A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus
Identifieur interne : 000A22 ( Pmc/Curation ); précédent : 000A21; suivant : 000A23A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus
Auteurs : Andrew Smith [États-Unis] ; Laura Rodriguez [États-Unis] ; Maya El Ghouayel [États-Unis] ; Aitor Nogales [États-Unis] ; Jeffrey M. Chamberlain [États-Unis] ; Katherine Sortino [États-Unis] ; Emma Reilly [États-Unis] ; Changyong Feng [États-Unis] ; David J. Topham [États-Unis] ; Luis Martínez-Sobrido [États-Unis] ; Stephen Dewhurst [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2020.
Abstract
Seasonal influenza infection remains a major cause of disease and death, underscoring the need for improved vaccines. Among current influenza vaccines, the live attenuated influenza vaccine (LAIV) is unique in its ability to elicit T-cell immunity to the conserved internal proteins of the virus. Despite this, LAIV has shown limited efficacy in recent years. One possible reason is that the conserved, internal genes of all current LAIVs derive from virus strains that were isolated between 1957 and 1960 and that, as a result, do not resemble currently circulating influenza viruses. We have therefore developed and tested a new LAIV, based on a currently circulating pandemic strain of influenza. Our results show that this new LAIV elicits improved protective immunity compared to a more conventional LAIV.
Url:
DOI: 10.1128/JVI.01065-19
PubMed: 31748399
PubMed Central: 6997774
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A22
Links to Exploration step
PMC:6997774Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus</title><author><name sortKey="Smith, Andrew" sort="Smith, Andrew" uniqKey="Smith A" first="Andrew" last="Smith">Andrew Smith</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Medical Scientist Training Program, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Scientist Training Program, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Laura" sort="Rodriguez, Laura" uniqKey="Rodriguez L" first="Laura" last="Rodriguez">Laura Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="El Ghouayel, Maya" sort="El Ghouayel, Maya" uniqKey="El Ghouayel M" first="Maya" last="El Ghouayel">Maya El Ghouayel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Nogales, Aitor" sort="Nogales, Aitor" uniqKey="Nogales A" first="Aitor" last="Nogales">Aitor Nogales</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Chamberlain, Jeffrey M" sort="Chamberlain, Jeffrey M" uniqKey="Chamberlain J" first="Jeffrey M." last="Chamberlain">Jeffrey M. Chamberlain</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sortino, Katherine" sort="Sortino, Katherine" uniqKey="Sortino K" first="Katherine" last="Sortino">Katherine Sortino</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Reilly, Emma" sort="Reilly, Emma" uniqKey="Reilly E" first="Emma" last="Reilly">Emma Reilly</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Changyong" sort="Feng, Changyong" uniqKey="Feng C" first="Changyong" last="Feng">Changyong Feng</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Dewhurst, Stephen" sort="Dewhurst, Stephen" uniqKey="Dewhurst S" first="Stephen" last="Dewhurst">Stephen Dewhurst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31748399</idno><idno type="pmc">6997774</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997774</idno><idno type="RBID">PMC:6997774</idno><idno type="doi">10.1128/JVI.01065-19</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000A22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A22</idno><idno type="wicri:Area/Pmc/Curation">000A22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus</title><author><name sortKey="Smith, Andrew" sort="Smith, Andrew" uniqKey="Smith A" first="Andrew" last="Smith">Andrew Smith</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Medical Scientist Training Program, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Scientist Training Program, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Laura" sort="Rodriguez, Laura" uniqKey="Rodriguez L" first="Laura" last="Rodriguez">Laura Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="El Ghouayel, Maya" sort="El Ghouayel, Maya" uniqKey="El Ghouayel M" first="Maya" last="El Ghouayel">Maya El Ghouayel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Nogales, Aitor" sort="Nogales, Aitor" uniqKey="Nogales A" first="Aitor" last="Nogales">Aitor Nogales</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Chamberlain, Jeffrey M" sort="Chamberlain, Jeffrey M" uniqKey="Chamberlain J" first="Jeffrey M." last="Chamberlain">Jeffrey M. Chamberlain</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Sortino, Katherine" sort="Sortino, Katherine" uniqKey="Sortino K" first="Katherine" last="Sortino">Katherine Sortino</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Reilly, Emma" sort="Reilly, Emma" uniqKey="Reilly