Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010
Identifieur interne : 000921 ( Pmc/Curation ); précédent : 000920; suivant : 000922Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010
Auteurs : Ritsuko Kubota-Koketsu ; Mikihiro Yunoki [Japon] ; Yoshinobu Okuno ; Kazuyoshi IkutaSource :
- Biologics : Targets & Therapy [ 1177-5475 ] ; 2012.
Abstract
Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957 to 1967, although there have been no cases reported in humans in the past 40 years. A vaccination program was introduced in Japan in the 1960s. Older Japanese donors could have been naturally infected with the H2N2 virus or vaccinated in the early 1960s. Human intravenous immunoglobulin (IVIG) reflects the epidemiological status of the donating population in a given time period. Here, the possible viral neutralizing (VN) activities of IVIG against the H2N2 virus were examined. Hemagglutination inhibition (HI) and VN activities of IVIG lots manufactured from 1993 to 2010 in Japan and the United States were evaluated against H2N2 viruses. High HI and VN activities against H2N2 viruses were found in all the IVIG lots investigated. HI titers were 32–64 against the isolate in 1957 and 64–128 against the isolates in 1965. VN titers were 80–320 against the isolate in 1957 and 1280–5120 against the isolates in 1965. Both the HI and VN titers were higher against the isolate in 1965 than in 1957. Thus, antibody titers of IVIG against influenza viruses are well correlated with the history of infection and the vaccine program in Japan. Therefore, evaluation of antibody titers provides valuable information about IVIGs, which could be used for immune stimulation when a new influenza virus emerges in the human population.
Url:
DOI: 10.2147/BTT.S33495
PubMed: 22888217
PubMed Central: 3413397
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000921
Links to Exploration step
PMC:3413397Curation
No country items
Ritsuko Kubota-Koketsu<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-btt-6-245">Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Pathogenic Risk Management, Benesis Corporation, Osaka</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010</title>
<author><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-btt-6-245">Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Pathogenic Risk Management, Benesis Corporation, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22888217</idno>
<idno type="pmc">3413397</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413397</idno>
<idno type="RBID">PMC:3413397</idno>
<idno type="doi">10.2147/BTT.S33495</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000921</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000921</idno>
<idno type="wicri:Area/Pmc/Curation">000921</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000921</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010</title>
<author><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-btt-6-245">Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Pathogenic Risk Management, Benesis Corporation, Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Biologics : Targets & Therapy</title>
<idno type="ISSN">1177-5475</idno>
<idno type="eISSN">1177-5491</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957
to 1967, although there have been no cases reported in humans in the past 40
years. A vaccination program was introduced in Japan in the 1960s. Older
Japanese donors could have been naturally infected with the H2N2 virus or
vaccinated in the early 1960s. Human intravenous immunoglobulin (IVIG) reflects
the epidemiological status of the donating population in a given time period.
Here, the possible viral neutralizing (VN) activities of IVIG against the H2N2
virus were examined. Hemagglutination inhibition (HI) and VN activities of IVIG
lots manufactured from 1993 to 2010 in Japan and the United States were
evaluated against H2N2 viruses. High HI and VN activities against H2N2 viruses
were found in all the IVIG lots investigated. HI titers were 32–64
against the isolate in 1957 and 64–128 against the isolates in 1965. VN
titers were 80–320 against the isolate in 1957 and 1280–5120
against the isolates in 1965. Both the HI and VN titers were higher against the
isolate in 1965 than in 1957. Thus, antibody titers of IVIG against influenza
viruses are well correlated with the history of infection and the vaccine
program in Japan. Therefore, evaluation of antibody titers provides valuable
information about IVIGs, which could be used for immune stimulation when a new
influenza virus emerges in the human population.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hirota, Y" uniqKey="Hirota Y">Y Hirota</name>
</author>
<author><name sortKey="Kaji, M" uniqKey="Kaji M">M Kaji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name>
</author>
<author><name sortKey="Vincent, Al" uniqKey="Vincent A">AL Vincent</name>
</author>
<author><name sortKey="Gramer, Mr" uniqKey="Gramer M">MR Gramer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yunoki, M" uniqKey="Yunoki M">M Yunoki</name>
</author>
<author><name sortKey="Kubota Koketsu, R" uniqKey="Kubota Koketsu R">R Kubota-Koketsu</name>
</author>
<author><name sortKey="Urayama, T" uniqKey="Urayama T">T Urayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name>
</author>
<author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K Tanaka</name>
</author>
<author><name sortKey="Baba, K" uniqKey="Baba K">K Baba</name>
</author>
<author><name sortKey="Maeda, A" uniqKey="Maeda A">A Maeda</name>
</author>
<author><name sortKey="Kunita, N" uniqKey="Kunita N">N Kunita</name>
</author>
<author><name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name>
</author>
<author><name sortKey="Wei, Cj" uniqKey="Wei C">CJ Wei</name>
</author>
<author><name sortKey="Ledgerwood, Je" uniqKey="Ledgerwood J">JE Ledgerwood</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biologics</journal-id>
<journal-id journal-id-type="iso-abbrev">Biologics</journal-id>
<journal-id journal-id-type="publisher-id">Biologics: Targets &
Therapy</journal-id>
<journal-title-group><journal-title>Biologics : Targets & Therapy</journal-title>
</journal-title-group>
<issn pub-type="ppub">1177-5475</issn>
<issn pub-type="epub">1177-5491</issn>
<publisher><publisher-name>Dove Medical Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22888217</article-id>
<article-id pub-id-type="pmc">3413397</article-id>
<article-id pub-id-type="doi">10.2147/BTT.S33495</article-id>
<article-id pub-id-type="publisher-id">btt-6-245</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kubota-Koketsu</surname>
<given-names>Ritsuko</given-names>
</name>
<xref ref-type="aff" rid="af1-btt-6-245"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af2-btt-6-245"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yunoki</surname>
<given-names>Mikihiro</given-names>
</name>
<xref ref-type="aff" rid="af2-btt-6-245"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af3-btt-6-245"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Okuno</surname>
<given-names>Yoshinobu</given-names>
</name>
<xref ref-type="aff" rid="af1-btt-6-245"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ikuta</surname>
<given-names>Kazuyoshi</given-names>
</name>
<xref ref-type="aff" rid="af2-btt-6-245"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="c1-btt-6-245"></xref>
</contrib>
</contrib-group>
<aff id="af1-btt-6-245"><label>1</label>
Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</aff>
<aff id="af2-btt-6-245"><label>2</label>
Department of Virology, Research Institute for Microbial Diseases, Osaka University</aff>
<aff id="af3-btt-6-245"><label>3</label>
Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</aff>
<author-notes><corresp id="c1-btt-6-245">Correspondence: Kazuyoshi Ikuta, Department of Virology,
Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka,
Suita, Osaka 565-0871, Japan, Tel +81 6 6879 8307, Fax +81 6
6879 8310, Email <email>ikuta@biken.osaka-u.ac.jp</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>7</month>
<year>2012</year>
</pub-date>
<volume>6</volume>
<fpage>245</fpage>
<lpage>247</lpage>
<history><date date-type="received"><day>26</day>
<month>7</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© 2012 Kubota-Koketsu et al, publisher and licensee Dove
Medical Press Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<license><license-p>This is an Open Access article which permits unrestricted noncommercial use,
provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957
to 1967, although there have been no cases reported in humans in the past 40
years. A vaccination program was introduced in Japan in the 1960s. Older
Japanese donors could have been naturally infected with the H2N2 virus or
vaccinated in the early 1960s. Human intravenous immunoglobulin (IVIG) reflects
the epidemiological status of the donating population in a given time period.
