The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children
Identifieur interne : 000A00 ( Pmc/Curation ); précédent : 000999; suivant : 000A01The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children
Auteurs : Yang Fei ; Hongbo Zhang ; Chi ZhangSource :
- Journal of Clinical Laboratory Analysis [ 0887-8013 ] ; 2019.
Abstract
To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A–positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.
One hundred and ninety‐one influenza A–positive children, two hundred and nineteen influenza A–negative children with influenza‐like symptoms, and two hundred and forty‐seven healthy children were included in this study. They were divided into three groups: influenza A–positive patient group, influenza A–negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS‐800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte‐to‐monocyte ratio (LMR), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.
The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A–negative patients with influenza‐like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.
Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza‐like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.
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DOI: 10.1002/jcla.22995
PubMed: 31420904
PubMed Central: 6868406
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children</title><author><name sortKey="Fei, Yang" sort="Fei, Yang" uniqKey="Fei Y" first="Yang" last="Fei">Yang Fei</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Hongbo" sort="Zhang, Hongbo" uniqKey="Zhang H" first="Hongbo" last="Zhang">Hongbo Zhang</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Chi" sort="Zhang, Chi" uniqKey="Zhang C" first="Chi" last="Zhang">Chi Zhang</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31420904</idno><idno type="pmc">6868406</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868406</idno><idno type="RBID">PMC:6868406</idno><idno type="doi">10.1002/jcla.22995</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A00</idno><idno type="wicri:Area/Pmc/Curation">000A00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children</title><author><name sortKey="Fei, Yang" sort="Fei, Yang" uniqKey="Fei Y" first="Yang" last="Fei">Yang Fei</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Hongbo" sort="Zhang, Hongbo" uniqKey="Zhang H" first="Hongbo" last="Zhang">Hongbo Zhang</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Chi" sort="Zhang, Chi" uniqKey="Zhang C" first="Chi" last="Zhang">Chi Zhang</name><affiliation><nlm:aff id="jcla22995-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Laboratory Analysis</title><idno type="ISSN">0887-8013</idno><idno type="eISSN">1098-2825</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="jcla22995-sec-0001"><title>Background</title><p>To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A–positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.</p></sec><sec id="jcla22995-sec-0002"><title>Methods</title><p>One hundred and ninety‐one influenza A–positive children, two hundred and nineteen influenza A–negative children with influenza‐like symptoms, and two hundred and forty‐seven healthy children were included in this study. They were divided into three groups: influenza A–positive patient group, influenza A–negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS‐800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte‐to‐monocyte ratio (LMR), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.</p></sec><sec id="jcla22995-sec-0003"><title>Results</title><p>The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A–negative patients with influenza‐like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.</p></sec><sec id="jcla22995-sec-0004"><title>Conclusions</title><p>Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza‐like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Lab Anal</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Lab. Anal</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1098-2825</journal-id><journal-id journal-id-type="publisher-id">JCLA</journal-id><journal-title-group><journal-title>Journal of Clinical Laboratory Analysis</journal-title></journal-title-group><issn pub-type="ppub">0887-8013</issn><issn pub-type="epub">1098-2825</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31420904</article-id><article-id pub-id-type="pmc">6868406</article-id><article-id pub-id-type="doi">10.1002/jcla.22995</article-id><article-id pub-id-type="publisher-id">JCLA22995</article-id><article-categories><subj-group subj-group-type="overline"><subject>Research Article</subject></subj-group><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title>The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children</article-title><alt-title alt-title-type="left-running-head">Fei et al.</alt-title></title-group><contrib-group><contrib id="jcla22995-cr-0001" contrib-type="author"><name><surname>Fei</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="jcla22995-aff-0001"><sup>1</sup></xref></contrib><contrib id="jcla22995-cr-0002" contrib-type="author"><name><surname>Zhang</surname><given-names>Hongbo</given-names></name><xref ref-type="aff" rid="jcla22995-aff-0001"><sup>1</sup></xref></contrib><contrib id="jcla22995-cr-0003" contrib-type="author" corresp="yes"><name><surname>Zhang</surname><given-names>Chi</given-names></name><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2468-7068</contrib-id><xref ref-type="aff" rid="jcla22995-aff-0001"><sup>1</sup></xref><address><email>zccdfile@163.com</email></address></contrib></contrib-group><aff id="jcla22995-aff-0001"><label><sup>1</sup></label><named-content content-type="organisation-division">Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College</named-content><institution>Huazhong University of Science and Technology</institution><named-content content-type="city">Wuhan</named-content><country country="CN">China</country></aff><author-notes><corresp id="correspondenceTo"><label>*</label><bold>Correspondence</bold><break></break>Chi Zhang, Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, China.<break></break>Email: <email>zccdfile@163.com</email><break></break></corresp></author-notes><pub-date pub-type="epub"><day>16</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>11</month><year>2019</year></pub-date><volume>33</volume><issue>9</issue><issue-id pub-id-type="doi">10.1002/jcla.v33.9</issue-id><elocation-id>e22995</elocation-id><history><date date-type="received"><day>11</day><month>6</month><year>2019</year></date><date date-type="rev-recd"><day>13</day><month>7</month><year>2019</year></date><date date-type="accepted"><day>15</day><month>7</month><year>2019</year></date></history><permissions><pmc-comment> Copyright © 2019 Wiley Periodicals, Inc. </pmc-comment>
<copyright-statement content-type="article-copyright">© 2019 The Authors.<italic> Journal of Clinical Laboratory Analysis</italic> published by Wiley Periodicals, Inc.</copyright-statement><license license-type="creativeCommonsBy"><license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:JCLA-33-na.pdf"></self-uri><abstract id="jcla22995-abs-0001"><title>Abstract</title><sec id="jcla22995-sec-0001"><title>Background</title><p>To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A–positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.</p></sec><sec id="jcla22995-sec-0002"><title>Methods</title><p>One hundred and ninety‐one influenza A–positive children, two hundred and nineteen influenza A–negative children with influenza‐like symptoms, and two hundred and forty‐seven healthy children were included in this study. They were divided into three groups: influenza A–positive patient group, influenza A–negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS‐800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte‐to‐monocyte ratio (LMR), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.</p></sec><sec id="jcla22995-sec-0003"><title>Results</title><p>The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A–negative patients with influenza‐like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.</p></sec><sec id="jcla22995-sec-0004"><title>Conclusions</title><p>Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza‐like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.</p></sec></abstract><kwd-group kwd-group-type="author-generated"><kwd id="jcla22995-kwd-0001">influenza A</kwd><kwd id="jcla22995-kwd-0002">lymphopenia</kwd><kwd id="jcla22995-kwd-0003">mean platelet volume</kwd><kwd id="jcla22995-kwd-0004">thrombocytopenia</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="3"></table-count><page-count count="8"></page-count><word-count count="4860"></word-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>component-id</meta-name><meta-value>jcla22995</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>November 2019</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:5.7.2 mode:remove_FC converted:21.11.2019</meta-value></custom-meta></custom-meta-group></article-meta><notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="jcla22995-cit-1001"><string-name><surname>Fei</surname><given-names>Y</given-names></string-name>, <string-name><surname>Zhang</surname><given-names>H</given-names></string-name>, <string-name><surname>Zhang</surname><given-names>C</given-names></string-name>. <article-title>The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children</article-title>. <source xml:lang="en">J Clin Lab Anal</source>. <year>2019</year>;<volume>33</volume>:<elocation-id>e22995</elocation-id><pub-id pub-id-type="doi">10.1002/jcla.22995</pub-id></mixed-citation></p><fn-group id="jcla22995-ntgp-0001"><fn fn-type="equal" id="jcla22995-note-0001"><p>Yang, Hongbo are contributed equally to this work.</p></fn></fn-group></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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