E" first="Emma" last="Reilly">Emma Reilly</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Changyong" sort="Feng, Changyong" uniqKey="Feng C" first="Changyong" last="Feng">Changyong Feng</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Dewhurst, Stephen" sort="Dewhurst, Stephen" uniqKey="Dewhurst S" first="Stephen" last="Dewhurst">Stephen Dewhurst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal influenza infection remains a major cause of disease and death, underscoring the need for improved vaccines. Among current influenza vaccines, the live attenuated influenza vaccine (LAIV) is unique in its ability to elicit T-cell immunity to the conserved internal proteins of the virus. Despite this, LAIV has shown limited efficacy in recent years. One possible reason is that the conserved, internal genes of all current LAIVs derive from virus strains that were isolated between 1957 and 1960 and that, as a result, do not resemble currently circulating influenza viruses. We have therefore developed and tested a new LAIV, based on a currently circulating pandemic strain of influenza. Our results show that this new LAIV elicits improved protective immunity compared to a more conventional LAIV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mullooly, Jp" uniqKey="Mullooly J">JP Mullooly</name></author><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name></author><author><name sortKey="Jackson, La" uniqKey="Jackson L">LA Jackson</name></author><author><name sortKey="Black, S" uniqKey="Black S">S Black</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dutta, A" uniqKey="Dutta A">A Dutta</name></author><author><name sortKey="Huang, Ct" uniqKey="Huang C">CT Huang</name></author><author><name sortKey="Lin, Cy" uniqKey="Lin C">CY Lin</name></author><author><name sortKey="Chen, Tc" uniqKey="Chen T">TC Chen</name></author><author><name sortKey="Lin, Yc" uniqKey="Lin Y">YC Lin</name></author><author><name sortKey="Chang, Cs" uniqKey="Chang C">CS Chang</name></author><author><name sortKey="He, Yc" uniqKey="He Y">YC He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S Sridhar</name></author><author><name sortKey="Begom, S" uniqKey="Begom S">S Begom</name></author><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name></author><author><name sortKey="Adamson, W" uniqKey="Adamson W">W Adamson</name></author><author><name sortKey="Carman, W" uniqKey="Carman W">W Carman</name></author><author><name sortKey="Bean, T" uniqKey="Bean T">T Bean</name></author><author><name sortKey="Barclay, W" uniqKey="Barclay W">W Barclay</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Lalvani, A" uniqKey="Lalvani A">A Lalvani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilchuk, P" uniqKey="Gilchuk P">P Gilchuk</name></author><author><name sortKey="Hill, Tm" uniqKey="Hill T">TM Hill</name></author><author><name sortKey="Guy, C" uniqKey="Guy C">C Guy</name></author><author><name sortKey="Mcmaster, Sr" uniqKey="Mcmaster S">SR McMaster</name></author><author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name></author><author><name sortKey="Rabacal, Wa" uniqKey="Rabacal W">WA Rabacal</name></author><author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name></author><author><name sortKey="Shyr, Y" uniqKey="Shyr Y">Y Shyr</name></author><author><name sortKey="Kohlmeier, Je" uniqKey="Kohlmeier J">JE Kohlmeier</name></author><author><name sortKey="Sebzda, E" uniqKey="Sebzda E">E Sebzda</name></author><author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name></author><author><name sortKey="Joyce, S" uniqKey="Joyce S">S Joyce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Lee, Yt" uniqKey="Lee Y">YT Lee</name></author><author><name sortKey="Bouchard, Kr" uniqKey="Bouchard K">KR Bouchard</name></author><author><name sortKey="Benechet, A" uniqKey="Benechet A">A Benechet</name></author><author><name sortKey="Khanna, K" uniqKey="Khanna K">K Khanna</name></author><author><name sortKey="Cauley, Ls" uniqKey="Cauley L">LS Cauley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zens, Kd" uniqKey="Zens K">KD Zens</name></author><author><name sortKey="Chen, Jk" uniqKey="Chen J">JK Chen</name></author><author><name sortKey="Farber, Dl" uniqKey="Farber D">DL Farber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slutter, B" uniqKey="Slutter B">B Slutter</name></author><author><name sortKey="Van Braeckel Budimir, N" uniqKey="Van Braeckel Budimir N">N Van Braeckel-Budimir</name></author><author><name sortKey="Abboud, G" uniqKey="Abboud G">G Abboud</name></author><author><name sortKey="Varga, Sm" uniqKey="Varga S">SM Varga</name></author><author><name sortKey="Salek Ardakani, S" uniqKey="Salek Ardakani S">S Salek-Ardakani</name></author><author><name sortKey="Harty, Jt" uniqKey="Harty J">JT Harty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizzolla, A" uniqKey="Pizzolla A">A Pizzolla</name></author><author><name sortKey="Nguyen, Tho" uniqKey="Nguyen T">THO Nguyen</name></author><author><name sortKey="Smith, Jm" uniqKey="Smith J">JM Smith</name></author><author><name sortKey="Brooks, Ag" uniqKey="Brooks A">AG Brooks</name></author><author><name sortKey="Kedzieska, K" uniqKey="Kedzieska K">K Kedzieska</name></author><author><name sortKey="Heath, Wr" uniqKey="Heath W">WR Heath</name></author><author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name></author><author><name sortKey="Wakim, Lm" uniqKey="Wakim L">LM Wakim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Braeckel Budimir, N" uniqKey="Van Braeckel Budimir N">N Van Braeckel-Budimir</name></author><author><name sortKey="Varga, Sm" uniqKey="Varga S">SM Varga</name></author><author><name sortKey="Badovinac, Vp" uniqKey="Badovinac V">VP Badovinac</name></author><author><name sortKey="Harty, Jt" uniqKey="Harty J">JT Harty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amorij, Jp" uniqKey="Amorij J">JP Amorij</name></author><author><name sortKey="Hinrichs, W" uniqKey="Hinrichs W">W Hinrichs</name></author><author><name sortKey="Frijlink, Hw" uniqKey="Frijlink H">HW Frijlink</name></author><author><name sortKey="Wilschut, Jc" uniqKey="Wilschut J">JC Wilschut</name></author><author><name sortKey="Huckriede, A" uniqKey="Huckriede A">A Huckriede</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name></author><author><name sortKey="Gruber, Wc" uniqKey="Gruber W">WC Gruber</name></author><author><name sortKey="Mendelman, Pm" uniqKey="Mendelman P">PM Mendelman</name></author><author><name sortKey="Cho, I" uniqKey="Cho I">I Cho</name></author><author><name sortKey="Reisinger, K" uniqKey="Reisinger K">K Reisinger</name></author><author><name sortKey="Block, Sl" uniqKey="Block S">SL Block</name></author><author><name sortKey="Wittes, J" uniqKey="Wittes J">J Wittes</name></author><author><name sortKey="Iacuzio, D" uniqKey="Iacuzio D">D Iacuzio</name></author><author><name sortKey="Piedra, P" uniqKey="Piedra P">P Piedra</name></author><author><name sortKey="Treanor, J" uniqKey="Treanor J">J Treanor</name></author><author><name sortKey="King, J" uniqKey="King J">J King</name></author><author><name sortKey="Kotloff, K" uniqKey="Kotloff K">K Kotloff</name></author><author><name sortKey="Bernstein, Di" uniqKey="Bernstein D">DI Bernstein</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author><author><name sortKey="Zangwill, K" uniqKey="Zangwill K">K Zangwill</name></author><author><name sortKey="Yan, L" uniqKey="Yan L">L Yan</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name></author><author><name sortKey="Gruber, Wc" uniqKey="Gruber W">WC Gruber</name></author><author><name sortKey="Mendelman, Pm" uniqKey="Mendelman P">PM Mendelman</name></author><author><name sortKey="Mehta, Hb" uniqKey="Mehta H">HB Mehta</name></author><author><name sortKey="Mahmood, K" uniqKey="Mahmood K">K Mahmood</name></author><author><name sortKey="Reisinger, K" uniqKey="Reisinger K">K Reisinger</name></author><author><name sortKey="Treanor, J" uniqKey="Treanor J">J Treanor</name></author><author><name sortKey="Zangwill, K" uniqKey="Zangwill K">K Zangwill</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author><author><name sortKey="Bernstein, Di" uniqKey="Bernstein D">DI Bernstein</name></author><author><name sortKey="Kotloff, K" uniqKey="Kotloff K">K Kotloff</name></author><author><name sortKey="King, J" uniqKey="King J">J King</name></author><author><name sortKey="Piedra, Pa" uniqKey="Piedra P">PA Piedra</name></author><author><name sortKey="Block, Sl" uniqKey="Block S">SL Block</name></author><author><name sortKey="Yan, L" uniqKey="Yan L">L Yan</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Rj" uniqKey="Cox R">RJ Cox</name></author><author><name sortKey="Brokstad, Ka" uniqKey="Brokstad K">KA Brokstad</name></author><author><name sortKey="Ogra, P" uniqKey="Ogra P">P Ogra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forrest, Bd" uniqKey="Forrest B">BD Forrest</name></author><author><name sortKey="Pride, Mw" uniqKey="Pride M">MW Pride</name></author><author><name sortKey="Dunning, Aj" uniqKey="Dunning A">AJ Dunning</name></author><author><name sortKey="Capeding, Mr" uniqKey="Capeding M">MR Capeding</name></author><author><name sortKey="Chotpitayasunondh, T" uniqKey="Chotpitayasunondh T">T Chotpitayasunondh</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Rappaport, R" uniqKey="Rappaport R">R Rappaport</name></author><author><name sortKey="Eldridge, Jh" uniqKey="Eldridge J">JH Eldridge</name></author><author><name sortKey="Gruber, Wc" uniqKey="Gruber W">WC Gruber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Xs" uniqKey="He X">XS He</name></author><author><name sortKey="Holmes, Th" uniqKey="Holmes T">TH Holmes</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Mahmood, K" uniqKey="Mahmood K">K Mahmood</name></author><author><name sortKey="Kemble, Gw" uniqKey="Kemble