Here, the possible viral neutralizing (VN) activities of IVIG against the H2N2
virus were examined. Hemagglutination inhibition (HI) and VN activities of IVIG
lots manufactured from 1993 to 2010 in Japan and the United States were
evaluated against H2N2 viruses. High HI and VN activities against H2N2 viruses
were found in all the IVIG lots investigated. HI titers were 32–64
against the isolate in 1957 and 64–128 against the isolates in 1965. VN
titers were 80–320 against the isolate in 1957 and 1280–5120
against the isolates in 1965. Both the HI and VN titers were higher against the
isolate in 1965 than in 1957. Thus, antibody titers of IVIG against influenza
viruses are well correlated with the history of infection and the vaccine
program in Japan. Therefore, evaluation of antibody titers provides valuable
information about IVIGs, which could be used for immune stimulation when a new
influenza virus emerges in the human population.</p>
</abstract>
<kwd-group><kwd>IVIG</kwd>
<kwd>influenza</kwd>
<kwd>H2N2</kwd>
<kwd>neutralization</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><table-wrap id="t1-btt-6-245" position="float"><label>Table 1</label>
<caption><p>Cross-reactivity of intravenous immunoglobulins to the influenza H2N2
virus</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="3" colspan="1"><bold>IVIG</bold>
</th>
<th colspan="6" align="left" valign="top" rowspan="1"><bold>H2N2 virus</bold>
<hr></hr>
</th>
</tr>
<tr><th colspan="2" align="left" valign="top" rowspan="1"><bold>Okuda/1957</bold>
<hr></hr>
</th>
<th colspan="2" align="left" valign="top" rowspan="1"><bold>Izumi/5/1965</bold>
<hr></hr>
</th>
<th colspan="2" align="left" valign="top" rowspan="1"><bold>Kaizuka/2/1965</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" rowspan="1" colspan="1"><bold>HI</bold>
</th>
<th align="left" valign="top" rowspan="1" colspan="1"><bold>VN<sub>50</sub>
</bold>
</th>
<th align="left" valign="top" rowspan="1" colspan="1"><bold>HI</bold>
</th>
<th align="left" valign="top" rowspan="1" colspan="1"><bold>VN<sub>50</sub>
</bold>
</th>
<th align="left" valign="top" rowspan="1" colspan="1"><bold>HI</bold>
</th>
<th align="left" valign="top" rowspan="1" colspan="1"><bold>VN<sub>50</sub>
</bold>
</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">1993JP, Lot A</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1993US, Lot B</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">320</td>
<td align="left" valign="top" rowspan="1" colspan="1">128</td>
<td align="left" valign="top" rowspan="1" colspan="1">5120</td>
<td align="left" valign="top" rowspan="1" colspan="1">128</td>
<td align="left" valign="top" rowspan="1" colspan="1">2560</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1999JP-A, Lot C</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1999JP-B, Lot D</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">80</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1999JP-C, Lot E</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1999JP-D, Lot F</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">1999US, Lot G</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">320</td>
<td align="left" valign="top" rowspan="1" colspan="1">128</td>
<td align="left" valign="top" rowspan="1" colspan="1">5120</td>
<td align="left" valign="top" rowspan="1" colspan="1">128</td>
<td align="left" valign="top" rowspan="1" colspan="1">2560</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2000JP, Lot H</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2003JP, Lot I</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">80</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2006JP, Lot J</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2007JP, Lot K</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2008JP, Lot L</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">160</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2009JP, Lot M</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">80</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">2010JP, Lot N</td>
<td align="left" valign="top" rowspan="1" colspan="1">32</td>
<td align="left" valign="top" rowspan="1" colspan="1">80</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">1280</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn1-btt-6-245"><p><bold>Abbreviations:</bold>
HI, hemagglutination inhibition titer; IVIG,
intravenous immunoglobulin; JP, Japan; US, United States;
VN<sub>50</sub>
, virus neutralization titer giving 50%
inhibition of infectivity.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000921 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000921 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:3413397 |texte= Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010 }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22888217" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |