogated this neutralization. These findings highlight a cross-neutralization determinant influenced by a point mutation in HA2 and suggest that HA2 may be evolving under direct or indirect immune pressure.</p>
</abstract>
<abstract abstract-type="summary">
<title>Author Summary</title>
<p>Influenza A viruses mutate to escape neutralization by antibodies. These mutations predominantly occur in the globular head of the hemagglutinin protein, while the stalk is more conserved. Pandemic 2009 H1N1 influenza virus differs from seasonal H1N1 strains that circulated in the past 50 years and resembles a strain that did not circulate but was used in the 1976 swine influenza vaccine. We investigated whether persons immunized with either the 1976 swine influenza or recent seasonal influenza vaccines, or both, have antibodies that cross-neutralize pandemic 2009 H1N1. Sera from 1976 swine influenza vaccine trials cross-neutralized pandemic 2009 H1N1 and to a lesser extent the A/New Caledonia/20/1999 H1N1 strain that was used in vaccines during the 2000/01–2006/07 influenza seasons. Sera from persons who received several seasonal influenza vaccines containing A/New Caledonia/20/1999 H1N1 cross-neutralized pandemic 2009 H1N1, regardless of whether they received the 1976 swine influenza vaccine. We found that cross-neutralization between 2009 H1N1 and A/New Caledonia/20/1999 frequently mapped to the hemagglutinin stalk. A mutation in the stalk of strains circulating during the 2007/08–2008/09 seasons abrogates this neutralization. These findings highlight a cross-neutralization determinant influenced by a point mutation in the hemagglutinin stalk and suggest that the stalk may be evolving under direct or indirect immune pressure.</p>
</abstract>
<counts>
<page-count count="12"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C04 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000C04 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:3111540
   |texte=   Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:21695241" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021