G">GW Kemble</name></author><author><name sortKey="Lewis, Db" uniqKey="Lewis D">DB Lewis</name></author><author><name sortKey="Dekker, Cl" uniqKey="Dekker C">CL Dekker</name></author><author><name sortKey="Greenberg, Hb" uniqKey="Greenberg H">HB Greenberg</name></author><author><name sortKey="Arvin, Am" uniqKey="Arvin A">AM Arvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoft, Df" uniqKey="Hoft D">DF Hoft</name></author><author><name sortKey="Babusis, E" uniqKey="Babusis E">E Babusis</name></author><author><name sortKey="Worku, S" uniqKey="Worku S">S Worku</name></author><author><name sortKey="Spencer, Ct" uniqKey="Spencer C">CT Spencer</name></author><author><name sortKey="Lottenbach, K" uniqKey="Lottenbach K">K Lottenbach</name></author><author><name sortKey="Truscott, Sm" uniqKey="Truscott S">SM Truscott</name></author><author><name sortKey="Abate, G" uniqKey="Abate G">G Abate</name></author><author><name sortKey="Sakala, Ig" uniqKey="Sakala I">IG Sakala</name></author><author><name sortKey="Edwards, Km" uniqKey="Edwards K">KM Edwards</name></author><author><name sortKey="Creech, Cb" uniqKey="Creech C">CB Creech</name></author><author><name sortKey="Gerber, Ma" uniqKey="Gerber M">MA Gerber</name></author><author><name sortKey="Bernstein, Di" uniqKey="Bernstein D">DI Bernstein</name></author><author><name sortKey="Newman, F" uniqKey="Newman F">F Newman</name></author><author><name sortKey="Graham, I" uniqKey="Graham I">I Graham</name></author><author><name sortKey="Anderson, El" uniqKey="Anderson E">EL Anderson</name></author><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rudenko, Lg" uniqKey="Rudenko L">LG Rudenko</name></author><author><name sortKey="Lonskaya, Ni" uniqKey="Lonskaya N">NI Lonskaya</name></author><author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name></author><author><name sortKey="Vasilieva, Ri" uniqKey="Vasilieva R">RI Vasilieva</name></author><author><name sortKey="Ramirez, A" uniqKey="Ramirez A">A Ramirez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C" uniqKey="Wu C">C Wu</name></author><author><name sortKey="Zanker, D" uniqKey="Zanker D">D Zanker</name></author><author><name sortKey="Valkenburg, S" uniqKey="Valkenburg S">S Valkenburg</name></author><author><name sortKey="Tan, B" uniqKey="Tan B">B Tan</name></author><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Zou, Qm" uniqKey="Zou Q">QM Zou</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, W" uniqKey="Chan W">W Chan</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G Kemble</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Isakova Sivak, I" uniqKey="Isakova Sivak I">I Isakova-Sivak</name></author><author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name></author><author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y Matsuoka</name></author><author><name sortKey="Voeten, Jt" uniqKey="Voeten J">JT Voeten</name></author><author><name sortKey="Kiseleva, I" uniqKey="Kiseleva I">I Kiseleva</name></author><author><name sortKey="Heldens, Jg" uniqKey="Heldens J">JG Heldens</name></author><author><name sortKey="Den Bosch, H" uniqKey="Den Bosch H">H den Bosch</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A Klimov</name></author><author><name sortKey="Rudenko, L" uniqKey="Rudenko L">L Rudenko</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Donis, Ro" uniqKey="Donis R">RO Donis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, A" uniqKey="Cox A">A Cox</name></author><author><name sortKey="Baker, Sf" uniqKey="Baker S">SF Baker</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S Dewhurst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G Kemble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name></author><author><name sortKey="Mcauliffe, J" uniqKey="Mcauliffe J">J McAuliffe</name></author><author><name sortKey="Mills, Kl" uniqKey="Mills K">KL Mills</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H Jin</name></author><author><name sortKey="Duke, G" uniqKey="Duke G">G Duke</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Luke, Cj" uniqKey="Luke C">CJ Luke</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B Murphy</name></author><author><name sortKey="Swayne, De" uniqKey="Swayne D">DE Swayne</name></author><author><name sortKey="Kemble, G" uniqKey="Kemble G">G Kemble</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Speer, Sd" uniqKey="Speer S">SD Speer</name></author><author><name sortKey="Subba, A" uniqKey="Subba A">A Subba</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Chauche, C" uniqKey="Chauche C">C Chauche</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Reilly, Ec" uniqKey="Reilly E">EC Reilly</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Murcia, Pr" uniqKey="Murcia P">PR Murcia</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Murcia, Pr" uniqKey="Murcia P">PR Murcia</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Reilly, Ec" uniqKey="Reilly E">EC Reilly</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Murcia, Pr" uniqKey="Murcia P">PR Murcia</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Reedy, S" uniqKey="Reedy S">S Reedy</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Murcia, Pr" uniqKey="Murcia P">PR Murcia</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, L" uniqKey="Rodriguez L">L Rodriguez</name></author><author><name sortKey="Blanco Lobo, P" uniqKey="Blanco Lobo P">P Blanco-Lobo</name></author><author><name sortKey="Reilly, Ec" uniqKey="Reilly E">EC Reilly</name></author><author><name sortKey="Maehigashi, T" uniqKey="Maehigashi T">T Maehigashi</name></author><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S Dewhurst</name></author><author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martínez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hobson, D" uniqKey="Hobson D">D Hobson</name></author><author><name sortKey="Curry, Rl" uniqKey="Curry R">RL Curry</name></author><author><name sortKey="Beare, As" uniqKey="Beare A">AS Beare</name></author><author><name sortKey="Ward Gardner, A" uniqKey="Ward Gardner A">A Ward-Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Santiago, F" uniqKey="Santiago F">F Santiago</name></author><author><name sortKey="Lambert, K" uniqKey="Lambert K">K Lambert</name></author><author><name sortKey="Takimoto, T" uniqKey="Takimoto T">T Takimoto</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Xie, W" uniqKey="Xie W">W Xie</name></author><author><name sortKey="Altman, Jd" uniqKey="Altman J">JD Altman</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Townsend, Ar" uniqKey="Townsend A">AR Townsend</name></author><author><name sortKey="Rothbard, J" uniqKey="Rothbard J">J Rothbard</name></author><author><name sortKey="Gotch, Fm" uniqKey="Gotch F">FM Gotch</name></author><author><name sortKey="Bahadur, G" uniqKey="Bahadur G">G Bahadur</name></author><author><name sortKey="Wraith, D" uniqKey="Wraith D">D Wraith</name></author><author><name sortKey="Mcmichael, Aj" uniqKey="Mcmichael A">AJ McMichael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erbelding, Ej" uniqKey="Erbelding E">EJ Erbelding</name></author><author><name sortKey="Post, Dj" uniqKey="Post D">DJ Post</name></author><author><name sortKey="Stemmy, Ej" uniqKey="Stemmy E">EJ Stemmy</name></author><author><name sortKey="Roberts, Pc" uniqKey="Roberts P">PC Roberts</name></author><author><name sortKey="Augustine, Ad" uniqKey="Augustine A">AD Augustine</name></author><author><name sortKey="Ferguson, S" uniqKey="Ferguson S">S Ferguson</name></author><author><name sortKey="Paules, Ci" uniqKey="Paules C">CI Paules</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korenkov, D" uniqKey="Korenkov D">D Korenkov</name></author><author><name sortKey="Nguyen, Tho" uniqKey="Nguyen T">THO Nguyen</name></author><author><name sortKey="Isakova Sivak, I" uniqKey="Isakova Sivak I">I Isakova-Sivak</name></author><author><name sortKey="Smolonogina, T" uniqKey="Smolonogina T">T Smolonogina</name></author><author><name sortKey="Brown, Le" uniqKey="Brown L">LE Brown</name></author><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Rudenko, L" uniqKey="Rudenko L">L Rudenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korenkov, Da" uniqKey="Korenkov D">DA Korenkov</name></author><author><name sortKey="Laurie, Kl" uniqKey="Laurie K">KL Laurie</name></author><author><name sortKey="Reading, Pc" uniqKey="Reading P">PC Reading</name></author><author><name sortKey="Carolan, La" uniqKey="Carolan L">LA Carolan</name></author><author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name></author><author><name sortKey="Isakova, S" uniqKey="Isakova S">S Isakova</name></author><author><name sortKey="Smolonogina, Ta" uniqKey="Smolonogina T">TA Smolonogina</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name></author><author><name sortKey="Villanueva, J" uniqKey="Villanueva J">J Villanueva</name></author><author><name sortKey="Shcherbik, S" uniqKey="Shcherbik S">S Shcherbik</name></author><author><name sortKey="Bousse, T" uniqKey="Bousse T">T Bousse</name></author><author><name sortKey="Rudenko, Lg" uniqKey="Rudenko L">LG Rudenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Gir N, Jv" uniqKey="Perez Gir N J">JV Pérez-Girón</name></author><author><name sortKey="Belicha Villanueva, A" uniqKey="Belicha Villanueva A">A Belicha-Villanueva</name></author><author><name sortKey="Hassan, E" uniqKey="Hassan E">E Hassan</name></author><author><name sortKey="G Mez Medina, S" uniqKey="G Mez Medina S">S Gómez-Medina</name></author><author><name sortKey="Cruz, Jlg" uniqKey="Cruz J">JLG Cruz</name></author><author><name sortKey="Ludtke, A" uniqKey="Ludtke A">A Lüdtke</name></author><author><name sortKey="Ruibal, P" uniqKey="Ruibal P">P Ruibal</name></author><author><name sortKey="Albrecht, Ra" uniqKey="Albrecht R">RA Albrecht</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author><author><name sortKey="Mu Oz Fontela, C" uniqKey="Mu Oz Fontela C">C Muñoz-Fontela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Fan, Hy" uniqKey="Fan H">HY Fan</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Huang, Jn" uniqKey="Huang J">JN Huang</name></author><author><name sortKey="Ye, Y" uniqKey="Ye Y">Y Ye</name></author><author><name sortKey="Liao, M" uniqKey="Liao M">M Liao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author><author><name sortKey="Kashyap, Ak" uniqKey="Kashyap A">AK Kashyap</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name></author><author><name sortKey="Rubrum, A" uniqKey="Rubrum A">A Rubrum</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name></author><author><name sortKey="Khayat, R" uniqKey="Khayat R">R Khayat</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Dillon, Ma" uniqKey="Dillon M">MA Dillon</name></author><author><name sortKey="O Eil, Re" uniqKey="O Eil R">RE O’Neil</name></author><author><name sortKey="Faynboym, Am" uniqKey="Faynboym A">AM Faynboym</name></author><author><name sortKey="Horowitz, M" uniqKey="Horowitz M">M Horowitz</name></author><author><name sortKey="Horowitz, L" uniqKey="Horowitz L">L Horowitz</name></author><author><name sortKey="Ward, Ab" uniqKey="Ward A">AB Ward</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Webby, R" uniqKey="Webby R">R Webby</name></author><author><name sortKey="Lerner, Ra" uniqKey="Lerner R">RA Lerner</name></author><author><name sortKey="Bhatt, Rr" uniqKey="Bhatt R">RR Bhatt</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author><author><name sortKey="Nieto, Gr" uniqKey="Nieto G">GR Nieto</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, A" uniqKey="Cox A">A Cox</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S Dewhurst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pena, L" uniqKey="Pena L">L Pena</name></author><author><name sortKey="Vincent, Al" uniqKey="Vincent A">AL Vincent</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name></author><author><name sortKey="Ciacci Zanella, Jr" uniqKey="Ciacci Zanella J">JR Ciacci-Zanella</name></author><author><name sortKey="Angel, M" uniqKey="Angel M">M Angel</name></author><author><name sortKey="Lorusso, A" uniqKey="Lorusso A">A Lorusso</name></author><author><name sortKey="Gauger, Pc" uniqKey="Gauger P">PC Gauger</name></author><author><name sortKey="Janke, Bh" uniqKey="Janke B">BH Janke</name></author><author><name sortKey="Loving, Cl" uniqKey="Loving C">CL Loving</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solorzano, A" uniqKey="Solorzano A">A Solorzano</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gustin, Km" uniqKey="Gustin K">KM Gustin</name></author><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thangavel, Rr" uniqKey="Thangavel R">RR Thangavel</name></author><author><name sortKey="Bouvier, Nm" uniqKey="Bouvier N">NM Bouvier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author><author><name sortKey="Xin, L" uniqKey="Xin L">L Xin</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Zhang, Th" uniqKey="Zhang T">TH Zhang</name></author><author><name sortKey="Wu, Nc" uniqKey="Wu N">NC Wu</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author><author><name sortKey="Gong, D" uniqKey="Gong D">D Gong</name></author><author><name sortKey="Brar, G" uniqKey="Brar G">G Brar</name></author><author><name sortKey="Shu, S" uniqKey="Shu S">S Shu</name></author><author><name sortKey="Luo, J" uniqKey="Luo J">J Luo</name></author><author><name sortKey="Reiley, W" uniqKey="Reiley W">W Reiley</name></author><author><name sortKey="Tseng, Yw" uniqKey="Tseng Y">YW Tseng</name></author><author><name sortKey="Bai, H" uniqKey="Bai H">H Bai</name></author><author><name sortKey="Wu, Tt" uniqKey="Wu T">TT Wu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moratorio, G" uniqKey="Moratorio G">G Moratorio</name></author><author><name sortKey="Henningsson, R" uniqKey="Henningsson R">R Henningsson</name></author><author><name sortKey="Barbezange, C" uniqKey="Barbezange C">C Barbezange</name></author><author><name sortKey="Carrau, L" uniqKey="Carrau L">L Carrau</name></author><author><name sortKey="Borderia, Av" uniqKey="Borderia A">AV Borderia</name></author><author><name sortKey="Blanc, H" uniqKey="Blanc H">H Blanc</name></author><author><name sortKey="Beaucourt, S" uniqKey="Beaucourt S">S Beaucourt</name></author><author><name sortKey="Poirier, Ez" uniqKey="Poirier E">EZ Poirier</name></author><author><name sortKey="Vallet, T" uniqKey="Vallet T">T Vallet</name></author><author><name sortKey="Boussier, J" uniqKey="Boussier J">J Boussier</name></author><author><name sortKey="Mounce, Bc" uniqKey="Mounce B">BC Mounce</name></author><author><name sortKey="Fontes, M" uniqKey="Fontes M">M Fontes</name></author><author><name sortKey="Vignuzzi, M" uniqKey="Vignuzzi M">M Vignuzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Baker, Sf" uniqKey="Baker S">SF Baker</name></author><author><name sortKey="Ortiz Ria O, E" uniqKey="Ortiz Ria O E">E Ortiz-Riaño</name></author><author><name sortKey="Dewhurst, S" uniqKey="Dewhurst S">S Dewhurst</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martínez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogales, A" uniqKey="Nogales A">A Nogales</name></author><author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name></author><author><name sortKey="Topham, Dj" uniqKey="Topham D">DJ Topham</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name></author><author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31748399</article-id><article-id pub-id-type="pmc">6997774</article-id><article-id pub-id-type="publisher-id">01065-19</article-id><article-id pub-id-type="doi">10.1128/JVI.01065-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Vaccines and Antiviral Agents</subject></subj-group></article-categories><title-group><article-title>A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus</article-title><alt-title alt-title-type="running-head">Internal Genes Contribute to Protection by LAIV</alt-title><alt-title alt-title-type="short-authors">Smith et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>El Ghouayel</surname><given-names>Maya</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nogales</surname><given-names>Aitor</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chamberlain</surname><given-names>Jeffrey M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sortino</surname><given-names>Katherine</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reilly</surname><given-names>Emma</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Changyong</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-9435-8673</contrib-id><name><surname>Topham</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martínez-Sobrido</surname><given-names>Luis</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0001-7729-7920</contrib-id><name><surname>Dewhurst</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label><addr-line>Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></aff><aff id="aff2"><label>b</label><addr-line>Medical Scientist Training Program, University of Rochester, Rochester, New York, USA</addr-line></aff><aff id="aff3"><label>c</label><addr-line>David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA</addr-line></aff><aff id="aff4"><label>d</label><addr-line>Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA</addr-line></aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Heise</surname><given-names>Mark T.</given-names></name><role>Editor</role><aff>University of North Carolina at Chapel Hill</aff></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to Stephen Dewhurst, <email>Stephen_Dewhurst@urmc.rochester.edu</email>.</corresp><fn id="fn1" fn-type="present-address"><label>*</label><p>Present address: Laura Rodriguez, Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain.</p></fn><fn fn-type="other"><p><bold>Citation</bold> Smith A, Rodriguez L, El Ghouayel M, Nogales A, Chamberlain JM, Sortino K, Reilly E, Feng C, Topham DJ, Martínez-Sobrido L, Dewhurst S. 2020. A live attenuated influenza vaccine elicits enhanced heterologous protection when the internal genes of the vaccine are matched to those of the challenge virus. J Virol 94:e01065-19. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/JVI.01065-19">https://doi.org/10.1128/JVI.01065-19</ext-link>.</p></fn></author-notes><pub-date pub-type="epreprint"><day>20</day><month>11</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>31</day><month>1</month><year>2020</year></pub-date><pub-date pub-type="collection"><month>2</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>1</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>94</volume><issue>4</issue><elocation-id>e01065-19</elocation-id><history><date date-type="received"><day>25</day><month>6</month><year>2019</year></date><date date-type="accepted"><day>8</day><month>11</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2020 Smith et al.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Smith et al.</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="JVI.01065-19.pdf"></self-uri><abstract abstract-type="precis"><p>Seasonal influenza infection remains a major cause of disease and death, underscoring the need for improved vaccines. Among current influenza vaccines, the live attenuated influenza vaccine (LAIV) is unique in its ability to elicit T-cell immunity to the conserved internal proteins of the virus. Despite this, LAIV has shown limited efficacy in recent years. One possible reason is that the conserved, internal genes of all current LAIVs derive from virus strains that were isolated between 1957 and 1960 and that, as a result, do not resemble currently circulating influenza viruses. We have therefore developed and tested a new LAIV, based on a currently circulating pandemic strain of influenza. Our results show that this new LAIV elicits improved protective immunity compared to a more conventional LAIV.</p></abstract><abstract><title>ABSTRACT</title><p>Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based, contains either the internal genes of the 1960 A/Ann Arbor/6/60 or the 1957 A/Leningrad/17/57 H2N2 viruses (i.e., they diverge considerably from currently circulating strains). We previously showed that introduction of the temperature-sensitive (<italic>ts</italic>) residue signature of the AA/60 MDV into a 2009 pandemic A/California/04/09 H1N1 virus (Cal/09) results in only 10-fold <italic>in vivo</italic> attenuation in mice. We have previously shown that the <italic>ts</italic> residue signature of the Russian A/Leningrad/17/57 H2N2 LAIV (Len LAIV) more robustly attenuates the prototypical A/Puerto Rico/8/1934 (PR8) H1N1 virus. In this work, we therefore introduced the <italic>ts</italic> signature from Len LAIV into Cal/09. This new Cal/09 LAIV is <italic>ts in vitro</italic>, highly attenuated (<italic>att</italic>) in mice, and protects from a lethal homologous challenge. In addition, when our Cal/09 LAIV with PR8 hemagglutinin and neuraminidase was used to vaccinate mice, it provided enhanced protection against a wild-type Cal/09 challenge relative to a PR8 LAIV with the same attenuating mutations. These findings suggest it may be possible to improve the efficacy of LAIVs by better matching the sequence of the MDV to currently circulating strains.</p><p><bold>IMPORTANCE</bold> Seasonal influenza infection remains a major cause of disease and death, underscoring the need for improved vaccines. Among current influenza vaccines, the live attenuated influenza vaccine (LAIV) is unique in its ability to elicit T-cell immunity to the conserved internal proteins of the virus. Despite this, LAIV has shown limited efficacy in recent years. One possible reason is that the conserved, internal genes of all current LAIVs derive from virus strains that were isolated between 1957 and 1960 and that, as a result, do not resemble currently circulating influenza viruses. We have therefore developed and tested a new LAIV, based on a currently circulating pandemic strain of influenza. Our results show that this new LAIV elicits improved protective immunity compared to a more conventional LAIV.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>influenza</kwd><kwd>live attenuated influenza vaccine</kwd><kwd>LAIV</kwd><kwd>inactivated influenza vaccine</kwd><kwd>IIV</kwd><kwd>master donor virus</kwd><kwd>MDV</kwd><kwd>heterologous immunity and protection</kwd></kwd-group><funding-group><award-group id="award1"><funding-source><institution-wrap><institution>HHS | National Institutes of Health (NIH)</institution><institution-id>https://doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id>T32GM068411</award-id><award-id>T32GM007356</award-id><principal-award-recipient><name><surname>Smith</surname><given-names>Andrew</given-names></name></principal-award-recipient></award-group><award-group id="award2"><funding-source><institution-wrap><institution>HHS | National Institutes of Health (NIH)</institution><institution-id>https://doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id>HHSN272201400005C</award-id><principal-award-recipient><name><surname>Topham</surname><given-names>David J.</given-names></name></principal-award-recipient></award-group><award-group id="award3"><funding-source><institution-wrap><institution>U.S. Department of Defense (DOD)</institution><institution-id>https://doi.org/10.13039/100000005</institution-id></institution-wrap></funding-source><award-id>W81XWH-17-1-0168</award-id><principal-award-recipient><name><surname>Dewhurst</surname><given-names>Stephen</given-names></name></principal-award-recipient></award-group><award-group id="award4"><funding-source><institution-wrap><institution>U.S. Department of Defense (DOD)</institution><institution-id>https://doi.org/10.13039/100000005</institution-id></institution-wrap></funding-source><award-id>W81XWH-18-1-0460</award-id><principal-award-recipient><name><surname>Martínez-Sobrido</surname><given-names>Luis</given-names></name></principal-award-recipient></award-group></funding-group><counts><fig-count count="7"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="63"></ref-count><page-count count="15"></page-count><word-count count="10726"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>February 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A22 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000A22 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:6997774
|texte= A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:31748399" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |