Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
Identifieur interne : 000B67 ( Pmc/Curation ); précédent : 000B66; suivant : 000B68Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
Auteurs : Eric A. Weaver [États-Unis] ; Michael A. Barry [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied
Url:
DOI: 10.1371/journal.pone.0073313
PubMed: 23991187
PubMed Central: 3749993
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines</title><author><name sortKey="Weaver, Eric A" sort="Weaver, Eric A" uniqKey="Weaver E" first="Eric A." last="Weaver">Eric A. Weaver</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23991187</idno><idno type="pmc">3749993</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749993</idno><idno type="RBID">PMC:3749993</idno><idno type="doi">10.1371/journal.pone.0073313</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000B67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B67</idno><idno type="wicri:Area/Pmc/Curation">000B67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines</title><author><name sortKey="Weaver, Eric A" sort="Weaver, Eric A" uniqKey="Weaver E" first="Eric A." last="Weaver">Eric A. Weaver</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author><author><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied <italic>in vivo</italic>, these species D Ad vectors performed quite differently as compared to species C Ad vectors depending on the route of immunization. By intramuscular injection, species D vaccines were markedly weaker than species C vaccines. In contrast, the species D vaccines were equally efficient as species C when delivered mucosally by the intranasal route. Intranasal adenovirus vaccine doses as low as 10<sup>8</sup> virus particles per mouse induced complete protection against a stringent lethal challenge dose of influenza. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23991187</article-id><article-id pub-id-type="pmc">3749993</article-id><article-id pub-id-type="publisher-id">PONE-D-13-11559</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0073313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines</article-title><alt-title alt-title-type="running-head">Species D Adenovirus Flu Vaccines</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Weaver</surname><given-names>Eric A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barry</surname><given-names>Michael A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Miyaji</surname><given-names>Eliane Namie</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Instituto Butantan, Brazil</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>weaver.eric@mayo.edu</email></corresp><fn fn-type="COI-statement"><p><bold>Competing Interests: </bold>It should be noted that EAW and MAB serve as academic editors for PLoS ONE and that this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: EAW MAB. Performed the experiments: EAW. Analyzed the data: EAW MAB. Contributed reagents/materials/analysis tools: EAW MAB. Wrote the manuscript: EAW MAB. </p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>8</month><year>2013</year></pub-date><volume>8</volume><issue>8</issue><elocation-id>e73313</elocation-id><history><date date-type="received"><day>12</day><month>3</month><year>2013</year></date><date date-type="accepted"><day>29</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 Weaver et al</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Weaver et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><abstract><p>Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied <italic>in vivo</italic>, these species D Ad vectors performed quite differently as compared to species C Ad vectors depending on the route of immunization. By intramuscular injection, species D vaccines were markedly weaker than species C vaccines. In contrast, the species D vaccines were equally efficient as species C when delivered mucosally by the intranasal route. Intranasal adenovirus vaccine doses as low as 10<sup>8</sup> virus particles per mouse induced complete protection against a stringent lethal challenge dose of influenza. These data support translation of species D adenoviruses as mucosal vaccines and highlight the fundamental effects of differences in virus tropism on vaccine applications.</p></abstract><funding-group><funding-statement>This work was supported by National Institutes of Health National Institute of Allergy and Infectious Diseases grant AI097241 and the Walter & Lucille Rubin Fund in Infectious Diseases Honoring Michael Camilleri, M.D. at Mayo Clinic. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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