The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Identifieur interne : 000A12 ( Pmc/Curation ); précédent : 000A11; suivant : 000A13The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Auteurs : Xavier Saelens [Belgique]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2019.
Abstract
The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.
Url:
DOI: 10.1093/infdis/jiz003
PubMed: 30715367
PubMed Central: 6452325
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Xavier Saelens<affiliation><nlm:aff id="AF0001">VIB-UGent Center for Medical Biotechnology, Ghent</nlm:aff>
<wicri:noCountry code="subfield">Ghent</wicri:noCountry>
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<affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Biomedical Molecular Biology, Ghent University, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biomedical Molecular Biology, Ghent University</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="AF0003">Department of Biochemistry and Microbiology, Ghent University, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biochemistry and Microbiology, Ghent University</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30715367</article-id>
<article-id pub-id-type="pmc">6452325</article-id>
<article-id pub-id-type="doi">10.1093/infdis/jiz003</article-id>
<article-id pub-id-type="publisher-id">jiz003</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Supplement Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3861-6965</contrib-id>
<name><surname>Saelens</surname>
<given-names>Xavier</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="corresp" rid="c1"></xref>
<pmc-comment>Xavier.saelens@vib-ugent.be </pmc-comment>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
VIB-UGent Center for Medical Biotechnology, Ghent</aff>
<aff id="AF0002"><label>2</label>
Department of Biomedical Molecular Biology, Ghent University, Belgium</aff>
<aff id="AF0003"><label>3</label>
Department of Biochemistry and Microbiology, Ghent University, Belgium</aff>
<author-notes><corresp id="c1">Correspondence. X. Saelens, VIB-UGent Center for Medical Biotechnology, Technologiepark 927, 9052 Ghent, Belgium (<email>Xavier.saelens@vib-ugent.be</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2019-04-08"><day>08</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>08</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
<volume>219</volume>
<issue>Suppl 1</issue>
<issue-title>100 Years of Fighting Pandemic Influenza 1918/19–2018/19</issue-title>
<fpage>S68</fpage>
<lpage>S74</lpage>
<permissions><copyright-statement>© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="cc-by" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="jiz003.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.</p>
</abstract>
<kwd-group><kwd>M2e</kwd>
<kwd>universal influenza vaccine</kwd>
<kwd>clinical studies</kwd>
<kwd>Fc receptors</kwd>
</kwd-group>
<funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">Fonds voor Wetenschappelijk Onderzoek</named-content>
</funding-source>
<award-id>G043515N</award-id>
</award-group>
<award-group award-type="grant"><funding-source><named-content content-type="funder-name">Ghent University Bijzonder Onderzoeksfonds</named-content>
</funding-source>
<award-id>BOFGOA2017000502</award-id>
</award-group>
<award-group award-type="grant"><funding-source><named-content content-type="funder-name">Sanofi Pasteur</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><page-count count="7"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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