Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine
Identifieur interne : 000938 ( Pmc/Curation ); précédent : 000937; suivant : 000939Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine
Auteurs : Chao Qiu ; Yang Huang [République populaire de Chine] ; Qian Wang [République populaire de Chine] ; Di Tian ; Wanju Zhang ; Yunwen Hu ; Zhenghong Yuan ; Xiaoyan Zhang ; Jianqing XuSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2011.
Abstract
Our data demonstrated that the inoculation with vaccine derived from the 2009 pandemic influenza raised vigorous neutralization antibodies against both cognate H1N1 and heterotypic influenza viruses. This observation has important implication for vaccine development.
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DOI: 10.1093/cid/cir753
PubMed: 22052887
PubMed Central: 3243653
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Chao Qiu<affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine</title><author><name sortKey="Qiu, Chao" sort="Qiu, Chao" uniqKey="Qiu C" first="Chao" last="Qiu">Chao Qiu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Huang, Yang" sort="Huang, Yang" uniqKey="Huang Y" first="Yang" last="Huang">Yang Huang</name><affiliation wicri:level="1"><nlm:aff id="aff3">VacDiagn Biotechnology, Suzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VacDiagn Biotechnology, Suzhou</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name><affiliation wicri:level="1"><nlm:aff id="aff3">VacDiagn Biotechnology, Suzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VacDiagn Biotechnology, Suzhou</wicri:regionArea></affiliation></author><author><name sortKey="Tian, Di" sort="Tian, Di" uniqKey="Tian D" first="Di" last="Tian">Di Tian</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Wanju" sort="Zhang, Wanju" uniqKey="Zhang W" first="Wanju" last="Zhang">Wanju Zhang</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Hu, Yunwen" sort="Hu, Yunwen" uniqKey="Hu Y" first="Yunwen" last="Hu">Yunwen Hu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Zhenghong" sort="Yuan, Zhenghong" uniqKey="Yuan Z" first="Zhenghong" last="Yuan">Zhenghong Yuan</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Xiaoyan" sort="Zhang, Xiaoyan" uniqKey="Zhang X" first="Xiaoyan" last="Zhang">Xiaoyan Zhang</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Jianqing" sort="Xu, Jianqing" uniqKey="Xu J" first="Jianqing" last="Xu">Jianqing Xu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22052887</idno><idno type="pmc">3243653</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243653</idno><idno type="RBID">PMC:3243653</idno><idno type="doi">10.1093/cid/cir753</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000938</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000938</idno><idno type="wicri:Area/Pmc/Curation">000938</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine</title><author><name sortKey="Qiu, Chao" sort="Qiu, Chao" uniqKey="Qiu C" first="Chao" last="Qiu">Chao Qiu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Huang, Yang" sort="Huang, Yang" uniqKey="Huang Y" first="Yang" last="Huang">Yang Huang</name><affiliation wicri:level="1"><nlm:aff id="aff3">VacDiagn Biotechnology, Suzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VacDiagn Biotechnology, Suzhou</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name><affiliation wicri:level="1"><nlm:aff id="aff3">VacDiagn Biotechnology, Suzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VacDiagn Biotechnology, Suzhou</wicri:regionArea></affiliation></author><author><name sortKey="Tian, Di" sort="Tian, Di" uniqKey="Tian D" first="Di" last="Tian">Di Tian</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Wanju" sort="Zhang, Wanju" uniqKey="Zhang W" first="Wanju" last="Zhang">Wanju Zhang</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Hu, Yunwen" sort="Hu, Yunwen" uniqKey="Hu Y" first="Yunwen" last="Hu">Yunwen Hu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Zhenghong" sort="Yuan, Zhenghong" uniqKey="Yuan Z" first="Zhenghong" last="Yuan">Zhenghong Yuan</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Xiaoyan" sort="Zhang, Xiaoyan" uniqKey="Zhang X" first="Xiaoyan" last="Zhang">Xiaoyan Zhang</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Jianqing" sort="Xu, Jianqing" uniqKey="Xu J" first="Jianqing" last="Xu">Jianqing Xu</name><affiliation><nlm:aff id="aff1">Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</nlm:aff><wicri:noCountry code="subfield">Institutes of Biomedical Sciences</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</nlm:aff><wicri:noCountry code="subfield">Shanghai</wicri:noCountry></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our data demonstrated that the inoculation with vaccine derived from the 2009 pandemic influenza raised vigorous neutralization antibodies against both cognate H1N1 and heterotypic influenza viruses. This observation has important implication for vaccine development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Fc" uniqKey="Zhu F">FC Zhu</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Fang, Hh" uniqKey="Fang H">HH Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Middleton D">D Middleton</name></author><author><name sortKey="Lowther, S" uniqKey="Lowther S">S Lowther</name></author><author><name sortKey="Kelso, A" uniqKey="Kelso A">A Kelso</name></author><author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name></author><author><name sortKey="Van De Velde, La" uniqKey="Van De Velde L">LA Van De Velde</name></author><author><name sortKey="Allison, Kj" uniqKey="Allison K">KJ Allison</name></author><author><name sortKey="Branum, Kc" uniqKey="Branum K">KC Branum</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Flynn, Pm" uniqKey="Flynn P">PM Flynn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Vj" uniqKey="Lee V">VJ Lee</name></author><author><name sortKey="Tay, Jk" uniqKey="Tay J">JK Tay</name></author><author><name sortKey="Chen, Mi" uniqKey="Chen M">MI Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichinohe, T" uniqKey="Ichinohe T">T Ichinohe</name></author><author><name sortKey="Tamura, S" uniqKey="Tamura S">S Tamura</name></author><author><name sortKey="Kawaguchi, A" uniqKey="Kawaguchi A">A Kawaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quan, Fs" uniqKey="Quan F">FS Quan</name></author><author><name sortKey="Compans, Rw" uniqKey="Compans R">RW Compans</name></author><author><name sortKey="Nguyen, Hh" uniqKey="Nguyen H">HH Nguyen</name></author><author><name sortKey="Kang, Sm" uniqKey="Kang S">SM Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J Sheehan</name></author><author><name sortKey="Hwang, Wc" uniqKey="Hwang W">WC 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22052887</article-id><article-id pub-id-type="pmc">3243653</article-id><article-id pub-id-type="doi">10.1093/cid/cir753</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject></subj-group></article-categories><title-group><article-title>Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Qiu</surname><given-names>Chao</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="author-notes" rid="fn1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="author-notes" rid="fn1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qian</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tian</surname><given-names>Di</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Wanju</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Yunwen</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Zhenghong</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Xiaoyan</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Xu</surname><given-names>Jianqing</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences</aff><aff id="aff2"><label>2</label>Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Fudan University, Shanghai</aff><aff id="aff3"><label>3</label>VacDiagn Biotechnology, Suzhou, China</aff><author-notes><corresp>Correspondence: Jianqing Xu, PhD, Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Shanghai, China (<email>jianqingxu2008@gmail.com</email>).</corresp><fn id="fn1"><label>a</label><p>C. Q. and Y. H. contributed equally to this article.</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>3</day><month>11</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>11</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>54</volume><issue>1</issue><fpage>17</fpage><lpage>24</lpage><history><date date-type="received"><day>21</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>12</day><month>9</month><year>2011</year></date></history><permissions><copyright-statement>© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please email:journals.permissions@oup.com.</copyright-statement><copyright-year>2011</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract abstract-type="precis"><p>Our data demonstrated that the inoculation with vaccine derived from the 2009 pandemic influenza raised vigorous neutralization antibodies against both cognate H1N1 and heterotypic influenza viruses. This observation has important implication for vaccine development.</p></abstract><abstract><p><bold><italic>Background.</italic></bold> A mass vaccination has been implemented to prevent the spread of 2009 pandemic influenza virus in China. Highly limited information is available on whether this vaccine induces cross-reactive neutralization antibodies against other subtypes of influenza viruses.</p><p><bold><italic>Methods.</italic></bold> We employed pseudovirus-based assays to analyze heterosubtypic neutralization responses in serum samples of 23 recipients of 2009 pandemic influenza vaccine.</p><p><bold><italic>Results.</italic></bold> One dose of pandemic vaccine not only stimulated good neutralization antibodies against cognate influenza virus 2009 influenza A (H1N1), but also raised broad cross-reactive neutralization activities against seasonal H3N2 and highly pathogenic avian influenza virus H5N1 and lesser to H2N2. The cross-reactive neutralization activities were completely abolished after the removal of immunoglobin G (IgG). In contrast, H1N1 vaccination alone in influenza-naive mice elicited only vigorous homologous neutralizing activities but not cross-reactive neutralization activities.</p><p><bold><italic>Conclusions.</italic></bold> Our data suggest that the cross-reactive neutralization epitopes do exist in this vaccine and could elicit significant cross-reactive neutralizing IgG antibodies in the presence of preexisting responses. The exposure to H1N1 vaccine is likely to modify the hierarchical order of preexisting immune responses to influenza viruses. These findings provide insights into the evolution of human immunity to influenza viruses after experiencing multiple influenza virus infections and vaccinations.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22052887" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |