Predicting “Airborne” Influenza Viruses: (Trans-) mission Impossible?
Identifieur interne : 000579 ( Pmc/Curation ); précédent : 000578; suivant : 000580Predicting “Airborne” Influenza Viruses: (Trans-) mission Impossible?
Auteurs : E. M. Sorrell [Pays-Bas] ; E. J. A. Schrauwen [Pays-Bas] ; M. Linster [Pays-Bas] ; M. De Graaf [Royaume-Uni] ; S. Herfst [Pays-Bas] ; R. A. M. Fouchier [Pays-Bas]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2011.
Abstract
Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine – out of thousands of influenza virus isolates collected in animal surveillance studies each year – which viruses have the potential to become “airborne”, and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that the minimal requirements for efficient transmission of an animal influenza virus between humans are: efficient virus attachment to (upper) respiratory tissues, replication to high titers in these tissues, and release and aerosolization of single virus particles. Investigating “airborne” transmission of influenza viruses is key to understand – and predict – influenza pandemics.
Url:
DOI: 10.1016/j.coviro.2011.07.003
PubMed: 22440921
PubMed Central: 3311991
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Schrauwen</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Linster, M" sort="Linster, M" uniqKey="Linster M" first="M." last="Linster">M. Linster</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Graaf, M" sort="De Graaf, M" uniqKey="De Graaf M" first="M." last="De Graaf">M. De Graaf</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ</wicri:regionArea></affiliation></author><author><name sortKey="Herfst, S" sort="Herfst, S" uniqKey="Herfst S" first="S." last="Herfst">S. Herfst</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. 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Sorrell</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Schrauwen, E J A" sort="Schrauwen, E J A" uniqKey="Schrauwen E" first="E. J. A." last="Schrauwen">E. J. A. Schrauwen</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Linster, M" sort="Linster, M" uniqKey="Linster M" first="M." last="Linster">M. Linster</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Graaf, M" sort="De Graaf, M" uniqKey="De Graaf M" first="M." last="De Graaf">M. De Graaf</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ</wicri:regionArea></affiliation></author><author><name sortKey="Herfst, S" sort="Herfst, S" uniqKey="Herfst S" first="S." last="Herfst">S. Herfst</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fouchier, R A M" sort="Fouchier, R A M" uniqKey="Fouchier R" first="R. A. M." last="Fouchier">R. A. M. Fouchier</name><affiliation wicri:level="1"><nlm:aff id="A1">National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine – out of thousands of influenza virus isolates collected in animal surveillance studies each year – which viruses have the potential to become “airborne”, and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that the minimal requirements for efficient transmission of an animal influenza virus between humans are: efficient virus attachment to (upper) respiratory tissues, replication to high titers in these tissues, and release and aerosolization of single virus particles. Investigating “airborne” transmission of influenza viruses is key to understand – and predict – influenza pandemics.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101560941</journal-id><journal-id journal-id-type="pubmed-jr-id">39304</journal-id><journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Opin Virol</journal-id><journal-title-group><journal-title>Current Opinion in Virology</journal-title></journal-title-group><issn pub-type="ppub">1879-6257</issn><issn pub-type="epub">1879-6265</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22440921</article-id><article-id pub-id-type="pmc">3311991</article-id><article-id pub-id-type="doi">10.1016/j.coviro.2011.07.003</article-id><article-id pub-id-type="manuscript">NIHMS320587</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Predicting “Airborne” Influenza Viruses: (Trans-) mission Impossible?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sorrell</surname><given-names>E.M.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Schrauwen</surname><given-names>E.J.A.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Linster</surname><given-names>M.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>De Graaf</surname><given-names>M.</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Herfst</surname><given-names>S.</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Fouchier</surname><given-names>R.A.M.</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, P.O. Box 2040, 3000CA Rotterdam, The Netherlands</aff><aff id="A2"><label>b</label>Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom</aff><author-notes><corresp id="FN1">Corresponding Author Ron A.M. Fouchier, Erasmus Medical Center, P.O. Box 2040, 3000CA Rotterdam, The Netherlands, Phone +31 10 7044066, Fax +31 10 7044760</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>3</day><month>9</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2012</year></pub-date><volume>1</volume><issue>6</issue><fpage>635</fpage><lpage>642</lpage><abstract><p id="P1">Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine – out of thousands of influenza virus isolates collected in animal surveillance studies each year – which viruses have the potential to become “airborne”, and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that the minimal requirements for efficient transmission of an animal influenza virus between humans are: efficient virus attachment to (upper) respiratory tissues, replication to high titers in these tissues, and release and aerosolization of single virus particles. Investigating “airborne” transmission of influenza viruses is key to understand – and predict – influenza pandemics.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>HHSN266200700010C || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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